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STAT2 (mouse)

Overview STAT2 transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Binds to the IFN-stimulated response element (ISRE) and to the Gas element. This multiprotein transcription factor is termed ISGF3. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor Cellular Component: cytoplasm; plasma membrane; nucleus Molecular Function: protein binding Reference #:  Q9WVL2 (UniProtKB) Alt. Names/Synonyms: 1600010G07Rik; AW496480; Signal transducer and activator of transcription 2; Stat2 Gene Symbols: Stat2 Molecular weight: 105,417 Da Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below STAT2 2KA4 - B=786-838 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  Source  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse ► Hide Isoforms
0	1		F157	GLHVDIEFLVRSIRQ
0	1		K238-u	LPKLDEWkVQQQKSC
0	1		S284	LKQLKEMSCLRYQGD
1	1		R287	LKEMSCLRYQGDMFA
0	1		-	gap
0	1		A294	RYQGDMFAKGVDLRN
0	2		K295	YQGDMFAKGVDLRNA
0	1		K374	SDLPGFRKFNILTSN
0	1		K383	NILTSNQKTLTPEKG
0	1		K383	NILTSNQKTLTPEKG
0	3		K522	QLGMLRTKLFGKSCK
0	1		K542	LSWVDFCKRESPPGK
0	2		S594-p	RLLKKMLsGTFLLRF
0	1		T596	LKKMLsGTFLLRFSE
1	0		Y630	EIYSVQPYTKEVLQS
0	2		K680	FGCYYQEKVNLEEQE
9	0		Y689-p	NLEEQEEyLKHKLIV
0	6		-	gap
0	1		S903	ESSGDETSIPYHSHF

	STAT2 iso3
F157	GLHVDIEFLVRSIRQ
K238	LPKLDEWKVQQQKSC
S283	LKQLKEMSHMLRYkG
R287	KEMSHMLRYkGDMFG
K289-u	MSHMLRYkGDMFGQG
G294	RYkGDMFGQGVDLQN
Q295	YkGDMFGQGVDLQNA
K374	SDLPGFRKFNILTSN
K383	NILTSNQKTLTPEEG
K383	NILTSNQKTLTPEEG
K521	QLGMLRTKLFGKSCK
K541	LSWVDFCKRESPPGK
S593	RLLKKMLSGTFLLRF
T595	LKKMLSGTFLLRFSE
Y629	EIYSVQPYTKEVLQS
K679	FGCYYQEKVNFEEQR
Y688	NFEEQRKYLKHKLIV
-	gap
S902	ESSGDETSIPYHSHF

	human
K158-a	DLRAMMEkLVKSISQ
K239	LPKLEEWKAQQQKAC
S283-p	LKELKGLsCLVsYQD
S287-p	KGLsCLVsYQDDPLt
-	gap
T294-p	sYQDDPLtkGVDLRN
K295-u	YQDDPLtkGVDLRNA
K375-a	PQLQGFRkFNILTSN
K384-a	NILTSNQkTLTPEKG
K384-u	NILTSNQkTLTPEKG
K523-u	QLSMLRNkLFGQNCR
K543-u	LSWADFTkRESPPGK
S595-p	RLLKKTMsGtFLLRF
T597-p	LKKTMsGtFLLRFSE
Y631-p	LIYSVQPyTKEVLQS
K681-u	FGCYYQEkVNLQERR
Y690-p	NLQERRKyLKHRLIV
T800-p	CDLRHLNtEPMEIFR
Y833-p	QNTVDEVyVSRPSHF

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