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Casp7 iso2 (fruit fly)

Overview Casp7 iso2 Involved in the activation cascade of caspases responsible for apoptosis execution (By similarity). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Loss of zygotic DCP-1 function causes larval lethality and melanotic tumors. Protein type: Endoplasmic reticulum; Protease; EC 3.4.22.60; EC 3.4.22.-; Mitochondrial; Apoptosis Molecular Function: cysteine-type endopeptidase activity Biological Process: apoptosis; multicellular organismal development; salivary gland cell autophagic cell death; programmed cell death; actin filament organization; ovarian nurse cell to oocyte transport; nurse cell apoptosis; proteolysis; cleavage of lamin; cytoplasmic transport, nurse cell to oocyte; embryonic development; autophagic cell death; actin cytoskeleton organization and biogenesis; neuron remodeling Reference #:  O02002 (UniProtKB) Alt. Names/Synonyms: Caspase-1; Caspase-1 subunit p13; Caspase-1 subunit p22; CG5370; Dcp-1; Dcp1 Gene Symbols: Dcp-1 Molecular weight: 35,927 Da Basal Isoelectric point: 7.63  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Casp7 iso2 3SIP - A/C=78-230 D/B=231-339 (fruit fly) 3SIR - A/D/C/B=78-332 (fruit fly) 1F1J - A/B=2-303 (human) 1GQF - A/B=47-303 (human) 1I4O - A/B=24-303 (human) 1I51 - A/C=51-198, B/D=199-303 (human) 1K86 - A/B=51-303 (human) 1K88 - A/B=51-303 (human) 1KMC - A/B=1-303 (human) 1MIA - A=57-193, B=211-303 (human) 1SHJ - A/B=50-303 (human) 1SHL - A/B=57-303 (human) 2QL5 - A/C=24-196, B/D=207-303 (human) 2QL7 - A/C=24-196, B/D=207-303 (human) 2QL9 - A/C=24-196, B/D=207-303 (human) 2QLB - A/C=24-196, B/D=207-303 (human) 2QLF - A/C=24-196, B/D=207-303 (human) 2QLJ - A/C=24-196, B/D=207-303 (human) 3EDR - A/C=24-196 D/B=207-303 (human) 3H1P - A/B=50-303 (human) 3IBC - A/C=24-196 D/B=207-303 (human) 3IBF - A/C=24-196 D/B=207-303 (human) 3R5K - A/B=1-303 (human) 4FDL - A/B=2-303 (human) 4FEA - A/B=57-303 (human) 4JR1 - A/B=57-303 (human) 4JR2 - A/B=57-303 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			fruit fly ► Hide Isoforms
0	4		-	gap
0	1		-	gap
0	2		-	gap
0	1		-	gap
1	1		-	gap
0	2		-	gap
0	5		-	gap
0	6		-	gap
0	1		V106	FNHEHFEVPTLKSRA
1	0		S198	FTANHCPSLAGKPKL
1	0		S265	WRNTTRGSWFMQSLC

	Casp7 iso2
-	gap
-	gap
S25	NGSENRGSFIMADNT
-	gap
-	gap
-	gap
-	gap
-	gap
-	under review
S183	FTATFCPSLAGKPKL
S250	WRNINNGSWYMQSLI

	human
S16	EEQGVEDSANEDSVD
A17	EQGVEDSANEDSVDA
N18	QGVEDSANEDSVDAK
S29-p	VDAKPDRssFVPSLF
S30-p	DAKPDRssFVPSLFs
S37-p	sFVPSLFsKKKKNVt
T44-p	sKKKKNVtMRsIKTT
S47-p	KKNVtMRsIKTTRDR
K80	INNKNFDKVTGMGVR
T173-p	FRGDRCKtLLEKPKL
S239-p	WRSPGRGsWFVQALC

	mouse
S16-p	AELEKVDsssEDGVD
S17-p	ELEKVDsssEDGVDA
S18-p	LEKVDsssEDGVDAK
S29	VDAKPDRSSIISSIL
S30	DAKPDRSSIISSILL
L37	SIISSILLKKKRNAS
S44	LKKKRNASAGPVRTG
P47	KRNASAGPVRTGRDR
K80-u	INNKNFDkATGMDVR
T173	FRGDRCKTLLEKPKL
S239	WRNPGKGSWFVQALC

	rat
S16	AELEMADSSTEDGVD
S17	ELEMADSSTEDGVDA
T18	LEMADSSTEDGVDAK
S29	VDAKPDRSTIISSLL
T30	DAKPDRSTIISSLLW
W37	TIISSLLWKKKKNAS
S44	WKKKKNASMCPVSTT
-	gap
K80	INNKNFDKATGMDVR
T173	FRGDRCKTLLEKPKL
S239	WRNPGKGSWFVQALC

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