Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
ACSL1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ACSL1 Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate. Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Lipid Metabolism - fatty acid; Ligase; EC 6.2.1.3; Membrane protein, integral
Cellular Component: peroxisomal membrane; mitochondrial outer membrane; endoplasmic reticulum membrane; mitochondrion; plasma membrane; integral to membrane
Molecular Function: ATP binding; long-chain-fatty-acid-CoA ligase activity
Biological Process: response to drug; response to oleate; unsaturated fatty acid metabolic process; lipid biosynthetic process; linoleic acid metabolic process; adiponectin-mediated signaling pathway; triacylglycerol biosynthetic process; long-chain fatty acid metabolic process; cellular lipid metabolic process; response to organic cyclic substance; response to nutrient; xenobiotic catabolic process
Reference #:  P33121 (UniProtKB)
Alt. Names/Synonyms: ACS1; ACSL1; Acyl-CoA synthetase 1; acyl-CoA synthetase long-chain family member 1; FACL1; FACL2; fatty-acid-Coenzyme A ligase, long-chain 1; fatty-acid-Coenzyme A ligase, long-chain 2; LACS; LACS 1; LACS 2; LACS1; LACS2; lignoceroyl-CoA synthase; Long-chain acyl-CoA synthetase 1; Long-chain acyl-CoA synthetase 2; Long-chain fatty acid-CoA ligase 2; long-chain fatty-acid-coenzyme A ligase 1; Long-chain-fatty-acid--CoA ligase 1; Palmitoyl-CoA ligase 1; Palmitoyl-CoA ligase 2; paltimoyl-CoA ligase 1
Gene Symbols: ACSL1
Molecular weight: 77,943 Da
Basal Isoelectric point: 6.81  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ACSL1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K52 ATRPKPLKPPCDLSM
0 1 E80 SALLDSDEPLVYFYD
0 1 Y84 DSDEPLVYFYDDVTT
0 1 S103-p FQRGIQVsNNGPCLG
0 1 K113 GPCLGSRKPDQPYEW
0 1 K202 LSLVFVDKPEKAKLL
0 1 K207 VDKPEKAKLLLEGVE
0 1 K216 LLEGVENKLIPGLKI
0 11 K216-u LLEGVENkLIPGLKI
0 2 A229 KIIVVMDAYGSELVE
0 1 S232 VVMDAYGSELVERGQ
0 1 R240 ELVERGQRCGVEVTS
0 2 K356-u RLLMDDLkVLQPTVF
0 22 K386-a GQANTTLkRWLLDFA
0 1 K386 GQANTTLKRWLLDFA
0 1 S394-p RWLLDFAskRKEAEL
0 7 K395-a WLLDFAskRKEAELR
0 3 K395-u WLLDFAskRKEAELR
0 1 S410 SGIIRNNSLWDRLIF
0 1 R414 RNNSLWDRLIFHkVQ
0 7 K419-u WDRLIFHkVQSSLGG
0 1 R427 VQSSLGGRVRLMVTG
0 1 K511 GEGEVCVKGPNVFQG
0 1 Q517 VKGPNVFQGYLKDPA
0 1 K521 NVFQGYLKDPAKTAE
0 2 K532-u KTAEALDkDGWLHTG
0 5 K543 LHTGDIGKWLPNGTL
0 1 K551 WLPNGTLKIIDRKKH
0 1 K561 DRKKHIFKLAQGEyI
0 18 Y567-p FKLAQGEyIAPEKIE
0 17 Y577-p PEKIENIyMRSEPVA
0 3 S620 QKRGFEGSFEELCRN
0 1 K632 CRNKDVKKAILEDMV
0 1 K632 CRNKDVKKAILEDMV
0 1 R640 AILEDMVRLGKDSGL
0 1 K643 EDMVRLGKDSGLKPF
0 1 K654 LKPFEQVKGITLHPE
0 1 K675 GLLTPTMKAKRPELR
0 10 Y693-p RSQIDDLySTIKV__
0 1 K697 DDLySTIKV______
  mouse

 
K52-u ATRPKALkPPCDLSM
K81-u SAVLEDDkLLVYYYD
Y85 EDDkLLVYYYDDVRT
S104 FQRGIQVSNNGPCLG
K114-u GPCLGSRkPNQPYEW
K203-u LSVIFADkPEKAkLL
K208-u ADkPEKAkLLLEGVE
K217-a LLEGVENkLTPCLKI
K217-u LLEGVENkLTPCLKI
S230-p KIIVIMDsYGsDLVE
S233-p VIMDsYGsDLVERGK
K241-u DLVERGKkCGVEIIS
K357-u RLLMDDLkVLQPTIF
K387-a GQANTSLkRWLLDFA
K387-u GQANTSLkRWLLDFA
S395 RWLLDFASkRKEAEL
K396-a WLLDFASkRKEAELR
K396-u WLLDFASkRKEAELR
S411-p SGIVRNNsLWDkLIF
K415-u RNNsLWDkLIFHkIQ
K420-u WDkLIFHkIQSSLGG
K428-u IQSSLGGkVRLMITG
K512-u GEGEVCVkGANVFkG
K518-u VkGANVFkGYLkDPA
K522-u NVFkGYLkDPARTAE
K533-u RTAEALDkDGWLHTG
K544-a LHTGDIGkWLPNGTL
K552-u WLPNGTLkIIDRKKH
K562-u DRKKHIFkLAQGEYI
Y568 FkLAQGEYIAPEKIE
Y578 PEKIENIYLRSEAVA
S621-p QKRGLQGsFEELCRN
K633 CRNKDINKAILDDLL
K633-u CRNKDINkAILDDLL
K641-u AILDDLLkLGkEAGL
K644-u DDLLkLGkEAGLKPF
K655-u LKPFEQVkGIAVHPE
K676-u GLLTPTLkAKRPELR
Y694 RSQIDELYATIkI__
K698-u DELYATIkI______
  rat

 
K52 ATRPKALKPPCDLSM
K81 SAVLEDDKLLLyYYD
Y85-p EDDKLLLyYYDDVRT
S104 FQRGIQVSNDGPCLG
K114 GPCLGSRKPNQPYEW
K203 LSVIFADKPEKAKLL
K208 ADKPEKAKLLLEGVE
K217 LLEGVENKLTPCLKI
K217 LLEGVENKLTPCLKI
S230 KIIVIMDSYDNDLVE
N233 VIMDSYDNDLVERGQ
K241 DLVERGQKCGVEIIG
K357 RLLMDDLKVLQPTIF
K387 GQANTSVKRWLLDFA
K387 GQANTSVKRWLLDFA
S395 RWLLDFASKRKEAEL
K396 WLLDFASKRKEAELR
K396 WLLDFASKRKEAELR
S411 SGIVRNNSLWDKLIF
K415 RNNSLWDKLIFHKIQ
K420 WDKLIFHKIQSSLGG
K428 IQSSLGGKVRLMITG
K512 GEGEVCVKGANVFKG
K518 VKGANVFKGYLKDPA
K522 NVFKGYLKDPARTAE
K533 RTAEALDKDGWLHTG
K544 LHTGDIGKWLPNGTL
K552 WLPNGTLKIIDRKKH
K562 DRKKHIFKLAQGEYI
Y568 FKLAQGEYIAPEKIE
Y578 PEKIENIYLRSEAVA
S621 QKRGFQGSFEELCRN
K633-a CRNKDINkAILEDMV
K633 CRNKDINKAILEDMV
K641 AILEDMVKLGKNAGL
K644 EDMVKLGKNAGLKPF
K655 LKPFEQVKGIAVHPE
K676 GLLTPTLKAKRPELR
Y694 RSQIDELYSTIKI__
K698 DELYSTIKI______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.