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TICAM2 (human)

Overview TICAM2 a toll-like receptor adapter that participates in induction of type 1 interferons. Transiently phosphorylated on serine-16 during LPS/Toll-like receptor 4 (TLR4) signaling. Activated TLR4 associates with four adapter proteins, MyD88, TIRAP, TICAM-1 (Trif), and TICAM-2. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold Cellular Component: Golgi apparatus; plasma membrane; endosome membrane Molecular Function: signal transducer activity Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; toll-like receptor 3 signaling pathway; inflammatory response; toll-like receptor 4 signaling pathway; Toll signaling pathway Reference #:  Q86XR7 (UniProtKB) Alt. Names/Synonyms: cytoplasmic adaptor; MGC129876; MGC129877; NF-kappa-B-activating protein 502; Putative NF-kappa-B-activating protein 502; TCAM2; TICAM-2; TICAM2; TIR domain-containing adapter molecule 2; TIR-containing adapter molecule-2; TIRAP3; TIRP; toll-like receptor adaptor molecule 2; Toll-like receptor adaptor protein 3; toll/interleukin-1 receptor (TIR) domain-containing adapter protein; Toll/interleukin-1 receptor domain-containing protein; TRAM; TRIF-related adapter molecule; TRIF-related adaptor molecule Gene Symbols: TICAM2 Molecular weight: 26,916 Da Basal Isoelectric point: 4.99  Predict pI for various phosphorylation states CST Pathways:  Toll-like Receptors Pathway

Select Structure to View Below TICAM2

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S14-p	KINSCPLsLsWGKRH
1	2		S16-p	NSCPLsLsWGKRHSV
0	1		Y154	TWCNFQFYTSLMNSV

	mouse
-	gap
S14	KLDKCPLSWHKKDSV
Y151-p	TWCNFQFyTSLMNSV

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