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HER2
a proto-oncogenic receptor tyrosine kinase of the EGFR family. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. Not activated by EGF, TGF- alpha and amphiregulin. Amplified in breast cancer. Overexpression induces constitutive activity, and the gene is amplified or overexpressed in up to 30% of breast cancers, correlating with poor survival. The antibody Herceptin is approved for treatment of metastatic breast cancer with HER2 amplification/overexpression. Somatic mutations seen in 4% of lung cancers and also in breast, gastric, ovarian cancer and glioblastoma. One SNP shows predisposition to breast and gastric cancer. Inhibitors: Herceptin, lapatinib, PKI-166, EKB-569, CI-1033. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; EC 2.7.10.1; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; EGFR family |
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Cellular Component: microvillus; lateral loop; basolateral plasma membrane; integral to membrane; lipid raft; postsynaptic membrane; perinuclear region of cytoplasm; apical plasma membrane; basal plasma membrane; plasma membrane; endosome membrane; nucleus; receptor complex
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Molecular Function: protein C-terminus binding; protein dimerization activity; identical protein binding; epidermal growth factor receptor activity; transmembrane receptor protein tyrosine kinase activity; Hsp90 protein binding; receptor signaling protein tyrosine kinase activity; protein phosphatase binding; protein binding; transmembrane receptor activity; ErbB-3 class receptor binding; protein heterodimerization activity; growth factor binding; ubiquitin protein ligase binding; protein-tyrosine kinase activity; glycoprotein binding; ATP binding
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Biological Process: myelination; tongue development; axon guidance; mammary gland involution; phosphoinositide 3-kinase cascade; positive regulation of cell adhesion; wound healing; positive regulation of translation; protein amino acid autophosphorylation; heart development; motor axon guidance; signal transduction; enzyme linked receptor protein signaling pathway; protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase I promoter; positive regulation of MAP kinase activity; sympathetic nervous system development; glial cell differentiation; cell surface receptor linked signal transduction; mammary gland development; positive regulation of MAPKKK cascade; response to axon injury; neuromuscular junction development; response to drug; negative regulation of immature T cell proliferation in the thymus; epidermal growth factor receptor signaling pathway; nervous system development; regulation of microtubule-based process; phosphoinositide-mediated signaling; transcription, DNA-dependent; liver development; regulation of angiogenesis; positive regulation of cell growth; peripheral nervous system development; positive regulation of phosphoinositide 3-kinase cascade; cell proliferation; positive regulation of transcription from RNA polymerase III promoter; positive regulation of protein amino acid phosphorylation; positive regulation of Ras protein signal transduction; response to progesterone stimulus; estrus; positive regulation of epithelial cell proliferation; positive regulation of Rho GTPase activity; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis
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Reference #:
P04626 (UniProtKB)
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| Alt. Names/Synonyms: c-erb B2/neu protein; CD340; erbB-2; ERBB2; HER-2; HER-2/neu; HER2; herstatin; Metastatic lymph node gene 19 protein; MLN 19; MLN19; NEU; neuroblastoma/glioblastoma derived oncogene homolog; NGL; p185erbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) |
| Gene Symbols: ERBB2 |
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Molecular weight: 137,910 Da
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Basal Isoelectric point: 5.58
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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Tyrosine Kinases
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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