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Protein Page:
PDE4DIP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PDE4DIP May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes. A chromosomal aberration involving PDE4DIP may be the cause of a myeloproliferative disorder (MBD) associated with eosinophilia. Translocation t(1;5)(q23;q33) that forms a PDE4DIP- PDGFRB fusion protein. 11 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: Golgi apparatus; centrosome; myofibril; cytoplasm; nucleus
Molecular Function: protein binding; enzyme binding
Biological Process: cellular protein complex assembly
Reference #:  Q5VU43-2 (UniProtKB)
Alt. Names/Synonyms: cardiomyopathy associated 2; Cardiomyopathy-associated protein 2; CMYA2; DKFZp781J054; KIAA0454; KIAA0477; MGC75440; MMGL; MYOME; Myomegalin; PDE4DIP; phosphodiesterase 4D interacting protein; Phosphodiesterase 4D-interacting protein
Gene Symbols: PDE4DIP
Molecular weight: 128,464 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
Select Structure to View Below

PDE4DIP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 - gap
0 1 - gap
0 1 N112 GAEIKAGNGTVDMSV
0 1 T114 EIKAGNGTVDMSVLP
0 1 S118 GNGTVDMSVLPDARY
0 20 S178-p AALRVADsDyEAICK
0 155 Y180-p LRVADsDyEAICKVP
0 1 S193-p VPRKVARsIsCGPss
0 5 S195-p RKVARsIsCGPssRW
0 1 S199-p RsIsCGPssRWSTSI
0 1 S200-p sIsCGPssRWSTSIC
0 2 S252-p LDASVQAsPPQQKDE
0 1 K287 PQHGCNHKLELALSM
0 1 K296 ELALSMIKGLDYKPI
0 1 S305-p LDYKPIQsPRGSRLP
0 1 S340-p SSGFLNRsLKPLYKT
0 1 S389-p LKQQKLNsHETTITQ
0 1 Y622-p EFRELLQyRDNsDKT
0 1 S626-p LLQyRDNsDKTLEAN
0 1 K639 ANEMLLEKLRQRIHD
0 1 T867-p SNQQAEVtPTGCLGK
0 2 S880-p GKQTDQGsMQIPSRD
0 1 S891-p PSRDDSTsLTAKEDV
0 1 S903-p EDVSIPRstLGDLDt
0 1 T904-p DVSIPRstLGDLDtV
0 1 T910-p stLGDLDtVAGLEKE
0 1 S940-p RESQMELsALQsMMA
0 1 S944-p MELsALQsMMAVQEE
0 1 K1003 EVLLLREKVASVESQ
0 1 S1015-ga ESQGQEIsGNRRQQL
0 1 R1018 GQEIsGNRRQQLLLM
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
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0 1 - gap
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0 19 - gap
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  PDE4DIP iso1  
- gap
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Y37 EERMQQKYEASREDI
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- under review  
- under review  
S226 LKQQKLNSHETTITQ
Y459 EFRELLQYRDNSDKT
S463 LLQYRDNSDKTLEAN
K476 ANEMLLEKLRQRIHD
T704 SNQQAEVTPTGCLGK
S717 GKQTDQGSMQIPSRD
S728 PSRDDSTSLTAKEDV
S740 EDVSIPRSTLGDLDT
T741 DVSIPRSTLGDLDTV
T747 STLGDLDTVAGLEKE
S777 RESQMELSALQSMMA
S781 MELSALQSMMAVQEE
K840 EVLLLREKVASVESQ
S852 ESQGQEISGNRRQQL
R855 GQEISGNRRQQLLLM
K1079-ac EIEEDKEkGEVMVET
S1127 KEQLVLSSKEGNSKL
K1128 EQLVLSSKEGNSKLT
S1156-p INTELVGsPGKHQHQ
Y1251-p QANELEKyRVMLtGE
T1256-p EKyRVMLtGEsLVKQ
S1259-p RVMLtGEsLVKQDsK
S1265-p EsLVKQDsKQIQVDL
S1325-p RRGSTLAsssERKPL
S1326-p RGSTLAsssERKPLE
S1327-p GSTLAsssERKPLEN
P1413 GSSPHSVPDEDEGWL
T1424 EGWLSDGTGAFYSPG
S1671-p SQGAKAEsNsNPISL
S1673-p GAKAEsNsNPISLPt
T1680-p sNPISLPtPQNTPKE
S1758-p KQLGESAsTVPPAST
S1770-p ASTATLLsNDLEADS
S1783-p DSSYYLNsAQPHSPP
S2023-p YEALYGNsKKGLKAY
S2086 GAGKASLSPSSINQN
T2153-p ANGLGLDtsPVMKTP
S2154-p NGLGLDtsPVMKTPP
S2213 SLVRSACSFPGLEAQ
R2277 KVGESTERELLELRT
S2309 NANQQKESMEQFIVS
- gap
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- gap
- gap
  PDE4DIP iso8  
S33-p AHYTPYRsGDAtRTP
T37-p PYRsGDAtRTPQSPR
Y174 EERMQQKYEASREDI
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- gap
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- under review  
- under review  
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- gap
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  mouse

► Hide Isoforms
 
- gap
- gap
- gap
S112-p GEENKAGsGtVDIsG
T114-p ENKAGsGtVDIsGLP
S118-p GsGtVDIsGLPDMRY
S178 AALRVADSDyEAICK
Y180-p LRVADSDyEAICKVP
S193 VPRKVARSIsYAPSS
S195-p RKVARSIsYAPSSRW
S199 RSIsYAPSSRWSTSI
S200 SIsYAPSSRWSTSIC
S252 LDASVQASPPQQKDE
K287-ac PQHLCNHkLELALSM
K296-ac ELALSMIkGLDYKPI
S305 LDYKPIQSPRGSKLP
P340 SSSFLNRPLKPLYRT
L389 PTQQKPDLHETPTTQ
Y622 ELQELLQYRDNADKT
A626 LLQYRDNADKTLDTN
K639-ub TNEVFLEkLRQRIQD
T868 SNQPAGVTSIGPHHG
S882 GEQTDQGSMQMPSRD
S893 PSRDDSTSLTAREEA
S905-p EEASIPRsTLGDSDT
T906 EASIPRsTLGDSDTV
T912 sTLGDSDTVAGLEKE
S942 RESQMELSALQSMMA
S946 MELSALQSMMAMQEE
K1005-ub EVLLLREkVASVEPQ
S1017 EPQGQEVSGNkRQQL
K1020-ub GQEVSGNkRQQLLLM
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  PDE4DIP iso1  
- gap
- gap
Y37-p EERMQQKyEVSREDV
- gap
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- gap
- gap
- gap
- gap
- gap
- gap
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L168 PDQYSEALAQRDRRI
- under review  
L226 PTQQKPDLHETPTTQ
Y459 ELQELLQYRDNADKT
A463 LLQYRDNADKTLDTN
K476 TNEVFLEKLRQRIQD
T705 SNQPAGVTSIGPHHG
S719 GEQTDQGSMQMPSRD
S730 PSRDDSTSLTAREEA
S742-p EEASIPRsTLGDSDT
T743 EASIPRsTLGDSDTV
T749 sTLGDSDTVAGLEKE
S779 RESQMELSALQSMMA
S783 MELSALQSMMAMQEE
K842 EVLLLREKVASVEPQ
S854 EPQGQEVSGNKRQQL
K857 GQEVSGNKRQQLLLM
K1026 EVEEDKEKGEVMLET
S1074-p KEQLLLRssEGNSKE
S1075-p EQLLLRssEGNSKEM
L1103 MNTGLPSLGKHQHQE
Y1198 QANQLEKYRAVFSES
S1203 EKYRAVFSESLVKQD
S1205 YRAVFSESLVKQDSK
S1211 ESLVKQDSKQIQVDL
S1271 YLDPVLVSPPAKKPL
P1272 LDPVLVSPPAKKPLE
P1273 DPVLVSPPAKKPLEN
T1359-p GASPHSVtDEDEGWL
T1370-p EGWLSDGtGAFYPPG
S1600 SQGLKGESSSSPISL
S1602 GLKGESSSSPISLPT
T1609 SSPISLPTPQNPPKE
S1687 KQLGESVSIAPPAST
S1699 ASTSTLLSNQTEASS
P1712 SSPHYINPAQPHTPT
P1905 YESLCENPKKALKAF
G1966 GAGKASLGPIAVGQS
D2031 NNELSSDDSAAMKNP
S2032 NELSSDDSAAMKNPP
S2091-p SLMRSARsIPGQEAQ
K2155-ac KEGQLMEkELLDLRA
S2187-p RANQRKKsMEQFIVS
- gap
- gap
- gap
- gap
  PDE4DIP iso3  
- gap
- gap
Y157 EERMQQKYEVSREDV
- gap
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- gap
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- under review  
- under review  
- gap
Y579 ELQELLQYRDNADKT
A583 LLQYRDNADKTLDTN
K596 TNEVFLEKLRQRIQD
T825 SNQPAGVTSIGPHHG
S839 GEQTDQGSMQMPSRD
S850 PSRDDSTSLTAREEA
S862 EEASIPRSTLGDSDT
T863 EASIPRSTLGDSDTV
T869 STLGDSDTVAGLEKE
S899 RESQMELSALQSMMA
S903 MELSALQSMMAMQEE
K962 EVLLLREKVASVEPQ
S974 EPQGQEVSGNKRQQL
K977 GQEVSGNKRQQLLLM
K1201 EVEEDKEKGEVMLET
S1249 KEQLLLRSSEGNSKE
S1250 EQLLLRSSEGNSKEM
L1278 MNTGLPSLGKHQHQE
Y1373 QANQLEKYRAVFSES
S1378 EKYRAVFSESLVKQD
S1380 YRAVFSESLVKQDSK
S1386 ESLVKQDSKQIQVDL
S1446 YLDPVLVSPPAKKPL
P1447 LDPVLVSPPAKKPLE
P1448 DPVLVSPPAKKPLEN
T1534 GASPHSVTDEDEGWL
T1545 EGWLSDGTGAFYPPG
S1775 SQGLKGESSSSPISL
S1777 GLKGESSSSPISLPT
T1784 SSPISLPTPQNPPKE
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S2110-p CEEKQQLsLsLQsEL
S2112-p EKQQLsLsLQsELQI
S2115-p QLsLsLQsELQIyES
Y2120-p LQsELQIyESLCENP
  rat

 
- gap
- gap
Y37 EERMQQKYEVSREDV
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- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- under review  
- under review  
L226 PTQQKPDLNETPTTQ
Y459 ELQELLQYRDTTDKT
T463 LLQYRDTTDKTLDTN
K476 TNEVFLEKLRQRIQD
T705 SNQPAGATSVGPHHG
S719 GEQTDQGSTQMPSRD
S730 PSRDDSTSLTAREEA
S742 EEASIPRSTLGDSDT
T743 EASIPRSTLGDSDTV
T749 STLGDSDTVAGLEKE
S779 RESQIELSALQSMMA
S783 IELSALQSMMAVQEE
K842 EVLLLREKVASVEPQ
S854 EPQGQEGSENRRQQL
R857 GQEGSENRRQQLLLM
K1081 EVEEDKEKGEVMVET
S1129 KEQLVLRSSEGNTKE
S1130 EQLVLRSSEGNTKEM
S1158 MNMGLPSSEKHQHQE
Y1252 QANQLEKYRAILSES
S1257 EKYRAILSESLVKQD
S1259 YRAILSESLVKQDSK
S1265 ESLVKQDSKQIQVDL
S1325 YLDPVLVSSPVKNPW
S1326 LDPVLVSSPVKNPWR
P1327 DPVLVSSPVKNPWRT
T1412 GASPHSVTDEDEGLL
T1423 EGLLSDGTGAFYPPG
P1653 SQGLKGEPRSSSISL
S1655 GLKGEPRSSSISLPT
T1662 SSSISLPTPQNPPKE
S1740 KQLGRSVSIAPPTST
S1752 TSTSTLLSNHTEASS
P1765 SSPRYSNPAQPHSPA
P2004 YESLYENPKKGLKAF
S2065-p GAGKASLsSCPVNQS
E2131 RTNNGSDESAATKTP
S2132 TNNGSDESAATKTPP
S2191 SLTRPARSVPALDAQ
K2255 EEGNLMEKELLDLRA
S2287 TANQRKKSMEQFIVS
- gap
- gap
- gap
- gap
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