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EN1
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]
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| Protein type: Cell development/differentiation; Transcription factor; DNA binding protein |
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Cellular Component: nucleus
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Molecular Function: sequence-specific DNA binding; transcription factor activity
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Biological Process: embryonic forelimb morphogenesis; anatomical structure morphogenesis; dorsal/ventral pattern formation; pigmentation; midbrain development; midbrain-hindbrain boundary development; neuron development; positive regulation of transcription from RNA polymerase II promoter; skeletal development; proximal/distal pattern formation; hindbrain development
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Reference #:
Q05925 (UniProtKB)
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| Alt. Names/Synonyms: HME1; Homeobox protein en-1; Homeobox protein engrailed-1; Hu-En-1 |
| Gene Symbols: EN1 |
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Molecular weight: 40,115 Da
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Basal Isoelectric point: 9.55
Predict pI for various phosphorylation states
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