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Protein Page:
PCDH15 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PCDH15 Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function. Defects in PCDH15 are the cause of Usher syndrome type 1F (USH1F). USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness. Defects in PCDH15 are a cause of Usher syndrome type 1D/F (USH1DF). USH1DF patients are heterozygous for mutations in CDH23 and PCDH15, indicating a digenic inheritance pattern. Defects in PCDH15 are the cause of deafness autosomal recessive type 23 (DFNB23). DFNB23 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell adhesion; Cell development/differentiation
Cellular Component: stereocilium; extracellular space; photoreceptor outer segment; membrane; cytoplasm; plasma membrane; extracellular region; integral to membrane; synapse
Molecular Function: protein binding; calcium ion binding
Biological Process: startle response; adult locomotory behavior; righting reflex; multicellular organism growth; photoreceptor cell maintenance; actin filament organization; auditory receptor cell differentiation; locomotory behavior; detection of mechanical stimulus involved in sensory perception of sound; adult walking behavior; detection of mechanical stimulus involved in equilibrioception; sensory perception of sound; visual perception; sensory cilium biogenesis; sensory perception of light stimulus; morphogenesis of an epithelium; auditory receptor cell stereocilium organization and biogenesis; cell adhesion; homophilic cell adhesion; inner ear development; equilibrioception
Reference #:  Q99PJ1 (UniProtKB)
Alt. Names/Synonyms: Ames waltzer; BB078305; ENSMUSG00000046980; Gm9815; nmf19; PCD15; Pcdh15; protocadherin 15; protocadherin-15; Ush1f
Gene Symbols: Pcdh15
Molecular weight: 214,738 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Select Structure to View Below

PCDH15

Protein Structure Not Found.


STRING  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

► Hide Isoforms
 
0 1 S55-p IVAIDEEsRNGtILV
0 1 T59-p DEEsRNGtILVDNML
0 1 K68-ub LVDNMLIkGTAGGPD
0 1 T77-p TAGGPDPtIELSLKD
0 1 T353 HPRTAELTLLEPVNR
0 1 Y584 ELIVGQTYALTVQAS
0 2 Y777-p ITSNGSIytAVKLNR
0 1 T778-p TSNGSIytAVKLNRE
0 1 S863 NVSYRIRSPEVKHLF
0 1 K946-ac MVAPDAVkGTPITTV
0 1 Y1154 PVFQKKFYIGGVSED
0 1 Y1186 GNYSAMAYRLIIPPI
0 1 P1508 EPAHVEGPLKESQPN
0 1 P1524 ARTFSFVPDEDNLST
0 1 Y1536 LSTHNPLYMESIGQR
0 1 S1569 RTQVKSQSLRGPREK
0 1 S1584 IQRVWNQSVSFPRRL
0 1 S1586 RVWNQSVSFPRRLMW
0 1 S1629 HPSQRGSSNVLLATE
0 2 K1875 KGILRHVKNLAELEK
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
  PCDH15 iso10  
S55 IVAIDEESRNGTILV
T59 DEESRNGTILVDNML
K68 LVDNMLIKGTAGGPD
T77 TAGGPDPTIELSLKD
T353 HPRTAELTLLEPVNR
Y591 ELIVGQTYALTVQAS
Y784 ITSNGSIYTAVKLNR
T785 TSNGSIYTAVKLNRE
S870 NVSYRIRSPEVKHLF
K953 MVAPDAVKGTPITTV
Y1161 PVFQKKFYIGGVSED
Y1193 GNYSAMAYRLIIPPI
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
R1546-m1 PTYPTWKrARIFPMI
S1629 ETTEESESETPSEEA
S1633 ESESETPSEEAEESS
T1641 EEAEESSTPESEESE
S1652 EESESTESEGEKARK
- gap
  human

► Hide Isoforms
 
S50 IVAIDEESRNGTILV
T54 DEESRNGTILVDNML
K63 LVDNMLIKGTAGGPD
T72 TAGGPDPTIELSLKD
S348-p HPRTAELsLLEPVNR
Y579-p EMIVGRTyALTVQAA
Y772 ITSNGSIYTAVKLNR
T773 TSNGSIYTAVKLNRE
S858-p NVSYRIRsPEVKHFF
K941 MVAPDAVKGTPITTV
Y1149-p PVFQKKFyIGGVSED
Y1181-p GNYSVMAyRLIIPPI
S1501-p KSAHVDGsLKSNKLK
S1517-p ARKFTFLsDEDDLSA
Y1529-p LSAHNPLyKENISQV
S1562-p KIQAKSKsLRGPREK
S1577-p IQRLWSQsVsLPRRL
S1579-p RLWSQsVsLPRRLMR
S1622-p CTNKRGSsNPLLTTE
K1887-ac KGILRHVkNLAELEK
- gap
- gap
- gap
- gap
- gap
- gap
  PCDH15 iso4  
S50 IVAIDEESRNGTILV
T54 DEESRNGTILVDNML
K63 LVDNMLIKGTAGGPD
T72 TAGGPDPTIELSLKD
S348 HPRTAELSLLEPVNR
Y579 EMIVGRTYALTVQAA
Y701 ITSNGSIYTAVKLNR
T702 TSNGSIYTAVKLNRE
S787 NVSYRIRSPEVKHFF
K870 MVAPDAVKGTPITTV
Y1078 PVFQKKFYIGGVSED
Y1110 GNYSVMAYRLIIPPI
S1432 KSAHVDGSLKSNKLK
S1448 ARKFTFLSDEDDLSA
Y1460 LSAHNPLYKENISQV
S1493 KIQAKSKSLRGPREK
S1508 IQRLWSQSVSLPRRL
S1510 RLWSQSVSLPRRLMR
S1553 CTNKRGSSNPLLTTE
K1818 KGILRHVKNLAELEK
- gap
- gap
- gap
- gap
- gap
- gap
  PCDH15 iso5  
S55 IVAIDEESRNGTILV
T59 DEESRNGTILVDNML
K68 LVDNMLIKGTAGGPD
T77 TAGGPDPTIELSLKD
S353 HPRTAELSLLEPVNR
Y591 EMIVGRTYALTVQAA
Y784 ITSNGSIYTAVKLNR
T785 TSNGSIYTAVKLNRE
S870 NVSYRIRSPEVKHFF
K953 MVAPDAVKGTPITTV
Y1161 PVFQKKFYIGGVSED
Y1193 GNYSVMAYRLIIPPI
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
R1547 PTYTTWKRARIFPMI
S1633-p TTEEESEsETPsEEE
S1637-p ESEsETPsEEEESSt
T1644-p sEEEESStPESEESE
S1655-p EESESTEsEGEKARK
- gap
  PCDH15 iso15  
S50 IVAIDEESRNGTILV
T54 DEESRNGTILVDNML
K63 LVDNMLIKGTAGGPD
T72 TAGGPDPTIELSLKD
S348 HPRTAELSLLEPVNR
Y579 EMIVGRTYALTVQAA
Y772 ITSNGSIYTAVKLNR
T773 TSNGSIYTAVKLNRE
S858 NVSYRIRSPEVKHFF
K941 MVAPDAVKGTPITTV
Y1149 PVFQKKFYIGGVSED
Y1181 GNYSVMAYRLIIPPI
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Y1507-p KLVVDREyETSSTGE
  rat

 
S56 SGPLEEQSRSGTILV
T60 EEQSRSGTILVDNML
K69 LVDNMLIKGTAGGPD
T78 TAGGPDPTIELSLKD
T354 HPRTAELTLLEPVNR
Y585 ELVVGQTYALTVQAS
Y778-p ITSNGSIyTAVKLNR
T779 TSNGSIyTAVKLNRE
S864 NVSYRIRSPEVKHLF
K947 MVAPDAVKGTPITTV
Y1155 PVFQKKFYIGGVSED
Y1187 GNYSAMAYRLIIPPI
P1507 EPAHVEGPLDNQANP
P1522 ARTFSFLPDEDDLST
Y1534 LSTHNPLYMESIGQR
S1567 RTQVKSQSLRGPREK
S1582 IQRVWNQSVRFPRRL
R1584 RVWNQSVRFPRRLMW
S1627 HPSQQGSSNLMVTTE
K1873 KGILRHVKNLAELEK
- gap
- gap
- gap
- gap
- gap
- gap
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