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Protein Page:
TICAM2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TICAM2 a toll-like receptor adapter that participates in induction of type 1 interferons. Transiently phosphorylated on serine-16 during LPS/Toll-like receptor 4 (TLR4) signaling. Activated TLR4 associates with four adapter proteins, MyD88, TIRAP, TICAM-1 (Trif), and TICAM-2. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 5q23.1
Cellular Component: Golgi apparatus; early endosome membrane; late endosome membrane; endoplasmic reticulum; late endosome; early endosome; plasma membrane; endosome membrane
Molecular Function: signal transducer activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; innate immune response; toll-like receptor 3 signaling pathway; inflammatory response; toll-like receptor 4 signaling pathway
Reference #:  Q86XR7 (UniProtKB)
Alt. Names/Synonyms: cytoplasmic adaptor; MGC129876; MGC129877; NF-kappa-B-activating protein 502; Putative NF-kappa-B-activating protein 502; TCAM2; TICAM-2; TICAM2; TIR domain-containing adapter molecule 2; TIR-containing adapter molecule-2; TIRAP3; TIRP; toll-like receptor adaptor molecule 2; Toll-like receptor adaptor protein 3; toll/interleukin-1 receptor (TIR) domain-containing adapter protein; Toll/interleukin-1 receptor domain-containing protein; TRAM; TRIF-related adapter molecule; TRIF-related adaptor molecule
Gene Symbols: TICAM2
Molecular weight: 26,916 Da
Basal Isoelectric point: 4.99  Predict pI for various phosphorylation states
CST Pathways:  Toll-Like Receptor Signaling
Select Structure to View Below

TICAM2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 2 - gap
0 2 S14-p KINSCPLsLsWGKRH
1 2 S16-p NSCPLsLsWGKRHsV
0 1 S22-p LsWGKRHsVDTSPGY
0 1 K35 GYHESDSKKSEDLSL
0 1 K36 YHESDSKKSEDLSLC
0 1 Y154 TWCNFQFYTSLMNSV
  TICAM2 iso2  
K46-ub FELPDNAkQCFYEDI
K83-ub RLEDPDGkVLYKEMK
S153 QMESACVSIHEALKS
H155 ESACVSIHEALKSVI
S191 TRVAYWHSVDTSPGY
K204-ac GYHESDSkkSEDLSL
K205-ac YHESDSkkSEDLSLC
Y323 TWCNFQFYTSLMNSV
  mouse

 
- gap
- gap
- gap
S14 KLDKCPLSWHKKDSV
S20 LSWHKKDSVDADQDG
K33 DGHESDSKNSEEACL
N34 GHESDSKNSEEACLR
Y151-p TWCNFQFyTSLMNSV
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