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Protein Page:
STAT6 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STAT6 transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. May function in the differentiation of T helper 2 cells and class switch of immunoglobulins. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: cytoplasm; nuclear chromatin; nucleus; lipid raft
Molecular Function: identical protein binding; signal transducer activity; DNA binding; sequence-specific DNA binding; transcription factor activity; protein phosphatase binding
Biological Process: T-helper 1 cell lineage commitment; regulation of transcription, DNA-dependent; transcription, DNA-dependent; negative regulation of T-helper 2 type immune response; cytokine and chemokine mediated signaling pathway; response to cytokine stimulus; mammary gland epithelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; signal transduction; positive regulation of isotype switching to IgE isotypes; regulation of cell proliferation
Reference #:  P52633 (UniProtKB)
Alt. Names/Synonyms: signal transducer and activator of transcription 6; Signal transducer and transcription activator 6; Stat6
Gene Symbols: Stat6
Molecular weight: 93,497 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STAT6

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: Y641‑p
protein degradation: Y641‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 S2 ______MSLWGLISK
0 2 S8 MSLWGLISKMSPEKL
1 0 R27-me VDFPQRLrHLLADWL
0 1 K94-ub IYQRDPLkLVATIRQ
0 1 K129-ac HRKQEELkFTTALGR
0 1 K277-ub TSSFLVEkQPPQVLK
1 0 S407 LIQLQALSLPLVVIV
0 1 T525 FDGVLDLTKRCLRSY
0 2 K595-ub NIQPFSAkDLSIRSL
0 1 K619-ac LKNLYPKkPkDEAFR
0 1 K621-ac NLYPKkPkDEAFRSH
15 81 Y641-p MGKDGRGyVSTTIKM
0 2 T645 GRGyVSTTIKMTVER
1 0 - gap
1 0 S747 SQEHAVSSPEPMLCS
  human

 
S2-p ______MsLWGLVsK
S8-p MsLWGLVsKMPPEKV
R27 VDFPQHLRHLLGDWL
K94 IYQRDPLKLVATFRQ
K129 HWKQEELKFKTGLRR
K277 TSCFLVEKQPPQVLK
S407-p PIQLQALsLPLVVIV
T525-p FDGVLDLtKRCLRSY
K595-ub NIQPFSAkDLSIRSL
K619 LKNLYPKKPKDEAFR
K621 NLYPKKPKDEAFRSH
Y641-p MGKDGRGyVPAtIKM
T645-p GRGyVPAtIKMTVER
S707-p IPPYQGLsPEESVNV
S756-p PQEHAVSsPDPLLCS
9361 : Phospho-Stat6 (Tyr641) Antibody
9364 : Phospho-Stat6 (Tyr641) (C11A12) Rabbit mAb
  rat

 
S2 ______MSLWSLVSK
S8 MSLWSLVSKMSPEKL
R27 VDFPQHLRHLLAEWL
K94 IYQRDPLKLVATIRQ
K129 HRKQEELKFTTALGR
K277 TSSFLVEKQPPQVLK
S407 LIQLQALSLPLVVIV
T525 FDGVLDLTKRCLRSY
K595 NIQPFSAKDLSIRSL
K619 LKNLYPKKPKDEAFR
K621 NLYPKKPKDEAFRSH
Y641-p MGKDGRGyVSTTIKM
T645 GRGyVSTTIKMTVER
P702 IHSFQSIPLEESMSV
S751 SQEHAVSSPEPLLCS
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