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Protein Page:
SOD1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SOD1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Homodimer; non-disulfide linked. Homodimerization may take place via the ditryptophan cross-link at Trp-33. The pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 interact with RNF19A, whereas wild-type protein does not. The pathogenic variants ALS1 Arg-86 and Ala-94 interact with MARCH5, whereas wild-type protein does not. Belongs to the Cu-Zn superoxide dismutase family. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Oxidoreductase; EC 1.15.1.1; Apoptosis
Cellular Component: dendrite cytoplasm; extracellular space; protein complex; mitochondrion; extracellular region; mitochondrial intermembrane space; cytosol; extracellular matrix; cell soma; mitochondrial matrix; cytoplasm; nucleolus; plasma membrane; peroxisome; cytoplasmic vesicle; nucleus
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; copper ion binding; zinc ion binding; chaperone binding; superoxide dismutase activity; Rac GTPase binding; protein phosphatase 2B binding
Biological Process: positive regulation of catalytic activity; activation of MAPK activity; positive regulation of apoptosis; cellular iron ion homeostasis; myeloid cell homeostasis; retrograde axon cargo transport; muscle maintenance; retinal homeostasis; glutathione metabolic process; regulation of mitochondrial membrane potential; neurofilament cytoskeleton organization and biogenesis; positive regulation of superoxide release; negative regulation of neuron apoptosis; placenta development; response to drug; positive regulation of cytokine production; platelet activation; cell aging; regulation of organ growth; transmission of nerve impulse; response to ethanol; response to heat; heart contraction; superoxide release; cell death; relaxation of vascular smooth muscle; removal of superoxide radicals; locomotory behavior; response to organic substance; platelet degranulation; sensory perception of sound; ovarian follicle development; regulation of blood pressure; auditory receptor cell stereocilium organization and biogenesis; response to axon injury; anterograde axon cargo transport; negative regulation of cholesterol biosynthetic process; regulation of Rac GTPase activity; response to nutrient levels; response to superoxide; thymus development; regulation of T cell differentiation in the thymus; response to amphetamine; superoxide metabolic process; myelin maintenance in the peripheral nervous system; regulation of multicellular organism growth; response to hydrogen peroxide; response to copper ion; spermatogenesis; blood coagulation; regulation of protein kinase activity; embryo implantation; hydrogen peroxide biosynthetic process
Reference #:  P00441 (UniProtKB)
Alt. Names/Synonyms: ALS; ALS1; Cu/Zn superoxide dismutase; homodimer; indophenoloxidase A; IPOA; SOD; SOD, soluble; SOD1; SODC; superoxide dismutase; superoxide dismutase 1, soluble; Superoxide dismutase [Cu-Zn]; superoxide dismutase, cystolic
Gene Symbols: SOD1
Molecular weight: 15,936 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SOD1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T3-p _____MAtKAVCVLk
0 3 K10-ub tKAVCVLkGDGPVQG
0 1 K10-sc tKAVCVLkGDGPVQG
0 2 K10-ac tKAVCVLkGDGPVQG
0 2 I18 GDGPVQGIINFEQkE
0 1 K24-ac GIINFEQkESNGPVk
0 2 K24-ub GIINFEQkESNGPVk
0 1 K31-ub kESNGPVkVWGsIKG
0 6 S35-p GPVkVWGsIKGLTEG
0 1 T59-p GDNTAGCtsAGPHFN
0 1 S60-p DNTAGCtsAGPHFNP
0 1 K71 HFNPLSRKHGGPkDE
0 2 K71 HFNPLSRKHGGPkDE
1 0 K76-sm SRKHGGPkDEERHVG
0 1 K76-sc SRKHGGPkDEERHVG
0 2 K76-ub SRKHGGPkDEERHVG
0 2 T89-p VGDLGNVtADKDGVA
0 1 K92 LGNVtADKDGVADVs
0 2 K92 LGNVtADKDGVADVs
0 1 K92 LGNVtADKDGVADVs
0 13 S99-p KDGVADVsIEDsVIs
0 2 S103-p ADVsIEDsVIsLSGD
0 4 S106-p sIEDsVIsLSGDHCI
0 7 S108 EDsVIsLSGDHCIIG
0 1 C112 IsLSGDHCIIGRTLV
0 7 K123-ac RTLVVHEkADDLGKG
0 2 K123-ub RTLVVHEkADDLGKG
0 1 K123-sc RTLVVHEkADDLGKG
0 1 K129 EkADDLGKGGNEEST
0 13 K137-ub GGNEESTkTGNAGSR
0 1 K137 GGNEESTKTGNAGSR
0 3 K137 GGNEESTKTGNAGSR
  mouse

 
M3 _____MAMKAVCVLk
K10-ub MKAVCVLkGDGPVQG
K10 MKAVCVLKGDGPVQG
K10-ac MKAVCVLkGDGPVQG
T18-p GDGPVQGtIHFEQKA
K24 GtIHFEQKASGEPVV
K24 GtIHFEQKASGEPVV
V31 KASGEPVVLSGQITG
Q35 EPVVLSGQITGLTEG
T59 GDNTQGCTSAGPHFN
S60 DNTQGCTSAGPHFNP
K71-ac HFNPHSKkHGGPADE
K71-ub HFNPHSKkHGGPADE
A76 SKkHGGPADEERHVG
A76 SKkHGGPADEERHVG
A76 SKkHGGPADEERHVG
T89 VGDLGNVTAGkDGVA
K92-ac LGNVTAGkDGVANVs
K92-ub LGNVTAGkDGVANVs
K92-sc LGNVTAGkDGVANVs
S99-p kDGVANVsIEDRVIs
R103 ANVsIEDRVIsLsGE
S106-p sIEDRVIsLsGEHsI
S108-p EDRVIsLsGEHsIIG
S112-p IsLsGEHsIIGRTMV
K123-ac RTMVVHEkQDDLGkG
K123-ub RTMVVHEkQDDLGkG
K123-sc RTMVVHEkQDDLGkG
K129-sc EkQDDLGkGGNEEST
K137-ub GGNEESTkTGNAGSR
K137-sc GGNEESTkTGNAGSR
K137-ac GGNEESTkTGNAGSR
  rat

 
M3 _____MAMKAVCVLK
K10 MKAVCVLKGDGPVQG
K10 MKAVCVLKGDGPVQG
K10 MKAVCVLKGDGPVQG
V18 GDGPVQGVIHFEQKA
K24 GVIHFEQKASGEPVV
K24 GVIHFEQKASGEPVV
V31 KASGEPVVVSGQITG
Q35 EPVVVSGQITGLTEG
T59 GDNTQGCTTAGPHFN
T60 DNTQGCTTAGPHFNP
K71 HFNPHSKKHGGPADE
K71 HFNPHSKKHGGPADE
A76 SKKHGGPADEERHVG
A76 SKKHGGPADEERHVG
A76 SKKHGGPADEERHVG
A89 VGDLGNVAAGKDGVA
K92 LGNVAAGKDGVANVs
K92 LGNVAAGKDGVANVs
K92 LGNVAAGKDGVANVs
S99-p KDGVANVsIEDRVIs
R103 ANVsIEDRVIsLsGE
S106-p sIEDRVIsLsGEHSI
S108-p EDRVIsLsGEHSIIG
S112 IsLsGEHSIIGRTMV
K123 RTMVVHEKQDDLGKG
K123 RTMVVHEKQDDLGKG
K123 RTMVVHEKQDDLGKG
K129 EKQDDLGKGGNEEST
K137 GGNEESTKTGNAGSR
K137 GGNEESTKTGNAGSR
K137 GGNEESTKTGNAGSR
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