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ENG (human)

Overview ENG Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. Interacts with ARRB2. Endoglin is restricted to endothelial cells in all tissues except bone marrow. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Cellular Component: extracellular space; cell surface; cytoplasm; nucleolus; nucleus; external side of plasma membrane Molecular Function: transforming growth factor beta receptor activity; protein binding; transmembrane receptor activity; protein homodimerization activity; glycosaminoglycan binding; transforming growth factor beta binding; galactose binding; punt binding; activin binding; transforming growth factor beta receptor, cytoplasmic mediator activity Biological Process: wound healing; cell motility involved in cell locomotion; positive regulation of systemic arterial blood pressure; negative regulation of transcription from RNA polymerase II promoter; BMP signaling pathway; extracellular matrix disassembly; smooth muscle development; central nervous system vasculogenesis; venous blood vessel morphogenesis; regulation of transforming growth factor beta receptor signaling pathway; regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; negative regulation of protein amino acid autophosphorylation; heart looping; chronological cell aging; cell adhesion; vasculogenesis; negative regulation of cell migration; positive regulation of BMP signaling pathway; regulation of cell adhesion; cell migration; regulation of phosphorylation; negative regulation of nitric-oxide synthase activity; regulation of cell proliferation; patterning of blood vessels; negative regulation of endothelial cell proliferation; response to hypoxia; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway Reference #:  P17813 (UniProtKB) Alt. Names/Synonyms: CD105; CD105 antigen; EGLN; END; Endoglin; ENG; FLJ41744; HHT1; ORW; ORW1 Gene Symbols: ENG Molecular weight: 70,578 Da Basal Isoelectric point: 6.14  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ENG

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 131195 187300  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell motility, altered: S646‑p phosphorylation: S634‑p, S635‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	1		S634-p	VAVAAPAssESSStN
1	1		S635-p	AVAAPAssESSStNH
1	0		T640-p	AssESSStNHSIGsT
1	0		S646-p	StNHSIGsTQstPCS
1	0		S649-p	HSIGsTQstPCStSS
2	0		T650-p	SIGsTQstPCStSSM
1	0		T654-p	TQstPCStSSMA___

	mouse
S629	VAVAAPASSESSSTN
S630	AVAAPASSESSSTNH
T635	ASSESSSTNHSIGST
S641	STNHSIGSTQSTPCS
S644	HSIGSTQSTPCSTSS
T645	SIGSTQSTPCSTSSM
T649	TQSTPCSTSSMA___

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