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Protein Page:
TICAM2 (human)

Overview
TICAM2 a toll-like receptor adapter that participates in induction of type 1 interferons. Transiently phosphorylated on serine-16 during LPS/Toll-like receptor 4 (TLR4) signaling. Activated TLR4 associates with four adapter proteins, MyD88, TIRAP, TICAM-1 (Trif), and TICAM-2. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: Golgi apparatus; endoplasmic reticulum; late endosome membrane; early endosome membrane; late endosome; early endosome; plasma membrane; endosome membrane
Molecular Function: signal transducer activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; innate immune response; toll-like receptor 3 signaling pathway; inflammatory response; toll-like receptor 4 signaling pathway
Reference #:  Q86XR7 (UniProtKB)
Alt. Names/Synonyms: cytoplasmic adaptor; MGC129876; MGC129877; NF-kappa-B-activating protein 502; Putative NF-kappa-B-activating protein 502; TCAM2; TICAM-2; TICAM2; TIR domain-containing adapter molecule 2; TIR-containing adapter molecule-2; TIRAP3; TIRP; toll-like receptor adaptor molecule 2; Toll-like receptor adaptor protein 3; toll/interleukin-1 receptor (TIR) domain-containing adapter protein; Toll/interleukin-1 receptor domain-containing protein; TRAM; TRIF-related adapter molecule; TRIF-related adaptor molecule
Gene Symbols: TICAM2
Molecular weight: 26,916 Da
Basal Isoelectric point: 4.99  Predict pI for various phosphorylation states
CST Pathways:  Toll-Like Receptor Signaling
Select Structure to View Below

TICAM2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S14-p KINSCPLsLsWGKRH
1 2 S16-p NSCPLsLsWGKRHSV
  mouse

 
- gap
S14 KLDKCPLSWHKKDSV
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