Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
K4 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
K4 Heterotetramer of two type I and two type II keratins. Keratin-4 is generally associated with keratin-13. Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa. Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer. Belongs to the intermediate filament family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Cellular Component: keratin filament; intermediate filament
Molecular Function: structural molecule activity
Biological Process: epithelial cell differentiation; cytoskeleton organization and biogenesis; negative regulation of epithelial cell proliferation
Reference #:  P19013 (UniProtKB)
Alt. Names/Synonyms: CK-4; CK4; CYK4; cytokeratin 4; Cytokeratin-4; FLJ31692; K2C4; K4; keratin 4; Keratin, type II cytoskeletal 4; Keratin-4; KRT4; Type-II keratin Kb4
Gene Symbols: KRT4
Molecular weight: 57,285 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

K4

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 R13 QCVRGGPRGFSCGSA
0 1 S19 PRGFSCGSAIVGGGK
0 1 S34 RGAFSSVSMSGGAGR
0 11 S51-p SGGFGSRsLyNLRGN
0 72 Y53-p GFGSRsLyNLRGNKS
0 5 S164-p LLNNKFAsFIDkVQF
0 4 K168-u KFAsFIDkVQFLEQQ
0 55 Y266-p KKDVDAAyLNKVELE
0 92 Y329-p IAEVRAQyEEIAQRS
0 85 Y344-p KAEAEALyQtKVQQL
0 3 T346-p EAEALyQtKVQQLQI
0 11 K455 IEIATYRKLLEGEEY
  mouse

 
R13-m1 SSVRGASrGFSSGsA
S19-p SrGFSSGsAIAGGVK
S34-p RVAFSSGsMSGGAGR
S51 SGGFGSRSLYNLGGH
Y53 GFGSRSLYNLGGHKS
S159-p TLNNKFAsFIDkVRF
K163-u KFAsFIDkVRFLEQQ
Y261 KKDVDAAYMIKVELE
Y324 IAEVRAQYEDIARKS
Y339 KAEVESWYQIKVQQL
I341 EVESWYQIKVQQLQM
K450-u VEIATYRkLLEGEEC
  rat

 
R13 SSVRGVSRGFSSGSA
S19 SRGFSSGSAVAGGVK
S34 RVAFSSASMSGGAGR
S51 SGGFGSRSLYNLGGH
Y53 GFGSRSLYNLGGHKS
S159 TLNNKFASFIDKVRF
K163 KFASFIDKVRFLEQQ
Y261 KKDVDAAYMIKVELE
Y324 IAEVRAQYEEIARKS
Y339 KAEVESWYQIKVQQL
I341 EVESWYQIKVQQLQM
K448 VEIATYRKLLEGEEC
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.