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Protein Page:
K4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
K4 Heterotetramer of two type I and two type II keratins. Keratin-4 is generally associated with keratin-13. Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa. Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer. Belongs to the intermediate filament family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Cellular Component: intermediate filament cytoskeleton; cell surface; keratin filament; intermediate filament; nucleus
Molecular Function: protein binding; structural molecule activity
Biological Process: epithelial cell differentiation; cytoskeleton organization and biogenesis; negative regulation of epithelial cell proliferation
Reference #:  P19013 (UniProtKB)
Alt. Names/Synonyms: CK-4; CK4; CYK4; cytokeratin 4; Cytokeratin-4; FLJ31692; K2C4; K4; keratin 4; Keratin, type II cytoskeletal 4; Keratin-4; KRT4; Type-II keratin Kb4
Gene Symbols: KRT4
Molecular weight: 57,285 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

K4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 R13 QCVRGGPRGFSCGSA
0 1 S19 PRGFSCGSAIVGGGk
0 1 K26-ac SAIVGGGkRGAFSsV
0 1 S32-p GkRGAFSsVSMsGGA
0 1 S34 RGAFSsVSMsGGAGR
0 1 S36-p AFSsVSMsGGAGRCS
0 1 S49-p CSSGGFGsRsLyNLR
0 11 S51-p SGGFGsRsLyNLRGN
0 72 Y53-p GFGsRsLyNLRGNKS
0 1 S64-p GNKSISMsVAGSRQG
0 6 S164-p LLNNKFAsFIDkVQF
0 4 K168-ub KFAsFIDkVQFLEQQ
0 1 K259-ac ENDFVVLkKDVDAAy
0 55 Y266-p kKDVDAAyLNkVELE
0 1 K269-ac VDAAyLNkVELEAKV
0 92 Y329-p IAEVRAQyEEIAQRS
0 85 Y344-p KAEAEALyQtKVQQL
0 3 T346-p EAEALyQtKVQQLQI
0 1 S413-p NALKDAHsKRVELEA
0 11 K455 IEIATYRKLLEGEEY
  mouse

 
R13-m1 SSVRGASrGFSSGsA
S19-p SrGFSSGsAIAGGVK
K26 sAIAGGVKRVAFSSG
S32 VKRVAFSSGsMSGGA
S34-p RVAFSSGsMSGGAGR
S36 AFSSGsMSGGAGRCS
S49 CSSGGFGSRSLYNLG
S51 SGGFGSRSLYNLGGH
Y53 GFGSRSLYNLGGHKS
S64 GHKSISMSVAGSCQG
S159-p TLNNKFAsFIDkVRF
K163-ub KFAsFIDkVRFLEQQ
K254 ENDFVVLKKDVDAAY
Y261 KKDVDAAYMIKVELE
K264 VDAAYMIKVELEAKM
Y324 IAEVRAQYEDIARKS
Y339 KAEVESWYQIKVQQL
I341 EVESWYQIKVQQLQM
S408 LALKDAYSKRAELET
K450-ub VEIATYRkLLEGEEC
  rat

 
R13 SSVRGVSRGFSSGSA
S19 SRGFSSGSAVAGGVK
K26 SAVAGGVKRVAFSSA
S32 VKRVAFSSASMSGGA
S34 RVAFSSASMSGGAGR
S36 AFSSASMSGGAGRCS
S49 CSSGGFGSRSLYNLG
S51 SGGFGSRSLYNLGGH
Y53 GFGSRSLYNLGGHKS
S64 GHKSISMSVAGSCQG
S159 TLNNKFASFIDKVRF
K163 KFASFIDKVRFLEQQ
K254 ENDFVVLKKDVDAAY
Y261 KKDVDAAYMIKVELE
K264 VDAAYMIKVELEAKM
Y324 IAEVRAQYEEIARKS
Y339 KAEVESWYQIKVQQL
I341 EVESWYQIKVQQLQM
T406 LALKDAYTKRADLET
K448 VEIATYRKLLEGEEC
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