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Protein Page:
STAT2 (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
STAT2 transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Binds to the IFN-stimulated response element (ISRE) and to the Gas element. This multiprotein transcription factor is termed ISGF3. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: cytoplasm; plasma membrane; nucleus
Molecular Function: identical protein binding; protein binding; signal transducer activity; DNA binding; calcium ion binding; transcription factor activity
Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; signal transduction
Reference #:  Q9WVL2 (UniProtKB)
Alt. Names/Synonyms: 1600010G07Rik; AW496480; Signal transducer and activator of transcription 2; Stat2
Gene Symbols: Stat2
Molecular weight: 105,417 Da
Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STAT2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

► Hide Isoforms
 
0 1 K238-u LPKLDEWkVQQQKSC
0 1 S284 LKQLKEMSCLRYQGD
1 1 R287 LKEMSCLRYQGDMFA
0 1 - gap
0 1 A294 RYQGDMFAKGVDLRN
0 2 K295 YQGDMFAKGVDLRNA
0 1 K374 SDLPGFRKFNILTSN
0 1 K383 NILTSNQKTLTPEKG
0 1 K383 NILTSNQKTLTPEKG
0 3 K522 QLGMLRTKLFGKSCK
0 1 K542 LSWVDFCKRESPPGK
0 2 S594-p RLLKKMLsGTFLLRF
1 0 Y630 EIYSVQPYTKEVLQS
0 2 K680 FGCYYQEKVNLEEQE
9 0 Y689-p NLEEQEEyLKHKLIV
0 7 - gap
  STAT2 iso3  
K238 LPKLDEWKVQQQKSC
S283 LKQLKEMSHMLRYkG
R287 KEMSHMLRYkGDMFG
K289-u MSHMLRYkGDMFGQG
G294 RYkGDMFGQGVDLQN
Q295 YkGDMFGQGVDLQNA
K374 SDLPGFRKFNILTSN
K383 NILTSNQKTLTPEEG
K383 NILTSNQKTLTPEEG
K521 QLGMLRTKLFGKSCK
K541 LSWVDFCKRESPPGK
S593 RLLKKMLSGTFLLRF
Y629 EIYSVQPYTKEVLQS
K679 FGCYYQEKVNFEEQR
Y688 NFEEQRKYLKHKLIV
- gap
  human

 
K239 LPKLEEWKAQQQKAC
S283-p LKELKGLsCLVsYQD
S287-p KGLsCLVsYQDDPLt
- gap
T294-p sYQDDPLtkGVDLRN
K295-u YQDDPLtkGVDLRNA
K375-a PQLQGFRkFNILTSN
K384-a NILTSNQkTLTPEKG
K384-u NILTSNQkTLTPEKG
K523-u QLSMLRNkLFGQNCR
K543-u LSWADFTkRESPPGK
S595-p RLLKKTMsGTFLLRF
Y631-p LIYSVQPyTKEVLQS
K681-u FGCYYQEkVNLQERR
Y690-p NLQERRKyLKHRLIV
T800-p CDLRHLNtEPMEIFR
4441 : Phospho-Stat2 (Tyr690) Antibody
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