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Protein Page:
CYCS (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CYCS Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Belongs to the cytochrome c family. Note: This description may include information from UniProtKB.
Protein type: Protein phosphatase, Ser/Thr (non-receptor); Oxidoreductase; Mitochondrial; Apoptosis
Cellular Component: mitochondrion; cytosol
Molecular Function: electron carrier activity; heme binding
Biological Process: apoptosis; hydrogen peroxide metabolic process; caspase activation via cytochrome c
Reference #:  P62897 (UniProtKB)
Alt. Names/Synonyms: CYC; Cycs; Cytochrome c, somatic
Gene Symbols: Cycs
Molecular weight: 11,605 Da
Basal Isoelectric point: 9.61  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CYCS

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
1 0 K6 __MGDVEKGKkIFVQ
1 0 K8 MGDVEKGKkIFVQKC
2 1 K9-a GDVEKGKkIFVQKCA
1 0 K14 GKkIFVQKCAQCHTV
1 0 K23 AQCHTVEKGGKHktG
1 0 K26 HTVEKGGKHktGPNL
2 11 K28-a VEKGGKHktGPNLHG
0 1 K28-u VEKGGKHktGPNLHG
0 4 T29-p EKGGKHktGPNLHGL
1 0 K40 LHGLFGRKTGQAAGF
0 4 K40-u LHGLFGRkTGQAAGF
0 3 F47 kTGQAAGFsyTDANk
0 8 S48-p TGQAAGFsyTDANkN
3 5 Y49-p GQAAGFsyTDANkNK
0 1 T50 QAAGFsyTDANkNKG
1 0 K54 FsyTDANKNKGITWG
0 2 K54-u FsyTDANkNKGITWG
1 0 K56 yTDANkNKGITWGED
2 85 K73-a MEYLENPkkYIPGTk
0 1 K73-u MEYLENPkkYIPGTk
1 19 K74-a EYLENPkkYIPGTkM
0 2 T79 PkkYIPGTkMIFAGI
1 0 K80 kkYIPGTKMIFAGIk
0 2 K80-u kkYIPGTkMIFAGIk
2 22 K87-a kMIFAGIkKKGERAD
0 2 K87-u kMIFAGIkKKGERAD
2 1 K88 MIFAGIkKKGERADL
1 1 K89 IFAGIkKKGERADLI
2 64 Y98-p ERADLIAyLkKATNE
1 22 K100-a ADLIAyLkKATNE__
0 4 K100-u ADLIAyLkKATNE__
1 0 K101 DLIAyLkKATNE___
  human

 
K6 __MGDVEKGKKIFIM
K8 MGDVEKGKKIFIMKC
K9 GDVEKGKKIFIMKCS
K14 GKKIFIMKCSQCHTV
K23 SQCHTVEKGGKHKtG
K26 HTVEKGGKHKtGPNL
K28 VEKGGKHKtGPNLHG
K28 VEKGGKHKtGPNLHG
T29-p EKGGKHKtGPNLHGL
K40 LHGLFGRKTGQAPGy
K40-u LHGLFGRkTGQAPGy
Y47-p kTGQAPGysytAANk
S48-p TGQAPGysytAANkN
Y49-p GQAPGysytAANkNK
T50-p QAPGysytAANkNKG
K54 ysytAANKNKGIIWG
K54-u ysytAANkNKGIIWG
K56 ytAANkNKGIIWGED
K73-a MEYLENPkkYIPGtk
K73 MEYLENPKkYIPGtk
K74-a EYLENPkkYIPGtkM
T79-p PkkYIPGtkMIFVGI
K80 kkYIPGtKMIFVGIk
K80-u kkYIPGtkMIFVGIk
K87-a kMIFVGIkkkEERAD
K87-u kMIFVGIkkkEERAD
K88-a MIFVGIkkkEERADL
K89-a IFVGIkkkEERADLI
Y98-p ERADLIAyLkKATNE
K100-a ADLIAyLkKATNE__
K100-u ADLIAyLkKATNE__
K101 DLIAyLkKATNE___
  rat

 
K6 __MGDVEKGKKIFVQ
K8 MGDVEKGKKIFVQKC
K9 GDVEKGKKIFVQKCA
K14 GKKIFVQKCAQCHTV
K23 AQCHTVEKGGKHKTG
K26 HTVEKGGKHKTGPNL
K28 VEKGGKHKTGPNLHG
K28 VEKGGKHKTGPNLHG
T29 EKGGKHKTGPNLHGL
K40 LHGLFGRKTGQAAGF
K40 LHGLFGRKTGQAAGF
F47 KTGQAAGFSyTDANK
S48 TGQAAGFSyTDANKN
Y49-p GQAAGFSyTDANKNK
T50 QAAGFSyTDANKNKG
K54 FSyTDANKNKGITWG
K54 FSyTDANKNKGITWG
K56 yTDANKNKGITWGED
K73 MEYLENPKKYIPGTK
K73 MEYLENPKKYIPGTK
K74 EYLENPKKYIPGTKM
T79 PKKYIPGTKMIFAGI
K80 KKYIPGTKMIFAGIK
K80 KKYIPGTKMIFAGIK
K87 KMIFAGIKKKGERAD
K87 KMIFAGIKKKGERAD
K88 MIFAGIKKKGERADL
K89 IFAGIKKKGERADLI
Y98-p ERADLIAyLKKATNE
K100 ADLIAyLKKATNE__
K100 ADLIAyLKKATNE__
K101 DLIAyLKKATNE___
  pig

 
K6 __MGDVEKGKKIFVQ
K8 MGDVEKGKKIFVQKC
K9 GDVEKGKKIFVQKCA
K14 GKKIFVQKCAQCHTV
K23 AQCHTVEKGGKHKTG
K26 HTVEKGGKHKTGPNL
K28 VEKGGKHKTGPNLHG
K28 VEKGGKHKTGPNLHG
T29 EKGGKHKTGPNLHGL
K40 LHGLFGRKTGQAPGF
K40 LHGLFGRKTGQAPGF
F47 KTGQAPGFSYTDANK
S48 TGQAPGFSYTDANKN
Y49 GQAPGFSYTDANKNK
T50 QAPGFSYTDANKNKG
K54 FSYTDANKNKGITWG
K54 FSYTDANKNKGITWG
K56 YTDANKNKGITWGEE
K73 MEYLENPKKYIPGTK
K73 MEYLENPKKYIPGTK
K74 EYLENPKKYIPGTKM
T79 PKKYIPGTKMIFAGI
K80 KKYIPGTKMIFAGIK
K80 KKYIPGTKMIFAGIK
K87 KMIFAGIKKKGERED
K87 KMIFAGIKKKGERED
K88 MIFAGIKKKGEREDL
K89 IFAGIKKKGEREDLI
Y98-p EREDLIAyLKKATNE
K100 EDLIAyLKKATNE__
K100 EDLIAyLKKATNE__
K101 DLIAyLKKATNE___
  cow

 
K6-a __MGDVEkGkkIFVQ
K8-a MGDVEkGkkIFVQkC
K9-a GDVEkGkkIFVQkCA
K14-a GkkIFVQkCAQCHTV
K23-a AQCHTVEkGGkHkTG
K26-a HTVEkGGkHkTGPNL
K28-a VEkGGkHkTGPNLHG
K28 VEkGGkHKTGPNLHG
T29 EkGGkHkTGPNLHGL
K40-a LHGLFGRkTGQAPGF
K40 LHGLFGRKTGQAPGF
F47 kTGQAPGFSyTDANk
S48 TGQAPGFSyTDANkN
Y49-p GQAPGFSyTDANkNk
T50 QAPGFSyTDANkNkG
K54-a FSyTDANkNkGITWG
K54 FSyTDANKNkGITWG
K56-a yTDANkNkGITWGEE
K73-a MEYLENPkkYIPGTk
K73 MEYLENPKkYIPGTk
K74-a EYLENPkkYIPGTkM
T79 PkkYIPGTkMIFAGI
K80-a kkYIPGTkMIFAGIk
K80 kkYIPGTKMIFAGIk
K87-a kMIFAGIkkkGERED
K87 kMIFAGIKkkGERED
K88-a MIFAGIkkkGEREDL
K89-a IFAGIkkkGEREDLI
Y98-p EREDLIAyLkkATNE
K100-a EDLIAyLkkATNE__
K100 EDLIAyLKkATNE__
K101-a DLIAyLkkATNE___
  horse

 
K6 __MGDVEKGKkIFVQ
K8 MGDVEKGKkIFVQKC
K9-a GDVEKGKkIFVQKCA
K14 GKkIFVQKCAQCHTV
K23 AQCHTVEKGGKHkTG
K26 HTVEKGGKHkTGPNL
K28-a VEKGGKHkTGPNLHG
K28 VEKGGKHKTGPNLHG
T29 EKGGKHkTGPNLHGL
K40 LHGLFGRKTGQAPGF
K40 LHGLFGRKTGQAPGF
F47 KTGQAPGFTYTDANK
T48 TGQAPGFTYTDANKN
Y49 GQAPGFTYTDANKNK
T50 QAPGFTYTDANKNKG
K54 FTYTDANKNKGITWK
K54 FTYTDANKNKGITWK
K56 YTDANKNKGITWKEE
K73-a MEYLENPkKYIPGTK
K73 MEYLENPKKYIPGTK
K74 EYLENPkKYIPGTKM
T79 PkKYIPGTKMIFAGI
K80 kKYIPGTKMIFAGIk
K80 kKYIPGTKMIFAGIk
K87-a KMIFAGIkkKTERED
K87 KMIFAGIKkKTERED
K88-a MIFAGIkkKTEREDL
K89 IFAGIkkKTEREDLI
Y98 EREDLIAYLKKATNE
K100 EDLIAYLKKATNE__
K100 EDLIAYLKKATNE__
K101 DLIAYLKKATNE___
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