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Smad3 (mouse)

Overview Smad3 transcription factor phosphorylated and activated by TGF-beta-type receptors. A receptor-regulated Smad (R-smad). Binds directly to consensus DNA-binding elements in the promoters of target genes. In mouse required for establishemnt of the mucosal immune response and proper development of skeleton. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein; Nuclear receptor co-regulator Cellular Component: transcription factor complex; protein complex; cytoplasm; plasma membrane; nuclear inner membrane; intracellular; nucleus; receptor complex Molecular Function: ubiquitin binding; protein homodimerization activity; zinc ion binding; chromatin DNA binding; metal ion binding; beta-catenin binding; transcription factor binding; protein kinase binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; phosphatase binding; collagen binding; protein binding; DNA binding; sequence-specific DNA binding; ubiquitin protein ligase binding; double-stranded DNA binding; chromatin binding; SMAD binding; transcription factor activity; transforming growth factor beta receptor binding Biological Process: developmental growth; positive regulation of positive chemotaxis; positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; paraxial mesoderm morphogenesis; gastrulation; embryonic pattern specification; regulation of transforming growth factor beta receptor signaling pathway; transforming growth factor beta receptor signaling pathway; positive regulation of stress fiber formation; embryonic foregut morphogenesis; negative regulation of osteoblast differentiation; negative regulation of mitotic cell cycle; cell cycle arrest; regulation of striated muscle development; pericardium development; somitogenesis; transcription, DNA-dependent; embryonic cranial skeleton morphogenesis; osteoblast development; positive regulation of chondrocyte differentiation; mesoderm formation; negative regulation of osteoblast proliferation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein catabolic process; endoderm development; negative regulation of apoptosis; transcription from RNA polymerase II promoter; evasion of host defenses by virus; T cell activation; negative regulation of transcription from RNA polymerase II promoter; regulation of epithelial cell proliferation; negative regulation of cell proliferation; positive regulation of focal adhesion formation; regulation of transcription, DNA-dependent; negative regulation of protein amino acid phosphorylation; transport; positive regulation of transforming growth factor-beta3 production; thyroid gland development; positive regulation of transcription factor import into nucleus; heart looping; skeletal development; caspase activation; intercellular junction assembly and maintenance; regulation of transforming growth factor-beta2 production; regulation of immune response; regulation of binding; protein stabilization; in utero embryonic development; positive regulation of bone mineralization; liver development; SMAD protein complex assembly; osteoblast differentiation; positive regulation of interleukin-1 beta production; immune system development; negative regulation of inflammatory response; induction of apoptosis; response to hypoxia; immune response; negative regulation of cell growth; positive regulation of cell migration Reference #:  Q8BUN5 (UniProtKB) Alt. Names/Synonyms: AU022421; MAD homolog 3; MAD homolog 3 (Drosophila); Mad3; Madh3; mMad3; Mothers against decapentaplegic homolog 3; Mothers against DPP homolog 3; OTTMUSP00000023917; SMAD 3; SMAD family member 3; Smad3 Gene Symbols: Smad3 Molecular weight: 48,081 Da Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states CST Pathways:  Angiogenesis  |  Cell Cycle: G1/S Checkpoint  |  ESC Pluripotency and Differentiation  |  TGF-ß Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Smad3 1MHD - A/B=1-132 (human) 1MJS - A=229-425 (human) 1MK2 - A=220-425 (human) 1OZJ - A/B=1-144 (human) 1U7F - A/C=228-424 (human) 2LAJ - B=202-211 (human) 2LB2 - B=178-189 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
5	1		T8	MSSILPFTPPIVKRL
0	5		K19	VKRLLGWKKGEQNGQ
0	1		K29	EQNGQEEKWCEKAVK
0	1		Y125	DEVCVNPYHYQRVEt
0	2		T132-p	YHYQRVEtPVLPPVL
10	0		T179	PQSNIPETPPPGYLS
11	0		S204	NHSMDAGSPNLSPNP
11	0		S208	DAGSPNLSPNPMSPA
8	0		S213	NLSPNPMSPAHNNLD
2	0		S309-p	EVFAECLsDSAIFVQ
1	1		K378	TIRMSFVKGWGAEYR
2	0		T388-p	GAEYRRQtVTSTPCW
1	1		S416	KVLTQMGSPSIRCSs
2	0		S418	LTQMGSPSIRCSsVs
1	0		S422	GSPSIRCSsVs____
16	5		S423-p	SPSIRCSsVs_____
16	5		S425-p	SIRCSsVs_______

	human
T8-p	MSSILPFtPPIVKRL
K19-a	VKRLLGWkKGEQNGQ
K29-a	EQNGQEEkWCEKAVK
Y125-p	DEVCVNPyHYQRVEt
T132-p	yHYQRVEtPVLPPVL
T179-p	PQSNIPEtPPPGYLS
S204-p	NHSMDAGsPNLsPNP
S208-p	DAGsPNLsPNPMsPA
S213-p	NLsPNPMsPAHNNLD
S309-p	EVFAECLsDSAIFVQ
K378-a	TIRMSFVkGWGAEYR
T388-p	GAEYRRQtVTSTPCW
S416-p	KVLTQMGsPsIRCss
S418-p	LTQMGsPsIRCssVs
S422-p	GsPsIRCssVs____
S423-p	sPsIRCssVs_____
S425-p	sIRCssVs_______

	rat
T8	MSSILPFTPPIVKRL
K19	VKRLLGWKKGEQNGQ
K29	EQNGQEEKWCEKAVK
Y125	DEVCVNPYHYQRVET
T132	YHYQRVETPVLPPVL
T179	PQSNIPETPPPGYLS
S204	NHSMDAGSPNLSPNP
S208	DAGSPNLSPNPMSPA
S213	NLSPNPMSPAHNNLD
S309	EVFAECLSDSAIFVQ
K378	TIRMSFVKGWGAEYR
T388	GAEYRRQTVTSTPCW
S416	KVLTQMGSPSIRCSs
S418	LTQMGSPSIRCSsVs
S422	GSPSIRCSsVs____
S423-p	SPSIRCSsVs_____
S425-p	SIRCSsVs_______

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