Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
SOD1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SOD1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Homodimer; non-disulfide linked. Homodimerization may take place via the ditryptophan cross-link at Trp-33. The pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 interact with RNF19A, whereas wild-type protein does not. The pathogenic variants ALS1 Arg-86 and Ala-94 interact with MARCH5, whereas wild-type protein does not. Belongs to the Cu-Zn superoxide dismutase family. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; EC 1.15.1.1; Mitochondrial; Apoptosis
Cellular Component: dendrite cytoplasm; extracellular space; protein complex; mitochondrion; extracellular region; mitochondrial intermembrane space; cytosol; extracellular matrix; cell soma; mitochondrial matrix; cytoplasm; nucleolus; plasma membrane; peroxisome; cytoplasmic vesicle; nucleus
Molecular Function: identical protein binding; protein binding; copper ion binding; protein homodimerization activity; zinc ion binding; chaperone binding; superoxide dismutase activity; Rac GTPase binding; protein phosphatase 2B binding
Biological Process: positive regulation of catalytic activity; positive regulation of apoptosis; cellular iron ion homeostasis; activation of MAPK activity; myeloid cell homeostasis; retrograde axon cargo transport; muscle maintenance; retinal homeostasis; glutathione metabolic process; regulation of mitochondrial membrane potential; neurofilament cytoskeleton organization and biogenesis; positive regulation of superoxide release; negative regulation of neuron apoptosis; placenta development; response to drug; positive regulation of cytokine production; platelet activation; cell aging; transmission of nerve impulse; regulation of organ growth; response to ethanol; response to heat; heart contraction; superoxide release; relaxation of vascular smooth muscle; removal of superoxide radicals; locomotory behavior; response to organic substance; sensory perception of sound; platelet degranulation; ovarian follicle development; double-strand break repair; regulation of blood pressure; DNA fragmentation during apoptosis; response to axon injury; auditory receptor cell stereocilium organization and biogenesis; anterograde axon cargo transport; negative regulation of cholesterol biosynthetic process; regulation of Rac GTPase activity; response to nutrient levels; response to superoxide; thymus development; regulation of T cell differentiation in the thymus; response to amphetamine; superoxide metabolic process; myelin maintenance in the peripheral nervous system; regulation of multicellular organism growth; response to hydrogen peroxide; response to copper ion; spermatogenesis; regulation of protein kinase activity; blood coagulation; embryo implantation; hydrogen peroxide biosynthetic process
Reference #:  P00441 (UniProtKB)
Alt. Names/Synonyms: ALS; ALS1; Cu/Zn superoxide dismutase; homodimer; indophenoloxidase A; IPOA; SOD; SOD, soluble; SOD1; SODC; superoxide dismutase; superoxide dismutase 1, soluble; Superoxide dismutase [Cu-Zn]; superoxide dismutase, cystolic
Gene Symbols: SOD1
Molecular weight: 15,936 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SOD1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T3-p _____MAtKAVCVLk
0 3 K10-u tKAVCVLkGDGPVQG
0 1 K10 tKAVCVLKGDGPVQG
0 2 I18 GDGPVQGIINFEQkE
0 2 K24-u GIINFEQkESNGPVk
0 1 K31-u kESNGPVkVWGsIKG
0 6 S35-p GPVkVWGsIKGLTEG
0 1 T59-p GDNTAGCtsAGPHFN
0 1 S60-p DNTAGCtsAGPHFNP
0 1 K71 HFNPLSRKHGGPkDE
0 2 K71 HFNPLSRKHGGPkDE
1 0 K76-s SRKHGGPkDEERHVG
0 2 K76-u SRKHGGPkDEERHVG
0 2 K92 LGNVTADKDGVADVs
0 11 S99-p KDGVADVsIEDsVIs
0 2 S103-p ADVsIEDsVIsLSGD
0 3 S106-p sIEDsVIsLSGDHCI
0 6 S108 EDsVIsLSGDHCIIG
0 1 C112 IsLSGDHCIIGRTLV
0 6 K123-a RTLVVHEkADDLGKG
0 2 K123-u RTLVVHEkADDLGKG
0 13 K137-u GGNEESTkTGNAGSR
0 2 K137 GGNEESTKTGNAGSR
  mouse

 
M3 _____MAMKAVCVLk
K10-u MKAVCVLkGDGPVQG
K10-a MKAVCVLkGDGPVQG
T18-p GDGPVQGtIHFEQKA
K24 GtIHFEQKASGEPVV
V31 KASGEPVVLSGQITG
Q35 EPVVLSGQITGLTEG
T59 GDNTQGCTSAGPHFN
S60 DNTQGCTSAGPHFNP
K71-a HFNPHSKkHGGPADE
K71-u HFNPHSKkHGGPADE
A76 SKkHGGPADEERHVG
A76 SKkHGGPADEERHVG
K92-u LGNVTAGkDGVANVs
S99-p kDGVANVsIEDRVIs
R103 ANVsIEDRVIsLsGE
S106-p sIEDRVIsLsGEHsI
S108-p EDRVIsLsGEHsIIG
S112-p IsLsGEHsIIGRTMV
K123-a RTMVVHEkQDDLGKG
K123-u RTMVVHEkQDDLGKG
K137-u GGNEESTkTGNAGSR
K137-a GGNEESTkTGNAGSR
  rat

 
M3 _____MAMKAVCVLK
K10 MKAVCVLKGDGPVQG
K10 MKAVCVLKGDGPVQG
V18 GDGPVQGVIHFEQKA
K24 GVIHFEQKASGEPVV
V31 KASGEPVVVSGQITG
Q35 EPVVVSGQITGLTEG
T59 GDNTQGCTTAGPHFN
T60 DNTQGCTTAGPHFNP
K71 HFNPHSKKHGGPADE
K71 HFNPHSKKHGGPADE
A76 SKKHGGPADEERHVG
A76 SKKHGGPADEERHVG
K92 LGNVAAGKDGVANVs
S99-p KDGVANVsIEDRVIs
R103 ANVsIEDRVIsLsGE
S106-p sIEDRVIsLsGEHSI
S108-p EDRVIsLsGEHSIIG
S112 IsLsGEHSIIGRTMV
K123 RTMVVHEKQDDLGKG
K123 RTMVVHEKQDDLGKG
K137 GGNEESTKTGNAGSR
K137 GGNEESTKTGNAGSR
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.