a proto-oncogenic receptor tyrosine kinase of the EGFR family. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. Not activated by EGF, TGF- alpha and amphiregulin. Amplified in breast cancer. Overexpression induces constitutive activity, and the gene is amplified or overexpressed in up to 30% of breast cancers, correlating with poor survival. The antibody Herceptin is approved for treatment of metastatic breast cancer with HER2 amplification/overexpression. Somatic mutations seen in 4% of lung cancers and also in breast, gastric, ovarian cancer and glioblastoma. One SNP shows predisposition to breast and gastric cancer. Inhibitors: Herceptin, lapatinib, PKI-166, EKB-569, CI-1033. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 188.8.131.52; Protein kinase, tyrosine (receptor); Protein kinase, TK; Membrane protein, integral; TK group; EGFR family
Cellular Component: microvillus; basolateral plasma membrane; lateral loop; integral to membrane; lipid raft; postsynaptic membrane; membrane; perinuclear region of cytoplasm; apical plasma membrane; cytoplasm; basal plasma membrane; plasma membrane; endosome membrane; cytoplasmic vesicle; nucleus; receptor complex
Molecular Function: protein C-terminus binding; identical protein binding; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; Hsp90 protein binding; receptor signaling protein tyrosine kinase activity; protein phosphatase binding; protein kinase activity; transferase activity; protein binding; transmembrane receptor activity; protein heterodimerization activity; protein-tyrosine kinase activity; growth factor binding; ubiquitin protein ligase binding; transferase activity, transferring phosphorus-containing groups; kinase activity; glycoprotein binding; ATP binding
Biological Process: myelination; phosphoinositide 3-kinase cascade; peptidyl-tyrosine phosphorylation; positive regulation of cell adhesion; positive regulation of translation; wound healing; protein amino acid autophosphorylation; heart development; motor axon guidance; signal transduction; protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase I promoter; positive regulation of MAP kinase activity; sympathetic nervous system development; glial cell differentiation; cell surface receptor linked signal transduction; regulation of transcription, DNA-dependent; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; response to axon injury; neuromuscular junction development; negative regulation of immature T cell proliferation in the thymus; regulation of microtubule-based process; nervous system development; transcription, DNA-dependent; positive regulation of cell growth; peripheral nervous system development; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of transcription from RNA polymerase III promoter; positive regulation of protein amino acid phosphorylation; positive regulation of Ras protein signal transduction; estrus; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of Rho GTPase activity; positive regulation of epithelial cell proliferation; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.