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CPT1A (human)

Overview CPT1A Belongs to the carnitine/choline acetyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Lipid Metabolism - fatty acid; Membrane protein, integral; Transferase; Mitochondrial; EC 2.3.1.21 Cellular Component: mitochondrial outer membrane; mitochondrion; mitochondrial inner membrane; integral to mitochondrial outer membrane Molecular Function: identical protein binding; carnitine O-palmitoyltransferase activity Biological Process: response to drug; eating behavior; glucose metabolic process; cellular lipid metabolic process; long-chain fatty acid metabolic process; carnitine shuttle; response to organic cyclic substance; positive regulation of fatty acid beta-oxidation; fatty acid beta-oxidation; triacylglycerol metabolic process; regulation of fatty acid oxidation; carnitine metabolic process; regulation of insulin secretion; protein homooligomerization Reference #:  P50416 (UniProtKB) Alt. Names/Synonyms: Carnitine O-palmitoyltransferase 1, liver isoform; Carnitine O-palmitoyltransferase I, liver isoform; Carnitine palmitoyltransferase 1A; carnitine palmitoyltransferase 1A (liver); carnitine palmitoyltransferase I, liver; CPT I; CPT1; CPT1-L; CPT1A; CPTI-L; L-CPT1 Gene Symbols: CPT1A Molecular weight: 88,368 Da Basal Isoelectric point: 8.85  Predict pI for various phosphorylation states CST Pathways:  AMPK Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CPT1A 2LE3 - A=1-42 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  DISEASE 255120 600528  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		R29	RLSHEALRQIYLSGL
0	2		K86-u	PSLGIIAkINRTLET
0	1		T90	IIAkINRTLETANCM
0	1		T93	kINRTLETANCMSSQ
0	1		S98	LETANCMSSQTKNVV
0	1		S106-p	SQTKNVVsGVLFGTG
0	1		S158-p	MGMVKIFsGRkPMLy
0	2		K161-u	VKIFsGRkPMLySFQ
0	2		Y165-p	sGRkPMLySFQTSLP
0	14		K180-u	RLPVPAVkDTVNRYL
0	4		K195-u	QSVRPLMkEEDFkRM
0	1		K200-u	LMkEEDFkRMTALAQ
0	1		Y282	AIHAILLYRRKLDRE
0	2		K292-u	KLDREEIkPIRLLGS
0	1		R329	TDTIQHMRDSKHIVV
0	1		R393	GDRVPWARCRQAYFG
0	1		K405-u	YFGRGKNkQSLDAVE
0	1		K441	TSMDSYAKSLLHGRC
0	1		K463	SFTFVVFKNGKMGLN
0	4		Y514-p	DINPNIPyPTRLQWD
0	1		Y514	DINPNIPYPTRLQWD
0	1		T588	DMGKFCLTYEASMTR
0	1		T604	FREGRTETVRSCTTE
0	3		Y661	DRHLFCLYVVSKYLA
0	11		K675-u	AVESPFLkEVLSEPW
1	1		S741	FHISSKFSCPETDSH
1	1		S747	FSCPETDSHRFGRHL
0	1		R752	TDSHRFGRHLKEAMT
0	1		S771-p	LFGLSSNskK_____
0	2		K772-u	FGLSSNskK______

	mouse
K29-u	RLSHEALkQICLSGL
K86	PSLGMIAKINRTLDT
T90	MIAKINRTLDTTGRM
T93	KINRTLDTTGRMSSQ
S98	LDTTGRMSSQTKNIV
S106	SQTKNIVSGVLFGTG
S158	MAMVKVFSGRkPMLY
K161-u	VKVFSGRkPMLYSFQ
Y165	SGRkPMLYSFQTSLP
K180-u	RLPVPAVkDTVSRYL
K195-u	ESVRPLMkEGDFQRM
Q200	LMkEGDFQRMTALAQ
Y282	TIHAILLYRRTVDRE
K292-u	TVDREELkPIRLLGS
K329-u	TDTIQHVkDSRHIVV
K393-u	ADRVPWAkCRQTYFA
K405	YFARGKNKQSLDAVE
K441-u	ASIDSYAkSLLHGRC
K463-u	SITFVVFkNSKIGIN
K514	DKNPNIPKPTRLQWD
K514-u	DKNPNIPkPTRLQWD
T588	DMGKFCLTYEASMTR
T604	FREGRTETVRSCTTE
Y661	DRHLFCLYVVSKYLA
K675-u	AVDSPFLkEVLSEPW
S741	FHISSKFSSPETDSH
S747	FSSPETDSHRFGkHL
K752-a	TDSHRFGkHLRQAMM
S771	LFGLTANSkK_____
K772-u	FGLTANSkK______

	rat
K29	RLSHEALKQICLSGL
K86	PSLGMIAKISRtLDt
T90-p	MIAKISRtLDtTGRM
T93-p	KISRtLDtTGRMsSQ
S98-p	LDtTGRMsSQTKNIV
S106	SQTKNIVSGVLFGTG
S158	MAMVKVLSGRKPMLY
K161	VKVLSGRKPMLYSFQ
Y165	SGRKPMLYSFQTSLP
K180	RLPVPAVKDTVSRYL
K195	ESVRPLMKEEDFQRM
Q200	LMKEEDFQRMTALAQ
Y282-p	TIHAILLyRRTLDRE
K292	TLDREELKPIRLLGS
K329	TDTIQHIKDSRHIVV
K393	ADRVPWAKCRQTYFA
K405	YFARGKNKQSLDAVE
K441	ASIDSYAKSLLHGRC
K463	SITFVVFKNSKIGIN
K514	DTNPNIPKPTRLQWD
K514	DTNPNIPKPTRLQWD
T588-p	DMGKFCLtYEASMTR
T604-p	FREGRTEtVRSCTME
Y661-p	DRHLFCLyVVSKYLA
K675	AVDSPFLKEVLSEPW
S741-p	FHISSKFsSPETDsH
S747-p	FsSPETDsHRFGKHL
K752	TDsHRFGKHLRQAMM
S771	LFGLTINSKK_____
K772	FGLTINSKK______

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