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Protein Page:
ENG (mouse)

Overview
ENG Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. Interacts with ARRB2. Endoglin is restricted to endothelial cells in all tissues except bone marrow. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Motility/polarity/chemotaxis; Membrane protein, integral
Cellular Component: extracellular space; cell surface; membrane; cytoplasm; integral to membrane; nucleus; external side of plasma membrane
Molecular Function: transforming growth factor beta receptor activity; protein binding; protein homodimerization activity; glycosaminoglycan binding; transforming growth factor beta binding; galactose binding; punt binding; transforming growth factor beta receptor, cytoplasmic mediator activity
Biological Process: wound healing; heart development; positive regulation of collagen biosynthetic process; cell motility involved in cell locomotion; positive regulation of systemic arterial blood pressure; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; extracellular matrix disassembly; smooth muscle development; regulation of transforming growth factor beta receptor signaling pathway; central nervous system vasculogenesis; venous blood vessel morphogenesis; regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway; negative regulation of protein amino acid autophosphorylation; angiogenesis; heart looping; vasculogenesis; cell adhesion; negative regulation of cell migration; positive regulation of BMP signaling pathway; cell migration; negative regulation of nitric-oxide synthase activity; patterning of blood vessels; positive regulation of angiogenesis; negative regulation of endothelial cell proliferation; response to hypoxia; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation
Reference #:  Q63961 (UniProtKB)
Alt. Names/Synonyms: AI528660; AI662476; CD105; Cell surface MJ7/18 antigen; Edg; EGLN; Endoglin; Eng; OTTMUSP00000012838; S-endoglin; transmembrane glycoprotein
Gene Symbols: Eng
Molecular weight: 70,021 Da
Basal Isoelectric point: 5.8  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ENG

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
1 0 Y607 LLTAALWYIYSHTRG
1 0 Y609 TAALWYIYSHTRGPS
1 1 S629 VAVAAPASSESSSTN
1 1 S630 AVAAPASSESSSTNH
1 0 T635 ASSESSSTNHSIGST
1 0 S641 STNHSIGSTQSTPCS
1 0 S644 HSIGSTQSTPCSTSS
2 0 T645 SIGSTQSTPCSTSSM
1 0 T649 TQSTPCSTSSMA___
  human

 
Y612-p LLTAALWyIySHTRS
Y614-p TAALWyIySHTRSPS
S634-p VAVAAPAssESSStN
S635-p AVAAPAssESSStNH
T640-p AssESSStNHSIGsT
S646-p StNHSIGsTQstPCS
S649-p HSIGsTQstPCStSS
T650-p SIGsTQstPCStSSM
T654-p TQstPCStSSMA___
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