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Protein Page:
STAT2 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STAT2 transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Binds to the IFN-stimulated response element (ISRE) and to the Gas element. This multiprotein transcription factor is termed ISGF3. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: cytoplasm; plasma membrane; nucleus
Molecular Function: identical protein binding; protein binding; signal transducer activity; DNA binding; transcription factor activity
Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; signal transduction
Reference #:  Q9WVL2 (UniProtKB)
Alt. Names/Synonyms: 1600010G07Rik; AW496480; Signal transducer and activator of transcription 2; Stat2
Gene Symbols: Stat2
Molecular weight: 105,417 Da
Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STAT2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

► Hide Isoforms
 
0 1 F157 GLHVDIEFLVRSIRQ
0 1 K238-ub LPKLDEWkVQQQKSC
0 1 S284 LKQLKEMSCLRYQGD
1 1 R287 LKEMSCLRYQGDMFA
0 1 - gap
0 1 A294 RYQGDMFAKGVDLRN
0 2 K295 YQGDMFAKGVDLRNA
0 1 K374 SDLPGFRKFNILTSN
0 1 K383 NILTSNQKTLTPEKG
0 1 K383 NILTSNQKTLTPEKG
0 3 K522 QLGMLRTKLFGKSCK
0 1 K542 LSWVDFCKRESPPGK
0 2 S594-p RLLKKMLsGTFLLRF
0 1 T596 LKKMLsGTFLLRFSE
1 0 Y630 EIYSVQPYTKEVLQS
0 2 K680 FGCYYQEKVNLEEQE
10 0 Y689-p NLEEQEEyLKHKLIV
0 1 - under review  
0 7 - gap
0 1 S903 ESSGDETSIPYHSHF
  STAT2 iso3  
F157 GLHVDIEFLVRSIRQ
K238 LPKLDEWKVQQQKSC
S283 LKQLKEMSHMLRYkG
R287 KEMSHMLRYkGDMFG
K289-ub MSHMLRYkGDMFGQG
G294 RYkGDMFGQGVDLQN
Q295 YkGDMFGQGVDLQNA
K374 SDLPGFRKFNILTSN
K383 NILTSNQKTLTPEEG
K383 NILTSNQKTLTPEEG
K521 QLGMLRTKLFGKSCK
K541 LSWVDFCKRESPPGK
S593 RLLKKMLSGTFLLRF
T595 LKKMLSGTFLLRFSE
Y629 EIYSVQPYTKEVLQS
K679 FGCYYQEKVNFEEQR
Y688 NFEEQRKYLKHKLIV
V821 QLEPAPQVLLELAPQ
- gap
S902 ESSGDETSIPYHSHF
  human

 
K158-ac DLRAMMEkLVKSISQ
K239 LPKLEEWKAQQQKAC
S283-p LKELKGLsCLVsYQD
S287-p KGLsCLVsYQDDPLt
- gap
T294-p sYQDDPLtkGVDLRN
K295-ub YQDDPLtkGVDLRNA
K375-ac PQLQGFRkFNILTSN
K384-ac NILTSNQkTLTPEKG
K384-ub NILTSNQkTLTPEKG
K523-ub QLSMLRNkLFGQNCR
K543-ub LSWADFTkRESPPGK
S595-p RLLKKTMsGtFLLRF
T597-p LKKTMsGtFLLRFSE
Y631-p LIYSVQPyTKEVLQS
K681-ub FGCYYQEkVNLQERR
Y690-p NLQERRKyLKHRLIV
S753-p DLGPELEsVLESTLE
T800-p CDLRHLNtEPMEIFR
Y833-p QNTVDEVyVSRPSHF
4441 : Phospho-Stat2 (Tyr690) Antibody
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