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eIF4E (mouse)

Overview eIF4E a protein of the eukaryotic initiation factor 4E family. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the EIF4F complex. Note: This description may include information from UniProtKB. Protein type: Translation initiation; Translation Cellular Component: mRNA cap complex; protein complex; stress granule; cytoplasm; eukaryotic translation initiation factor 4F complex Molecular Function: protein binding; eukaryotic initiation factor 4G binding; RNA binding; translation initiation factor activity Biological Process: regulation of translation; translation; translational initiation; positive regulation of mitotic cell cycle; G1/S transition of mitotic cell cycle Reference #:  P63073 (UniProtKB) Alt. Names/Synonyms: EG668879; eIF-4E; eIF-4F 25 kDa subunit; Eif4e; Eif4e-ps; Eukaryotic translation initiation factor 4E; If4e; MGC103177; mRNA cap-binding protein Gene Symbols: Eif4e Molecular weight: 25,053 Da Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states CST Pathways:  Angiogenesis  |  Insulin Receptor Signaling  |  Translation: eIF4E and p70S6K  |  Translational Control Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below eIF4E 1EJ1 - A/B=28-217 (mouse) 1EJ4 - A=28-217 (mouse) 1EJH - A/D/C/B=28-217 (mouse) 1L8B - A/B=28-217 (mouse) 1IPB - A=1-217 (human) 1IPC - A=1-217 (human) 1WKW - A=27-217 (human) 2GPQ - A=1-217 (human) 2V8W - A/E=1-217 (human) 2V8X - A/E=1-217 (human) 2V8Y - A/E=1-217 (human) 2W97 - A/B=1-217 (human) 3AM7 - A=27-217 (human) 3SMU - A/B=1-217 (human) 3TF2 - A/D/C/B=1-217 (human) 3U7X - A/B=1-217 (human) 4AZA - A/C=1-217 (human) 4DT6 - A=1-217 (human) 4DUM - A=1-217 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1EJ1 1EJ4 1EJH 1L8B  |  Phospho3D  |  Source  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
carcinogenesis, induced: S209‑p cell growth, altered: S209‑p translation, altered: S209‑p molecular association, regulation: S209‑p, T210‑p protein conformation: S209‑p, T210‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	1		T3	_____MATVEPETTP
0	2		T9	ATVEPETTPTTNPPP
0	1		P16	TPTTNPPPAEEEKTE
0	1		A17	PTTNPPPAEEEKTEs
0	1		S24-p	AEEEKTEsNQEVANP
0	1		K36	ANPEHYIKHPLQNRW
2	0		S53	WFFKNDKSKTWQANL
0	1		K119-u	RWLITLNkQQRRSDL
1	0		K159	AVVNVRAKGDKIAIW
0	2		Y183	VTHIGRVYKERLGLP
0	1		T203	GYQSHADTATKSGst
38	2		S209-p	DTATKSGstTKNRFV
3	1		T210-p	TATKSGstTKNRFVV

	human
T3-p	_____MAtVEPETtP
T9-p	AtVEPETtPTPNPPt
T16-p	tPTPNPPttEEEKTE
T17-p	PTPNPPttEEEKTES
S24	tEEEKTESNQEVANP
K36-u	ANPEHYIkHPLQNRW
S53-p	WFFKNDKsKTWQANL
K119	RWLITLNKQQRRSDL
K159-u	AVVNVRAkGDKIAIW
Y183-p	VTHIGRVyKERLGLP
T203-p	GYQSHADtATKSGst
S209-p	DtATKSGstTKNRFV
T210-p	tATKSGstTKNRFVV

	rat
T3	_____MATVEPETTP
T9	ATVEPETTPTTNPPP
P16	TPTTNPPPAEEEKTE
A17	PTTNPPPAEEEKTES
S24	AEEEKTESNQEVANP
K36	ANPEHYIKHPLQNRW
S53	WFFKNDKSKTWQANL
K119	RWLITLNKQQRRSDL
K159	AVVNVRAKGDKIAIW
Y183-p	VTHIGRVyKERLGLP
T203	GYQSHADTATKSGsT
S209-p	DTATKSGsTTKNRFV
T210	TATKSGsTTKNRFVV

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