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Protein Page:
Bcl-10 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Bcl-10 a ubiquitous pro-apoptotic protein that promotes pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Self-associates via CARD-CARD interactions; forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Defects in BCL10 are involved in various types of cancer. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Transcription, coactivator/corepressor
Cellular Component: CBM complex; T cell receptor complex; protein complex; cytoplasmic microtubule; perinuclear region of cytoplasm; lysosome; cytoplasm; plasma membrane; immunological synapse; lipopolysaccharide receptor complex; nucleus; cytosol; lipid raft
Molecular Function: protein C-terminus binding; protein kinase B binding; ubiquitin binding; protease binding; protein self-association; transcription coactivator activity; protein kinase binding; transcription factor binding; NF-kappaB binding; protein binding; enzyme binding; ubiquitin protein ligase binding; kinase activator activity; kinase binding
Biological Process: cell death; response to fungus; positive regulation of transcription, DNA-dependent; B cell apoptosis; positive regulation of caspase activity; T cell receptor signaling pathway; interleukin-6 biosynthetic process; activation of NF-kappaB transcription factor; negative regulation of mature B cell apoptosis; response to molecule of bacterial origin; protein homooligomerization; response to food; adaptive immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-8 biosynthetic process; protein oligomerization; positive regulation of protein ubiquitination; lymphotoxin A biosynthetic process; regulation of T cell receptor signaling pathway; neural tube closure; toll-like receptor signaling pathway; cellular defense response; innate immune response; positive regulation of mast cell cytokine production; immunoglobulin mediated immune response; positive regulation of T cell activation; positive regulation of phosphorylation
Reference #:  O95999 (UniProtKB)
Alt. Names/Synonyms: B-cell CLL/lymphoma 10; B-cell lymphoma/leukemia 10; Bcl-10; BCL10; c-E10; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARD-like apoptotic protein; CARMEN; caspase-recruiting domain-containing protein; cCARMEN; CED-3/ICH-1 prodomain homologous E10-like regulator; Cellular homolog of vCARMEN; Cellular-E10; CIPER; CLAP; hCLAP; Mammalian CARD-containing adapter molecule E10; mE10
Gene Symbols: BCL10
Molecular weight: 26,252 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Bcl-10

Protein Structure Not Found.


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Sites Implicated In
cell motility, altered: S138‑p
cytoskeletal reorganization: S138‑p
transcription, altered: S138‑p
intracellular localization: S218‑p, S231‑p
molecular association, regulation: S134‑p, S218‑p, S231‑p
phosphorylation: S138‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K31-u LRVYLCEkIIAERHF
1 12 T52-p KILSREDtEEISCRT
1 0 K63-u SCRTSSRkRAGKLLD
0 1 S85-p GLDTLVEsIRREKTQ
0 1 S120 HLKGLKCSSCEPFPD
0 1 S121 LKGLKCSSCEPFPDG
0 1 T130 EPFPDGATNNLsRsN
3 5 S134-p DGATNNLsRsNsDEs
1 1 S136-p ATNNLsRsNsDEsNF
7 26 S138-p NNLsRsNsDEsNFsE
1 4 S141-p sRsNsDEsNFsEKLR
1 3 S144-p NsDEsNFsEKLRAST
0 2 T163-p PEGESSTtPFFSTNs
1 0 S170-p tPFFSTNssLNLPVL
1 0 S171-p PFFSTNssLNLPVLE
3 0 S218-p EEGTCANsSEMFLPL
1 1 S231-p PLRSRTVsRQ_____
  mouse

 
K31 LRVYLCEKIIAERHF
T52-p KILSREDtEEISCRT
K63 SCRTSSRKRAGKLLD
S85 GLDTLVESIRREKTQ
S120-p HLKGLKCssCEPFAA
S121-p LKGLKCssCEPFAAG
T130-p EPFAAGAtNNLsRCN
S134-p AGAtNNLsRCNsDEs
C136 AtNNLsRCNsDEsNL
S138-p NNLsRCNsDEsNLsE
S141-p sRCNsDEsNLsEKQR
S144-p NsDEsNLsEKQRAST
A163 PEGESSTAPFFSMAS
S170 APFFSMASSLNLPVL
S171 PFFSMASSLNLPVLE
S218 EGGSCGNSSEMFLPL
S231 PLRSRALSRQ_____
  rat

 
K31 LRVYLCEKIIAERHF
T52 KILSREDTEEISCRT
K63 SCRTSSRKRAGKLLD
S85 GLDTLVESIRREKTQ
S120 HLKGLKCSSCEPFAA
S121 LKGLKCSSCEPFAAG
T130 EPFAAGATNNLSRSN
S134 AGATNNLSRSNsDES
S136 ATNNLSRSNsDESNF
S138-p NNLSRSNsDESNFSE
S141 SRSNsDESNFSEKQR
S144 NsDESNFSEKQRPST
A163 PEGESSTAPFFSTES
S170 APFFSTESSLNLPVL
S171 PFFSTESSLNLPVLE
S218 EGGSCGNSSEMFLPL
S231 PLRSRALSRQ_____
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