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Protein Page:
HER2 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HER2 a proto-oncogenic receptor tyrosine kinase of the EGFR family. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. Not activated by EGF, TGF- alpha and amphiregulin. Amplified in breast cancer. Overexpression induces constitutive activity, and the gene is amplified or overexpressed in up to 30% of breast cancers, correlating with poor survival. The antibody Herceptin is approved for treatment of metastatic breast cancer with HER2 amplification/overexpression. Somatic mutations seen in 4% of lung cancers and also in breast, gastric, ovarian cancer and glioblastoma. One SNP shows predisposition to breast and gastric cancer. Inhibitors: Herceptin, lapatinib, PKI-166, EKB-569, CI-1033. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Kinase, protein; Protein kinase, TK; TK group; EGFR family
Cellular Component: microvillus; lateral loop; basolateral plasma membrane; integral to membrane; lipid raft; postsynaptic membrane; membrane; perinuclear region of cytoplasm; cytoplasm; apical plasma membrane; plasma membrane; basal plasma membrane; endosome membrane; cytoplasmic vesicle; nucleus; receptor complex
Molecular Function: protein C-terminus binding; identical protein binding; nucleotide binding; Hsp90 protein binding; transmembrane receptor protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; protein phosphatase binding; protein kinase activity; transferase activity; protein binding; transmembrane receptor activity; protein heterodimerization activity; protein-tyrosine kinase activity; ubiquitin protein ligase binding; growth factor binding; transferase activity, transferring phosphorus-containing groups; kinase activity; glycoprotein binding; ATP binding
Biological Process: myelination; phosphoinositide 3-kinase cascade; peptidyl-tyrosine phosphorylation; positive regulation of cell adhesion; wound healing; positive regulation of translation; heart development; protein amino acid autophosphorylation; motor axon guidance; signal transduction; protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase I promoter; positive regulation of MAP kinase activity; sympathetic nervous system development; glial cell differentiation; cell surface receptor linked signal transduction; regulation of transcription, DNA-dependent; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; response to axon injury; neuromuscular junction development; negative regulation of immature T cell proliferation in the thymus; nervous system development; regulation of microtubule-based process; transcription, DNA-dependent; positive regulation of cell growth; peripheral nervous system development; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of transcription from RNA polymerase III promoter; positive regulation of protein amino acid phosphorylation; positive regulation of Ras protein signal transduction; phosphorylation; estrus; positive regulation of Rho GTPase activity; positive regulation of epithelial cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis
Reference #:  P70424 (UniProtKB)
Alt. Names/Synonyms: avian erythroblastosis oncogene B 2; c-erbB-2; c-erbB2; c-neu; Erbb-2; Erbb2; HER-2; HER2; Kiaa3023; mKIAA3023; Neu; Neu oncogene; OTTMUSP00000002540; p185erbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Gene Symbols: Erbb2
Molecular weight: 138,579 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HER2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 K151 RSLTEILKGGVLIRG
0 1 K176 LWKDVLRKNNQLAPV
0 1 V183 KNNQLAPVDMDTNRS
5 0 T687-p RQKIRKYtMRRLLQE
0 30 T702-p TELVEPLtPsGAVPN
0 2 S704-p LVEPLtPsGAVPNQA
0 2 K725-ub ETELRKLkVLGSGAF
0 7 T734 LGSGAFGTVyKGIWI
1 141 Y736-p SGAFGTVyKGIWIPD
0 2 K737 GAFGTVyKGIWIPDG
0 2 K748-ub IPDGENVkIPVAIKV
0 1 K754 VkIPVAIKVLRENTS
0 3 Y773 KEILDEAYVMAGVGS
0 9 T876 RLLDIDETEyHADGG
18 110 Y878-p LDIDETEyHADGGKV
0 1 K888 DGGKVPIKWMALESI
1 1 Y924-p MTFGAKPyDGIPARE
0 3 S999 NEDLGPSSPMDSTFY
0 8 S1003 GPSSPMDSTFYRSLL
0 3 T1004 PSSPMDSTFYRSLLE
1 76 Y1006 SPMDSTFYRSLLEDD
0 1 S1008 MDSTFYRSLLEDDDM
7 33 Y1024 ELVDAEEYLVPQQGF
0 2 S1050 TAHRRHRSSSARSGG
0 4 S1051 AHRRHRSSSARSGGG
0 5 S1052 HRRHRSSSARSGGGE
0 1 A1053 RRHRSSSARSGGGEL
0 14 S1055 HRSSSARSGGGELTL
0 1 S1067 LTLGLEPSEEEPPRS
0 1 S1079 PRSPLAPSEGAGsDV
0 4 S1084-p APSEGAGsDVFDGDL
0 1 P1104 KGLQSLSPHDLSPLQ
0 4 S1108 SLSPHDLSPLQRysE
6 3 Y1113-p DLSPLQRysEDPTLP
1 0 S1114-p LSPLQRysEDPTLPL
0 1 P1123 DPTLPLPPETDGYVA
0 1 T1125 TLPLPPETDGYVAPL
0 12 Y1128 LPPETDGYVAPLACS
0 2 A1133 DGYVAPLACSPQPEY
0 5 S1135 YVAPLACSPQPEYVN
11 47 Y1140 ACSPQPEYVNQPEVR
0 47 L1152 EVRPQSPLTPEGPPP
0 3 T1167 PIRPAGATLERPKtL
1 1 T1173-p ATLERPKtLsPGKNG
1 3 S1175-p LERPKtLsPGKNGVV
8 6 Y1197-p GAVENPEyLAPRAGT
0 1 A1199 VENPEyLAPRAGTAS
0 3 S1215 PHPSPAFSPAFDNLy
20 14 Y1222-p SPAFDNLyyWDQNSS
24 8 Y1223-p PAFDNLyyWDQNSSE
0 1 S1236 SEQGPPPSTFEGTPT
0 1 T1237 EQGPPPSTFEGTPTA
0 9 T1241 PPSTFEGTPTAENPE
0 2 T1243 STFEGTPTAENPEyL
43 192 Y1249-p PTAENPEyLGLDVPV
2241 : Phospho-HER2/ErbB2 (Tyr877) Antibody
  human

► Hide Isoforms
 
K150-ub RSLTEILkGGVLIQR
K175-ub LWKDIFHkNNQLALt
T182-p kNNQLALtLIDTNRS
T686-p QQKIRKYtMRRLLQE
T701-p TELVEPLtPsGAMPN
S703-p LVEPLtPsGAMPNQA
K724-ub ETELRKVkVLGSGAF
T733-p LGSGAFGtVykGIWI
Y735-p SGAFGtVykGIWIPD
K736-ub GAFGtVykGIWIPDG
K747-ub IPDGENVkIPVAIkV
K753-ub VkIPVAIkVLRENTS
Y772-p KEILDEAyVMAGVGS
T875-p RLLDIDEtEyHADGG
Y877-p LDIDEtEyHADGGKV
K887-ub DGGKVPIkWMALESI
Y923-p MTFGAKPyDGIPARE
S998-p NEDLGPAsPLDstFy
S1002-p GPAsPLDstFyRsLL
T1003-p PAsPLDstFyRsLLE
Y1005-p sPLDstFyRsLLEDD
S1007-p LDstFyRsLLEDDDM
Y1023-p DLVDAEEyLVPQQGF
S1049-p MVHHRHRssstRsGG
S1050-p VHHRHRssstRsGGG
S1051-p HHRHRssstRsGGGD
T1052-p HRHRssstRsGGGDL
S1054-p HRssstRsGGGDLTL
S1066-p LTLGLEPsEEEAPRS
S1078 PRSPLAPSEGAGsDV
S1083-p APSEGAGsDVFDGDL
T1103-p KGLQSLPtHDPsPLQ
S1107-p SLPtHDPsPLQRySE
Y1112-p DPsPLQRySEDPTVP
S1113 PsPLQRySEDPTVPL
S1122-p DPTVPLPsEtDGyVA
T1124-p TVPLPsEtDGyVAPL
Y1127-p LPsEtDGyVAPLtCs
T1132-p DGyVAPLtCsPQPEy
S1134-p yVAPLtCsPQPEyVN
Y1139-p tCsPQPEyVNQPDVR
S1151-p DVRPQPPsPREGPLP
T1166-p AARPAGAtLERPKtL
T1172-p AtLERPKtLsPGKNG
S1174-p LERPKtLsPGKNGVV
Y1196-p GAVENPEyLtPQGGA
T1198-p VENPEyLtPQGGAAP
S1214-p PHPPPAFsPAFDNLy
Y1221-p sPAFDNLyyWDQDPP
Y1222-p PAFDNLyyWDQDPPE
S1235-p PERGAPPstFKGtPt
T1236-p ERGAPPstFKGtPtA
T1240-p PPstFKGtPtAENPE
T1242-p stFKGtPtAENPEyL
Y1248-p PtAENPEyLGLDVPV
2241 : Phospho-HER2/ErbB2 (Tyr877) Antibody
6942 : Phospho-HER2/ErbB2 (Tyr1196) (D66B7) Rabbit mAb
2243 : Phospho-HER2/ErbB2 (Tyr1221/1222) (6B12) Rabbit mAb
2249 : Phospho-HER2/ErbB2 (Tyr1221/1222) Antibody
2243 : Phospho-HER2/ErbB2 (Tyr1221/1222) (6B12) Rabbit mAb
2249 : Phospho-HER2/ErbB2 (Tyr1221/1222) Antibody
2244 : Phospho-HER2/ErbB2 (Tyr1248)/EGFR (Tyr1173) Antibody
2247 : Phospho-HER2/ErbB2 (Tyr1248) Antibody
  HER2 iso2  
- gap
- gap
- gap
T76 QQKIRKYTMRRLLQE
T91 TELVEPLTPSGAMPN
S93 LVEPLTPSGAMPNQA
K114 ETELRKVKVLGSGAF
T123 LGSGAFGTVYKGIWI
Y125 SGAFGTVYKGIWIPD
K126 GAFGTVYKGIWIPDG
K137 IPDGENVKIPVAIKV
K143 VKIPVAIKVLRENTS
Y162 KEILDEAYVMAGVGS
T265 RLLDIDETEYHADGG
Y267 LDIDETEYHADGGKV
K277 DGGKVPIKWMALESI
Y313 MTFGAKPYDGIPARE
S388 NEDLGPASPLDSTFY
S392 GPASPLDSTFYRSLL
T393 PASPLDSTFYRSLLE
Y395 SPLDSTFYRSLLEDD
S397 LDSTFYRSLLEDDDM
Y413 DLVDAEEYLVPQQGF
S439 MVHHRHRSSSTRSGG
S440 VHHRHRSSSTRSGGG
S441 HHRHRSSSTRSGGGD
T442 HRHRSSSTRSGGGDL
S444 HRSSSTRSGGGDLTL
S456 LTLGLEPSEEEAPRS
S468 PRSPLAPSEGAGSDV
S473 APSEGAGSDVFDGDL
T493 KGLQSLPTHDPSPLQ
S497 SLPTHDPSPLQRYSE
Y502 DPSPLQRYSEDPTVP
S503 PSPLQRYSEDPTVPL
S512 DPTVPLPSETDGYVA
T514 TVPLPSETDGYVAPL
Y517 LPSETDGYVAPLTCS
T522 DGYVAPLTCSPQPEY
S524 YVAPLTCSPQPEYVN
Y529 TCSPQPEYVNQPDVR
S541 DVRPQPPSPREGPLP
T556 AARPAGATLERPKTL
T562 ATLERPKTLSPGKNG
S564 LERPKTLSPGKNGVV
Y586 GAVENPEYLTPQGGA
T588 VENPEYLTPQGGAAP
S604 PHPPPAFSPAFDNLY
Y611 SPAFDNLYYWDQDPP
Y612 PAFDNLYYWDQDPPE
S625 PERGAPPSTFKGTPT
T626 ERGAPPSTFKGTPTA
T630 PPSTFKGTPTAENPE
T632 STFKGTPTAENPEYL
Y638 PTAENPEYLGLDVPV
  rat

 
K151 RSLTEILKGGVLIRG
K176 LWKDVFRKNNQLAPV
V183 KNNQLAPVDIDTNRS
T688-p RQKIRKYtMRRLLQE
T703 TELVEPLTPSGAMPN
S705 LVEPLTPSGAMPNQA
K726 ETELRKVKVLGSGAF
T735 LGSGAFGTVYKGIWI
Y737 SGAFGTVYKGIWIPD
K738 GAFGTVYKGIWIPDG
K749 IPDGENVKIPVAIKV
K755 VKIPVAIKVLRENTS
Y774 KEILDEAYVMAGVGS
T877 RLLDIDETEyHADGG
Y879-p LDIDETEyHADGGKV
K889 DGGKVPIKWMALESI
Y925 MTFGAKPYDGIPARE
S1000 NEDLGPSSPMDSTFY
S1004 GPSSPMDSTFYRSLL
T1005 PSSPMDSTFYRSLLE
Y1007 SPMDSTFYRSLLEDD
S1009 MDSTFYRSLLEDDDM
Y1025-p DLVDAEEyLVPQQGF
S1051 TAHRRHRSSSTRsGG
S1052 AHRRHRSSSTRsGGG
S1053 HRRHRSSSTRsGGGE
T1054 RRHRSSSTRsGGGEL
S1056-p HRSSSTRsGGGELTL
S1068 LTLGLEPSEEGPPRS
S1080-p PRSPLAPsEGAGsDV
S1085-p APsEGAGsDVFDGDL
P1105 KGLQSLSPHDLSPLQ
S1109 SLSPHDLSPLQRySE
Y1114-p DLSPLQRySEDPTLP
S1115 LSPLQRySEDPTLPL
P1124 DPTLPLPPETDGYVA
T1126 TLPLPPETDGYVAPL
Y1129 LPPETDGYVAPLACS
A1134 DGYVAPLACSPQPEy
S1136 YVAPLACSPQPEyVN
Y1141-p ACSPQPEyVNQSEVQ
L1153 EVQPQPPLTPEGPLP
T1168 PVRPAGATLERPKTL
T1174 ATLERPKTLsPGKNG
S1176-p LERPKTLsPGKNGVV
Y1198-p GAVENPEyLVPREGT
V1200 VENPEyLVPREGTAS
S1216 PHPSPAFSPAFDNLy
Y1223-p SPAFDNLyyWDQNSS
Y1224-p PAFDNLyyWDQNSSE
S1237 SEQGPPPSNFEGTPT
N1238 EQGPPPSNFEGTPTA
T1242 PPSNFEGTPTAENPE
T1244 SNFEGTPTAENPEyL
Y1250-p PTAENPEyLGLDVPV
2241 : Phospho-HER2/ErbB2 (Tyr877) Antibody
2247 : Phospho-HER2/ErbB2 (Tyr1248) Antibody
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