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Protein Page:
ATP5F1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ATP5F1 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Belongs to the eukaryotic ATPase B chain family. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Mitochondrial
Cellular Component: mitochondrion; membrane; mitochondrial matrix; mitochondrial inner membrane; nucleus; mitochondrial proton-transporting ATP synthase complex
Molecular Function: protein binding; ATPase activity; hydrogen ion transporting ATP synthase activity, rotational mechanism; transmembrane transporter activity
Biological Process: ATP catabolic process; cellular metabolic process; ATP synthesis coupled proton transport; substantia nigra development; mitochondrial ATP synthesis coupled proton transport
Reference #:  P24539 (UniProtKB)
Alt. Names/Synonyms: AT5F1; ATP synthase B chain, mitochondrial; ATP synthase subunit b, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1; ATP5F1; ATPase subunit b; cell proliferation-inducing protein 47; H+-ATP synthase subunit b; MGC24431; PIG47
Gene Symbols: ATP5F1
Molecular weight: 28,909 Da
Basal Isoelectric point: 9.37  Predict pI for various phosphorylation states
Select Structure to View Below

ATP5F1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 T31-p GPGVLQAtRTFHTGQ
0 32 K53-ac PLPEYGGkVRYGLIP
0 1 K53 PLPEYGGKVRYGLIP
0 1 K53 PLPEYGGKVRYGLIP
0 1 K115 VMVYGIKKyGPFVAD
0 2 Y116-p MVYGIKKyGPFVADF
0 1 K126 FVADFADKLNEQkLA
0 1 K126-ub FVADFADkLNEQkLA
0 2 K131-ac ADkLNEQkLAQLEEA
0 2 K131-ub ADkLNEQkLAQLEEA
0 1 K131-sc ADkLNEQkLAQLEEA
0 2 K139 LAQLEEAKQAsIQHI
0 2 K139-ub LAQLEEAkQAsIQHI
0 1 K139 LAQLEEAKQAsIQHI
0 1 S142-p LEEAkQAsIQHIQNA
0 1 Q144 EAkQAsIQHIQNAID
0 1 Q144 EAkQAsIQHIQNAID
0 1 Q144 EAkQAsIQHIQNAID
0 1 T152-p HIQNAIDtEkSQQAL
0 15 K154-ac QNAIDtEkSQQALVQ
0 1 K154-ub QNAIDtEkSQQALVQ
0 1 K154 QNAIDtEKSQQALVQ
0 113 K162-ac SQQALVQkRHyLFDV
0 1 K162-ub SQQALVQkRHyLFDV
0 2 K162-sc SQQALVQkRHyLFDV
0 64 Y165-p ALVQkRHyLFDVQRN
0 1 R188 TYRERLYRVYKEVKN
0 1 K191 ERLYRVYKEVKNRLD
0 2 K194 YRVYKEVKNRLDyHI
0 1 Y199-p EVKNRLDyHISVQNM
0 4 K221-ac HMINWVEkHVVQsIS
0 1 K221 HMINWVEKHVVQsIS
0 29 Q225 WVEkHVVQsIStQQE
0 1 Q225 WVEkHVVQsIStQQE
0 2 Q225 WVEkHVVQsIStQQE
0 2 S226-p VEkHVVQsIStQQEk
0 1 T229-p HVVQsIStQQEkETI
0 5 K233-ac sIStQQEkETIAkCI
0 2 K233-ub sIStQQEkETIAkCI
0 2 K233-sc sIStQQEkETIAkCI
0 2 K238-ac QEkETIAkCIADLkL
0 1 K238 QEkETIAKCIADLkL
0 5 K244-ac AkCIADLkLLAkKAQ
0 2 K244-sc AkCIADLkLLAkKAQ
0 3 K248-ac ADLkLLAkKAQAQPV
  mouse

 
T31 GPGVLQATRAFHTGQ
K53 PLPEYGGKVRLGLIP
K53-ub PLPEYGGkVRLGLIP
K53-sc PLPEYGGkVRLGLIP
K115-ac LIVYVIKkYGASFGE
Y116 IVYVIKkYGASFGEF
K126-ac SFGEFIDkLNEEkIA
K126 SFGEFIDKLNEEkIA
K131-ac IDkLNEEkIAQLEEV
K131-ub IDkLNEEkIAQLEEV
K131-sc IDkLNEEkIAQLEEV
K139-ac IAQLEEVkQSSMkQI
K139-ub IAQLEEVkQSSMkQI
K139-sc IAQLEEVkQSSMkQI
S142 LEEVkQSSMkQIQDA
K144-ac EVkQSSMkQIQDAID
K144-ub EVkQSSMkQIQDAID
K144-sc EVkQSSMkQIQDAID
M152 QIQDAIDMEkAQQAL
K154-ac QDAIDMEkAQQALVQ
K154 QDAIDMEKAQQALVQ
K154-sc QDAIDMEkAQQALVQ
K162-ac AQQALVQkRHyLFDV
K162 AQQALVQKRHyLFDV
K162-sc AQQALVQkRHyLFDV
Y165-p ALVQkRHyLFDVQRN
K188-ac TYRERLHkAYkEVkN
K191-ac ERLHkAYkEVkNRLD
K194-ac HkAYkEVkNRLDYHI
Y199 EVkNRLDYHISVQNM
K221-ac HMIDWVEkHVVksIS
K221-sc HMIDWVEkHVVksIS
K225-ac WVEkHVVksISVQQE
K225-ub WVEkHVVksISVQQE
K225-sc WVEkHVVksISVQQE
S226-p VEkHVVksISVQQEk
V229 HVVksISVQQEkETI
K233-ac sISVQQEkETIAkCI
K233-ub sISVQQEkETIAkCI
K233-sc sISVQQEkETIAkCI
K238-ac QEkETIAkCIEDLkL
K238-ub QEkETIAkCIEDLkL
K244-ac AkCIEDLkLLAkKAQ
K244-sc AkCIEDLkLLAkKAQ
K248-ac EDLkLLAkKAQAQPI
  rat

 
T31 GPGVLQATRVFHTGQ
K53 PLPEYGGKVRLGLIP
K53 PLPEYGGKVRLGLIP
K53 PLPEYGGKVRLGLIP
K115 LIVYVIKKYGASIGE
Y116 IVYVIKKYGASIGEF
K126-ac SIGEFIDkLNEEkIA
K126 SIGEFIDKLNEEkIA
K131-ac IDkLNEEkIAQLEEI
K131 IDkLNEEKIAQLEEI
K131 IDkLNEEKIAQLEEI
K139-ac IAQLEEIkQSSMkQI
K139 IAQLEEIKQSSMkQI
K139 IAQLEEIKQSSMkQI
S142 LEEIkQSSMkQIQDA
K144-ac EIkQSSMkQIQDAIN
K144 EIkQSSMKQIQDAIN
K144 EIkQSSMKQIQDAIN
R152 QIQDAINREkAQQAL
K154-ac QDAINREkAQQALVQ
K154 QDAINREKAQQALVQ
K154 QDAINREKAQQALVQ
K162-ac AQQALVQkRHYLFDV
K162 AQQALVQKRHYLFDV
K162 AQQALVQKRHYLFDV
Y165 ALVQkRHYLFDVQRN
K188-ac TYRERLHkAYkEVkN
K191-ac ERLHkAYkEVkNRLD
K194-ac HkAYkEVkNRLDYHI
Y199 EVkNRLDYHISVQDM
K221-ac HMINWVEkHVIQSIS
K221 HMINWVEKHVIQSIS
Q225 WVEkHVIQSISAQQE
Q225 WVEkHVIQSISAQQE
Q225 WVEkHVIQSISAQQE
S226 VEkHVIQSISAQQEk
A229 HVIQSISAQQEkETI
K233-ac SISAQQEkETIAkCI
K233 SISAQQEKETIAkCI
K233 SISAQQEKETIAkCI
K238-ac QEkETIAkCIGDLkM
K238 QEkETIAKCIGDLkM
K244-ac AkCIGDLkMLAKKAQ
K244 AkCIGDLKMLAKKAQ
K248 GDLkMLAKKAQAQPI
  cow

 
T31 GPGVLQATRIFHTGQ
K53 PLPEHGGKVRFGLIP
K53 PLPEHGGKVRFGLIP
K53 PLPEHGGKVRFGLIP
K115 FLVYIVKKYGASVGE
Y116 LVYIVKKYGASVGEF
K126 SVGEFADKLNEQKIA
K126 SVGEFADKLNEQKIA
K131 ADKLNEQKIAQLEEV
K131 ADKLNEQKIAQLEEV
K131 ADKLNEQKIAQLEEV
K139 IAQLEEVKQASIKQI
K139 IAQLEEVKQASIKQI
K139 IAQLEEVKQASIKQI
S142 LEEVKQASIKQIQDA
K144 EVKQASIKQIQDAID
K144 EVKQASIKQIQDAID
K144 EVKQASIKQIQDAID
M152 QIQDAIDMEKSQQAL
K154 QDAIDMEKSQQALVQ
K154 QDAIDMEKSQQALVQ
K154 QDAIDMEKSQQALVQ
K162 SQQALVQKRHYLFDV
K162 SQQALVQKRHYLFDV
K162 SQQALVQKRHYLFDV
Y165 ALVQKRHYLFDVQRN
R188 TYRERLHRVYREVKN
R191 ERLHRVYREVKNRLD
K194 HRVYREVKNRLDYHI
Y199 EVKNRLDYHISVQNM
K221 HMINWVEKRVVQSIS
K221 HMINWVEKRVVQSIS
Q225 WVEKRVVQSISAQQE
Q225 WVEKRVVQSISAQQE
Q225 WVEKRVVQSISAQQE
S226 VEKRVVQSISAQQEK
A229 RVVQSISAQQEKETI
K233 SISAQQEKETIAKCI
K233 SISAQQEKETIAKCI
K233 SISAQQEKETIAKCI
K238 QEKETIAKCIADLKL
K238 QEKETIAKCIADLKL
K244 AKCIADLKLLSKKAQ
K244 AKCIADLKLLSKKAQ
K248 ADLKLLSKKAQAQPV
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