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Protein Page:
EN1 (human)

Overview
EN1 Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]
Protein type: Transcription factor; Cell development/differentiation; DNA binding protein
Chromosomal Location of Human Ortholog: 2q14.2
Cellular Component: membrane; nucleus
Molecular Function: sequence-specific DNA binding; transcription factor activity
Biological Process: embryonic forelimb morphogenesis; anatomical structure morphogenesis; dorsal/ventral pattern formation; pigmentation; midbrain development; midbrain-hindbrain boundary development; neuron development; positive regulation of transcription from RNA polymerase II promoter; response to cocaine; skeletal development; proximal/distal pattern formation; hindbrain development
Reference #:  Q05925 (UniProtKB)
Alt. Names/Synonyms: HME1; Homeobox protein en-1; Homeobox protein engrailed-1; Hu-En-1
Gene Symbols: EN1
Molecular weight: 40,115 Da
Basal Isoelectric point: 9.55  Predict pI for various phosphorylation states
Select Structure to View Below

EN1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T149-p VERDRGQtAAGRDPV
0 1 S234 GSGGGAGSPGAQGTK
  mouse

 
T156 VERDRGQTGAGRDPV
S244-p GSGGNAGsPGAQGAK
  rat

 
T71 VERDRSQTGAGRDPV
S159 GSGGSAGSPGAQGAK
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