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STAT3 (mouse)

Overview STAT3 transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Constitutively active in a number of human tumors. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; DNA binding protein; Nuclear receptor co-regulator; Transcription factor Cellular Component: cytoplasm; plasma membrane; nucleus Molecular Function: protein dimerization activity; signal transducer activity; ligand-dependent nuclear receptor activity; protein binding; DNA binding; sequence-specific DNA binding; calcium ion binding; transcription factor binding; protein kinase binding; transcription factor activity; CCR5 chemokine receptor binding; glucocorticoid receptor binding Biological Process: transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; radial glial cell differentiation; thermoregulation; glucose homeostasis; signal transduction; response to estradiol stimulus; regulation of transcription, DNA-dependent; astrocyte differentiation; protein import into nucleus; acute-phase response; positive regulation of Notch signaling pathway; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; eating behavior; cytokine and chemokine mediated signaling pathway; stem cell maintenance; regulation of multicellular organism growth; JAK-STAT cascade; cellular response to hormone stimulus; cell proliferation; sexual reproduction; response to cytokine stimulus; positive regulation of transcription from RNA polymerase II promoter; eye photoreceptor cell differentiation Reference #:  P42227 (UniProtKB) Alt. Names/Synonyms: 1110034C02Rik; acute phase response factor; Acute-phase response factor; Aprf; AW109958; OTTMUSP00000002052; OTTMUSP00000002053; Signal transducer and activator of transcription 3; Stat3 Gene Symbols: Stat3 Molecular weight: 88,054 Da Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states CST Pathways:  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Jak/Stat/IL-6 Signaling  |  MAPK/Erk in Growth and Differentiation  |  Regulation of Microtubule Dynamics  |  SAPK/JNK Signaling Cascades Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below STAT3 1BG1 - A=1-715 (mouse) 3CWG - A/B=127-688 (mouse) 4E68 - A=127-722 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1BG1 3CWG 4E68  |  Phospho3D  |  Source  |  NURSA  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, inhibited: Y705‑p cell cycle regulation: Y705‑p cell growth, altered: Y705‑p, S727‑p transcription, altered: Y705‑p, S727‑p activation: Y705‑p, S727‑p intracellular localization: Y705‑p, S727‑p molecular association, regulation: Y705‑p, S727‑p phosphorylation: S727‑p ubiquitination: Y705‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse ► Hide Isoforms
1	0		R31-m	DSFPMELrQFLAPWI
0	17		Y45-p	IESQDWAyAASkESH
3	0		K49-a	DWAyAASkESHATLV
0	1		K49-u	DWAyAASkESHATLV
0	10		Y79	LQESNVLYQHNLRRI
4	0		K87-a	QHNLRRIkQFLQSRY
0	2		K87-u	QHNLRRIkQFLQSRY
0	1		K97	LQSRYLEKPMEIARI
0	5		K177-u	DDFDFNYkTLkSQGD
0	7		K180-u	DFNYkTLkSQGDMQD
0	4		S181	FNYkTLkSQGDMQDL
0	1		S194	DLNGNNQSVTRQKMQ
0	1		T196	NGNNQSVTRQKMQQL
0	1		K199	NQSVTRQKMQQLEQM
0	3		K244-u	DEELADWkRRQQIAC
0	1		T268	DRLENWITSLAESQL
0	1		S269	RLENWITSLAESQLQ
0	1		S273	WITSLAESQLQTRQQ
0	5		K294-u	LQQKVSYkGDPIVQH
0	1		K318-u	ELFRNLMkSAFVVER
0	1		K363-u	PELNYQLkIKVCIDK
0	1		S429	GRANCDASLIVTEEL
0	1		T440	TEELHLITFETEVYH
0	1		Y446	ITFETEVYHQGLKID
0	138		Y539-p	LLGPGVNySGCQITW
0	9		S540	LGPGVNySGCQITWA
0	1		K574	NIIDLVKKYILALWN
0	1		T605	LSTKPPGTFLLRFSE
0	3		K626-u	VTFTWVEkDISGkTQ
0	2		K631-u	VEkDISGkTQIQSVE
0	2		Y674	VSPLVYLYPDIPkEE
1	0		K679-a	YLYPDIPkEEAFGkY
8	0		K685-a	PkEEAFGkYCRPESQ
0	12		Y686	kEEAFGkYCRPESQE
0	4		S691	GkYCRPESQEHPEAD
0	61		S701	HPEADPGSAAPyLkt
247	3051		Y705-p	DPGSAAPyLktkFIC
1	0		K707-a	GSAAPyLktkFICVt
0	1		K707-u	GSAAPyLktkFICVt
0	161		T708-p	SAAPyLktkFICVtP
1	0		K709-a	AAPyLktkFICVtPT
0	15		T714-p	ktkFICVtPTTCSNt
0	1		T717	FICVtPTTCSNtIDL
0	3		S719	CVtPTTCSNtIDLPM
0	2		T721-p	tPTTCSNtIDLPMsP
120	82		S727-p	NtIDLPMsPRTLDSL

	STAT3 iso2
R31	DSFPMELRQFLAPWI
Y45	IESQDWAYAASKESH
K49	DWAYAASKESHATLV
K49	DWAYAASKESHATLV
Y79	LQESNVLYQHNLRRI
K87	QHNLRRIKQFLQSRY
K87	QHNLRRIKQFLQSRY
K97	LQSRYLEKPMEIARI
K177	DDFDFNYKTLKSQGD
K180	DFNYKTLKSQGDMQD
S181	FNYKTLKSQGDMQDL
S194	DLNGNNQSVTRQKMQ
T196	NGNNQSVTRQKMQQL
K199	NQSVTRQKMQQLEQM
K244	DEELADWKRRQQIAC
T268	DRLENWITSLAESQL
S269	RLENWITSLAESQLQ
S273	WITSLAESQLQTRQQ
K294	LQQKVSYKGDPIVQH
K318	ELFRNLMKSAFVVER
K363	PELNYQLKIKVCIDK
S429	GRANCDASLIVTEEL
T440	TEELHLITFETEVYH
Y446	ITFETEVYHQGLKID
Y539	LLGPGVNYSGCQITW
S540	LGPGVNYSGCQITWA
K574	NIIDLVKKYILALWN
T605	LSTKPPGTFLLRFSE
K626	VTFTWVEKDISGKTQ
K631	VEKDISGKTQIQSVE
Y674	VSPLVYLYPDIPKEE
K679	YLYPDIPKEEAFGKY
K685	PKEEAFGKYCRPESQ
Y686	KEEAFGKYCRPESQE
S691	GKYCRPESQEHPEAD
S701	HPEADPGSAAPyLKT
Y705-p	DPGSAAPyLKTKFIC
K707	GSAAPyLKTKFICVT
K707	GSAAPyLKTKFICVT
T708	SAAPyLKTKFICVTP
K709	AAPyLKTKFICVTPF
T714	KTKFICVTPFIDAVW
-	gap
-	gap
-	gap
-	gap

	STAT3 iso3
R31	DSFPMELRQFLAPWI
Y45	IESQDWAYAASKESH
K49	DWAYAASKESHATLV
K49	DWAYAASKESHATLV
Y79	LQESNVLYQHNLRRI
K87	QHNLRRIKQFLQSRY
K87	QHNLRRIKQFLQSRY
K97	LQSRYLEKPMEIARI
K177	DDFDFNYKTLKSQGD
K180	DFNYKTLKSQGDMQD
S181	FNYKTLKSQGDMQDL
S194	DLNGNNQSVTRQKMQ
T196	NGNNQSVTRQKMQQL
K199	NQSVTRQKMQQLEQM
K244	DEELADWKRRQQIAC
T268	DRLENWITSLAESQL
S269	RLENWITSLAESQLQ
S273	WITSLAESQLQTRQQ
K294	LQQKVSYKGDPIVQH
K318	ELFRNLMKSAFVVER
K363	PELNYQLKIKVCIDK
S429	GRANCDASLIVTEEL
T440	TEELHLITFETEVYH
Y446	ITFETEVYHQGLKID
Y539	LLGPGVNYSGCQITW
S540	LGPGVNYSGCQITWA
K574	NIIDLVKKYILALWN
T605	LSTKPPGTFLLRFSE
K626	VTFTWVEKDISGKTQ
K631	VEKDISGKTQIQSVE
Y674	VSPLVYLYPDIPKEE
K679	YLYPDIPKEEAFGKY
K685	PKEEAFGKYCRPESQ
Y686	KEEAFGKYCRPESQE
S691	GKYCRPESQEHPEAD
-	gap
Y704-p	ADPGAAPyLKTKFIC
K706	PGAAPyLKTKFICVt
K706	PGAAPyLKTKFICVt
T707	GAAPyLKTKFICVtP
K708	AAPyLKTKFICVtPT
T713-p	KTKFICVtPTTCSNt
T716	FICVtPTTCSNtIDL
S718	CVtPTTCSNtIDLPM
T720-p	tPTTCSNtIDLPMsP
S726-p	NtIDLPMsPRTLDSL

	human ► Hide Isoforms
R31	DSFPMELRQFLAPWI
Y45-p	IESQDWAyAASkESH
K49-a	DWAyAASkESHATLV
K49	DWAyAASKESHATLV
Y79-p	LQESNVLyQHNLRRI
K87-a	QHNLRRIkQFLQSRY
K87-u	QHNLRRIkQFLQSRY
K97-u	LQSRYLEkPMEIARI
K177-u	DDFDFNYkTLksQGD
K180-u	DFNYkTLksQGDMQD
S181-p	FNYkTLksQGDMQDL
S194-p	DLNGNNQsVtRQkMQ
T196-p	NGNNQsVtRQkMQQL
K199-u	NQsVtRQkMQQLEQM
K244-u	DEELADWkRRQQIAC
T268	DRLENWITSLAESQL
S269	RLENWITSLAESQLQ
S273	WITSLAESQLQTRQQ
K294-u	LQQKVSYkGDPIVQH
K318	ELFRNLMKSAFVVER
K363	PELNYQLKIKVCIDK
S429-p	GRANCDAsLIVTEEL
T440-p	TEELHLItFETEVyH
Y446-p	ItFETEVyHQGLKID
Y539-p	LLGPGVNysGCQITW
S540-p	LGPGVNysGCQITWA
K574-u	NIIDLVKkYILALWN
T605-p	LSTKPPGtFLLRFSE
K626-u	VTFTWVEkDISGkTQ
K631-u	VEkDISGkTQIQSVE
Y674-p	VSPLVYLyPDIPkEE
K679-a	YLyPDIPkEEAFGky
K685-a	PkEEAFGkyCRPEsQ
Y686-p	kEEAFGkyCRPEsQE
S691-p	GkyCRPEsQEHPEAD
S701-p	HPEADPGsAAPyLkt
Y705-p	DPGsAAPyLktKFIC
K707-a	GsAAPyLktKFICVt
K707	GsAAPyLKtKFICVt
T708-p	sAAPyLktKFICVtP
K709	AAPyLktKFICVtPT
T714-p	ktKFICVtPTTCsNt
T717	FICVtPTTCsNtIDL
S719-p	CVtPTTCsNtIDLPM
T721-p	tPTTCsNtIDLPMsP
S727-p	NtIDLPMsPRTLDSL

	STAT3 iso2
R31	DSFPMELRQFLAPWI
Y45	IESQDWAYAASKESH
K49	DWAYAASKESHATLV
K49	DWAYAASKESHATLV
Y79	LQESNVLYQHNLRRI
K87	QHNLRRIKQFLQSRY
K87	QHNLRRIKQFLQSRY
K97	LQSRYLEKPMEIARI
K177	DDFDFNYKTLKSQGD
K180	DFNYKTLKSQGDMQD
S181	FNYKTLKSQGDMQDL
S194	DLNGNNQSVTRQKMQ
T196	NGNNQSVTRQKMQQL
K199	NQSVTRQKMQQLEQM
K244	DEELADWKRRQQIAC
T268	DRLENWITSLAESQL
S269	RLENWITSLAESQLQ
S273	WITSLAESQLQTRQQ
K294	LQQKVSYKGDPIVQH
K318	ELFRNLMKSAFVVER
K363	PELNYQLKIKVCIDK
S429	GRANCDASLIVTEEL
T440	TEELHLITFETEVYH
Y446	ITFETEVYHQGLKID
Y539-p	LLGPGVNySGCQITW
S540	LGPGVNySGCQITWA
K574	NIIDLVKKYILALWN
T605	LSTKPPGTFLLRFSE
K626	VTFTWVEKDISGKTQ
K631	VEKDISGKTQIQSVE
Y674	VSPLVYLYPDIPKEE
K679	YLYPDIPKEEAFGKY
K685	PKEEAFGKYCRPESQ
Y686	KEEAFGKYCRPESQE
S691	GKYCRPESQEHPEAD
-	gap
Y704-p	ADPGAAPyLKtKFIC
K706	PGAAPyLKtKFICVT
K706	PGAAPyLKtKFICVT
T707-p	GAAPyLKtKFICVTP
K708	AAPyLKtKFICVTPT
T713	KtKFICVTPTTCSNT
T716	FICVTPTTCSNTIDL
S718	CVTPTTCSNTIDLPM
T720	TPTTCSNTIDLPMSP
S726	NTIDLPMSPRTLDSL

	STAT3 iso3
R31	DSFPMELRQFLAPWI
Y45	IESQDWAYAASKESH
K49	DWAYAASKESHATLV
K49	DWAYAASKESHATLV
Y79	LQESNVLYQHNLRRI
K87	QHNLRRIKQFLQSRY
K87	QHNLRRIKQFLQSRY
K97	LQSRYLEKPMEIARI
K177	DDFDFNYKTLKSQGD
K180	DFNYKTLKSQGDMQD
S181	FNYKTLKSQGDMQDL
S194	DLNGNNQSVTRQKMQ
T196	NGNNQSVTRQKMQQL
K199	NQSVTRQKMQQLEQM
K244	DEELADWKRRQQIAC
T268	DRLENWITSLAESQL
S269	RLENWITSLAESQLQ
S273	WITSLAESQLQTRQQ
K294	LQQKVSYKGDPIVQH
K318	ELFRNLMKSAFVVER
K363	PELNYQLKIKVCIDK
S429	GRANCDASLIVTEEL
T440	TEELHLITFETEVYH
Y446	ITFETEVYHQGLKID
Y539-p	LLGPGVNySGCQITW
S540	LGPGVNySGCQITWA
K574	NIIDLVKKYILALWN
T605	LSTKPPGTFLLRFSE
K626	VTFTWVEKDISGKTQ
K631	VEKDISGKTQIQSVE
Y674	VSPLVYLYPDIPKEE
K679	YLYPDIPKEEAFGKY
K685	PKEEAFGKYCRPESQ
Y686	KEEAFGKYCRPESQE
S691	GKYCRPESQEHPEAD
S701-p	HPEADPGsAAPyLKt
Y705-p	DPGsAAPyLKtKFIC
K707	GsAAPyLKtKFICVT
K707	GsAAPyLKtKFICVT
T708-p	sAAPyLKtKFICVTP
K709	AAPyLKtKFICVTPF
T714	KtKFICVTPFIDAVW
-	gap
-	gap
-	gap
-	gap

	rat
R31	DSFPMELRQFLAPWI
Y45	IESQDWAYAASKESH
K49	DWAYAASKESHATLV
K49	DWAYAASKESHATLV
Y79	LQESNVLYQHNLRRI
K87	QHNLRRIKQFLQSRY
K87	QHNLRRIKQFLQSRY
K97	LQSRYLEKPMEIARI
K177	DDFDFNYKTLKSQGD
K180	DFNYKTLKSQGDMQD
S181	FNYKTLKSQGDMQDL
S194	DLNGNNQSVTRQKMQ
T196	NGNNQSVTRQKMQQL
K199	NQSVTRQKMQQLEQM
K244	DEELADWKRRQQIAC
T268-p	DRLENWItsLAEsQL
S269-p	RLENWItsLAEsQLQ
S273-p	WItsLAEsQLQTRQQ
K294	LQQKVSYKGDPIVQH
K318	DLFRNLMKSAFVVER
K363	PELNYQLKIKVCIDK
S429	GRANCDASLIVTEEL
T440	TEELHLITFETEVYH
Y446	ITFETEVYHQGLKID
Y539	LLGPGVNYSGCQITW
S540	LGPGVNYSGCQITWA
K574	NIIDLVKKYILALWN
T605	LSTKPPGTFLLRFSE
K626	VTFTWVEKDISGKTQ
K631	VEKDISGKTQIQSVE
Y674	VSPLVYLYPDIPKEE
K679	YLYPDIPKEEAFGKY
K685	PKEEAFGKYCRPESQ
Y686	KEEAFGKYCRPESQE
S691	GKYCRPESQEHPEAD
S701	HPEADPGSAAPyLKT
Y705-p	DPGSAAPyLKTKFIC
K707	GSAAPyLKTKFICVt
K707	GSAAPyLKTKFICVt
T708	SAAPyLKTKFICVtP
K709	AAPyLKTKFICVtPT
T714-p	KTKFICVtPTtCSNT
T717-p	FICVtPTtCSNTIDL
S719	CVtPTtCSNTIDLPM
T721	tPTtCSNTIDLPMsP
S727-p	NTIDLPMsPRTLDSL

	cow
R31	DSFPMELRQLLAPWI
Y45	IESQDWAYAASKESH
K49	DWAYAASKESHATLV
K49	DWAYAASKESHATLV
Y79	LQESNVLYQHNLRRI
K87	QHNLRRIKQFLQSRY
K87	QHNLRRIKQFLQSRY
K97	LQSRYLEKPMEIARI
K177	DDFDFNYKTLKSQGD
K180	DFNYKTLKSQGDMQD
S181	FNYKTLKSQGDMQDL
S194	DLNGNNQSVTRQKMQ
T196	NGNNQSVTRQKMQQL
K199	NQSVTRQKMQQLEQM
K244	DEELADWKRRQQIAC
T268	DRLENWITSLAESQL
S269	RLENWITSLAESQLQ
S273	WITSLAESQLQTRQQ
K294	LQQKVSYKGDPIVQH
K318	ELFRNLMKSAFVVER
K363	PELNYQLKIKVCIDK
S429	GRANCDASLIVTEEL
T440	TEELHLITFETEVYH
Y446	ITFETEVYHQGLKID
Y539	LLGPGVNYSGCQITW
S540	LGPGVNYSGCQITWA
K574	NIIDLVKKYILALWN
T605	LSTKPPGTCLLRFSE
K626	VTFTWVEKDISGKTQ
K631	VEKDISGKTQIQSVE
Y674	VSPLVYLYPDIPKED
K679	YLYPDIPKEDAFGKY
K685	PKEDAFGKYCRPESQ
Y686	KEDAFGKYCRPESQE
S691	GKYCRPESQEHPEAD
S701	HPEADPGSAAPyLKT
Y705-p	DPGSAAPyLKTKFIC
K707	GSAAPyLKTKFICVT
K707	GSAAPyLKTKFICVT
T708	SAAPyLKTKFICVTP
K709	AAPyLKTKFICVTPT
T714	KTKFICVTPTTCSNT
T717	FICVTPTTCSNTIDL
S719	CVTPTTCSNTIDLPM
T721	TPTTCSNTIDLPMsP
S727-p	NTIDLPMsPRTLDSL

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