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Protein Page:
CPT1A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CPT1A Belongs to the carnitine/choline acetyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Lipid Metabolism - fatty acid; Membrane protein, integral; Transferase; Mitochondrial; EC 2.3.1.21; Membrane protein, multi-pass
Cellular Component: mitochondrial outer membrane; membrane; mitochondrion; mitochondrial inner membrane; integral to mitochondrial outer membrane
Molecular Function: identical protein binding; carnitine O-palmitoyltransferase activity
Biological Process: response to drug; eating behavior; glucose metabolic process; long-chain fatty acid metabolic process; cellular lipid metabolic process; carnitine shuttle; response to organic cyclic substance; positive regulation of fatty acid beta-oxidation; fatty acid beta-oxidation; triacylglycerol metabolic process; epithelial cell differentiation; carnitine metabolic process; regulation of insulin secretion; protein homooligomerization
Reference #:  P50416 (UniProtKB)
Alt. Names/Synonyms: Carnitine O-palmitoyltransferase 1, liver isoform; Carnitine O-palmitoyltransferase I, liver isoform; Carnitine palmitoyltransferase 1A; carnitine palmitoyltransferase 1A (liver); carnitine palmitoyltransferase I, liver; CPT I; CPT1; CPT1-L; CPT1A; CPTI-L; L-CPT1
Gene Symbols: CPT1A
Molecular weight: 88,368 Da
Basal Isoelectric point: 8.85  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CPT1A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 R29 RLSHEALRQIYLSGL
0 2 K86-ub PSLGIIAkINRTLET
0 1 T90 IIAkINRTLETANCM
0 1 T93 kINRTLETANCMSSQ
0 1 S98 LETANCMSSQTKNVV
0 1 S106-p SQTKNVVsGVLFGTG
0 1 S158-p MGMVKIFsGRkPMLy
0 2 K161-ub VKIFsGRkPMLySFQ
0 2 Y165-p sGRkPMLySFQTSLP
0 14 K180-ub RLPVPAVkDTVNRYL
0 1 K180 RLPVPAVKDTVNRYL
0 1 K195 QSVRPLMKEEDFkRM
0 4 K195-ub QSVRPLMkEEDFkRM
0 1 K200-ub LMkEEDFkRMTALAQ
0 1 Y282 AIHAILLYRRKLDRE
0 1 K292 KLDREEIKPIRLLGS
0 2 K292-ub KLDREEIkPIRLLGS
0 1 R329 TDTIQHMRDSKHIVV
0 1 S371-p QRILDNTsEPQPGEA
0 1 R379 EPQPGEARLAALTAG
0 1 R393 GDRVPWARCRQAYFG
0 1 K405-ub YFGRGKNkQSLDAVE
0 1 K441 TSMDSYAKSLLHGRC
0 1 K463 SFTFVVFKNGKMGLN
0 5 Y514-p DINPNIPyPTRLQWD
0 1 Y514 DINPNIPYPTRLQWD
0 1 K580 ALQLAHYKDMGKFCL
0 1 T588 DMGKFCLTYEASMTR
0 1 T604 FREGRTETVRSCTTE
0 3 Y661 DRHLFCLYVVSKYLA
0 1 K675 AVESPFLKEVLSEPW
0 11 K675-ub AVESPFLkEVLSEPW
1 1 S741 FHISSKFSCPETDSH
1 1 S747 FSCPETDSHRFGRHL
0 1 R752 TDSHRFGRHLKEAMT
0 1 S771-p LFGLSSNskK_____
0 2 K772-ub FGLSSNskK______
  mouse

 
K29-ub RLSHEALkQICLSGL
K86 PSLGMIAKINRTLDT
T90 MIAKINRTLDTTGRM
T93 KINRTLDTTGRMSSQ
S98 LDTTGRMSSQTKNIV
S106 SQTKNIVSGVLFGTG
S158 MAMVKVFSGRkPMLY
K161-ub VKVFSGRkPMLYSFQ
Y165 SGRkPMLYSFQTSLP
K180-ub RLPVPAVkDTVSRYL
K180-sc RLPVPAVkDTVSRYL
K195-ac ESVRPLMkEGDFQRM
K195-ub ESVRPLMkEGDFQRM
Q200 LMkEGDFQRMTALAQ
Y282 TIHAILLYRRTVDRE
K292-ac TVDREELkPIRLLGS
K292-ub TVDREELkPIRLLGS
K329-ub TDTIQHVkDSRHIVV
S371 QQILDDTSEPQPGEA
K379-ac EPQPGEAkLAALTAA
K393-ub ADRVPWAkCRQTYFA
K405 YFARGKNKQSLDAVE
K441-ub ASIDSYAkSLLHGRC
K463-ub SITFVVFkNSKIGIN
K514 DKNPNIPKPTRLQWD
K514-ub DKNPNIPkPTRLQWD
K580-ac ALQLAHYkDMGKFCL
T588 DMGKFCLTYEASMTR
T604 FREGRTETVRSCTTE
Y661 DRHLFCLYVVSKYLA
K675-ac AVDSPFLkEVLSEPW
K675-ub AVDSPFLkEVLSEPW
S741 FHISSKFSSPETDSH
S747 FSSPETDSHRFGkHL
K752-ac TDSHRFGkHLRQAMM
S771 LFGLTANSkK_____
K772-ub FGLTANSkK______
  rat

 
K29 RLSHEALKQICLSGL
K86 PSLGMIAKISRtLDt
T90-p MIAKISRtLDtTGRM
T93-p KISRtLDtTGRMsSQ
S98-p LDtTGRMsSQTKNIV
S106 SQTKNIVSGVLFGTG
S158 MAMVKVLSGRKPMLY
K161 VKVLSGRKPMLYSFQ
Y165 SGRKPMLYSFQTSLP
K180 RLPVPAVKDTVSRYL
K180 RLPVPAVKDTVSRYL
K195-ac ESVRPLMkEEDFQRM
K195 ESVRPLMKEEDFQRM
Q200 LMkEEDFQRMTALAQ
Y282-p TIHAILLyRRTLDRE
K292-ac TLDREELkPIRLLGS
K292 TLDREELKPIRLLGS
K329 TDTIQHIKDSRHIVV
S371 QQILDDPSEPQPGEA
K379 EPQPGEAKLAALTAA
K393 ADRVPWAKCRQTYFA
K405 YFARGKNKQSLDAVE
K441 ASIDSYAKSLLHGRC
K463 SITFVVFKNSKIGIN
K514 DTNPNIPKPTRLQWD
K514 DTNPNIPKPTRLQWD
K580 ALQLAHYKDMGKFCL
T588-p DMGKFCLtYEASMTR
T604-p FREGRTEtVRSCTME
Y661-p DRHLFCLyVVSKYLA
K675 AVDSPFLKEVLSEPW
K675 AVDSPFLKEVLSEPW
S741-p FHISSKFsSPETDsH
S747-p FsSPETDsHRFGKHL
K752 TDsHRFGKHLRQAMM
S771 LFGLTINSKK_____
K772 FGLTINSKK______
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