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CCND2 (human)

Overview CCND2 Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/p27Kip1, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/p27Kip1 required for nuclear translocation and modulation of CDK4-mediated kinase activity. Belongs to the cyclin family. Cyclin D subfamily. Note: This description may include information from UniProtKB. Protein type: Cell cycle regulation; Motility/polarity/chemotaxis Cellular Component: nuclear membrane; cyclin-dependent protein kinase holoenzyme complex; nucleolus; nucleus; cytosol; chromatin Molecular Function: protein kinase binding Biological Process: response to cAMP; positive regulation of cyclin-dependent protein kinase activity; regulation of neuron differentiation; response to testosterone stimulus; liver development; cell cycle; response to estradiol stimulus; response to ethanol; ovarian follicle development; cellular response to insulin stimulus; cell division; spermatogenesis; positive regulation of protein amino acid phosphorylation; positive regulation of epithelial cell proliferation Reference #:  P30279 (UniProtKB) Alt. Names/Synonyms: CCND2; cyclin D2; G1/S-specific cyclin D2; G1/S-specific cyclin-D2; KIAK0002; MGC102758 Gene Symbols: CCND2 Molecular weight: 33,067 Da Basal Isoelectric point: 5.06  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G1/S Checkpoint Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CCND2

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	Sites Implicated In
protein degradation: T280‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		K49-u	SYFKCVQkDIQPYMR
0	3		K113-u	MFLASKLkETSPLTA
0	2		K244-u	NTDVDCLkACQEQIE
0	3		S269-p	RQDQRDGsKsEDELD
0	2		S271-p	DQRDGsKsEDELDQA
0	1		S279-p	EDELDQAstPtDVRD
2	11		T280-p	DELDQAstPtDVRDI
0	2		T282-p	LDQAstPtDVRDIDL

	mouse
K48	SYFKCVQKDIQPYMR
K112	MFLASKLKETIPLTA
K243	HTDVDCLKACQEQIE
S269	QEQHNAGSKSVEDPD
S271	QHNAGSKSVEDPDQA
T279	VEDPDQATtPtDVRD
T280-p	EDPDQATtPtDVRDV
T282-p	PDQATtPtDVRDVDL

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