MYH7 (human)

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Protein Page:

MYH7 (human)

p	Phosphorylation
a	Acetylation
m	Methylation
m1	Mono-methylation
m2	Di-methylation
m3	Tri-methylation
u	Ubiquitination
s	Sumoylation
n	Neddylation
gl	O-GlcNAc
ga	O-GalNAc
h	Palmitoylation
ad	Adenylylation
sn	S-Nitrosylation
ca	Caspase cleavage

Overview

MYH7 Muscle contraction. Defects in MYH7 are the cause of familial hypertrophic cardiomyopathy type 1 (CMH1). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Defects in MYH7 are the cause of myopathy myosin storage (MYOMS). In this disorder, muscle biopsy shows type 1 fiber predominance and increased interstitial fat and connective tissue. Inclusion bodies consisting of the beta cardiac myosin heavy chain are present in the majority of type 1 fibers, but not in type 2 fibers. Defects in MYH7 are the cause of scapuloperoneal myopathy MYH7-related (SPMM); also known as scapuloperoneal syndrome myopathic type. SPMM is a progressive muscular atrophia beginning in the lower legs and affecting the shoulder region earlier and more severely than distal arm. Defects in MYH7 are a cause of cardiomyopathy dilated type 1S (CMD1S). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in MYH7 are the cause of myopathy distal type 1 (MPD1). MPD1 is a muscular disorder characterized by early-onset selective weakness of the great toe and ankle dorsiflexors, followed by weakness of the finger extensors. Mild proximal weakness occasionally develops years later after the onset of the disease. Note: This description may include information from UniProtKB.

Protein type: Motor protein; Motility/polarity/chemotaxis

Cellular Component: sarcomere; focal adhesion; cytoplasm; stress fiber; nucleolus; muscle myosin complex; myosin complex; Z disc; nucleus

Molecular Function: microfilament motor activity; calmodulin binding; protein binding; protein homodimerization activity; structural constituent of muscle; protein heterodimerization activity; ATPase activity; actin-dependent ATPase activity; actin binding; ATP binding

Biological Process: ATP catabolic process; adult heart development; response to reactive oxygen species; muscle contraction; regulation of heart rate; ventricular cardiac muscle morphogenesis; muscle filament sliding

Reference #: P12883 (UniProtKB)

Alt. Names/Synonyms: beta-myosin heavy chain; CMD1S; CMH1; DKFZp451F047; MGC138376; MGC138378; MPD1; MYH7; MyHC-beta; MyHC-slow; MYHCB; myopathy, distal 1; myosin heavy chain (AA 1-96); Myosin heavy chain 7; Myosin heavy chain slow isoform; Myosin heavy chain, cardiac muscle beta isoform; myosin, heavy chain 7, cardiac muscle, beta; myosin, heavy polypeptide 7, cardiac muscle, beta; Myosin-7; rhabdomyosarcoma antigen MU-RMS-40.7A; SPMD; SPMM

Gene Symbols: MYH7

Molecular weight: 223,097 Da

Basal Isoelectric point: 5.63 Predict pI for various phosphorylation states

Select Structure to View Below

	MYH7

Modification Sites and Domains

Show Modification Legend

Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

Show Multiple Sequence Alignment

SS SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.		human

0	1	S4-p	____MGDsEMAVFGA
0	1	Y15-p	VFGAAAPyLRKSEKE
0	56	K34-a	QTRPFDLkkDVFVPD
0	1	K34	QTRPFDLKkDVFVPD
0	2	K35-a	TRPFDLkkDVFVPDD
0	1	K43	DVFVPDDKQEFVKAK
0	2	K58-u	IVSREGGkVtAEtEy
0	1	T60-p	SREGGkVtAEtEyGK
0	1	T63-p	GGkVtAEtEyGKTVt
0	7	Y65-p	kVtAEtEyGKTVtVK
0	1	K67	tAEtEyGKTVtVKED
0	1	T70-p	tEyGKTVtVKEDQVM
0	1	K72	yGKTVtVKEDQVMQQ
0	29	Y103-p	LHEPAVLyNLKDRYG
0	1	K129-a	CVTVNPYkWLPVYTP
0	1	K207	AIGDRSKKDQsPGKG
0	1	S210-p	DRSKKDQsPGKGtLE
0	1	K213	KKDQsPGKGtLEDQI
0	2	T215-p	DQsPGKGtLEDQIIQ
0	1	T235-p	EAFGNAKtVRNDNSS
0	1	K246-a	DNSSRFGkFIRIHFG
0	1	K257	IHFGATGKLASADIE
0	1	Y266-p	ASADIETyLLEKSRV
0	2	K270	IETyLLEKSRVIFQL
0	2	K278-u	SRVIFQLkAERDYHI
0	6	K363-a	IMHFGNMkFKLKQRE
0	2	T378-p	EQAEPDGtEEADKSA
0	14	Y386-p	EEADKSAyLMGLNSA
0	2	K405	GLCHPRVKVGNEyVt
0	194	Y410-p	RVKVGNEyVtkGQNV
0	10	T412-p	KVGNEyVtkGQNVQQ
0	1	K413-a	VGNEyVtkGQNVQQV
0	67	Y422-p	QNVQQVIyATGALAK
0	2	K450-u	INATLETkQPRQYFI
0	32	K502-a	VLEQEEYkKEGIEWT
0	35	K549-a	KATDMTFkAKLFDNH
0	12	F553	MTFkAKLFDNHLGKS
0	1	K559	LFDNHLGKSANFQKP
0	1	K565	GKSANFQKPRNIKGK
0	1	Y582-p	AHFSLIHyAGIVDyN
0	1	Y588-p	HyAGIVDyNIIGWLQ
0	2	K598	IGWLQKNKDPLNETV
0	23	Y624-p	LSTLFANyAGADAPI
0	1	K640	KGKGKAKKGsSFQTV
0	1	S642-p	KGKAKKGsSFQTVSA
0	1	S680-p	IIPNETKsPGVMDNP
0	8	Y715-p	GFPNRILyGDFRQRY
0	3	S738-p	PEGQFIDsRKGAEKL
0	32	Y756-p	LDIDHNQykFGHTKV
0	43	K757-a	DIDHNQykFGHTKVF
0	2	K762	QykFGHTKVFFKAGL
0	1	S810	KLLERRDSLLVIQWN
0	2	S851-p	EREKEMAsMkEEFTR
0	1	K853-a	EKEMAsMkEEFTRLK
0	1	K853	EKEMAsMKEEFTRLK
0	1	K865-a	RLKEALEksEARRKE
0	2	K865-u	RLKEALEksEARRKE
0	1	S866-p	LKEALEksEARRKEL
0	1	S879	ELEEKMVSLLQEKND
0	1	K939-a	MNAELTAkKRkLEDE
0	1	K942-a	ELTAkKRkLEDECsE
0	2	S948-p	RkLEDECsELkRDID
0	58	K951-a	EDECsELkRDIDDLE
0	4	T1019-p	AEEDKVNtLTKAKVk
0	2	K1026-u	tLTKAKVkLEQQVDD
0	3	S1037-p	QVDDLEGsLEQEkkV
0	54	K1042-a	EGsLEQEkkVRMDLE
0	16	K1043-a	GsLEQEkkVRMDLER
0	1	K1052-a	RMDLERAkRKLEGDL
0	1	K1054	DLERAkRKLEGDLKL
1	0	S1102-gl	EDEQALGsQLQkkLK
0	2	S1102-p	EDEQALGsQLQkkLK
0	8	K1106-a	ALGsQLQkkLKELQA
0	1	K1106	ALGsQLQKkLKELQA
0	2	K1107-a	LGsQLQkkLKELQAR
0	1	K1109	sQLQkkLKELQARIE
0	4	T1127-p	EELEAERtARAKVEK
0	3	S1140-p	EKLRSDLsRELEEIS
0	2	S1158-p	EEAGGATsVQIEMNk
0	3	K1165-a	sVQIEMNkKREAEFQ
0	4	T1188-p	ATLQHEAtAAALRKk
0	1	K1195-u	tAAALRKkHADsVAE
0	6	S1199-p	LRKkHADsVAELGEQ
0	1	K1219-u	RVKQKLEkEKsEFkL
0	2	S1222-p	QKLEkEKsEFkLELD
0	1	K1225-u	EkEKsEFkLELDDVT
0	2	S1233-p	LELDDVTsNMEQIIk
0	2	K1240-u	sNMEQIIkAKANLEK
0	2	T1266-p	HRSKAEEtQRsVNDL
0	2	S1269-p	KAEEtQRsVNDLtsQ
0	1	T1274-p	QRsVNDLtsQRAKLQ
0	2	S1275-p	RsVNDLtsQRAKLQt
0	1	K1279	DLtsQRAKLQtENGE
0	2	T1282-p	sQRAKLQtENGELsR
0	1	S1288-p	QtENGELsRQLDEKE
0	5	S1299-p	DEKEALIsQLTRGkL
1	0	S1299-gl	DEKEALIsQLTRGkL
0	4	K1305-a	IsQLTRGkLtytQQL
0	1	K1305	IsQLTRGKLtytQQL
0	2	T1307-p	QLTRGkLtytQQLED
0	155	Y1308-p	LTRGkLtytQQLEDL
0	6	T1309-p	TRGkLtytQQLEDLk
0	59	K1316-a	tQQLEDLkRQLEEEV
0	1	K1324-m3	RQLEEEVkAKNALAH
0	2	K1326	LEEEVkAKNALAHAL
0	66	Y1347-p	CDLLREQyEEETEAK
0	2	S1362-p	AELQRVLskANsEVA
0	2	K1363-u	ELQRVLskANsEVAQ
0	3	S1366-p	RVLskANsEVAQWRt
0	14	T1373-p	sEVAQWRtKyEtDAI
0	2	K1374	EVAQWRtKyEtDAIQ
0	228	Y1375-p	VAQWRtKyEtDAIQR
0	5	T1377-p	QWRtKyEtDAIQRTE
0	51	K1390-a	TEELEEAkkkLAQRL
0	3	K1390	TEELEEAKkkLAQRL
0	33	K1391-a	EELEEAkkkLAQRLQ
0	1	K1391-u	EELEEAkkkLAQRLQ
0	2	K1392-a	ELEEAkkkLAQRLQE
0	3	K1410-u	AVEAVNAkCssLEKT
0	1	S1412-p	EAVNAkCssLEKTKH
0	1	S1413-p	AVNAkCssLEKTKHR
0	49	K1444-a	AAAAALDkkQRNFDK
0	2	K1444-u	AAAAALDkkQRNFDK
0	7	K1445-a	AAAALDkkQRNFDKI
0	2	K1457-u	DKILAEWkQkyEESQ
0	1	K1459-u	ILAEWkQkyEESQsE
0	79	Y1460-p	LAEWkQkyEESQsEL
0	3	S1465-p	QkyEESQsELESSQk
0	3	K1472-u	sELESSQkEARsLsT
0	3	S1476-p	SSQkEARsLsTELFK
0	3	S1478-p	QkEARsLsTELFKLk
0	2	K1485-u	sTELFKLkNAyEEsL
0	113	Y1488-p	LFKLkNAyEEsLEHL
0	5	S1491-p	LkNAyEEsLEHLETF
0	59	K1499-a	LEHLETFkRENKNLQ
0	2	K1499-u	LEHLETFkRENKNLQ
0	1	K1503	ETFkRENKNLQEEIs
0	2	S1510-p	KNLQEEIsDLtEQLG
0	1	T1513-p	QEEIsDLtEQLGssG
0	2	S1518-p	DLtEQLGssGKtIHE
0	1	S1519-p	LtEQLGssGKtIHEL
0	1	T1522-p	QLGssGKtIHELEKV
0	1	K1531	HELEKVRKQLEAEKM
0	1	K1537	RKQLEAEKMELQsAL
0	2	S1542-p	AEKMELQsALEEAEA
0	1	S1550-p	ALEEAEAsLEHEEGK
1	3	K1569-u	QLEFNQIkAEIERKL
0	48	K1587-a	DEEMEQAkRNHLRVV
0	2	K1587-u	DEEMEQAkRNHLRVV
0	4	S1596-p	NHLRVVDsLQTsLDA
1	0	S1596-gl	NHLRVVDsLQTsLDA
0	6	S1600-p	VVDsLQTsLDAEtRs
0	1	T1605-p	QTsLDAEtRsRNEAL
0	1	S1607-p	sLDAEtRsRNEALRV
0	1	K1644	AEAQKQVKSLQSLLK
0	3	K1700-u	EQTERSRkLAEQELI
0	2	S1710-p	EQELIETsERVQLLH
1	0	S1710-gl	EQELIETsERVQLLH
0	4	S1718-p	ERVQLLHsQNTsLIN
0	3	S1722-p	LLHsQNTsLINQkKK
0	44	K1727-a	NTsLINQkKKMDADL
0	2	K1727-u	NTsLINQkKKMDADL
0	1	S1735-p	KKMDADLsQLQtEVE
0	1	T1739-p	ADLsQLQtEVEEAVQ
0	1	K1770-a	AMMAEELkKEQDTSA
0	2	K1784-a	AHLERMKkNMEQTIk
0	2	K1791-u	kNMEQTIkDLQHRLD
0	3	K1806-a	EAEQIALkGGkkQLQ
0	1	K1806-u	EAEQIALkGGkkQLQ
0	49	K1809-a	QIALkGGkkQLQkLE
0	1	K1809-u	QIALkGGkkQLQkLE
0	4	K1810-a	IALkGGkkQLQkLEA
0	2	K1814-u	GGkkQLQkLEARVRE
0	53	K1831-a	NELEAEQkRNAESVk
0	2	K1831-u	NELEAEQkRNAESVk
0	2	K1838-u	kRNAESVkGMRKSER
0	1	R1841	AESVkGMRKSERRIk
0	1	K1848-u	RKSERRIkELtyQtE
0	10	T1851-p	ERRIkELtyQtEEDR
0	95	Y1852-p	RRIkELtyQtEEDRk
0	14	T1854-p	IkELtyQtEEDRkNL
0	1	K1859-a	yQtEEDRkNLLRLQD
0	3	K1870-u	RLQDLVDkLQLkVKA
0	2	K1874-u	LVDkLQLkVKAYKRQ
0	3	T1891-p	EAEEQANtNLSkFRk
0	2	K1895-u	QANtNLSkFRkVQHE
0	2	K1898-u	tNLSkFRkVQHELDE
0	4	S1915-p	ERADIAEsQVNkLRA
0	3	K1919-u	IAEsQVNkLRAKSRD

	mouse

A4	____MADAEMAAFGA
F15	AFGAAAPFLRKSEKE
K34	QTRPFDLKKDVFVPD
K34-m1	QTRPFDLkKDVFVPD
K35	TRPFDLkKDVFVPDD
K43-u	DVFVPDDkEEFVKAK
K58-u	IVSREGGkVTAETEN
T60	SREGGkVTAETENGk
T63	GGkVTAETENGkTVT
N65	kVTAETENGkTVTVk
K67-u	TAETENGkTVTVkED
T70	TENGkTVTVkEDQVM
K72-m1	NGkTVTVkEDQVMQQ
Y103	LHEPAVLYNLKERYA
K129	CVTVNPYKWLPVYNA
K207-u	AIGDRSKkDQTPGkG
T210	DRSKkDQTPGkGtLE
K213-u	KkDQTPGkGtLEDQI
T215-p	DQTPGkGtLEDQIIQ
T235-p	EAFGNAKtVRNDNSS
K246-a	DNSSRFGkFIRIHFG
K257-a	IHFGATGkLASADIE
Y266	ASADIETYLLEkSRV
K270-u	IETYLLEkSRVIFQL
K278-u	SRVIFQLkAERDYHI
K363	IMHFGNMKFKQKQRE
T378	EQAEPDGTEEADKSA
Y386	EEADKSAYLMGLNSA
K405-u	GLCHPRVkVGNEyVt
Y410-p	RVkVGNEyVtKGQNV
T412-p	kVGNEyVtKGQNVQQ
K413	VGNEyVtKGQNVQQV
Y422	QNVQQVSYAIGALAK
K450-u	INATLETkQPRQYFI
K502	VLEQEEYKKEGIEWT
K549	KATDMTFKAKLYDNH
Y553	MTFKAKLYDNHLGkS
K559-m1	LYDNHLGkSNNFQkP
K565-a	GkSNNFQkPRNVKGK
Y582	AHFSLVHYAGTVDYN
Y588	HYAGTVDYNILGWLQ
K598-u	LGWLQKNkDPLNETV
Y624	LSNLFANYAGADAPA
K640-m1	KGKGKAKkGsSFQTV
S642-p	KGKAKkGsSFQTVSA
S680	IIPNETKSPGVMDNP
Y715	GFPNRILYGDFRQRY
S738-p	PEGQFIDsRKGAEKL
Y756	LDIDHNQYkFGHTkV
K757-a	DIDHNQYkFGHTkVF
K762-u	QYkFGHTkVFFKAGL
S810-p	KLLERRDsLLIIQWN
T851	ETEKEMATMkEEFGR
K853	EKEMATMKEEFGRVK
K853-m1	EKEMATMkEEFGRVK
K865	RVKDALEKSEARRKE
K865-u	RVKDALEkSEARRKE
S866	VKDALEkSEARRKEL
S879-p	ELEEKMVsLLQEKND
K939	MNAELTAKKRKLEDE
K942	ELTAKKRKLEDECsE
S948-p	RKLEDECsELKRDID
K951	EDECsELKRDIDDLE
T1019-p	AEEDKVNtLTKAKVk
K1026-u	tLTKAKVkLEQQVDD
S1037-p	QVDDLEGsLEQEKKV
K1042	EGsLEQEKKVRMDLE
K1043	GsLEQEKKVRMDLER
K1052	RMDLERAKRkLEGDL
K1054-u	DLERAKRkLEGDLKL
S1102	EDEQALGSQLQkKLk
S1102	EDEQALGSQLQkKLk
K1106	ALGSQLQKKLkELQA
K1106-u	ALGSQLQkKLkELQA
K1107	LGSQLQkKLkELQAR
K1109-u	SQLQkKLkELQARIE
T1127-p	EELEAERtARAKVEK
S1140-p	EKLRSDLsRELEEIS
S1158-p	EEAGGATsVQIEMNK
K1165	sVQIEMNKKREAEFQ
T1188-p	ATLQHEAtAAALRKk
K1195-u	tAAALRKkHADsVAE
S1199-p	LRKkHADsVAELGEQ
K1219-u	RVKQKLEkEKsEFkL
S1222-p	QKLEkEKsEFkLELD
K1225-u	EkEKsEFkLELDDVT
S1233-p	LELDDVTsNMEQIIk
K1240-u	sNMEQIIkAKANLEK
T1266	HRSKAEETQRSVNDL
S1269	KAEETQRSVNDLTSQ
T1274	QRSVNDLTSQRAkLQ
S1275	RSVNDLTSQRAkLQT
K1279-u	DLTSQRAkLQTENGE
T1282	SQRAkLQTENGELSR
S1288	QTENGELSRQLDEKE
S1299-p	DEKEALIsQLTRGkL
S1299	DEKEALISQLTRGkL
K1305	IsQLTRGKLTYTQQL
K1305-u	IsQLTRGkLTYTQQL
T1307	QLTRGkLTYTQQLED
Y1308	LTRGkLTYTQQLEDL
T1309	TRGkLTYTQQLEDLk
K1316-a	TQQLEDLkRQLEEEV
K1324	RQLEEEVKAkNALAH
K1326-u	LEEEVKAkNALAHAL
Y1347	CDLLREQYEEETEAK
S1362-p	AELQRVLskANsEVA
K1363-u	ELQRVLskANsEVAQ
S1366-p	RVLskANsEVAQWRt
T1373-p	sEVAQWRtkyEtDAI
K1374-u	EVAQWRtkyEtDAIQ
Y1375-p	VAQWRtkyEtDAIQR
T1377-p	QWRtkyEtDAIQRTE
K1390-a	TEELEEAkkKLAQRL
K1390-u	TEELEEAkkKLAQRL
K1391	EELEEAkKKLAQRLQ
K1391-u	EELEEAkkKLAQRLQ
K1392	ELEEAkkKLAQRLQD
K1410-u	AVEAVNAkCSSLEKT
S1412	EAVNAkCSSLEKTKH
S1413	AVNAkCSSLEKTKHR
K1444	AAAAALDKKQRNFDK
K1444-u	AAAAALDkKQRNFDK
K1445	AAAALDkKQRNFDKI
K1457-u	DKILAEWkQkyEESQ
K1459-u	ILAEWkQkyEESQsE
Y1460-p	LAEWkQkyEESQsEL
S1465-p	QkyEESQsELESSQk
K1472-u	sELESSQkEARsLsT
S1476-p	SSQkEARsLsTELFK
S1478-p	QkEARsLsTELFKLk
K1485-u	sTELFKLkNAyEEsL
Y1488-p	LFKLkNAyEEsLEHL
S1491-p	LkNAyEEsLEHLETF
K1499-a	LEHLETFkRENkNLQ
K1499-u	LEHLETFkRENkNLQ
K1503-u	ETFkRENkNLQEEIs
S1510-p	kNLQEEIsDLTEQLG
T1513	QEEIsDLTEQLGSTG
S1518	DLTEQLGSTGKSIHE
T1519	LTEQLGSTGKSIHEL
S1522	QLGSTGKSIHELEKI
K1531-u	HELEKIRkQLEAEkL
K1537-u	RkQLEAEkLELQsAL
S1542-p	AEkLELQsALEEAEA
S1550	ALEEAEASLEHEEGK
K1569-u	QLEFNQIkAEIERKL
K1587-a	DEEMEQAkRNHLRMV
K1587-u	DEEMEQAkRNHLRMV
S1596-p	NHLRMVDsLQTsLDA
S1596	NHLRMVDSLQTsLDA
S1600-p	MVDsLQTsLDAETRS
T1605	QTsLDAETRSRNEAL
S1607	sLDAETRSRNEALRV
K1644-u	AEAQKQVkSLQSLLK
K1700-u	EQTERSRkLAEQELI
S1710-p	EQELIETsERVQLLH
S1710	EQELIETSERVQLLH
S1718-p	ERVQLLHsQNTsLIN
S1722-p	LLHsQNTsLINQkKK
K1727	NTsLINQKKKMDADL
K1727-u	NTsLINQkKKMDADL
S1735	KKMDADLSQLQTEVE
T1739	ADLSQLQTEVEEAVQ
K1770	AMMAEELKKEQDTSA
K1784	AHLERMKKNMEQTIk
K1791-u	KNMEQTIkDLQHRLD
K1806	EAEQIALKGGkKQLQ
K1806-u	EAEQIALkGGkKQLQ
K1809	QIALkGGKKQLQkLE
K1809-u	QIALkGGkKQLQkLE
K1810	IALkGGkKQLQkLEA
K1814-u	GGkKQLQkLEARVRE
K1831	NELEAEQKRNAESVk
K1831-u	NELEAEQkRNAESVk
K1838-u	kRNAESVkGMrKSER
R1841-m1	AESVkGMrKSERRIK
K1848	rKSERRIKELtYQTE
T1851-p	ERRIKELtYQTEEDR
Y1852	RRIKELtYQTEEDRK
T1854	IKELtYQTEEDRKNL
K1859	YQTEEDRKNLLRLQD
K1870-u	RLQDLVDkLQLkVKA
K1874-u	LVDkLQLkVKAYKRQ
T1891-p	EAEEQANtNLSkFRk
K1895-u	QANtNLSkFRkVQHE
K1898-u	tNLSkFRkVQHELDE
S1915-p	ERADIAEsQVNkLRA
K1919-u	IAEsQVNkLRAKSRD

	rat

R4	____MADREMAAFGA
F15	AFGAGAPFLRKSEKE
K34	QTRPFDLKKDVFVPD
K34	QTRPFDLKKDVFVPD
K35	TRPFDLKKDVFVPDD
K43	DVFVPDDKEEFVKAK
K58	IVSREGGKVTAETEN
T60	SREGGKVTAETENGK
T63	GGKVTAETENGKTVT
N65	KVTAETENGKTVTVK
K67	TAETENGKTVTVKED
T70	TENGKTVTVKEDQVM
K72	NGKTVTVKEDQVMQQ
Y103	LHEPAVLYNLKERYA
K129	CVTVNPYKWLPVYNA
K207	AIGDRSKKDQTPGKG
T210	DRSKKDQTPGKGTLE
K213	KKDQTPGKGTLEDQI
T215	DQTPGKGTLEDQIIQ
T235	EAFGNAKTVRNDNSS
K246	DNSSRFGKFIRIHFG
K257	IHFGATGKLASADIE
Y266	ASADIETYLLEKSRV
K270	IETYLLEKSRVIFQL
K278	SRVIFQLKAERDYHI
K363	IMHFGNMKFKQKQRE
T378	EQAEPDGTEEADKSA
Y386-p	EEADKSAyLMGLNSA
K405	GLCHPRVKVGNEyVt
Y410-p	RVKVGNEyVtKGQNV
T412-p	KVGNEyVtKGQNVQQ
K413	VGNEyVtKGQNVQQV
Y422-p	QNVQQVAyAIGALAK
K450	INATLETKQPRQYFI
K502	VLEQEEYKKEGIEWT
K549	KATDMTFKAKLyDNH
Y553-p	MTFKAKLyDNHLGKS
K559	LyDNHLGKSNNFQKP
K565	GKSNNFQKPRNIKGK
Y582	AHFSLIHYAGTVDYN
Y588	HYAGTVDYNILGWLQ
K598	LGWLQKNKDPLNETV
Y624-p	LSNLFANyAGADAPV
K640	KGKGKAKKGSSFQTV
S642	KGKAKKGSSFQTVSA
S680	IIPNETKSPGVMDNP
Y715-p	GFPNRILyGDFRQRY
S738	PEGQFIDSRKGAEKL
Y756-p	LDIDHNQyKFGHTKV
K757	DIDHNQyKFGHTKVF
K762	QyKFGHTKVFFKAGL
S810	KLLERRDSLLIIQWN
N851	ETEKEMANMKEEFGR
K853	EKEMANMKEEFGRVK
K853	EKEMANMKEEFGRVK
K865	RVKDALEKSEARRKE
K865	RVKDALEKSEARRKE
S866	VKDALEKSEARRKEL
S879	ELEEKMVSLLQEKND
K939	MNAELTAKKRKLEDE
K942	ELTAKKRKLEDECSE
S948	RKLEDECSELKRDID
K951	EDECSELKRDIDDLE
T1019	AEEDKVNTLTKAKVK
K1026	TLTKAKVKLEQQVDD
S1037	QVDDLEGSLDQDKKV
K1042	EGSLDQDKKVRMDLE
K1043	GSLDQDKKVRMDLER
K1052	RMDLERAKRKLEGDL
K1054	DLERAKRKLEGDLKL
S1102	EDEQALGSQLQKKLK
S1102	EDEQALGSQLQKKLK
K1106	ALGSQLQKKLKELQA
K1106	ALGSQLQKKLKELQA
K1107	LGSQLQKKLKELQAR
K1109	SQLQKKLKELQARIE
T1127	EELEAERTARAKVEK
S1140	EKLRSDLSRELEEIS
S1158	EEAGGATSVQIEMNK
K1165	SVQIEMNKKREAEFQ
T1188	ATLQHEATAAALRKK
K1195	TAAALRKKHADSVAE
S1199	LRKKHADSVAELGEQ
K1219	RVKQKLEKEKSEFKL
S1222	QKLEKEKSEFKLELD
K1225	EKEKSEFKLELDDVT
S1233	LELDDVTSNMEQIIK
K1240	SNMEQIIKAKANLEK
T1266	HRSKAEETQRSVNDL
S1269	KAEETQRSVNDLTRQ
T1274	QRSVNDLTRQRAKLQ
R1275	RSVNDLTRQRAKLQT
K1279	DLTRQRAKLQTENGE
T1282	RQRAKLQTENGELSR
S1288	QTENGELSRQLDEKE
S1299	DEKEALISQLTRGKL
S1299	DEKEALISQLTRGKL
K1305	ISQLTRGKLTyTQQL
K1305	ISQLTRGKLTyTQQL
T1307	QLTRGKLTyTQQLED
Y1308-p	LTRGKLTyTQQLEDL
T1309	TRGKLTyTQQLEDLK
K1316	TQQLEDLKRQLEEEV
K1324	RQLEEEVKAKNALAH
K1326	LEEEVKAKNALAHAL
Y1347-p	CDLLREQyEEETEAK
S1362	AELQRVLSKANSEVA
K1363	ELQRVLSKANSEVAQ
S1366	RVLSKANSEVAQWRT
T1373	SEVAQWRTKyETDAI
K1374	EVAQWRTKyETDAIQ
Y1375-p	VAQWRTKyETDAIQR
T1377	QWRTKyETDAIQRTE
K1390	TEELEEAKKKLAQRL
K1390	TEELEEAKKKLAQRL
K1391	EELEEAKKKLAQRLQ
K1391	EELEEAKKKLAQRLQ
K1392	ELEEAKKKLAQRLQD
K1410	AVEAVNAKCSSLEKT
S1412	EAVNAKCSSLEKTKH
S1413	AVNAKCSSLEKTKHR
K1444	AAAAALDKKQRNFDK
K1444	AAAAALDKKQRNFDK
K1445	AAAALDKKQRNFDKI
K1457	DKILVEWKQKyEESQ
K1459	ILVEWKQKyEESQSE
Y1460-p	LVEWKQKyEESQSEL
S1465	QKyEESQSELESSQK
K1472	SELESSQKEARSLST
S1476	SSQKEARSLSTELFK
S1478	QKEARSLSTELFKLK
K1485	STELFKLKNAyEESL
Y1488-p	LFKLKNAyEESLEHL
S1491	LKNAyEESLEHLETF
K1499	LEHLETFKRENKNLQ
K1499	LEHLETFKRENKNLQ
K1503	ETFKRENKNLQEEIS
S1510	KNLQEEISDLTEQLG
T1513	QEEISDLTEQLGSTG
S1518	DLTEQLGSTGKSIHE
T1519	LTEQLGSTGKSIHEL
S1522	QLGSTGKSIHELEKI
K1531	HELEKIRKQLEAEKL
K1537	RKQLEAEKLELQSAL
S1542	AEKLELQSALEEAEA
S1550	ALEEAEASLEHEEGK
K1569	QLEFNQIKAEIERKL
K1587	DEEMEQAKRNHLRVV
K1587	DEEMEQAKRNHLRVV
S1596	NHLRVVDSLQTSLDA
S1596	NHLRVVDSLQTSLDA
S1600	VVDSLQTSLDAETRS
T1605	QTSLDAETRSRNEAL
S1607	SLDAETRSRNEALRV
K1644	AEAQKQVKSLQSLLK
K1700	EQTERSRKLAEQELI
S1710	EQELIETSERVQLLH
S1710	EQELIETSERVQLLH
S1718	ERVQLLHSQNTSLIN
S1722	LLHSQNTSLINQKKK
K1727	NTSLINQKKKMDADL
K1727	NTSLINQKKKMDADL
S1735	KKMDADLSQLQTEVE
T1739	ADLSQLQTEVEEAVQ
K1770	AMMAEELKKEQDTSA
N1784	AHLERMKNNMEQTIK
K1791	NNMEQTIKDLQHRLD
K1806	EAEQIALKGGKKQLQ
K1806	EAEQIALKGGKKQLQ
K1809	QIALKGGKKQLQKLE
K1809	QIALKGGKKQLQKLE
K1810	IALKGGKKQLQKLEA
K1814	GGKKQLQKLEARVRE
K1831	NELEAEQKRNAESVK
K1831	NELEAEQKRNAESVK
K1838	KRNAESVKGMRKSER
R1841	AESVKGMRKSERRIK
K1848	RKSERRIKELTyQTE
T1851	ERRIKELTyQTEEDR
Y1852-p	RRIKELTyQTEEDRK
T1854	IKELTyQTEEDRKNL
K1859	yQTEEDRKNLLRLQD
K1870	RLQDLVDKLQLKVKA
K1874	LVDKLQLKVKAYKRQ
T1891	EAEEQANTNLSKFRK
K1895	QANTNLSKFRKVQHE
K1898	TNLSKFRKVQHELDE
S1915	ERADIAESQVNKLRA
K1919	IAESQVNKLRAKSRD

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