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Protein Page:
GABARAP (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
GABARAP is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Belongs to the MAP1 LC3 family. Interacts with GPHN and NSF. Interacts with GABRG2, beta-tubulin and ULK1. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Microtubule binding protein; Vesicle protein; Autophagy; Ubiquitin-like modifier
Cellular Component: Golgi membrane; microtubule; microtubule associated complex; smooth endoplasmic reticulum; perinuclear region of cytoplasm; lysosome; plasma membrane; autophagic vacuole; cytoplasmic vesicle; axoneme; actin cytoskeleton
Molecular Function: protein binding; microtubule binding; GABA receptor binding; beta-tubulin binding
Biological Process: synaptic transmission; induction of apoptosis via death domain receptors; autophagy; microtubule cytoskeleton organization and biogenesis; protein targeting
Reference #:  O95166 (UniProtKB)
Alt. Names/Synonyms: FLC3B; FLJ25768; GABA(A) receptor-associated protein; GABARAP; Gamma-aminobutyric acid receptor-associated protein; GBRAP; MGC120154; MGC120155; MM46
Gene Symbols: GABARAP
Molecular weight: 13,918 Da
Basal Isoelectric point: 8.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GABARAP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 K13-u KEEHPFEkRRSEGEK
0 8 K23-u SEGEKIRkkYPDRVP
0 20 K24-u EGEKIRkkYPDRVPV
0 6 K35-a RVPVIVEkAPKARIG
0 2 Y49-p GDLDKKKyLVPSDLT
0 3 Y61-p DLTVGQFyFLIRKRI
  mouse

 
K13-u KEEHPFEkRRSEGEK
K23-u SEGEKIRkkYPDRVP
K24-u EGEKIRkkYPDRVPV
K35-a RVPVIVEkAPKARIG
Y49 GDLDKKKYLVPSDLT
Y61 DLTVGQFYFLIRKRI
  rat

 
K13 KEEHPFEKRRSEGEK
K23 SEGEKIRKKYPDRVP
K24 EGEKIRKKYPDRVPV
K35 RVPVIVEKAPKARIG
Y49 GDLDKKKYLVPSDLT
Y61 DLTVGQFYFLIRKRI
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