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Protein Page:
DAGLBETA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DAGLBETA Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses. Belongs to the AB hydrolase superfamily. Lipase family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Lipase; EC 3.1.1.-
Cellular Component: lysosomal membrane; integral to membrane; plasma membrane
Molecular Function: triacylglycerol lipase activity; metal ion binding
Biological Process: platelet activation; neuroblast proliferation; arachidonic acid metabolic process; blood coagulation; lipid catabolic process; neurotransmitter biosynthetic process
Reference #:  Q8NCG7 (UniProtKB)
Alt. Names/Synonyms: DAGLB; DAGLBETA; DGL-beta; DGLB; diacylglycerol lipase, beta; FLJ33624; FLJ33909; FLJ45532; KCCR13L; Sn1-specific diacylglycerol lipase beta
Gene Symbols: DAGLB
Molecular weight: 73,732 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DAGLBETA

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S171-p PYSSAGPsHLDsHDS
0 2 S175-p AGPsHLDsHDSSQLL
0 3 Y318-p CRSRTTDyDLVGGDQ
0 1 S378-p VAVRGTMsLQDVLtD
0 1 T384-p MsLQDVLtDLSAESE
0 1 K477 PPRGLWSKALQEYSQ
0 1 R510 TNLEDLKRRILRVVA
0 6 S570-p QSLLTRWsPAysFss
0 1 Y573-p LTRWsPAysFssDsP
0 23 S574-p TRWsPAysFssDsPL
0 4 S576-p WsPAysFssDsPLDS
0 4 S577-p sPAysFssDsPLDSs
0 8 S579-p AysFssDsPLDSsPK
0 4 S583 ssDsPLDSsPKYPPL
0 1 S584-p sDsPLDSsPKYPPLY
0 1 K586 sPLDSsPKYPPLYPP
0 2 K628-ub SHEAEFSkILIGPKM
  mouse

 
E171 PYPPCIPEHLDSNSS
S175 CIPEHLDSNSSNRLL
Y318 CRARDIEYDAVEGDQ
S378 VAVRGTMSLQDVLTD
T384 MSLQDVLTDLSAESE
K477-ub PPRGLLSkSLYEYSK
R510 TNMEDLKRRILRVIA
S570-p QTLLTRYsPGYCssD
Y573 LTRYsPGYCssDsPL
C574 TRYsPGYCssDsPLD
S575-p RYsPGYCssDsPLDs
S576-p YsPGYCssDsPLDsP
S578-p PGYCssDsPLDsPTk
S582-p ssDsPLDsPTkYPTL
P583 sDsPLDsPTkYPTLY
K585-ub sPLDsPTkYPTLYPP
K627-ub AHEAEFSkILIGPKM
  rat

 
E171 PYPPCIPEHLDSNSS
S175 CIPEHLDSNSSNHLL
Y318 CRGRDIEYDAVEGDE
S378 VAVRGTMSLQDVLTD
T384 MSLQDVLTDLSAESE
K477 PPRGLLSKSLFEYSK
R510-m1 ANMEDLKrRILRVIA
S570 QTLLTRCSPGYCSGD
Y573 LTRCSPGYCSGDSPL
C574 TRCSPGYCSGDSPLD
S575 RCSPGYCSGDSPLDS
G576 CSPGYCSGDSPLDSP
S578 PGYCSGDSPLDSPKY
S582 SGDSPLDSPKYPTLY
P583 GDSPLDSPKYPTLYP
K584 DSPLDSPKYPTLYPP
K626 AHETEFSKILIGPKM
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