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SOD1 (human)

Overview SOD1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Homodimer; non-disulfide linked. Homodimerization may take place via the ditryptophan cross-link at Trp-33. The pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 interact with RNF19A, whereas wild-type protein does not. The pathogenic variants ALS1 Arg-86 and Ala-94 interact with MARCH5, whereas wild-type protein does not. Belongs to the Cu-Zn superoxide dismutase family. Note: This description may include information from UniProtKB. Protein type: Apoptosis; Oxidoreductase; EC 1.15.1.1; Mitochondrial Cellular Component: dendrite cytoplasm; extracellular space; protein complex; mitochondrion; extracellular region; cytosol; extracellular matrix; cell soma; mitochondrial matrix; cytoplasm; nucleolus; plasma membrane; peroxisome; cytoplasmic vesicle; nucleus Molecular Function: protein binding; copper ion binding; protein homodimerization activity; zinc ion binding; chaperone binding; superoxide dismutase activity; protein phosphatase 2B binding Biological Process: positive regulation of catalytic activity; cellular iron ion homeostasis; positive regulation of apoptosis; activation of MAPK activity; myeloid cell homeostasis; retrograde axon cargo transport; muscle maintenance; retinal homeostasis; glutathione metabolic process; regulation of mitochondrial membrane potential; neurofilament cytoskeleton organization and biogenesis; negative regulation of neuron apoptosis; placenta development; response to drug; positive regulation of cytokine production; platelet activation; cell aging; regulation of organ growth; transmission of nerve impulse; response to ethanol; heart contraction; response to heat; superoxide release; relaxation of vascular smooth muscle; removal of superoxide radicals; locomotory behavior; response to organic substance; sensory perception of sound; platelet degranulation; ovarian follicle development; regulation of blood pressure; double-strand break repair; DNA fragmentation during apoptosis; auditory receptor cell stereocilium organization and biogenesis; response to axon injury; negative regulation of cholesterol biosynthetic process; anterograde axon cargo transport; response to nutrient levels; response to superoxide; thymus development; regulation of T cell differentiation in the thymus; response to amphetamine; superoxide metabolic process; myelin maintenance in the peripheral nervous system; regulation of multicellular organism growth; response to copper ion; response to hydrogen peroxide; spermatogenesis; blood coagulation; regulation of protein kinase activity; embryo implantation; hydrogen peroxide biosynthetic process Reference #:  P00441 (UniProtKB) Alt. Names/Synonyms: ALS; ALS1; Cu/Zn superoxide dismutase; homodimer; indophenoloxidase A; IPOA; SOD; SOD, soluble; SOD1; SODC; superoxide dismutase; superoxide dismutase 1, soluble; Superoxide dismutase [Cu-Zn]; superoxide dismutase, cystolic Gene Symbols: SOD1 Molecular weight: 15,936 Da Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SOD1 1AZV - A/B=1-154 (human) 1BA9 - A=1-154 (human) 1DSW - A=1-154 (human) 1FUN - A/B/C/D/E/F/G/H/I/J=1-154 (human) 1HL4 - A/B/C/D=1-154 (human) 1HL5 - A/B/C/D/E/F/H/I/J/K/L/M=1-154, G/N/O/P/Q/S=2-154 (human) 1KMG - A=1-154 (human) 1L3N - A/B=1-154 (human) 1MFM - A=1-154 (human) 1N18 - A/B/C/D/E/F/G/H/I/J=1-154 (human) 1N19 - A/B=1-154 (human) 1OEZ - W/X/Y/Z=1-154 (human) 1OZT - G/H/I/J/K/L/M/N=1-154 (human) 1OZU - A/B=1-154 (human) 1P1V - A/B/C=1-154 (human) 1PTZ - A/B=1-154 (human) 1PU0 - A/B/C/D/E/F/G/H/I/J=1-154 (human) 1RK7 - A=1-154 (human) 1SOS - A/B/C/D/E/F/G/H/I/J=1-154 (human) 1SPD - A/B=1-154 (human) 1UXL - A/B/C/D/E/F/G/H/I/J=1-154 (human) 1UXM - A/B/C/D/E/F/G/H/I/J/K/L=1-154 (human) 2AF2 - A/B=1-154 (human) 2C9S - A/F=1-154 (human) 2C9U - A/F=1-154 (human) 2C9V - A/F=1-154 (human) 2GBT - A/B/C/D=2-154 (human) 2GBU - A/B/C/D=2-154 (human) 2GBV - A/B/C/D/E/F/G/H/I/J=2-154 (human) 2LU5 - A=2-154 (human) 2NNX - A/B/C/D=1-154 (human) 2R27 - A/B=1-154 (human) 2V0A - A/F=2-154 (human) 2VR6 - F/A=2-154 (human) 2VR7 - F/A=2-154 (human) 2VR8 - F/A=2-154 (human) 2WKO - F/A=2-154 (human) 2WYT - F/A=2-154 (human) 2WYZ - F/A=2-154 (human) 2WZ0 - F/A=2-154 (human) 2WZ5 - F/A=2-154 (human) 2WZ6 - F/A=2-154 (human) 2XJK - A=2-154 (human) 2XJL - A=2-154 (human) 2ZKW - A/B=1-154 (human) 2ZKX - A/D/C/B=1-154 (human) 2ZKY - F/A/J/E/B/H/C/D/I/G=1-154 (human) 3CQP - A/D/C/B=2-154 (human) 3CQQ - A/B=2-154 (human) 3ECU - A/D/C/B=2-154 (human) 3ECV - A/D/C/B=2-154 (human) 3ECW - A/D/C/B=2-154 (human) 3GQF - F/A/D/C/E/B=2-154 (human) 3GTV - F/A/J/K/E/B/H/C/D/I/G/L=2-81 (human) 3GZO - F/A/J/E/B/H/C/D/I/G=2-154 (human) 3GZP - A/D/C/B=2-154 (human) 3GZQ - A/B=2-154 (human) 3H2P - A/B=2-154 (human) 3H2Q - A/D/C/B=2-154 (human) 3HFF - A=2-154 (human) 3K91 - A/B=2-154 (human) 3KH3 - F/A/J/K/E/B/H/C/D/I/G/L=2-154 (human) 3KH4 - F/A/D/C/E/B=2-154 (human) 3LTV - F/A/D/C/E/B=82-161 (human) 3QQD - A/B=2-154 (human) 3RE0 - A/D/C/B=2-154 (human) 3T5W - F/A/J/K/E/B/H/M/D/I/G/L=2-154 (human) 4A7G - F/A=2-154 (human) 4A7Q - F/A=2-154 (human) 4A7S - F/A=2-154 (human) 4A7T - F/A=2-154 (human) 4A7U - F/A=2-154 (human) 4A7V - F/A=2-154 (human) 4B3E - F/A/J/E/B/H/C/D/I/G=1-154 (human) 4BCY - A=2-154 (human) 4BCZ - A/B=141-154 (human) 4BD4 - F/A/E/B/H/C/D/I/G=141-154 (human) 4SOD - A=1-154 (human) 3GTT - F/A/D/C/E/B=2-154 (mouse) 3GTV - F/A/J/K/E/B/H/C/D/I/G/L=82-154 (mouse) 3LTV - F/A/D/C/E/B=2-81 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1AZV 1BA9 1DSW 1FUN 1HL4 1HL5 1KMG 1L3N 1MFM 1N18 1N19 1OEZ 1OZT 1OZU 1P1V 1PTZ 1PU0 1RK7 1SOS 1SPD 1UXL 1UXM 2AF2 2C9S 2C9U 2C9V 2GBT 2GBU 2GBV 2LU5 2NNX 2R27 2V0A 2VR6 2VR7 2VR8 2WKO 2WYT 2WYZ 2WZ0 2WZ5 2WZ6 2XJK 2XJL 2ZKW 2ZKX 2ZKY 3CQP 3CQQ 3ECU 3ECV 3ECW 3GQF 3GTV 3GZO 3GZP 3GZQ 3H2P 3H2Q 3HFF 3K91 3KH3 3KH4 3LTV 3QQD 3RE0 3T5W 4A7G 4A7Q 4A7S 4A7T 4A7U 4A7V 4B3E 4BCY 4BCZ 4BD4 4SOD  |  ENZYME  |  Phospho3D  |  DISEASE 105400 147450 158700  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T3-p	_____MAtKAVCVLk
0	3		K10-u	tKAVCVLkGDGPVQG
0	1		K10	tKAVCVLKGDGPVQG
0	2		I18	GDGPVQGIINFEQkE
0	2		K24-u	GIINFEQkESNGPVk
0	1		K31-u	kESNGPVkVWGsIKG
0	5		S35-p	GPVkVWGsIKGLTEG
0	1		T59-p	GDNTAGCtsAGPHFN
0	1		S60-p	DNTAGCtsAGPHFNP
0	1		K71	HFNPLSRKHGGPkDE
0	2		K71	HFNPLSRKHGGPkDE
1	0		K76-s	SRKHGGPkDEERHVG
0	2		K76-u	SRKHGGPkDEERHVG
0	1		T89-p	VGDLGNVtADKDGVA
0	2		K92	LGNVtADKDGVADVs
0	10		S99-p	KDGVADVsIEDsVIs
0	2		S103-p	ADVsIEDsVIsLSGD
0	3		S106-p	sIEDsVIsLSGDHCI
0	5		S108	EDsVIsLSGDHCIIG
0	1		C112	IsLSGDHCIIGRTLV
0	6		K123-a	RTLVVHEkADDLGKG
0	2		K123-u	RTLVVHEkADDLGKG
0	13		K137-u	GGNEESTkTGNAGSR
0	2		K137	GGNEESTKTGNAGSR

	mouse
M3	_____MAMKAVCVLk
K10-u	MKAVCVLkGDGPVQG
K10-a	MKAVCVLkGDGPVQG
T18-p	GDGPVQGtIHFEQKA
K24	GtIHFEQKASGEPVV
V31	KASGEPVVLSGQITG
Q35	EPVVLSGQITGLTEG
T59	GDNTQGCTSAGPHFN
S60	DNTQGCTSAGPHFNP
K71-a	HFNPHSKkHGGPADE
K71-u	HFNPHSKkHGGPADE
A76	SKkHGGPADEERHVG
A76	SKkHGGPADEERHVG
T89	VGDLGNVTAGkDGVA
K92-u	LGNVTAGkDGVANVs
S99-p	kDGVANVsIEDRVIs
R103	ANVsIEDRVIsLsGE
S106-p	sIEDRVIsLsGEHsI
S108-p	EDRVIsLsGEHsIIG
S112-p	IsLsGEHsIIGRTMV
K123-a	RTMVVHEkQDDLGKG
K123-u	RTMVVHEkQDDLGKG
K137-u	GGNEESTkTGNAGSR
K137-a	GGNEESTkTGNAGSR

	rat
M3	_____MAMKAVCVLK
K10	MKAVCVLKGDGPVQG
K10	MKAVCVLKGDGPVQG
V18	GDGPVQGVIHFEQKA
K24	GVIHFEQKASGEPVV
V31	KASGEPVVVSGQITG
Q35	EPVVVSGQITGLTEG
T59	GDNTQGCTTAGPHFN
T60	DNTQGCTTAGPHFNP
K71	HFNPHSKKHGGPADE
K71	HFNPHSKKHGGPADE
A76	SKKHGGPADEERHVG
A76	SKKHGGPADEERHVG
A89	VGDLGNVAAGKDGVA
K92	LGNVAAGKDGVANVs
S99-p	KDGVANVsIEDRVIs
R103	ANVsIEDRVIsLsGE
S106-p	sIEDRVIsLsGEHSI
S108-p	EDRVIsLsGEHSIIG
S112	IsLsGEHSIIGRTMV
K123	RTMVVHEKQDDLGKG
K123	RTMVVHEKQDDLGKG
K137	GGNEESTKTGNAGSR
K137	GGNEESTKTGNAGSR

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