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Protein Page:
MYL3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MYL3 Regulatory light chain of myosin. Does not bind calcium. Defects in MYL3 are the cause of familial hypertrophic cardiomyopathy type 8 (CMH8). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor protein
Cellular Component: I band; sarcomere; muscle myosin complex; cytosol; A band
Molecular Function: actin monomer binding; structural constituent of muscle; motor activity; myosin II heavy chain binding; calcium ion binding
Biological Process: skeletal muscle development; positive regulation of ATPase activity; metabolic process; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; regulation of the force of heart contraction; cardiac muscle contraction; muscle filament sliding
Reference #:  P08590 (UniProtKB)
Alt. Names/Synonyms: Cardiac myosin light chain 1; CMH8; CMLC1; MLC1SB; MLC1V; MYL3; Myosin light chain 1, slow-twitch muscle B/ventricular isoform; Myosin light chain 3; myosin, light chain 3, alkali; myosin, light polypeptide 3, alkali; ventricular, skeletal, slow; Ventricular/slow twitch myosin alkali light chain; VLC1
Gene Symbols: MYL3
Molecular weight: 21,932 Da
Basal Isoelectric point: 5.03  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Select Structure to View Below

MYL3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K18 DDAKAAPKAAPAPAP
0 2 K33 PPEPERPKEVEFDAS
0 2 K41 EVEFDASKIKIEFTP
0 2 K43 EFDASKIKIEFTPEQ
0 2 K66 MLFDRTPKCEMKITy
0 131 Y73-p KCEMKITyGQCGDVL
1 0 T88 RALGQNPTQAEVLRV
0 1 K98 EVLRVLGKPRQEELN
0 1 R100 LRVLGKPRQEELNTK
0 2 R100 LRVLGKPRQEELNTK
0 1 K123-ac PMLQHISkNkDTGty
0 1 K123 PMLQHISKNkDTGty
0 11 K125-ac LQHISkNkDTGtyED
0 1 K125 LQHISkNKDTGtyED
0 1 T127 HISkNkDTGtyEDFV
0 1 T129-p SkNkDTGtyEDFVEG
0 57 Y130-p kNkDTGtyEDFVEGL
0 2 K142-ub EGLRVFDkEGNGTVM
1 0 T159 ELRHVLATLGERLTE
0 2 K171 LTEDEVEKLMAGQED
0 3 S179-p LMAGQEDsNGCINyE
0 4 Y185-p DsNGCINyEAFVKHI
0 1 K190 INyEAFVKHIMSS__
  mouse

 
K19-ub DAKAAAPkAAPAPAA
K42-ub APEPERPkEAEFDAS
K50-ub EAEFDASkIkIEFTP
K52-ub EFDASkIkIEFTPEQ
K75-ub LLFDRTPkGEMKITy
Y82-p kGEMKITyGQCGDVL
T97 RALGQNPTQAEVLRV
K107-ub EVLRVLGkPkQEELN
K109-ac LRVLGkPkQEELNSK
K109-ub LRVLGkPkQEELNSK
K132 PMLQHISKNkDtGTy
K132-ub PMLQHISkNkDtGTy
K134 LQHISkNKDtGTyED
K134-ub LQHISkNkDtGTyED
T136-p HISkNkDtGTyEDFV
T138 SkNkDtGTyEDFVEG
Y139-p kNkDtGTyEDFVEGL
K151-ub EGLRVFDkEGNGTVM
T168 ELRHVLATLGERLTE
K180-ub LTEDEVEkLMAGQED
S188-p LMAGQEDsNGCINYE
Y194 DsNGCINYEAFVkHI
K199-ub INYEAFVkHIMAS__
  rat

 
K19 DAKTAAPKAAPAPAA
K38 APEPERPKEAEFDAS
K46 EAEFDASKIKIEFTP
K48 EFDASKIKIEFTPEQ
K71 QLFDRTPKGEMKITy
Y78-p KGEMKITyGQCGDVL
T93-gl RALGQNPtQAEVLRV
K103 EVLRVLGKPKQEELN
K105 LRVLGKPKQEELNSK
K105 LRVLGKPKQEELNSK
K128 PMLQHISKNKDTGTy
K128 PMLQHISKNKDTGTy
K130 LQHISKNKDTGTyED
K130 LQHISKNKDTGTyED
T132 HISKNKDTGTyEDFV
T134 SKNKDTGTyEDFVEG
Y135-p KNKDTGTyEDFVEGL
K147 EGLRVFDKEGNGTVM
T164-gl ELRHVLAtLGERLTE
K176 LTEDEVEKLMAGQED
S184 LMAGQEDSNGCINYE
Y190 DSNGCINYEAFVKHI
K195 INYEAFVKHIMAS__
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