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Protein Page:
ZIC3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ZIC3 Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. Defects in ZIC3 are the cause of visceral heterotaxy X- linked type 1 (HTX1). A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defects. Clinical features of visceral heterotaxy X- linked type 1 include dextrocardia, corrected transposition of great arteries, ventricular septal defect, patent ductus arteriosus, pulmonic stenosis, situs inversus viscerum, and asplenia and/or polysplenia. Defects in ZIC3 are a cause of VACTERL association X- linked with or without hydrocephalus (VACTERLX). A syndrome characterized by vertebral anomalies, anal atresia, cardiac malformations, tracheoesophageal fistula, renal anomalies (urethral atresia with hydronephrosis), and limb anomalies (hexadactyly, humeral hypoplasia, radial aplasia, and proximally placed thumb). Some patients may have hydrocephalus. Some cases of VACTERL-H are associated with increased chromosome breakage and rearrangement. Belongs to the GLI C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor; C2H2-type zinc finger protein
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; sequence-specific DNA binding; metal ion binding; transcription factor activity
Biological Process: anterior/posterior pattern formation; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; heart looping; cell differentiation; determination of left/right symmetry; lung development
Reference #:  O60481 (UniProtKB)
Alt. Names/Synonyms: ZIC3; Zinc finger protein of the cerebellum 3; Zinc finger protein ZIC 3
Gene Symbols: ZIC3
Molecular weight: 50,569 Da
Basal Isoelectric point: 8.89  Predict pI for various phosphorylation states
Select Structure to View Below

ZIC3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S18-p FPGLGVGsFGAPRHH
0 1 S59-p AAAAFKLsPAAAHDL
1 0 K248-sm RYMRQPIkQELSCKW
0 1 S412 KHMKVHESQGSDSSP
0 1 S423 DSSPAASSGYESSTP
0 1 Y425 SPAASSGYESSTPPA
  mouse

 
S18 FPGLGVGSFGAPRHH
S59 AAAAFKLSPATAHDL
K247 RYMRQPIKQELSCKW
S411-p KHMKVHEsQGSDSSP
S422-p DSSPAASsGyESSTP
Y424-p SPAASsGyESSTPPA
  rat

 
- gap
S33 AAAAFKLSPATAHDL
K221 RYMRQPIKQELSCKW
- gap
- gap
- gap
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