Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
ACSL1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ACSL1 Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate. Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 6.2.1.3; Ligase; Lipid Metabolism - fatty acid; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q35.1
Cellular Component: peroxisomal membrane; mitochondrial outer membrane; endoplasmic reticulum membrane; mitochondrion; membrane; plasma membrane; integral to membrane
Molecular Function: ATP binding; long-chain-fatty-acid-CoA ligase activity
Biological Process: response to drug; response to oleate; unsaturated fatty acid metabolic process; lipid biosynthetic process; adiponectin-mediated signaling pathway; linoleic acid metabolic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; long-chain fatty acid metabolic process; response to organic cyclic substance; response to nutrient; xenobiotic catabolic process
Reference #:  P33121 (UniProtKB)
Alt. Names/Synonyms: ACS1; ACSL1; Acyl-CoA synthetase 1; acyl-CoA synthetase long-chain family member 1; FACL1; FACL2; fatty-acid-Coenzyme A ligase, long-chain 1; fatty-acid-Coenzyme A ligase, long-chain 2; LACS; LACS 1; LACS 2; LACS1; LACS2; lignoceroyl-CoA synthase; Long-chain acyl-CoA synthetase 1; Long-chain acyl-CoA synthetase 2; Long-chain fatty acid-CoA ligase 2; long-chain fatty-acid-coenzyme A ligase 1; Long-chain-fatty-acid--CoA ligase 1; Palmitoyl-CoA ligase 1; Palmitoyl-CoA ligase 2; paltimoyl-CoA ligase 1
Gene Symbols: ACSL1
Molecular weight: 77,943 Da
Basal Isoelectric point: 6.81  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ACSL1

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K52 ATRPKPLKPPCDLSM
0 1 E80 SALLDSDEPLVYFYD
0 1 Y84 DSDEPLVYFYDDVTT
0 1 S103-p FQRGIQVsNNGPCLG
0 1 K113 GPCLGSRKPDQPYEW
0 1 S122-p DQPYEWLsYKQVAEL
0 1 Y188-p LGNEAITyIVNKAEL
0 1 K202 LSLVFVDKPEKAKLL
0 1 K202 LSLVFVDKPEKAKLL
0 1 K207 VDKPEKAKLLLEGVE
0 1 K207 VDKPEKAKLLLEGVE
0 1 K207 VDKPEKAKLLLEGVE
0 1 K216 LLEGVENKLIPGLkI
0 11 K216-ub LLEGVENkLIPGLkI
0 1 K222-ub NkLIPGLkIIVVMDA
0 3 A229 kIIVVMDAYGsELVE
0 1 Y230 IIVVMDAYGsELVER
0 2 S232-p VVMDAYGsELVERGQ
0 1 R240 ELVERGQRCGVEVTS
0 1 R240 ELVERGQRCGVEVTS
0 1 K263 RANRRKPKPPAPEDL
0 1 K356 RLLMDDLKVLQPTVF
0 2 K356-ub RLLMDDLkVLQPTVF
0 23 K386-ac GQANTTLkRWLLDFA
0 1 K386 GQANTTLKRWLLDFA
0 2 K386 GQANTTLKRWLLDFA
0 1 S394-p RWLLDFAskRKEAEL
0 7 K395-ac WLLDFAskRKEAELR
0 3 K395-ub WLLDFAskRKEAELR
0 4 S410-p SGIIRNNsLWDRLIF
0 1 R414 RNNsLWDRLIFHkVQ
0 7 K419-ub WDRLIFHkVQSSLGG
0 1 S423 IFHkVQSSLGGRVRL
0 1 R427 VQSSLGGRVRLMVTG
0 1 T441 GAAPVSATVLTFLRA
0 1 K511 GEGEVCVKGPNVFQG
0 1 K511 GEGEVCVKGPNVFQG
0 1 Q517 VKGPNVFQGYLKDPA
0 1 Q517 VKGPNVFQGYLKDPA
0 1 K521 NVFQGYLKDPAKTAE
0 1 K521 NVFQGYLKDPAKTAE
0 1 K532 KTAEALDKDGWLHTG
0 2 K532-ub KTAEALDkDGWLHTG
0 1 K532 KTAEALDKDGWLHTG
0 6 K543 LHTGDIGKWLPNGTL
0 1 K551 WLPNGTLKIIDRKKH
0 1 K551 WLPNGTLKIIDRKKH
0 1 K551 WLPNGTLKIIDRKKH
0 1 K561 DRKKHIFKLAQGEyI
0 1 K561 DRKKHIFKLAQGEyI
0 18 Y567-p FKLAQGEyIAPEKIE
0 1 K572 GEyIAPEKIENIyMR
0 17 Y577-p PEKIENIyMRSEPVA
0 5 S620-p QKRGFEGsFEELCRN
0 2 K632 CRNKDVKKAILEDMV
0 1 K632 CRNKDVKKAILEDMV
0 1 R640 AILEDMVRLGKDSGL
0 1 R640 AILEDMVRLGKDSGL
0 1 K643 EDMVRLGKDSGLKPF
0 1 K648 LGKDSGLKPFEQVKG
0 1 K654 LKPFEQVKGITLHPE
0 1 S664-p TLHPELFsIDNGLLT
0 1 T671 sIDNGLLTPTMKAKR
0 1 K675 GLLTPTMKAKRPELR
0 10 Y693-p RSQIDDLyStIKV__
0 1 T695-p QIDDLyStIKV____
0 1 K697 DDLyStIKV______
  mouse

 
K52-ub ATRPKALkPPCDLSM
K81-ub SAVLEDDkLLVYYYD
Y85 EDDkLLVYYYDDVRT
S104 FQRGIQVSNNGPCLG
K114-ub GPCLGSRkPNQPYEW
S123 NQPYEWISYKEVAEL
Y189 LGADAITYIVNKAEL
K203-ac LSVIFADkPEKAkLL
K203-ub LSVIFADkPEKAkLL
K208-ac ADkPEKAkLLLEGVE
K208-ub ADkPEKAkLLLEGVE
K208-sc ADkPEKAkLLLEGVE
K217-ac LLEGVENkLTPCLKI
K217-ub LLEGVENkLTPCLKI
K223 NkLTPCLKIIVIMDs
S230-p KIIVIMDsyGsDLVE
Y231-p IIVIMDsyGsDLVER
S233-p VIMDsyGsDLVERGK
K241-ub DLVERGKkCGVEIIS
K241-sc DLVERGKkCGVEIIS
K264-ac RVNRVKPkPPEPEDL
K357-ac RLLMDDLkVLQPTIF
K357-ub RLLMDDLkVLQPTIF
K387-ac GQANTSLkRWLLDFA
K387-ub GQANTSLkRWLLDFA
K387-sc GQANTSLkRWLLDFA
S395 RWLLDFASkRKEAEL
K396-ac WLLDFASkRKEAELR
K396-ub WLLDFASkRKEAELR
S411-p SGIVRNNsLWDkLIF
K415-ub RNNsLWDkLIFHkIQ
K420-ub WDkLIFHkIQSsLGG
S424-p IFHkIQSsLGGkVRL
K428-ub IQSsLGGkVRLMITG
T442-p GAAPVSAtVLTFLRT
K512-ub GEGEVCVkGANVFkG
K512-sc GEGEVCVkGANVFkG
K518-ub VkGANVFkGYLkDPA
K518-sc VkGANVFkGYLkDPA
K522-ub NVFkGYLkDPARTAE
K522-sc NVFkGYLkDPARTAE
K533-ac RTAEALDkDGWLHTG
K533-ub RTAEALDkDGWLHTG
K533-sc RTAEALDkDGWLHTG
K544-ac LHTGDIGkWLPNGTL
K552-ac WLPNGTLkIIDRKKH
K552-ub WLPNGTLkIIDRKKH
K552-sc WLPNGTLkIIDRKKH
K562-ac DRKKHIFkLAQGEYI
K562-ub DRKKHIFkLAQGEYI
Y568 FkLAQGEYIAPEkIE
K573-ac GEYIAPEkIENIYLR
Y578 PEkIENIYLRSEAVA
S621-p QKRGLQGsFEELCRN
K633-ac CRNKDINkAILDDLL
K633-ub CRNKDINkAILDDLL
K641-ac AILDDLLkLGkEAGL
K641-ub AILDDLLkLGkEAGL
K644-ub DDLLkLGkEAGLkPF
K649-ac LGkEAGLkPFEQVkG
K655-ub LkPFEQVkGIAVHPE
S665 AVHPELFSIDNGLLt
T672-p SIDNGLLtPTLkAKR
K676-ub GLLtPTLkAKRPELR
Y694 RSQIDELYATIkI__
T696 QIDELYATIkI____
K698-ub DELYATIkI______
  rat

 
K52 ATRPKALKPPCDLSM
K81 SAVLEDDKLLLyYYD
Y85-p EDDKLLLyYYDDVRT
S104 FQRGIQVSNDGPCLG
K114 GPCLGSRKPNQPYEW
- under review  
Y189 LGTDAITYIVNKAEL
K203-ac LSVIFADkPEKAKLL
K203 LSVIFADKPEKAKLL
K208 ADkPEKAKLLLEGVE
K208 ADkPEKAKLLLEGVE
K208 ADkPEKAKLLLEGVE
K217 LLEGVENKLTPCLKI
K217 LLEGVENKLTPCLKI
K223 NKLTPCLKIIVIMDS
S230 KIIVIMDSYDNDLVE
Y231 IIVIMDSYDNDLVER
N233 VIMDSYDNDLVERGQ
K241 DLVERGQKCGVEIIG
K241 DLVERGQKCGVEIIG
K264 RVNRTKPKPPEPEDL
K357-ac RLLMDDLkVLQPTIF
K357 RLLMDDLKVLQPTIF
K387-ac GQANTSVkRWLLDFA
K387 GQANTSVKRWLLDFA
K387 GQANTSVKRWLLDFA
S395 RWLLDFASKRKEAEL
K396 WLLDFASKRKEAELR
K396 WLLDFASKRKEAELR
S411-p SGIVRNNsLWDKLIF
K415 RNNsLWDKLIFHKIQ
K420 WDKLIFHKIQSSLGG
S424 IFHKIQSSLGGKVRL
K428 IQSSLGGKVRLMITG
T442 GAAPVSATVLTFLRA
K512 GEGEVCVKGANVFKG
K512 GEGEVCVKGANVFKG
K518 VKGANVFKGYLKDPA
K518 VKGANVFKGYLKDPA
K522 NVFKGYLKDPARTAE
K522 NVFKGYLKDPARTAE
K533-ac RTAEALDkDGWLHTG
K533 RTAEALDKDGWLHTG
K533 RTAEALDKDGWLHTG
K544-ac LHTGDIGkWLPNGTL
K552-ac WLPNGTLkIIDRKKH
K552 WLPNGTLKIIDRKKH
K552 WLPNGTLKIIDRKKH
K562 DRKKHIFKLAQGEYI
K562 DRKKHIFKLAQGEYI
Y568 FKLAQGEYIAPEkIE
K573-ac GEYIAPEkIENIYLR
Y578 PEkIENIYLRSEAVA
S621 QKRGFQGSFEELCRN
K633-ac CRNKDINkAILEDMV
K633 CRNKDINKAILEDMV
K641-ac AILEDMVkLGKNAGL
K641 AILEDMVKLGKNAGL
K644 EDMVkLGKNAGLkPF
K649-ac LGKNAGLkPFEQVKG
K655 LkPFEQVKGIAVHPE
S665 AVHPELFSIDNGLLT
T672 SIDNGLLTPTLKAKR
K676 GLLTPTLKAKRPELR
Y694 RSQIDELYSTIKI__
T696 QIDELYSTIKI____
K698 DELYSTIKI______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.