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Oct8
Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3'). Belongs to the POU transcription factor family. Class- 3 subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor; DNA binding protein |
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Cellular Component: nucleus
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Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity
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Biological Process: central nervous system development; positive regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex radially oriented cell migration; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; forebrain ventricular zone progenitor cell division; negative regulation of apoptosis
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Reference #:
P20264 (UniProtKB)
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| Alt. Names/Synonyms: Brain-1; Brain-specific homeobox/POU domain protein 1; Brn-1; BRN1; Oct-8; Octamer-binding protein 8; Octamer-binding transcription factor 8; OTF-8; OTF8; POU domain, class 3, transcription factor 3 |
| Gene Symbols: POU3F3 |
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Molecular weight: 50,327 Da
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Basal Isoelectric point: 7.51
Predict pI for various phosphorylation states
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