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ENG (mouse)

Overview ENG Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. Interacts with ARRB2. Endoglin is restricted to endothelial cells in all tissues except bone marrow. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Receptor, misc.; Motility/polarity/chemotaxis; Membrane protein, integral Cellular Component: extracellular space; cell surface; membrane; cytoplasm; integral to membrane; nucleus; external side of plasma membrane Molecular Function: transforming growth factor beta receptor activity; glycosaminoglycan binding; protein homodimerization activity; transforming growth factor beta binding; galactose binding; punt binding; transforming growth factor beta receptor, cytoplasmic mediator activity Biological Process: wound healing; heart development; cell motility involved in cell locomotion; positive regulation of systemic arterial blood pressure; negative regulation of transcription from RNA polymerase II promoter; smooth muscle development; extracellular matrix disassembly; central nervous system vasculogenesis; venous blood vessel morphogenesis; regulation of transforming growth factor beta receptor signaling pathway; regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; negative regulation of protein amino acid autophosphorylation; heart looping; angiogenesis; vasculogenesis; cell adhesion; negative regulation of cell migration; positive regulation of BMP signaling pathway; cell migration; negative regulation of nitric-oxide synthase activity; patterning of blood vessels; positive regulation of angiogenesis; negative regulation of endothelial cell proliferation; response to hypoxia; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation Reference #:  Q63961 (UniProtKB) Alt. Names/Synonyms: AI528660; AI662476; CD105; Cell surface MJ7/18 antigen; Edg; EGLN; Endoglin; Eng; OTTMUSP00000012838; S-endoglin; transmembrane glycoprotein Gene Symbols: Eng Molecular weight: 70,021 Da Basal Isoelectric point: 5.8  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ENG

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
1	1		S629	VAVAAPASSESSSTN
1	1		S630	AVAAPASSESSSTNH
1	0		T635	ASSESSSTNHSIGST
1	0		S641	STNHSIGSTQSTPCS
1	0		S644	HSIGSTQSTPCSTSS
2	0		T645	SIGSTQSTPCSTSSM
1	0		T649	TQSTPCSTSSMA___

	human
S634-p	VAVAAPAssESSStN
S635-p	AVAAPAssESSStNH
T640-p	AssESSStNHSIGsT
S646-p	StNHSIGsTQstPCS
S649-p	HSIGsTQstPCStSS
T650-p	SIGsTQstPCStSSM
T654-p	TQstPCStSSMA___

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