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Protein Page:
ENG (human)

Overview
ENG Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. Interacts with ARRB2. Endoglin is restricted to endothelial cells in all tissues except bone marrow. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component: extracellular space; cell surface; cytoplasm; nucleolus; nucleus; external side of plasma membrane
Molecular Function: transforming growth factor beta receptor activity; protein binding; protein homodimerization activity; transmembrane receptor activity; glycosaminoglycan binding; transforming growth factor beta binding; galactose binding; punt binding; activin binding; transforming growth factor beta receptor, cytoplasmic mediator activity
Biological Process: wound healing; positive regulation of collagen biosynthetic process; cell motility involved in cell locomotion; positive regulation of systemic arterial blood pressure; negative regulation of transcription from RNA polymerase II promoter; response to corticosteroid stimulus; BMP signaling pathway; smooth muscle development; extracellular matrix disassembly; regulation of transforming growth factor beta receptor signaling pathway; central nervous system vasculogenesis; venous blood vessel morphogenesis; regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; negative regulation of protein amino acid autophosphorylation; heart looping; chronological cell aging; vasculogenesis; cell adhesion; negative regulation of cell migration; positive regulation of BMP signaling pathway; regulation of cell adhesion; cell migration; regulation of phosphorylation; negative regulation of nitric-oxide synthase activity; regulation of cell proliferation; patterning of blood vessels; negative regulation of endothelial cell proliferation; response to hypoxia; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway
Reference #:  P17813 (UniProtKB)
Alt. Names/Synonyms: CD105; CD105 antigen; EGLN; END; Endoglin; ENG; FLJ41744; HHT1; ORW; ORW1
Gene Symbols: ENG
Molecular weight: 70,578 Da
Basal Isoelectric point: 6.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ENG

Protein Structure Not Found.


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Sites Implicated In
cell motility, altered: S646‑p
phosphorylation: S634‑p, S635‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 Y612-p LLTAALWyIySHTRS
1 0 Y614-p TAALWyIySHTRSPS
1 1 S634-p VAVAAPAssESSStN
1 1 S635-p AVAAPAssESSStNH
1 0 T640-p AssESSStNHSIGsT
1 0 S646-p StNHSIGsTQstPCS
1 0 S649-p HSIGsTQstPCStSS
2 0 T650-p SIGsTQstPCStSSM
1 0 T654-p TQstPCStSSMA___
  mouse

 
Y607 LLTAALWYIYSHTRG
Y609 TAALWYIYSHTRGPS
S629 VAVAAPASSESSSTN
S630 AVAAPASSESSSTNH
T635 ASSESSSTNHSIGST
S641 STNHSIGSTQSTPCS
S644 HSIGSTQSTPCSTSS
T645 SIGSTQSTPCSTSSM
T649 TQSTPCSTSSMA___
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