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Protein Page:
MYH7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MYH7 Muscle contraction. Defects in MYH7 are the cause of familial hypertrophic cardiomyopathy type 1 (CMH1). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Defects in MYH7 are the cause of myopathy myosin storage (MYOMS). In this disorder, muscle biopsy shows type 1 fiber predominance and increased interstitial fat and connective tissue. Inclusion bodies consisting of the beta cardiac myosin heavy chain are present in the majority of type 1 fibers, but not in type 2 fibers. Defects in MYH7 are the cause of scapuloperoneal myopathy MYH7-related (SPMM); also known as scapuloperoneal syndrome myopathic type. SPMM is a progressive muscular atrophia beginning in the lower legs and affecting the shoulder region earlier and more severely than distal arm. Defects in MYH7 are a cause of cardiomyopathy dilated type 1S (CMD1S). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in MYH7 are the cause of myopathy distal type 1 (MPD1). MPD1 is a muscular disorder characterized by early-onset selective weakness of the great toe and ankle dorsiflexors, followed by weakness of the finger extensors. Mild proximal weakness occasionally develops years later after the onset of the disease. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor protein
Cellular Component: sarcomere; focal adhesion; cytoplasm; nucleolus; stress fiber; muscle myosin complex; Z disc; myosin complex; nucleus
Molecular Function: calmodulin binding; microfilament motor activity; protein binding; ATPase activity; actin-dependent ATPase activity; actin binding; ATP binding
Biological Process: ATP catabolic process; adult heart development; striated muscle contraction; muscle contraction; regulation of heart rate; ventricular cardiac muscle morphogenesis; regulation of the force of heart contraction; muscle filament sliding
Reference #:  P12883 (UniProtKB)
Alt. Names/Synonyms: beta-myosin heavy chain; CMD1S; CMH1; DKFZp451F047; MGC138376; MGC138378; MPD1; MYH7; MyHC-beta; MyHC-slow; MYHCB; myopathy, distal 1; myosin heavy chain (AA 1-96); Myosin heavy chain 7; Myosin heavy chain slow isoform; Myosin heavy chain, cardiac muscle beta isoform; myosin, heavy chain 7, cardiac muscle, beta; myosin, heavy polypeptide 7, cardiac muscle, beta; Myosin-7; rhabdomyosarcoma antigen MU-RMS-40.7A; SPMD; SPMM
Gene Symbols: MYH7
Molecular weight: 223,097 Da
Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states
Select Structure to View Below

MYH7

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S4-p ____MGDsEMAVFGA
0 1 Y15-p VFGAAAPyLRKSEKE
0 56 K34-ac QTRPFDLkkDVFVPD
0 1 K34 QTRPFDLKkDVFVPD
0 2 K35-ac TRPFDLkkDVFVPDD
0 1 K43 DVFVPDDKQEFVKAK
0 2 K58 IVSREGGKVtAEtEy
0 1 T60-p SREGGKVtAEtEyGK
0 1 T63-p GGKVtAEtEyGKTVt
0 9 Y65-p KVtAEtEyGKTVtVK
0 1 K67 tAEtEyGKTVtVKED
0 1 T70-p tEyGKTVtVKEDQVM
0 1 K72 yGKTVtVKEDQVMQQ
0 31 Y103-p LHEPAVLyNLKDRYG
0 1 K129-ac CVTVNPYkWLPVYTP
0 1 K207 AIGDRSKKDQsPGKG
0 1 S210-p DRSKKDQsPGKGtLE
0 1 K213 KKDQsPGKGtLEDQI
0 2 T215-p DQsPGKGtLEDQIIQ
0 1 K246 DNSSRFGKFIRIHFG
0 1 K257 IHFGATGKLASADIE
0 1 Y266-p ASADIETyLLEKSRV
0 2 K270 IETyLLEKSRVIFQL
0 2 K278 SRVIFQLKAERDYHI
0 6 K363-ac IMHFGNMkFKLKQRE
0 4 T378-p EQAEPDGtEEADKSA
0 14 Y386-p EEADKSAyLMGLNSA
0 2 K405 GLCHPRVKVGNEyVt
0 203 Y410-p RVKVGNEyVtkGQNV
0 10 T412-p KVGNEyVtkGQNVQQ
0 1 K413-ac VGNEyVtkGQNVQQV
0 78 Y422-p QNVQQVIyATGALAK
0 2 K450 INATLETKQPRQYFI
0 32 K502-ac VLEQEEYkKEGIEWT
0 35 K549-ac KATDMTFkAKLFDNH
0 12 F553 MTFkAKLFDNHLGKS
0 1 K559 LFDNHLGKSANFQKP
0 1 K565 GKSANFQKPRNIKGK
0 1 Y582-p AHFSLIHyAGIVDyN
0 1 Y588-p HyAGIVDyNIIGWLQ
0 2 K598 IGWLQKNKDPLNETV
0 30 Y624-p LSTLFANyAGADAPI
0 1 K640 KGKGKAKKGSSFQTV
0 1 S680-p IIPNETKsPGVMDNP
0 8 Y715-p GFPNRILyGDFRQRY
0 3 S738-p PEGQFIDsRKGAEKL
0 39 Y756-p LDIDHNQykFGHTKV
0 43 K757-ac DIDHNQykFGHTKVF
0 2 K762 QykFGHTKVFFKAGL
0 1 S810 KLLERRDSLLVIQWN
0 2 S851-p EREKEMAsMkEEFTR
0 1 K853-ac EKEMAsMkEEFTRLK
0 1 K853 EKEMAsMKEEFTRLK
0 1 K865-ac RLKEALEksEARRKE
0 2 K865 RLKEALEKsEARRKE
0 1 S866-p LKEALEksEARRKEL
0 1 S879 ELEEKMVSLLQEKND
0 1 K939-ac MNAELTAkKRkLEDE
0 1 K942-ac ELTAkKRkLEDECsE
0 2 S948-p RkLEDECsELkRDID
0 58 K951-ac EDECsELkRDIDDLE
0 4 T1019-p AEEDKVNtLTKAKVK
0 2 K1026 tLTKAKVKLEQQVDD
0 3 S1037-p QVDDLEGsLEQEkkV
0 54 K1042-ac EGsLEQEkkVRMDLE
0 16 K1043-ac GsLEQEkkVRMDLER
0 1 K1052-ac RMDLERAkRKLEGDL
0 1 K1054 DLERAkRKLEGDLKL
1 0 S1102-gl EDEQALGsQLQkkLK
0 2 S1102-p EDEQALGsQLQkkLK
0 8 K1106-ac ALGsQLQkkLKELQA
0 1 K1106 ALGsQLQKkLKELQA
0 2 K1107-ac LGsQLQkkLKELQAR
0 1 K1109 sQLQkkLKELQARIE
0 4 T1127-p EELEAERtARAKVEK
0 3 S1140-p EKLRSDLsRELEEIS
0 2 S1158-p EEAGGATsVQIEMNk
0 3 K1165-ac sVQIEMNkKREAEFQ
0 4 T1188-p ATLQHEAtAAALRKK
0 1 K1195 tAAALRKKHADsVAE
0 6 S1199-p LRKKHADsVAELGEQ
0 1 K1219 RVKQKLEKEKsEFKL
0 2 S1222-p QKLEKEKsEFKLELD
0 1 K1225 EKEKsEFKLELDDVT
0 2 S1233-p LELDDVTsNMEQIIK
0 2 K1240 sNMEQIIKAKANLEK
0 2 T1266-p HRSKAEEtQRsVNDL
0 2 S1269-p KAEEtQRsVNDLtsQ
0 1 T1274-p QRsVNDLtsQRAKLQ
0 2 S1275-p RsVNDLtsQRAKLQt
0 1 K1279 DLtsQRAKLQtENGE
0 2 T1282-p sQRAKLQtENGELsR
0 1 S1288-p QtENGELsRQLDEKE
0 5 S1299-p DEKEALIsQLTRGkL
1 0 S1299-gl DEKEALIsQLTRGkL
0 4 K1305-ac IsQLTRGkLtytQQL
0 1 K1305 IsQLTRGKLtytQQL
0 2 T1307-p QLTRGkLtytQQLED
0 163 Y1308-p LTRGkLtytQQLEDL
0 7 T1309-p TRGkLtytQQLEDLk
0 59 K1316-ac tQQLEDLkRQLEEEV
0 1 K1324-m3 RQLEEEVkAKNALAH
0 2 K1326 LEEEVkAKNALAHAL
0 77 Y1347-p CDLLREQyEEETEAK
0 2 S1362-p AELQRVLsKANsEVA
0 2 K1363 ELQRVLsKANsEVAQ
0 3 S1366-p RVLsKANsEVAQWRt
0 15 T1373-p sEVAQWRtKyEtDAI
0 2 K1374 EVAQWRtKyEtDAIQ
0 237 Y1375-p VAQWRtKyEtDAIQR
0 5 T1377-p QWRtKyEtDAIQRTE
0 51 K1390-ac TEELEEAkkkLAQRL
0 3 K1390 TEELEEAKkkLAQRL
0 33 K1391-ac EELEEAkkkLAQRLQ
0 1 K1391 EELEEAkKkLAQRLQ
0 2 K1392-ac ELEEAkkkLAQRLQE
0 3 K1410 AVEAVNAKCssLEKT
0 1 S1412-p EAVNAKCssLEKTKH
0 1 S1413-p AVNAKCssLEKTKHR
0 49 K1444-ac AAAAALDkkQRNFDK
0 2 K1444 AAAAALDKkQRNFDK
0 7 K1445-ac AAAALDkkQRNFDKI
0 2 K1457 DKILAEWKQKyEESQ
0 1 K1459 ILAEWKQKyEESQsE
0 89 Y1460-p LAEWKQKyEESQsEL
0 3 S1465-p QKyEESQsELESSQK
0 3 K1472 sELESSQKEARsLsT
0 4 S1476-p SSQKEARsLsTELFK
0 4 S1478-p QKEARsLsTELFKLK
0 2 K1485 sTELFKLKNAyEEsL
0 123 Y1488-p LFKLKNAyEEsLEHL
0 5 S1491-p LKNAyEEsLEHLETF
0 59 K1499-ac LEHLETFkRENKNLQ
0 2 K1499 LEHLETFKRENKNLQ
0 1 K1503 ETFkRENKNLQEEIs
0 2 S1510-p KNLQEEIsDLtEQLG
0 1 T1513-p QEEIsDLtEQLGssG
0 2 S1518-p DLtEQLGssGKtIHE
0 1 S1519-p LtEQLGssGKtIHEL
0 1 T1522-p QLGssGKtIHELEKV
0 1 K1531 HELEKVRKQLEAEKM
0 1 K1537 RKQLEAEKMELQsAL
0 2 S1542-p AEKMELQsALEEAEA
0 1 S1550-p ALEEAEAsLEHEEGK
1 3 K1569 QLEFNQIKAEIERKL
0 48 K1587-ac DEEMEQAkRNHLRVV
0 2 K1587 DEEMEQAKRNHLRVV
0 4 S1596-p NHLRVVDsLQTsLDA
1 0 S1596-gl NHLRVVDsLQTsLDA
0 6 S1600-p VVDsLQTsLDAEtRs
0 1 T1605-p QTsLDAEtRsRNEAL
0 1 S1607-p sLDAEtRsRNEALRV
0 1 K1644 AEAQKQVKSLQSLLK
0 3 K1700 EQTERSRKLAEQELI
0 2 S1710-p EQELIETsERVQLLH
1 0 S1710-gl EQELIETsERVQLLH
0 5 S1718-p ERVQLLHsQNTsLIN
0 4 S1722-p LLHsQNTsLINQkKK
0 44 K1727-ac NTsLINQkKKMDADL
0 2 K1727 NTsLINQKKKMDADL
0 1 S1735-p KKMDADLsQLQtEVE
0 1 T1739-p ADLsQLQtEVEEAVQ
0 1 K1770-ac AMMAEELkKEQDTSA
0 2 K1784-ac AHLERMKkNMEQTIK
0 2 K1791 kNMEQTIKDLQHRLD
0 3 K1806-ac EAEQIALkGGkkQLQ
0 1 K1806 EAEQIALKGGkkQLQ
0 49 K1809-ac QIALkGGkkQLQKLE
0 1 K1809 QIALkGGKkQLQKLE
0 4 K1810-ac IALkGGkkQLQKLEA
0 2 K1814 GGkkQLQKLEARVRE
0 53 K1831-ac NELEAEQkRNAESVK
0 2 K1831 NELEAEQKRNAESVK
0 2 K1838 kRNAESVKGMRKSER
0 1 R1841 AESVKGMRKSERRIk
0 1 K1848-ub RKSERRIkELtyQtE
0 10 T1851-p ERRIkELtyQtEEDR
0 105 Y1852-p RRIkELtyQtEEDRk
0 15 T1854-p IkELtyQtEEDRkNL
0 1 K1859-ac yQtEEDRkNLLRLQD
0 3 K1870 RLQDLVDKLQLKVKA
0 2 K1874 LVDKLQLKVKAYKRQ
0 3 T1891-p EAEEQANtNLSKFRK
0 2 K1895 QANtNLSKFRKVQHE
0 2 K1898 tNLSKFRKVQHELDE
0 4 S1915-p ERADIAEsQVNKLRA
0 3 K1919 IAEsQVNKLRAKSRD
  mouse

 
A4 ____MADAEMAAFGA
F15 AFGAAAPFLRKSEKE
K34 QTRPFDLKKDVFVPD
K34-m1 QTRPFDLkKDVFVPD
K35 TRPFDLkKDVFVPDD
K43-ub DVFVPDDkEEFVKAK
K58-ub IVSREGGkVTAETEN
T60 SREGGkVTAETENGk
T63 GGkVTAETENGkTVT
N65 kVTAETENGkTVTVk
K67-ub TAETENGkTVTVkED
T70 TENGkTVTVkEDQVM
K72-m1 NGkTVTVkEDQVMQQ
Y103 LHEPAVLYNLKERYA
K129 CVTVNPYKWLPVYNA
K207-ub AIGDRSKkDQTPGkG
T210 DRSKkDQTPGkGtLE
K213-ub KkDQTPGkGtLEDQI
T215-p DQTPGkGtLEDQIIQ
K246-ac DNSSRFGkFIRIHFG
K257-ac IHFGATGkLASADIE
Y266 ASADIETYLLEkSRV
K270-ub IETYLLEkSRVIFQL
K278-ub SRVIFQLkAERDYHI
K363 IMHFGNMKFKQKQRE
T378 EQAEPDGTEEADKSA
Y386 EEADKSAYLMGLNSA
K405-ub GLCHPRVkVGNEyVt
Y410-p RVkVGNEyVtKGQNV
T412-p kVGNEyVtKGQNVQQ
K413 VGNEyVtKGQNVQQV
Y422 QNVQQVSYAIGALAK
K450-ub INATLETkQPRQYFI
K502 VLEQEEYKKEGIEWT
K549 KATDMTFKAKLYDNH
Y553 MTFKAKLYDNHLGkS
K559-m1 LYDNHLGkSNNFQkP
K565-ac GkSNNFQkPRNVKGK
Y582 AHFSLVHYAGTVDYN
Y588 HYAGTVDYNILGWLQ
K598-ub LGWLQKNkDPLNETV
Y624 LSNLFANYAGADAPA
K640-m1 KGKGKAKkGSSFQTV
S680 IIPNETKSPGVMDNP
Y715 GFPNRILYGDFRQRY
S738-p PEGQFIDsRKGAEKL
Y756 LDIDHNQYkFGHTkV
K757-ac DIDHNQYkFGHTkVF
K762-ub QYkFGHTkVFFKAGL
S810-p KLLERRDsLLIIQWN
T851 ETEKEMATMkEEFGR
K853 EKEMATMKEEFGRVK
K853-m1 EKEMATMkEEFGRVK
K865 RVKDALEKSEARRKE
K865-ub RVKDALEkSEARRKE
S866 VKDALEkSEARRKEL
S879-p ELEEKMVsLLQEKND
K939 MNAELTAKKRKLEDE
K942 ELTAKKRKLEDECsE
S948-p RKLEDECsELKRDID
K951 EDECsELKRDIDDLE
T1019-p AEEDKVNtLTKAKVk
K1026-ub tLTKAKVkLEQQVDD
S1037-p QVDDLEGsLEQEKKV
K1042 EGsLEQEKKVRMDLE
K1043 GsLEQEKKVRMDLER
K1052 RMDLERAKRkLEGDL
K1054-ub DLERAKRkLEGDLKL
S1102 EDEQALGSQLQkKLk
S1102 EDEQALGSQLQkKLk
K1106 ALGSQLQKKLkELQA
K1106-ub ALGSQLQkKLkELQA
K1107 LGSQLQkKLkELQAR
K1109-ub SQLQkKLkELQARIE
T1127-p EELEAERtARAKVEK
S1140-p EKLRSDLsRELEEIS
S1158-p EEAGGATsVQIEMNK
K1165 sVQIEMNKKREAEFQ
T1188-p ATLQHEAtAAALRKk
K1195-ub tAAALRKkHADsVAE
S1199-p LRKkHADsVAELGEQ
K1219-ub RVKQKLEkEKsEFkL
S1222-p QKLEkEKsEFkLELD
K1225-ub EkEKsEFkLELDDVT
S1233-p LELDDVTsNMEQIIk
K1240-ub sNMEQIIkAKANLEK
T1266 HRSKAEETQRSVNDL
S1269 KAEETQRSVNDLTSQ
T1274 QRSVNDLTSQRAkLQ
S1275 RSVNDLTSQRAkLQT
K1279-ub DLTSQRAkLQTENGE
T1282 SQRAkLQTENGELSR
S1288 QTENGELSRQLDEKE
S1299-p DEKEALIsQLTRGkL
S1299 DEKEALISQLTRGkL
K1305 IsQLTRGKLTYTQQL
K1305-ub IsQLTRGkLTYTQQL
T1307 QLTRGkLTYTQQLED
Y1308 LTRGkLTYTQQLEDL
T1309 TRGkLTYTQQLEDLk
K1316-ac TQQLEDLkRQLEEEV
K1324 RQLEEEVKAkNALAH
K1326-ub LEEEVKAkNALAHAL
Y1347 CDLLREQYEEETEAK
S1362-p AELQRVLskANsEVA
K1363-ub ELQRVLskANsEVAQ
S1366-p RVLskANsEVAQWRt
T1373-p sEVAQWRtkyEtDAI
K1374-ub EVAQWRtkyEtDAIQ
Y1375-p VAQWRtkyEtDAIQR
T1377-p QWRtkyEtDAIQRTE
K1390-ac TEELEEAkkKLAQRL
K1390-ub TEELEEAkkKLAQRL
K1391 EELEEAkKKLAQRLQ
K1391-ub EELEEAkkKLAQRLQ
K1392 ELEEAkkKLAQRLQD
K1410-ub AVEAVNAkCSSLEKT
S1412 EAVNAkCSSLEKTKH
S1413 AVNAkCSSLEKTKHR
K1444 AAAAALDKKQRNFDK
K1444-ub AAAAALDkKQRNFDK
K1445 AAAALDkKQRNFDKI
K1457-ub DKILAEWkQkyEESQ
K1459-ub ILAEWkQkyEESQsE
Y1460-p LAEWkQkyEESQsEL
S1465-p QkyEESQsELESSQk
K1472-ub sELESSQkEARsLsT
S1476-p SSQkEARsLsTELFK
S1478-p QkEARsLsTELFKLk
K1485-ub sTELFKLkNAyEEsL
Y1488-p LFKLkNAyEEsLEHL
S1491-p LkNAyEEsLEHLETF
K1499-ac LEHLETFkRENkNLQ
K1499-ub LEHLETFkRENkNLQ
K1503-ub ETFkRENkNLQEEIs
S1510-p kNLQEEIsDLTEQLG
T1513 QEEIsDLTEQLGSTG
S1518 DLTEQLGSTGKSIHE
T1519 LTEQLGSTGKSIHEL
S1522 QLGSTGKSIHELEKI
K1531-ub HELEKIRkQLEAEkL
K1537-ub RkQLEAEkLELQsAL
S1542-p AEkLELQsALEEAEA
S1550 ALEEAEASLEHEEGK
K1569-ub QLEFNQIkAEIERKL
K1587-ac DEEMEQAkRNHLRMV
K1587-ub DEEMEQAkRNHLRMV
S1596-p NHLRMVDsLQTsLDA
S1596 NHLRMVDSLQTsLDA
S1600-p MVDsLQTsLDAETRS
T1605 QTsLDAETRSRNEAL
S1607 sLDAETRSRNEALRV
K1644-ub AEAQKQVkSLQSLLK
K1700-ub EQTERSRkLAEQELI
S1710-p EQELIETsERVQLLH
S1710 EQELIETSERVQLLH
S1718-p ERVQLLHsQNTsLIN
S1722-p LLHsQNTsLINQkKK
K1727 NTsLINQKKKMDADL
K1727-ub NTsLINQkKKMDADL
S1735 KKMDADLSQLQTEVE
T1739 ADLSQLQTEVEEAVQ
K1770 AMMAEELKKEQDTSA
K1784 AHLERMKKNMEQTIk
K1791-ub KNMEQTIkDLQHRLD
K1806 EAEQIALKGGkKQLQ
K1806-ub EAEQIALkGGkKQLQ
K1809 QIALkGGKKQLQkLE
K1809-ub QIALkGGkKQLQkLE
K1810 IALkGGkKQLQkLEA
K1814-ub GGkKQLQkLEARVRE
K1831 NELEAEQKRNAESVk
K1831-ub NELEAEQkRNAESVk
K1838-ub kRNAESVkGMrKSER
R1841-m1 AESVkGMrKSERRIK
K1848 rKSERRIKELtYQTE
T1851-p ERRIKELtYQTEEDR
Y1852 RRIKELtYQTEEDRK
T1854 IKELtYQTEEDRKNL
K1859 YQTEEDRKNLLRLQD
K1870-ub RLQDLVDkLQLkVKA
K1874-ub LVDkLQLkVKAYKRQ
T1891-p EAEEQANtNLSkFRk
K1895-ub QANtNLSkFRkVQHE
K1898-ub tNLSkFRkVQHELDE
S1915-p ERADIAEsQVNkLRA
K1919-ub IAEsQVNkLRAKSRD
  rat

 
R4 ____MADREMAAFGA
F15 AFGAGAPFLRKSEKE
K34 QTRPFDLKKDVFVPD
K34 QTRPFDLKKDVFVPD
K35 TRPFDLKKDVFVPDD
K43 DVFVPDDKEEFVKAK
K58 IVSREGGKVTAETEN
T60 SREGGKVTAETENGK
T63 GGKVTAETENGKTVT
N65 KVTAETENGKTVTVK
K67 TAETENGKTVTVKED
T70 TENGKTVTVKEDQVM
K72 NGKTVTVKEDQVMQQ
Y103 LHEPAVLYNLKERYA
K129 CVTVNPYKWLPVYNA
K207 AIGDRSKKDQTPGKG
T210 DRSKKDQTPGKGTLE
K213 KKDQTPGKGTLEDQI
T215 DQTPGKGTLEDQIIQ
K246 DNSSRFGKFIRIHFG
K257 IHFGATGKLASADIE
Y266 ASADIETYLLEKSRV
K270 IETYLLEKSRVIFQL
K278 SRVIFQLKAERDYHI
K363 IMHFGNMKFKQKQRE
T378 EQAEPDGTEEADKSA
Y386-p EEADKSAyLMGLNSA
K405 GLCHPRVKVGNEyVt
Y410-p RVKVGNEyVtKGQNV
T412-p KVGNEyVtKGQNVQQ
K413 VGNEyVtKGQNVQQV
Y422-p QNVQQVAyAIGALAK
K450 INATLETKQPRQYFI
K502 VLEQEEYKKEGIEWT
K549 KATDMTFKAKLyDNH
Y553-p MTFKAKLyDNHLGKS
K559 LyDNHLGKSNNFQKP
K565 GKSNNFQKPRNIKGK
Y582 AHFSLIHYAGTVDYN
Y588 HYAGTVDYNILGWLQ
K598 LGWLQKNKDPLNETV
Y624-p LSNLFANyAGADAPV
K640 KGKGKAKKGSSFQTV
S680 IIPNETKSPGVMDNP
Y715-p GFPNRILyGDFRQRY
S738 PEGQFIDSRKGAEKL
Y756-p LDIDHNQyKFGHTKV
K757 DIDHNQyKFGHTKVF
K762 QyKFGHTKVFFKAGL
S810 KLLERRDSLLIIQWN
N851 ETEKEMANMKEEFGR
K853 EKEMANMKEEFGRVK
K853 EKEMANMKEEFGRVK
K865 RVKDALEKSEARRKE
K865 RVKDALEKSEARRKE
S866 VKDALEKSEARRKEL
S879 ELEEKMVSLLQEKND
K939 MNAELTAKKRKLEDE
K942 ELTAKKRKLEDECSE
S948 RKLEDECSELKRDID
K951 EDECSELKRDIDDLE
T1019 AEEDKVNTLTKAKVK
K1026 TLTKAKVKLEQQVDD
S1037 QVDDLEGSLDQDKKV
K1042 EGSLDQDKKVRMDLE
K1043 GSLDQDKKVRMDLER
K1052 RMDLERAKRKLEGDL
K1054 DLERAKRKLEGDLKL
S1102 EDEQALGSQLQKKLK
S1102 EDEQALGSQLQKKLK
K1106 ALGSQLQKKLKELQA
K1106 ALGSQLQKKLKELQA
K1107 LGSQLQKKLKELQAR
K1109 SQLQKKLKELQARIE
T1127 EELEAERTARAKVEK
S1140 EKLRSDLSRELEEIS
S1158 EEAGGATSVQIEMNK
K1165 SVQIEMNKKREAEFQ
T1188 ATLQHEATAAALRKK
K1195 TAAALRKKHADSVAE
S1199 LRKKHADSVAELGEQ
K1219 RVKQKLEKEKSEFKL
S1222 QKLEKEKSEFKLELD
K1225 EKEKSEFKLELDDVT
S1233 LELDDVTSNMEQIIK
K1240 SNMEQIIKAKANLEK
T1266 HRSKAEETQRSVNDL
S1269 KAEETQRSVNDLTRQ
T1274 QRSVNDLTRQRAKLQ
R1275 RSVNDLTRQRAKLQT
K1279 DLTRQRAKLQTENGE
T1282 RQRAKLQTENGELSR
S1288 QTENGELSRQLDEKE
S1299 DEKEALISQLTRGKL
S1299 DEKEALISQLTRGKL
K1305 ISQLTRGKLTyTQQL
K1305 ISQLTRGKLTyTQQL
T1307 QLTRGKLTyTQQLED
Y1308-p LTRGKLTyTQQLEDL
T1309 TRGKLTyTQQLEDLK
K1316 TQQLEDLKRQLEEEV
K1324 RQLEEEVKAKNALAH
K1326 LEEEVKAKNALAHAL
Y1347-p CDLLREQyEEETEAK
S1362 AELQRVLSKANSEVA
K1363 ELQRVLSKANSEVAQ
S1366 RVLSKANSEVAQWRT
T1373 SEVAQWRTKyETDAI
K1374 EVAQWRTKyETDAIQ
Y1375-p VAQWRTKyETDAIQR
T1377 QWRTKyETDAIQRTE
K1390 TEELEEAKKKLAQRL
K1390 TEELEEAKKKLAQRL
K1391 EELEEAKKKLAQRLQ
K1391 EELEEAKKKLAQRLQ
K1392 ELEEAKKKLAQRLQD
K1410 AVEAVNAKCSSLEKT
S1412 EAVNAKCSSLEKTKH
S1413 AVNAKCSSLEKTKHR
K1444 AAAAALDKKQRNFDK
K1444 AAAAALDKKQRNFDK
K1445 AAAALDKKQRNFDKI
K1457 DKILVEWKQKyEESQ
K1459 ILVEWKQKyEESQSE
Y1460-p LVEWKQKyEESQSEL
S1465 QKyEESQSELESSQK
K1472 SELESSQKEARSLST
S1476 SSQKEARSLSTELFK
S1478 QKEARSLSTELFKLK
K1485 STELFKLKNAyEESL
Y1488-p LFKLKNAyEESLEHL
S1491 LKNAyEESLEHLETF
K1499 LEHLETFKRENKNLQ
K1499 LEHLETFKRENKNLQ
K1503 ETFKRENKNLQEEIS
S1510 KNLQEEISDLTEQLG
T1513 QEEISDLTEQLGSTG
S1518 DLTEQLGSTGKSIHE
T1519 LTEQLGSTGKSIHEL
S1522 QLGSTGKSIHELEKI
K1531 HELEKIRKQLEAEKL
K1537 RKQLEAEKLELQSAL
S1542 AEKLELQSALEEAEA
S1550 ALEEAEASLEHEEGK
K1569 QLEFNQIKAEIERKL
K1587 DEEMEQAKRNHLRVV
K1587 DEEMEQAKRNHLRVV
S1596 NHLRVVDSLQTSLDA
S1596 NHLRVVDSLQTSLDA
S1600 VVDSLQTSLDAETRS
T1605 QTSLDAETRSRNEAL
S1607 SLDAETRSRNEALRV
K1644 AEAQKQVKSLQSLLK
K1700 EQTERSRKLAEQELI
S1710 EQELIETSERVQLLH
S1710 EQELIETSERVQLLH
S1718 ERVQLLHSQNTSLIN
S1722 LLHSQNTSLINQKKK
K1727 NTSLINQKKKMDADL
K1727 NTSLINQKKKMDADL
S1735 KKMDADLSQLQTEVE
T1739 ADLSQLQTEVEEAVQ
K1770 AMMAEELKKEQDTSA
N1784 AHLERMKNNMEQTIK
K1791 NNMEQTIKDLQHRLD
K1806 EAEQIALKGGKKQLQ
K1806 EAEQIALKGGKKQLQ
K1809 QIALKGGKKQLQKLE
K1809 QIALKGGKKQLQKLE
K1810 IALKGGKKQLQKLEA
K1814 GGKKQLQKLEARVRE
K1831 NELEAEQKRNAESVK
K1831 NELEAEQKRNAESVK
K1838 KRNAESVKGMRKSER
R1841 AESVKGMRKSERRIK
K1848 RKSERRIKELTyQTE
T1851 ERRIKELTyQTEEDR
Y1852-p RRIKELTyQTEEDRK
T1854 IKELTyQTEEDRKNL
K1859 yQTEEDRKNLLRLQD
K1870 RLQDLVDKLQLKVKA
K1874 LVDKLQLKVKAYKRQ
T1891 EAEEQANTNLSKFRK
K1895 QANTNLSKFRKVQHE
K1898 TNLSKFRKVQHELDE
S1915 ERADIAESQVNKLRA
K1919 IAESQVNKLRAKSRD
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