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CYCS (human)

Overview CYCS Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Belongs to the cytochrome c family. Note: This description may include information from UniProtKB. Protein type: Mitochondrial; Protein phosphatase, Ser/Thr (non-receptor); Oxidoreductase; Apoptosis Cellular Component: protein phosphatase type 2A complex; mitochondrial inner membrane; mitochondrial intermembrane space; nucleus; cytosol Molecular Function: electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity; protein binding; iron ion binding; heme binding; protein serine/threonine phosphatase activity Biological Process: apoptosis; cellular respiration; DNA fragmentation during apoptosis; caspase activation via cytochrome c Reference #:  P99999 (UniProtKB) Alt. Names/Synonyms: CYC; CYCS; Cytochrome c; cytochrome c, somatic; HCS; THC4 Gene Symbols: CYCS Molecular weight: 11,749 Da Basal Isoelectric point: 9.59  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CYCS 1J3S - A=1-105 (human) 3NWV - A/D/C/B=2-105 (human) 2B4Z - A=1-105 (cow) 2YBB - Y=2-105 (cow) 3J2T - H/J/M/N/K/I/L=2-105 (cow) 1AKK - A=1-104 (horse) 1CRC - A/B=1-104 (horse) 1FI7 - A=1-104 (horse) 1FI9 - A=1-104 (horse) 1GIW - A=1-104 (horse) 1HRC - A=1-104 (horse) 1I5T - A=1-104 (horse) 1LC1 - A=1-104 (horse) 1LC2 - A=1-104 (horse) 1M60 - A=1-104 (horse) 1OCD - A=1-104 (horse) 1U75 - B=1-104 (horse) 1WEJ - F=1-104 (horse) 2FRC - A=1-104 (horse) 2GIW - A=1-104 (horse) 2PCB - B=1-104 (horse) 3NBS - A/D/C/B=2-105 (horse) 3NBT - F/A/D/C/E/B=2-105 (horse) 3O1Y - A/C/B=2-105 (horse) 3O20 - A/C/B=2-105 (horse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1J3S 3NWV  |  Phospho3D  |  DISEASE 123970 612004  |  InnateDB  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		K6	__MGDVEKGKKIFIM
1	0		K8	MGDVEKGKKIFIMKC
2	1		K9	GDVEKGKKIFIMKCS
1	0		K14	GKKIFIMKCSQCHTV
1	0		K23	SQCHTVEKGGKHKtG
1	0		K26	HTVEKGGKHKtGPNL
2	11		K28	VEKGGKHKtGPNLHG
0	1		K28	VEKGGKHKtGPNLHG
0	4		T29-p	EKGGKHKtGPNLHGL
1	0		K40	LHGLFGRKTGQAPGy
0	4		K40-u	LHGLFGRkTGQAPGy
0	3		Y47-p	kTGQAPGysytAANk
0	8		S48-p	TGQAPGysytAANkN
3	5		Y49-p	GQAPGysytAANkNK
0	1		T50-p	QAPGysytAANkNKG
1	0		K54	ysytAANKNKGIIWG
0	2		K54-u	ysytAANkNKGIIWG
1	0		K56	ytAANkNKGIIWGED
2	85		K73-a	MEYLENPkkyIPGtk
0	1		K73	MEYLENPKkyIPGtk
1	19		K74-a	EYLENPkkyIPGtkM
0	1		Y75-p	YLENPkkyIPGtkMI
0	2		T79-p	PkkyIPGtkMIFVGI
1	0		K80	kkyIPGtKMIFVGIk
0	2		K80-u	kkyIPGtkMIFVGIk
2	22		K87-a	kMIFVGIkkkEERAD
0	2		K87-u	kMIFVGIkkkEERAD
2	1		K88-a	MIFVGIkkkEERADL
1	1		K89-a	IFVGIkkkEERADLI
2	63		Y98-p	ERADLIAyLkKATNE
1	22		K100-a	ADLIAyLkKATNE__
0	4		K100-u	ADLIAyLkKATNE__
1	0		K101	DLIAyLkKATNE___

	mouse
K6	__MGDVEKGKkIFVQ
K8	MGDVEKGKkIFVQKC
K9-a	GDVEKGKkIFVQKCA
K14	GKkIFVQKCAQCHTV
K23	AQCHTVEKGGKHktG
K26	HTVEKGGKHktGPNL
K28-a	VEKGGKHktGPNLHG
K28-u	VEKGGKHktGPNLHG
T29-p	EKGGKHktGPNLHGL
K40	LHGLFGRKTGQAAGF
K40-u	LHGLFGRkTGQAAGF
F47	kTGQAAGFsyTDANk
S48-p	TGQAAGFsyTDANkN
Y49-p	GQAAGFsyTDANkNK
T50	QAAGFsyTDANkNKG
K54	FsyTDANKNKGITWG
K54-u	FsyTDANkNKGITWG
K56	yTDANkNKGITWGED
K73-a	MEYLENPkkYIPGTk
K73-u	MEYLENPkkYIPGTk
K74-a	EYLENPkkYIPGTkM
Y75	YLENPkkYIPGTkMI
T79	PkkYIPGTkMIFAGI
K80	kkYIPGTKMIFAGIk
K80-u	kkYIPGTkMIFAGIk
K87-a	kMIFAGIkKKGERAD
K87-u	kMIFAGIkKKGERAD
K88	MIFAGIkKKGERADL
K89	IFAGIkKKGERADLI
Y98-p	ERADLIAyLkKATNE
K100-a	ADLIAyLkKATNE__
K100-u	ADLIAyLkKATNE__
K101	DLIAyLkKATNE___

	rat
K6	__MGDVEKGKKIFVQ
K8	MGDVEKGKKIFVQKC
K9	GDVEKGKKIFVQKCA
K14	GKKIFVQKCAQCHTV
K23	AQCHTVEKGGKHKTG
K26	HTVEKGGKHKTGPNL
K28	VEKGGKHKTGPNLHG
K28	VEKGGKHKTGPNLHG
T29	EKGGKHKTGPNLHGL
K40	LHGLFGRKTGQAAGF
K40	LHGLFGRKTGQAAGF
F47	KTGQAAGFSyTDANK
S48	TGQAAGFSyTDANKN
Y49-p	GQAAGFSyTDANKNK
T50	QAAGFSyTDANKNKG
K54	FSyTDANKNKGITWG
K54	FSyTDANKNKGITWG
K56	yTDANKNKGITWGED
K73	MEYLENPKKYIPGTK
K73	MEYLENPKKYIPGTK
K74	EYLENPKKYIPGTKM
Y75	YLENPKKYIPGTKMI
T79	PKKYIPGTKMIFAGI
K80	KKYIPGTKMIFAGIK
K80	KKYIPGTKMIFAGIK
K87	KMIFAGIKKKGERAD
K87	KMIFAGIKKKGERAD
K88	MIFAGIKKKGERADL
K89	IFAGIKKKGERADLI
Y98-p	ERADLIAyLKKATNE
K100	ADLIAyLKKATNE__
K100	ADLIAyLKKATNE__
K101	DLIAyLKKATNE___

	cow
K6-a	__MGDVEkGkkIFVQ
K8-a	MGDVEkGkkIFVQkC
K9-a	GDVEkGkkIFVQkCA
K14-a	GkkIFVQkCAQCHTV
K23-a	AQCHTVEkGGkHkTG
K26-a	HTVEkGGkHkTGPNL
K28-a	VEkGGkHkTGPNLHG
K28	VEkGGkHKTGPNLHG
T29	EkGGkHkTGPNLHGL
K40-a	LHGLFGRkTGQAPGF
K40	LHGLFGRKTGQAPGF
F47	kTGQAPGFSyTDANk
S48	TGQAPGFSyTDANkN
Y49-p	GQAPGFSyTDANkNk
T50	QAPGFSyTDANkNkG
K54-a	FSyTDANkNkGITWG
K54	FSyTDANKNkGITWG
K56-a	yTDANkNkGITWGEE
K73-a	MEYLENPkkYIPGTk
K73	MEYLENPKkYIPGTk
K74-a	EYLENPkkYIPGTkM
Y75	YLENPkkYIPGTkMI
T79	PkkYIPGTkMIFAGI
K80-a	kkYIPGTkMIFAGIk
K80	kkYIPGTKMIFAGIk
K87-a	kMIFAGIkkkGERED
K87	kMIFAGIKkkGERED
K88-a	MIFAGIkkkGEREDL
K89-a	IFAGIkkkGEREDLI
Y98-p	EREDLIAyLkkATNE
K100-a	EDLIAyLkkATNE__
K100	EDLIAyLKkATNE__
K101-a	DLIAyLkkATNE___

	horse
K6	__MGDVEKGKkIFVQ
K8	MGDVEKGKkIFVQKC
K9-a	GDVEKGKkIFVQKCA
K14	GKkIFVQKCAQCHTV
K23	AQCHTVEKGGKHkTG
K26	HTVEKGGKHkTGPNL
K28-a	VEKGGKHkTGPNLHG
K28	VEKGGKHKTGPNLHG
T29	EKGGKHkTGPNLHGL
K40	LHGLFGRKTGQAPGF
K40	LHGLFGRKTGQAPGF
F47	KTGQAPGFTYTDANK
T48	TGQAPGFTYTDANKN
Y49	GQAPGFTYTDANKNK
T50	QAPGFTYTDANKNKG
K54	FTYTDANKNKGITWK
K54	FTYTDANKNKGITWK
K56	YTDANKNKGITWKEE
K73-a	MEYLENPkKYIPGTK
K73	MEYLENPKKYIPGTK
K74	EYLENPkKYIPGTKM
Y75	YLENPkKYIPGTKMI
T79	PkKYIPGTKMIFAGI
K80	kKYIPGTKMIFAGIk
K80	kKYIPGTKMIFAGIk
K87-a	KMIFAGIkkKTERED
K87	KMIFAGIKkKTERED
K88-a	MIFAGIkkKTEREDL
K89	IFAGIkkKTEREDLI
Y98	EREDLIAYLKKATNE
K100	EDLIAYLKKATNE__
K100	EDLIAYLKKATNE__
K101	DLIAYLKKATNE___

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