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Protein Page:
SESN2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SESN2 Involved in the reduction of peroxiredoxins. Widely expressed. Belongs to the sestrin family. Note: This description may include information from UniProtKB.
Protein type: Enzyme, misc.
Chromosomal Location of Human Ortholog: 1p35.3
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding
Biological Process: fatty acid beta-oxidation; glucose import; protein kinase B signaling cascade; response to glucose stimulus; autophagy; mitochondrial DNA metabolic process; response to insulin stimulus
Reference #:  P58004 (UniProtKB)
Alt. Names/Synonyms: DKFZp761M0212; DKFZp761M02121; Hi95; hypoxia induced gene 95; SES2; SESN2; SEST2; sestrin 2; Sestrin-2
Gene Symbols: SESN2
Molecular weight: 54,494 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SESN2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S45-p RRGPRGPsAFIPVEE
0 3 S249-p SRDPLNNsGGFESAR
0 1 Y323-p VEDPTFGyEDFTRRG
0 1 K434-ub TVACYPEkTTRRMYN
0 1 Y470-p RMQAALLyALRAITR
  mouse

 
S45 RRGSRGPSAFIPVEE
S249 SGDPLNNSGGFEAAR
Y323 VEDPAFGYEDFTRRG
K434 TVACYPEKTTRRMYN
Y470 RMQAALLYALRAITR
  rat

 
S45 RRGPRGPSAFIPVEE
S249-p SRDPLNNsGGFEAAR
Y323 VEDPTFGYEDFTRRG
K434 TVACYPEKTTRRMYN
Y470 RMQAALLYALRAITR
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