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Protein Page:
CYCS (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CYCS Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Belongs to the cytochrome c family. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Apoptosis; Protein phosphatase, Ser/Thr (non-receptor); Oxidoreductase
Cellular Component: protein phosphatase type 2A complex; mitochondrion; mitochondrial inner membrane; mitochondrial intermembrane space; nucleus; cytosol
Molecular Function: electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity; protein binding; iron ion binding; heme binding; protein serine/threonine phosphatase activity
Biological Process: cellular metabolic process; dephosphorylation; apoptosis; cellular respiration; DNA fragmentation during apoptosis; caspase activation via cytochrome c
Reference #:  P99999 (UniProtKB)
Alt. Names/Synonyms: CYC; CYCS; Cytochrome c; cytochrome c, somatic; HCS; THC4
Gene Symbols: CYCS
Molecular weight: 11,749 Da
Basal Isoelectric point: 9.59  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CYCS

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K6 __MGDVEKGKKIFIM
1 0 K8 MGDVEKGKKIFIMKC
2 1 K9 GDVEKGKKIFIMKCS
1 0 K14 GKKIFIMKCSQCHTV
1 0 K23 SQCHTVEKGGKHktG
1 0 K26 HTVEKGGKHktGPNL
2 11 K28 VEKGGKHKtGPNLHG
0 1 K28 VEKGGKHKtGPNLHG
0 1 K28-sc VEKGGKHktGPNLHG
0 4 T29-p EKGGKHktGPNLHGL
1 0 K40 LHGLFGRKtGQAPGy
0 4 K40-ub LHGLFGRktGQAPGy
0 1 T41-p HGLFGRktGQAPGys
0 3 Y47-p ktGQAPGysytAANk
0 9 S48-p tGQAPGysytAANkN
3 5 Y49-p GQAPGysytAANkNK
0 2 T50-p QAPGysytAANkNKG
1 0 K54 ysytAANKNKGIIWG
0 2 K54-ub ysytAANkNKGIIWG
1 0 K56 ytAANkNKGIIWGED
0 1 K56 ytAANkNKGIIWGED
2 86 K73-ac MEYLENPkkyIPGtk
0 1 K73 MEYLENPKkyIPGtk
0 1 K73-sc MEYLENPkkyIPGtk
1 19 K74-ac EYLENPkkyIPGtkM
0 1 Y75-p YLENPkkyIPGtkMI
0 2 T79-p PkkyIPGtkMIFVGI
1 0 K80 kkyIPGtKMIFVGIk
0 2 K80-ub kkyIPGtkMIFVGIk
2 22 K87-ac kMIFVGIkkkEERAD
0 2 K87-ub kMIFVGIkkkEERAD
2 1 K88-ac MIFVGIkkkEERADL
1 1 K89-ac IFVGIkkkEERADLI
2 75 Y98-p ERADLIAyLkKATNE
1 22 K100-ac ADLIAyLkKATNE__
0 4 K100-ub ADLIAyLkKATNE__
0 2 K100-sc ADLIAyLkKATNE__
1 0 K101 DLIAyLkKATNE___
0 1 K101 DLIAyLkKATNE___
  mouse

 
K6 __MGDVEKGKkIFVQ
K8 MGDVEKGKkIFVQKC
K9-ac GDVEKGKkIFVQKCA
K14 GKkIFVQKCAQCHTV
K23 AQCHTVEKGGKHktG
K26 HTVEKGGKHktGPNL
K28-ac VEKGGKHktGPNLHG
K28-ub VEKGGKHktGPNLHG
K28 VEKGGKHKtGPNLHG
T29-p EKGGKHktGPNLHGL
K40 LHGLFGRKTGQAAGF
K40-ub LHGLFGRkTGQAAGF
T41 HGLFGRkTGQAAGFs
F47 kTGQAAGFsyTDANk
S48-p TGQAAGFsyTDANkN
Y49-p GQAAGFsyTDANkNk
T50 QAAGFsyTDANkNkG
K54 FsyTDANKNkGITWG
K54-ub FsyTDANkNkGITWG
K56 yTDANkNKGITWGED
K56-sc yTDANkNkGITWGED
K73-ac MEYLENPkkYIPGTk
K73-ub MEYLENPkkYIPGTk
K73-sc MEYLENPkkYIPGTk
K74-ac EYLENPkkYIPGTkM
Y75 YLENPkkYIPGTkMI
T79 PkkYIPGTkMIFAGI
K80 kkYIPGTKMIFAGIk
K80-ub kkYIPGTkMIFAGIk
K87-ac kMIFAGIkKKGERAD
K87-ub kMIFAGIkKKGERAD
K88 MIFAGIkKKGERADL
K89 IFAGIkKKGERADLI
Y98-p ERADLIAyLkkATNE
K100-ac ADLIAyLkkATNE__
K100-ub ADLIAyLkkATNE__
K100-sc ADLIAyLkkATNE__
K101 DLIAyLkKATNE___
K101-sc DLIAyLkkATNE___
  rat

 
K6-ac __MGDVEkGKkIFVQ
K8 MGDVEkGKkIFVQKC
K9-ac GDVEkGKkIFVQKCA
K14 GKkIFVQKCAQCHTV
K23 AQCHTVEKGGKHktG
K26 HTVEKGGKHktGPNL
K28-ac VEKGGKHktGPNLHG
K28 VEKGGKHKtGPNLHG
K28 VEKGGKHKtGPNLHG
T29-p EKGGKHktGPNLHGL
K40 LHGLFGRKTGQAAGF
K40 LHGLFGRKTGQAAGF
T41 HGLFGRKTGQAAGFs
F47 KTGQAAGFsyTDANK
S48-p TGQAAGFsyTDANKN
Y49-p GQAAGFsyTDANKNk
T50 QAAGFsyTDANKNkG
K54 FsyTDANKNkGITWG
K54 FsyTDANKNkGITWG
K56-ac yTDANKNkGITWGED
K56 yTDANKNKGITWGED
K73-ac MEYLENPkkYIPGTk
K73 MEYLENPKkYIPGTk
K73 MEYLENPKkYIPGTk
K74-ac EYLENPkkYIPGTkM
Y75 YLENPkkYIPGTkMI
T79 PkkYIPGTkMIFAGI
K80-ac kkYIPGTkMIFAGIK
K80 kkYIPGTKMIFAGIK
K87 kMIFAGIKKkGERAD
K87 kMIFAGIKKkGERAD
K88 MIFAGIKKkGERADL
K89-ac IFAGIKKkGERADLI
Y98-p ERADLIAyLKKATNE
K100 ADLIAyLKKATNE__
K100 ADLIAyLKKATNE__
K100 ADLIAyLKKATNE__
K101 DLIAyLKKATNE___
K101 DLIAyLKKATNE___
  pig

 
K6 __MGDVEKGKKIFVQ
K8 MGDVEKGKKIFVQKC
K9 GDVEKGKKIFVQKCA
K14 GKKIFVQKCAQCHTV
K23 AQCHTVEKGGKHKTG
K26 HTVEKGGKHKTGPNL
K28 VEKGGKHKTGPNLHG
K28 VEKGGKHKTGPNLHG
K28 VEKGGKHKTGPNLHG
T29 EKGGKHKTGPNLHGL
K40 LHGLFGRKTGQAPGF
K40 LHGLFGRKTGQAPGF
T41 HGLFGRKTGQAPGFS
F47 KTGQAPGFSYTDANK
S48 TGQAPGFSYTDANKN
Y49 GQAPGFSYTDANKNK
T50 QAPGFSYTDANKNKG
K54 FSYTDANKNKGITWG
K54 FSYTDANKNKGITWG
K56 YTDANKNKGITWGEE
K56 YTDANKNKGITWGEE
K73 MEYLENPKKYIPGTK
K73 MEYLENPKKYIPGTK
K73 MEYLENPKKYIPGTK
K74 EYLENPKKYIPGTKM
Y75 YLENPKKYIPGTKMI
T79 PKKYIPGTKMIFAGI
K80 KKYIPGTKMIFAGIK
K80 KKYIPGTKMIFAGIK
K87 KMIFAGIKKKGERED
K87 KMIFAGIKKKGERED
K88 MIFAGIKKKGEREDL
K89 IFAGIKKKGEREDLI
Y98-p EREDLIAyLKKATNE
K100 EDLIAyLKKATNE__
K100 EDLIAyLKKATNE__
K100 EDLIAyLKKATNE__
K101 DLIAyLKKATNE___
K101 DLIAyLKKATNE___
  cow

 
K6-ac __MGDVEkGkkIFVQ
K8-ac MGDVEkGkkIFVQkC
K9-ac GDVEkGkkIFVQkCA
K14-ac GkkIFVQkCAQCHTV
K23-ac AQCHTVEkGGkHkTG
K26-ac HTVEkGGkHkTGPNL
K28-ac VEkGGkHkTGPNLHG
K28 VEkGGkHKTGPNLHG
K28 VEkGGkHKTGPNLHG
T29 EkGGkHkTGPNLHGL
K40-ac LHGLFGRkTGQAPGF
K40 LHGLFGRKTGQAPGF
T41 HGLFGRkTGQAPGFS
F47 kTGQAPGFSyTDANk
S48 TGQAPGFSyTDANkN
Y49-p GQAPGFSyTDANkNk
T50 QAPGFSyTDANkNkG
K54-ac FSyTDANkNkGITWG
K54 FSyTDANKNkGITWG
K56-ac yTDANkNkGITWGEE
K56 yTDANkNKGITWGEE
K73-ac MEYLENPkkYIPGTk
K73 MEYLENPKkYIPGTk
K73 MEYLENPKkYIPGTk
K74-ac EYLENPkkYIPGTkM
Y75 YLENPkkYIPGTkMI
T79 PkkYIPGTkMIFAGI
K80-ac kkYIPGTkMIFAGIk
K80 kkYIPGTKMIFAGIk
K87-ac kMIFAGIkkkGERED
K87 kMIFAGIKkkGERED
K88-ac MIFAGIkkkGEREDL
K89-ac IFAGIkkkGEREDLI
Y98-p EREDLIAyLkkATNE
K100-ac EDLIAyLkkATNE__
K100 EDLIAyLKkATNE__
K100 EDLIAyLKkATNE__
K101-ac DLIAyLkkATNE___
K101 DLIAyLkKATNE___
  horse

 
K6 __MGDVEKGKkIFVQ
K8 MGDVEKGKkIFVQKC
K9-ac GDVEKGKkIFVQKCA
K14 GKkIFVQKCAQCHTV
K23 AQCHTVEKGGKHkTG
K26 HTVEKGGKHkTGPNL
K28-ac VEKGGKHkTGPNLHG
K28 VEKGGKHKTGPNLHG
K28 VEKGGKHKTGPNLHG
T29 EKGGKHkTGPNLHGL
K40 LHGLFGRKTGQAPGF
K40 LHGLFGRKTGQAPGF
T41 HGLFGRKTGQAPGFT
F47 KTGQAPGFTYTDANK
T48 TGQAPGFTYTDANKN
Y49 GQAPGFTYTDANKNK
T50 QAPGFTYTDANKNKG
K54 FTYTDANKNKGITWK
K54 FTYTDANKNKGITWK
K56 YTDANKNKGITWKEE
K56 YTDANKNKGITWKEE
K73-ac MEYLENPkKYIPGTK
K73 MEYLENPKKYIPGTK
K73 MEYLENPKKYIPGTK
K74 EYLENPkKYIPGTKM
Y75 YLENPkKYIPGTKMI
T79 PkKYIPGTKMIFAGI
K80 kKYIPGTKMIFAGIk
K80 kKYIPGTKMIFAGIk
K87-ac KMIFAGIkkKTERED
K87 KMIFAGIKkKTERED
K88-ac MIFAGIkkKTEREDL
K89 IFAGIkkKTEREDLI
Y98 EREDLIAYLKKATNE
K100 EDLIAYLKKATNE__
K100 EDLIAYLKKATNE__
K100 EDLIAYLKKATNE__
K101 DLIAYLKKATNE___
K101 DLIAYLKKATNE___
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