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Protein Page:
CCNT1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CCNT1 Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. Cyclin-T1 is the predominant cyclin that associates with CDK9 to form a heterodimer called P-TEFb. P-TEFb forms a complex with AFF4/AF5Q31. Interacts with the transactivation region of HIV-1, HIV-2 and SIV Tat. Component of a complex which is at least composed of HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, and NCL/nucleolin. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with MDFIC. Ubiquitously expressed. Belongs to the cyclin family. Cyclin C subfamily. Note: This description may include information from UniProtKB.
Protein type: Transcription initiation complex
Cellular Component: nucleoplasm; transcription elongation factor complex b; nucleolus; nucleus
Molecular Function: protein binding; snRNA binding; DNA binding; chromatin binding; protein kinase binding
Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; viral reproduction; transcription, DNA-dependent; positive regulation of viral transcription; cell cycle; protein amino acid phosphorylation; cell division; transforming growth factor beta receptor signaling pathway; RNA elongation from RNA polymerase II promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter; regulation of cyclin-dependent protein kinase activity
Reference #:  O60563 (UniProtKB)
Alt. Names/Synonyms: CCNT; CCNT1; CDK9-associated C-type protein; cyclin C-related protein; cyclin T1; cyclin T1b; Cyclin-T; Cyclin-T1; HIVE1; human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1; Human immunodeficiency virus-1 expression; subunit of positive elongation transcription factor b
Gene Symbols: CCNT1
Molecular weight: 80,685 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CCNT1

Protein Structure Not Found.


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Sites Implicated In
transcription, inhibited: S564‑p
enzymatic activity, inhibited: S564‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 T110-p HVIKVAHtCLHPQEs
0 1 S117-p tCLHPQEsLPDTRSE
0 2 T278-p DRGTDEKtsEQtILN
0 1 S279-p RGTDEKtsEQtILNM
0 1 T282-p DEKtsEQtILNMISQ
0 1 S290-p ILNMISQsSsDTTIA
0 1 S292-p NMISQsSsDTTIAGL
0 1 T307-p MSMSTSTtSAVPSLP
0 8 S340-p RWLSSQPsFKLEPTQ
1 0 K376-me SNAFISQkQNSkSVP
2 0 K380-ac ISQkQNSkSVPSAkV
2 0 K386-ac SkSVPSAkVsLkEYR
0 1 S388-p SVPSAkVsLkEYRAK
2 1 K390-ac PSAkVsLkEYRAKHA
1 2 K404-ac AEELAAQkRQLENME
0 4 Y418-p EANVKSQyAyAAQNL
0 1 Y420-p NVKSQyAyAAQNLLS
0 2 K476-ac GDKAASSkPEEIKMR
1 2 K492-ac KVHAAADkHNsVEDs
0 1 S495-p AAADkHNsVEDsVTK
0 2 S499-p kHNsVEDsVTKSREH
0 1 S529-p NHHSHKHsHsQLPVG
0 1 S531-p HSHKHsHsQLPVGTG
0 8 S549-p PGDPKHSsQTSNLAH
1 2 S564-p KTYSLSSsFSSSSsT
0 1 S570-p SsFSSSSsTRKRGPs
0 2 S577-p sTRKRGPsEETGGAV
1 0 S629-p GLSFSQPsCKTRVPH
0 2 Y690-p FVRPYSDyLNPRSGG
1 0 K707-ac SRSGNTDkPRPPPLP
  mouse

 
T110 HVIKVAHTCLHPQES
S117 TCLHPQESLPDTRSE
T278 DRGADENTSEQTILN
S279 RGADENTSEQTILNM
T282 DENTSEQTILNMISQ
T290 ILNMISQTSSDTTIA
S292 NMISQTSSDTTIAGL
T307 MSMSTASTSAVPSLP
P340 RWLSSQPPFKLEAAQ
K376 SSAFGSQKQASKSVP
K380 GSQKQASKSVPSAKV
K386 SKSVPSAKVSLKEYR
S388 SVPSAKVSLKEYRAK
K390 PSAKVSLKEYRAKHA
K404 AEELAAQKRQLENME
Y418 EANVKSQYAYAAQNL
Y420 NVKSQYAYAAQNLLS
K475 GDKAVSSKPEEIKMR
K491 KVHSAGDKHNSIEDs
S494 SAGDKHNSIEDsVTK
S498-p KHNSIEDsVTKSREH
S528 NHHSHRHSHLQLPAG
L530 HSHRHSHLQLPAGPV
S548 PSDPKHSSQTSTLAH
T563 KTYSLSSTLSSSSST
S569 STLSSSSSTRKRGPP
P576 STRKRGPPEETGAAV
S627 GLPFSQPSCKTRVPH
Y688 FVHSYGEYMNPRAGA
K705 SRSGTTDKPRPPPLP
  rat

 
T110 HVIKVAHTCLHPQES
S117 TCLHPQESLPDTRSE
T217 DRGADENTSEQTILN
S218 RGADENTSEQTILNM
T221 DENTSEQTILNMISQ
T229 ILNMISQTSSDTTIA
S231 NMISQTSSDTTIAGL
T246 MSMSAASTGAVPSLP
P279 RWLSSQPPFKLEASQ
K315 SNAFVSQKQTSKSVP
K319 VSQKQTSKSVPSAKV
K325 SKSVPSAKVSLKEYR
S327 SVPSAKVSLKEYRAK
K329 PSAKVSLKEYRAKHA
K343 AEELAAQKRQLENME
Y357 EANVKSQYAYAAQNL
Y359 NVKSQYAYAAQNLLS
K414 GDKAASSKPEEIKMR
K430 KVHSAGDKHNSVEDS
S433 SAGDKHNSVEDSVAK
S437 KHNSVEDSVAKSREH
S467 NHHSHKHSHLQLPVG
L469 HSHKHSHLQLPVGPV
S487 PSDPKHSSQTSTLAH
T502 KTYSLSSTLSSSSST
S508 STLSSSSSTRKRGPP
P515 STRKRGPPEETGAAV
S567 GLPFSQPSCKTRVPH
Y628 FVHSYGEYMNPRAAG
K644 SRSGNTDKPRPPPLP
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