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Protein Page:
CCND2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CCND2 Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/p27Kip1, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/p27Kip1 required for nuclear translocation and modulation of CDK4-mediated kinase activity. Belongs to the cyclin family. Cyclin D subfamily. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cell cycle regulation
Cellular Component: nuclear membrane; cyclin-dependent protein kinase holoenzyme complex; nucleolus; chromatin; nucleus; cytosol
Molecular Function: protein binding; protein kinase binding
Biological Process: positive regulation of cyclin-dependent protein kinase activity; cell division; positive regulation of protein amino acid phosphorylation; cell cycle
Reference #:  P30279 (UniProtKB)
Alt. Names/Synonyms: CCND2; cyclin D2; G1/S-specific cyclin D2; G1/S-specific cyclin-D2; KIAK0002; MGC102758
Gene Symbols: CCND2
Molecular weight: 33,067 Da
Basal Isoelectric point: 5.06  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CCND2

Protein Structure Not Found.


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Sites Implicated In
protein degradation: T280‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 K49-ub SYFKCVQkDIQPYMR
0 3 K113-ub MFLASKLkETSPLTA
0 2 K244-ub NTDVDCLkACQEQIE
0 4 S269-p RQDQRDGsKsEDELD
0 4 S271-p DQRDGsKsEDELDQA
0 1 S279-p EDELDQAstPtDVRD
3 11 T280-p DELDQAstPtDVRDI
0 4 T282-p LDQAstPtDVRDIDL
  mouse

 
K48 SYFKCVQKDIQPYMR
K112 MFLASKLKETIPLTA
K243 HTDVDCLKACQEQIE
S269 QEQHNAGSKSVEDPD
S271 QHNAGSKSVEDPDQA
T279 VEDPDQATtPtDVRD
T280-p EDPDQATtPtDVRDV
T282-p PDQATtPtDVRDVDL
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