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STAT6 (mouse)

Overview STAT6 transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. May function in the differentiation of T helper 2 cells and class switch of immunoglobulins. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein Cellular Component: cytoplasm; nuclear chromatin; nucleus Molecular Function: identical protein binding; signal transducer activity; DNA binding; sequence-specific DNA binding; calcium ion binding; transcription factor activity Biological Process: T-helper 1 cell lineage commitment; negative regulation of T-helper 2 type immune response; regulation of transcription, DNA-dependent; transcription, DNA-dependent; response to cytokine stimulus; cytokine and chemokine mediated signaling pathway; mammary gland epithelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; signal transduction; positive regulation of isotype switching to IgE isotypes; regulation of cell proliferation Reference #:  P52633 (UniProtKB) Alt. Names/Synonyms: signal transducer and activator of transcription 6; Signal transducer and transcription activator 6; Stat6 Gene Symbols: Stat6 Molecular weight: 93,497 Da Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below STAT6 1OJ5 - B=795-808 (human)

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	Sites Implicated In
intracellular localization: Y641‑p protein degradation: Y641‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	1		S8	MSLWGLISKMSPEKL
1	0		R27-m	VDFPQRLrHLLADWL
0	1		K94-u	IYQRDPLkLVATIRQ
0	1		K129-a	HRKQEELkFTTALGR
0	1		K277-u	TSSFLVEkQPPQVLK
1	0		S407	LIQLQALSLPLVVIV
0	1		T525	FDGVLDLTKRCLRSY
0	2		K595-u	NIQPFSAkDLSIRSL
0	1		K619-a	LKNLYPKkPkDEAFR
0	1		K621-a	NLYPKkPkDEAFRSH
15	69		Y641-p	MGKDGRGyVSTTIKM
0	2		T645	GRGyVSTTIKMTVER
1	0		-	gap
1	0		S747	SQEHAVSSPEPMLCS

	human
S8-p	MSLWGLVsKMPPEKV
R27	VDFPQHLRHLLGDWL
K94	IYQRDPLKLVATFRQ
K129	HWKQEELKFKTGLRR
K277	TSCFLVEKQPPQVLK
S407-p	PIQLQALsLPLVVIV
T525-p	FDGVLDLtKRCLRSY
K595-u	NIQPFSAkDLSIRSL
K619	LKNLYPKKPKDEAFR
K621	NLYPKKPKDEAFRSH
Y641-p	MGKDGRGyVPAtIKM
T645-p	GRGyVPAtIKMTVER
S707-p	IPPYQGLsPEESVNV
S756-p	PQEHAVSsPDPLLCS

	rat
S8	MSLWSLVSKMSPEKL
R27	VDFPQHLRHLLAEWL
K94	IYQRDPLKLVATIRQ
K129	HRKQEELKFTTALGR
K277	TSSFLVEKQPPQVLK
S407	LIQLQALSLPLVVIV
T525	FDGVLDLTKRCLRSY
K595	NIQPFSAKDLSIRSL
K619	LKNLYPKKPKDEAFR
K621	NLYPKKPKDEAFRSH
Y641-p	MGKDGRGyVSTTIKM
T645	GRGyVSTTIKMTVER
P702	IHSFQSIPLEESMSV
S751	SQEHAVSSPEPLLCS

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