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STAT1 (mouse)

Overview STAT1 transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of certain receptor tyrosine kinases, GPCRs, and receptors for various interleukins and interferons. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor Cellular Component: axon; dendrite; cytoplasm; nucleolus; nucleus Molecular Function: enzyme binding; protein homodimerization activity; DNA binding; sequence-specific DNA binding; double-stranded DNA binding; tumor necrosis factor receptor binding; transcription factor activity; CCR5 chemokine receptor binding Biological Process: response to peptide hormone stimulus; response to cAMP; blood circulation; positive regulation of transcription, DNA-dependent; positive regulation of smooth muscle cell proliferation; response to lipopolysaccharide; response to exogenous dsRNA; tumor necrosis factor-mediated signaling pathway; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; lipopolysaccharide-mediated signaling pathway; response to nutrient; response to drug; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; JAK-STAT cascade; negative regulation of angiogenesis; response to bacterium; cellular response to insulin stimulus; response to mechanical stimulus; response to cytokine stimulus; negative regulation of endothelial cell proliferation; induction of apoptosis; positive regulation of transcription from RNA polymerase II promoter Reference #:  P42225 (UniProtKB) Alt. Names/Synonyms: 2010005J02Rik; AA408197; Signal transducer and activator of transcription 1; Stat1 Gene Symbols: Stat1 Molecular weight: 87,197 Da Basal Isoelectric point: 5.42  Predict pI for various phosphorylation states CST Pathways:  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Jak/Stat/IL-6 Signaling  |  MAPK/Erk in Growth and Differentiation  |  Signaling Pathways Activating p38 MAPK Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below STAT1 1BF5 - A=136-683 (human) 1YVL - A/B=1-683 (human) 2KA6 - B=710-750 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  Source  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell cycle regulation: S727‑p cell growth, altered: Y701‑p, S727‑p transcription, altered: Y701‑p, S708‑p, S727‑p activation: S727‑p intracellular localization: Y701‑p molecular association, regulation: Y701‑p, S727‑p phosphorylation: Y701‑p protein degradation: S727‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
2	0		R31	DSFPMEIRQYLAQWL
1	0		R31	DSFPMEIRQYLAQWL
0	1		K40	YLAQWLEKQDWEHAA
0	11		Y68	LSQLDDQYSRFSLEN
0	18		Y106	VQMSMIIYNCLKEER
0	2		K138-u	QNTVMLDkQKELDSK
0	3		Y170	LEELQDEYDFKCKTS
0	1		K173	LQDEYDFKCKTSQNR
0	2		K173	LQDEYDFKCKTSQNR
0	1		A184	SQNREGEANGVAKSD
0	6		K193-u	GVAKSDQkQEQLLLH
0	1		F203	QLLLHKMFLMLDNKR
0	1		K209	MFLMLDNKRKEIIHK
0	1		S223	KIRELLNSIELTQNT
0	1		T227	LLNSIELTQNTLIND
0	4		K240	NDELVEWKRRQQSAC
0	7		K296-u	YEPDPITkNKQVLSD
0	1		K298	PDPITkNKQVLSDRT
0	2		K375	VNEKNTVKGFRkFNI
0	1		K379-u	NTVKGFRkFNILGTH
2	1		K410	ELRHLQLKEQKNAGN
0	11		K410	ELRHLQLKEQKNAGN
2	1		K413	HLQLKEQKNAGNRTN
0	1		N417	KEQKNAGNRTNEGPL
0	5		K511	WQFSSVTKRGLNADQ
0	2		K525-u	QLSMLGEkLLGPNAG
0	2		K544-u	IPWTRFCkENINDKN
0	13		K592-u	ERERALLkDQQPGTF
0	1		K636	HAVEPYTKkELSAVT
0	1		K637-u	AVEPYTKkELSAVTF
0	14		K652-u	PDIIRNYkVMAAENI
0	2		K665-u	NIPENPLkYLYPNID
0	3		Y668	ENPLkYLYPNIDkDH
0	1		K673-u	YLYPNIDkDHAFGkY
0	1		K679-u	DkDHAFGkYYSRPKE
0	7		T699	ELDDPKRTGyIKTEL
123	66		Y701-p	DDPKRTGyIKTELIs
6	1		K703	PKRTGyIKTELIsVS
0	2		T704	KRTGyIKTELIsVSE
1	0		S708-p	yIKTELIsVSEVHPS
78	88		S727-p	TDNLLPMsPEEFDEM
1	0		S744-p	IVGPEFDsMMsTV__
1	0		S747-p	PEFDsMMsTV_____

	human
R31-m1	DSFPMEIrQYLAQWL
R31-m2	DSFPMEIrQYLAQWL
K40-u	YLAQWLEkQDWEHAA
Y68-p	LSQLDDQySRFSLEN
Y106-p	IQMSMIIySCLKEER
K138-u	QSTVMLDkQKELDSK
Y170-p	LEDLQDEyDFkCKTL
K173-a	LQDEyDFkCKTLQNR
K173-u	LQDEyDFkCKTLQNR
T184-p	LQNREHEtNGVAKSD
K193-u	GVAKSDQkQEQLLLK
Y203-p	QLLLKKMyLMLDNkR
K209-u	MyLMLDNkRKEVVHK
V223	KIIELLNVTELTQNA
T227	LLNVTELTQNALIND
K240-u	NDELVEWkRRQQSAC
K296-u	YEHDPITkNkQVLWD
K298-u	HDPITkNkQVLWDRT
K375-u	VNERNTVkGFRKFNI
K379	NTVkGFRKFNILGTH
K410-a	EFRHLQLkEQkNAGt
K410-u	EFRHLQLkEQkNAGt
K413-a	HLQLkEQkNAGtRTN
T417-p	kEQkNAGtRTNEGPL
K511-u	WQFSSVTkRGLNVDQ
K525-u	QLNMLGEkLLGPNAS
K544-u	IPWTRFCkENINDKN
K592-u	ERERALLkDQQPGTF
K636-u	HAVEPYTkKELSAVT
K637	AVEPYTkKELSAVTF
K652-u	PDIIRNYkVMAAENI
K665-u	NIPENPLkYLyPNID
Y668-p	ENPLkYLyPNIDKDH
K673	YLyPNIDKDHAFGKY
K679	DKDHAFGKYYSRPKE
T699-p	ELDGPKGtGyIktEL
Y701-p	DGPKGtGyIktELIs
K703-s	PKGtGyIktELIsVS
T704-p	KGtGyIktELIsVSE
S708-p	yIktELIsVSEVHPS
S727-p	TDNLLPMsPEEFDEV
S745	VGSVEFDSMMNTV__
N748	VEFDSMMNTV_____

	rat
R31	DSFPMEIRQYLAQWL
R31	DSFPMEIRQYLAQWL
K40	YLAQWLEKQDWEHAA
Y68	LSQLDDQYSRFSLEN
H106	VQMSMIIHNCLKEER
K138	QNTVMLDKQKELDSK
Y170	LEDLQDEYDFKCKTS
K173	LQDEYDFKCKTSQNR
K173	LQDEYDFKCKTSQNR
A184	SQNRESEANGVAKSD
K193	GVAKSDQKQEQLLLH
F203	QLLLHKMFLMLDNKR
K209	MFLMLDNKRKEIIHK
S223-p	KIRELLNsIELtQNT
T227-p	LLNsIELtQNTLIND
K240	NDELVEWKRRQQSAC
K296	YEQDPITKNKQVLSD
K298	QDPITKNKQVLSDRT
K375	VNEKNTVKGFRKFNI
K379	NTVKGFRKFNILGTH
K410	EFRHLQLKEQKNAGN
K410	EFRHLQLKEQKNAGN
K413	HLQLKEQKNAGNRTN
N417	KEQKNAGNRTNEGPL
K511	WQFSSVTKRGLNADQ
K525	QLSMLGEKLLGPNAG
K544	IPWTRFCKENINDKN
K592	ERERALLKDQQPGTF
K636	HAVEPYTKKELSAVT
K637	AVEPYTKKELSAVTF
K652	PDIIRNYKVMAAENI
K665	NIPENPLKYLYPNID
Y668	ENPLKYLYPNIDKDH
K673	YLYPNIDKDHAFGKY
K679	DKDHAFGKYYSRPKE
T699	ELDDPKRTGyIKTEL
Y701-p	DDPKRTGyIKTELIS
K703	PKRTGyIKTELISVS
T704	KRTGyIKTELISVSE
S708	yIKTELISVSEVHPS
S727-p	TENLLPMsPEEFDEM
S744	IVGSEFDSMMSAV__
S747	SEFDSMMSAV_____

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