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Protein Page:
MYH6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MYH6 Muscle contraction. Defects in MYH6 are the cause of atrial septal defect type 3 (ASD3). ASD3 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. Defects in MYH6 are the cause of familial hypertrophic cardiomyopathy type 14 (CMH14). It is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations,and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Defects in MYH6 are the cause of cardiomyopathy dilated type 1EE (CMD1EE). It is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in MYH6 are the cause of susceptibility to sick sinus syndrome type 3 (SSS3). The term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia-bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors. MYH6 variations are associated with susceptibility to sick sinus syndrome (PubMed:21378987). The lifetime risk of being diagnosed with sick sinus syndrome is higher for carriers of variant p.Arg721Trp than for non-carriers (PubMed:21378987). Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor protein
Chromosomal Location of Human Ortholog: 14q12
Cellular Component: sarcomere; focal adhesion; myofibril; cytoplasm; nucleolus; stress fiber; muscle myosin complex; cytosol; Z disc; nucleus; myosin complex
Molecular Function: calmodulin binding; microfilament motor activity; ATPase activity; actin binding; actin-dependent ATPase activity; protein kinase binding; ATP binding
Biological Process: ATP catabolic process; adult heart development; striated muscle contraction; in utero embryonic development; atrial cardiac muscle morphogenesis; regulation of heart rate; sarcomere organization; Wnt receptor signaling pathway through beta-catenin; regulation of heart contraction; muscle filament sliding; visceral muscle development; BMP signaling pathway; regulation of ATPase activity; myofibril assembly; muscle contraction; cardiac muscle fiber development; regulation of blood pressure; ventricular cardiac muscle morphogenesis; regulation of the force of heart contraction
Reference #:  P13533 (UniProtKB)
Alt. Names/Synonyms: alpha myosin heavy chain; alpha-MHC; alpha-myosin heavy chain; ASD3; cardiomyopathy, hypertrophic 1; CMD1EE; CMH14; MYH6; MYHC; MyHC-alpha; MYHCA; Myosin heavy chain 6; Myosin heavy chain, cardiac muscle alpha isoform; myosin, heavy chain 6, cardiac muscle, alpha; myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1); Myosin-6
Gene Symbols: MYH6
Molecular weight: 223,735 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
Select Structure to View Below

MYH6

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T2-p ______MtDAQMADF
0 1 K21 QYLRKSEKERLEAQT
0 1 T28 KERLEAQTRPFDIRT
0 3 K43 ECFVPDDKEEFVKAK
0 2 K48 DDKEEFVKAKILSRE
0 2 K58 ILSREGGKVIAETEN
0 2 K67 IAETENGKTVTVKED
0 1 K72 NGKTVTVKEDQVLQQ
1 0 S173 LTDRENQSILITGES
1 0 S180 SILITGESGAGKTVN
0 1 S197 RVIQYFASIAAIGDR
1 0 S197 RVIQYFASIAAIGDR
0 1 K206 AAIGDRGKKDNANAN
0 1 K207 AIGDRGKKDNANANK
0 2 K214 KDNANANKGTLEDQI
0 1 T216 NANANKGTLEDQIIQ
0 1 K247 DNSSRFGKFIRIHFG
0 1 T256-p IRIHFGAtGKLASAD
0 1 K258 IHFGAtGKLASADIE
0 1 Y267-p ASADIETyLLEKSRV
0 2 K271 IETyLLEKSRVIFQL
0 2 K279 SRVIFQLKAERNYHI
0 1 Y351 SEEKAGVYKLtGAIM
0 1 K352 EEKAGVYKLtGAIMH
0 2 K352 EEKAGVYKLtGAIMH
0 2 T354-p KAGVYKLtGAIMHyG
0 2 Y360-p LtGAIMHyGNMKFKQ
0 1 K364 IMHyGNMKFKQKQRE
0 1 K368 GNMKFKQKQREEQAE
0 2 K384 DGTEDADKSAYLMGL
0 23 Y387 EDADKSAYLMGLNSA
1 0 S393 AYLMGLNSADLLKGL
0 2 K398 LNSADLLKGLCHPRV
0 2 K406 GLCHPRVKVGNEyVt
0 202 Y411-p RVKVGNEyVtkGQSV
0 11 T413-p KVGNEyVtkGQSVQQ
0 1 K414-ac VGNEyVtkGQSVQQV
0 21 Y422-p GQSVQQVyySIGALA
0 28 Y423-p QSVQQVyySIGALAK
0 2 T447-p MVTRINAtLETKQPR
0 2 K451 INAtLETKQPRQYFI
0 32 K503-ac VLEQEEYkKEGIEWT
0 35 K550-ac KATDMTFkAKLyDNH
0 1 K550 KATDMTFKAKLyDNH
0 17 Y554-p MTFkAKLyDNHLGKS
0 1 K560 LyDNHLGKSNNFQKP
0 1 K566 GKSNNFQKPRNIKGK
0 2 K599 LGWLEKNKDPLNETV
1 0 S623 KLMATLFSSYATADT
1 0 T627 TLFSSYATADTGDSG
0 1 K635 ADTGDSGKSKGGKKK
0 1 K642 KSKGGKKKGSSFQTV
0 1 S644 KGGKKKGSSFQTVsA
1 0 S644 KGGKKKGSSFQTVsA
0 1 S645 GGKKKGSSFQTVsAL
1 0 S645 GGKKKGSSFQTVsAL
0 1 S650-p GSSFQTVsALHRENL
0 2 T662-p ENLNKLMtNLRttHP
0 1 R665 NKLMtNLRttHPHFV
0 1 T666-p KLMtNLRttHPHFVR
0 1 T667-p LMtNLRttHPHFVRC
0 1 K681 CIIPNERKAPGVMDN
0 8 Y717-p GFPNRILyGDFRQRY
1 0 S750 GTEKLLSSLDIDHNQ
0 39 Y758-p LDIDHNQykFGHTKV
0 43 K759-ac DIDHNQykFGHTKVF
0 2 K764 QykFGHTKVFFKAGL
0 2 K849 LKSAETEKEMATMKE
0 1 K855 EKEMATMKEEFGRIK
0 2 K867 RIKETLEKSEARRKE
0 1 S881 ELEEKMVSLLQEKND
1 0 S881 ELEEKMVSLLQEKND
0 2 K914 CDQLIKNKIQLEAKV
0 1 K941-ac MNAELTAkKRKLEDE
0 3 S950-p RKLEDECsELkkDID
0 9 K953-ac EDECsELkkDIDDLE
0 2 K953 EDECsELKkDIDDLE
0 3 K954-ac DECsELkkDIDDLEL
0 2 K954 DECsELkKDIDDLEL
0 1 T962-p DIDDLELtLAKVEKE
0 1 K978 HATENKVKNLtEEMA
0 2 T981-p ENKVKNLtEEMAGLD
0 2 K1024 DKVNSLSKSKVKLEQ
0 1 K1026 VNSLSKSKVKLEQQV
0 2 K1028 SLSKSKVKLEQQVDD
0 4 S1039-p QVDDLEGsLEQEkkV
1 0 S1039 QVDDLEGSLEQEkkV
0 55 K1044-ac EGsLEQEkkVRMDLE
0 16 K1045-ac GsLEQEkkVRMDLER
0 1 K1054-ac RMDLERAkRKLEGDL
0 1 K1056 DLERAkRKLEGDLKL
0 1 K1062 RKLEGDLKLTQESIM
0 1 K1075 IMDLENDKLQLEEKL
0 1 K1081 DKLQLEEKLKKKEFD
0 1 N1090 KKKEFDINQQNSKIE
0 1 S1094 FDINQQNSKIEDEQV
0 1 K1095 DINQQNSKIEDEQVL
0 2 K1108 VLALQLQKKLKENQA
0 1 K1109 LALQLQKKLKENQAR
0 4 T1129-p EELEAERtARAKVEK
0 2 S1139-p AKVEKLRsDLsRELE
0 3 S1142-p EKLRsDLsRELEEIS
1 0 S1149 sRELEEISERLEEAG
0 2 S1160-p EEAGGATsVQIEMNk
1 0 S1160 EEAGGATSVQIEMNk
0 3 K1167-ac sVQIEMNkKREAEFQ
0 2 T1184-p RRDLEEAtLQHEAtA
0 4 T1190-p AtLQHEAtAAALRKK
1 0 T1190 AtLQHEATAAALRKK
0 1 K1197 tAAALRKKHADsVAE
0 6 S1201-p LRKKHADsVAELGEQ
1 0 S1201 LRKKHADSVAELGEQ
0 1 K1221 RVKQKLEKEKsEFKL
0 2 S1224-p QKLEKEKsEFKLELD
0 1 K1227 EKEKsEFKLELDDVT
0 2 S1235-p LELDDVTsNMEQIIK
0 2 K1242 sNMEQIIKAKANLEK
0 2 K1249 KAKANLEKVSRTLED
0 89 Y1261-p LEDQANEyRVKLEEA
0 1 K1264 QANEyRVKLEEAQRS
0 1 S1271 KLEEAQRSLNDFTTQ
0 1 T1277 RSLNDFTTQRAKLQT
0 4 K1281 DFTTQRAKLQTENGE
0 1 T1284 TQRAKLQTENGELAR
0 2 K1296 LARQLEEKEALIsQL
0 5 S1301-p EEKEALIsQLTRGKL
0 2 K1307 IsQLTRGKLsytQQM
0 6 S1309-p QLTRGKLsytQQMED
1 0 S1309 QLTRGKLSytQQMED
0 106 Y1310-p LTRGKLsytQQMEDL
0 4 T1311-p TRGKLsytQQMEDLk
0 17 K1318-ac tQQMEDLkRQLEEEG
0 1 K1318 tQQMEDLKRQLEEEG
0 1 S1337 ALAHALQSARHDCDL
1 0 S1337 ALAHALQSARHDCDL
0 92 Y1349-p CDLLREQyEEETEAK
0 1 K1356 yEEETEAKAELQRVL
0 2 S1364-p AELQRVLsKANsEVA
0 2 K1365 ELQRVLsKANsEVAQ
0 3 S1368-p RVLsKANsEVAQWRt
0 15 T1375-p sEVAQWRtKyEtDAI
0 1 K1376 EVAQWRtKyEtDAIQ
0 2 K1376 EVAQWRtKyEtDAIQ
0 237 Y1377-p VAQWRtKyEtDAIQR
0 5 T1379-p QWRtKyEtDAIQRtE
0 1 T1385-p EtDAIQRtEELEEAk
0 51 K1392-ac tEELEEAkkkLAQRL
0 3 K1392 tEELEEAKkkLAQRL
0 33 K1393-ac EELEEAkkkLAQRLQ
0 1 K1393 EELEEAkKkLAQRLQ
0 2 K1394-ac ELEEAkkkLAQRLQD
0 3 K1412 AVEAVNAKCSSLEKT
0 49 K1446-ac AAAAALDkkQRNFDK
0 2 K1446 AAAAALDKkQRNFDK
0 7 K1447-ac AAAALDkkQRNFDKI
0 2 K1459 DKILAEWKQKyEESQ
0 1 K1461 ILAEWKQKyEESQsE
0 131 Y1462-p LAEWKQKyEESQsEL
0 3 S1467-p QKyEESQsELESsQK
1 0 S1471 ESQsELESsQKEARs
0 1 S1472-p SQsELESsQKEARsL
1 0 S1472 SQsELESSQKEARsL
0 3 K1474 sELESsQKEARsLst
0 4 S1478-p SsQKEARsLstELFK
0 4 S1480-p QKEARsLstELFKLK
0 2 T1481-p KEARsLstELFKLKN
0 2 K1487 stELFKLKNAyEEsL
0 123 Y1490-p LFKLKNAyEEsLEHL
0 5 S1493-p LKNAyEEsLEHLETF
0 59 K1501-ac LEHLETFkRENKNLQ
0 2 K1501 LEHLETFKRENKNLQ
0 2 K1505 ETFkRENKNLQEEIS
0 2 S1512 KNLQEEISDLTEQLG
0 3 K1523 EQLGEGGKNVHELEK
0 2 K1530 KNVHELEKVRKQLEV
0 2 K1533 HELEKVRKQLEVEKL
0 1 K1539 RKQLEVEKLELQSAL
0 3 S1544 VEKLELQSALEEAEA
0 2 K1559 SLEHEEGKILRAQLE
0 4 K1571 QLEFNQIKAEIERKL
0 48 K1589-ac DEEMEQAkRNHQRVV
0 2 K1589 DEEMEQAKRNHQRVV
0 4 S1598-p NHQRVVDsLQTsLDA
1 0 S1598 NHQRVVDSLQTsLDA
1 0 T1601 RVVDsLQTsLDAETR
0 6 S1602-p VVDsLQTsLDAETRS
1 0 T1607 QTsLDAETRSRNEVL
0 1 K1618 NEVLRVKKKMEGDLN
0 1 K1619 EVLRVKKKMEGDLNE
0 3 S1632-p NEMEIQLsHANRMAA
0 1 A1639 sHANRMAAEAQKQVK
0 3 K1643 RMAAEAQKQVKSLQS
0 3 K1646 AEAQKQVKSLQSLLK
0 3 K1653 KSLQSLLKDTQIQLD
0 1 K1670 VRANDDLKENIAIVE
0 3 K1702 EQTERSRKLAEQELI
0 2 S1712-p EQELIETsERVQLLH
1 0 S1712 EQELIETSERVQLLH
0 5 S1720-p ERVQLLHsQNTsLIN
0 4 S1724-p LLHsQNTsLINQkKK
0 44 K1729-ac NTsLINQkKKMESDL
0 2 K1729 NTsLINQKKKMESDL
0 1 S1734 NQkKKMESDLTQLQS
0 1 K1772-ac AMMAEELkKEQDTSA
1 0 S1778 LkKEQDTSAHLERMK
0 2 K1786-ac AHLERMKkNMEQTIK
0 3 K1793 kNMEQTIKDLQHRLD
0 3 K1808-ac EAEQIALkGGkkQLQ
0 1 K1808 EAEQIALKGGkkQLQ
0 49 K1811-ac QIALkGGkkQLQKLE
0 1 K1811 QIALkGGKkQLQKLE
0 4 K1812-ac IALkGGkkQLQKLEA
0 2 K1816 GGkkQLQKLEARVRE
0 5 K1833-ac GELEAEQkRNAESVK
0 2 K1833 GELEAEQKRNAESVK
0 2 K1840 kRNAESVKGMRKSER
0 1 R1843 AESVKGMRKSERRIK
0 3 K1850 RKSERRIKELtyQTE
0 5 T1853-p ERRIKELtyQTEEDk
0 89 Y1854-p RRIKELtyQTEEDkK
0 2 T1856 IKELtyQTEEDkKNL
0 3 K1860-ac tyQTEEDkKNLLRLQ
0 1 K1860 tyQTEEDKKNLLRLQ
0 1 K1861 yQTEEDkKNLLRLQD
0 3 K1872 RLQDLVDKLQLKVKA
0 2 K1876 LVDKLQLKVKAYKRQ
0 3 T1893-p EAEEQANtNLsKFRK
0 2 S1896-p EQANtNLsKFRKVQH
0 2 K1897 QANtNLsKFRKVQHE
0 2 K1900 tNLsKFRKVQHELDE
0 4 S1917-p ERADIAEsQVNKLRA
1 0 S1917 ERADIAESQVNKLRA
0 3 K1921 IAEsQVNKLRAKSRD
0 2 K1932 KSRDIGAKQKMHDEE
0 2 K1934 RDIGAKQKMHDEE__
  mouse

 
T2 ______MTDAQMADF
K21-ub QYLRKSEkERLEAQt
T28-p kERLEAQtRPFDIRT
K43-ub ECFVPDDkEEYVkAK
K48-ub DDkEEYVkAKVVSRE
K58-ub VVSREGGkVTAETEN
K67-ub TAETENGkTVTIkED
K72-ub NGkTVTIkEDQVMQQ
S173 LTDRENQSILITGES
S180 SILITGESGAGKTVN
S197-p RVIQYFAsIAAIGDR
S197 RVIQYFASIAAIGDR
K206-ub AAIGDRSkkENPNAN
K207-ub AIGDRSkkENPNANk
K214-ub kENPNANkGtLEDQI
T216-p NPNANkGtLEDQIIQ
K247-ac DNSSRFGkFIRIHFG
T256 IRIHFGATGkLASAD
K258-ac IHFGATGkLASADIE
Y267 ASADIETYLLEkSRV
K271-ub IETYLLEkSRVIFQL
K279-ub SRVIFQLkAERNYHI
Y351-p AEEKAGVykLtGAIM
K352-m1 EEKAGVykLtGAIMH
K352-ub EEKAGVykLtGAIMH
T354-p KAGVykLtGAIMHYG
Y360 LtGAIMHYGNMkFKQ
K364-ub IMHYGNMkFKQkQRE
K368-ub GNMkFKQkQREEQAE
K384-ub DGTEDADkSAYLMGL
Y387 EDADkSAYLMGLNSA
S393 AYLMGLNSADLLkGL
K398-ub LNSADLLkGLCHPRV
K406-ub GLCHPRVkVGNEyVt
Y411-p RVkVGNEyVtKGQSV
T413-p kVGNEyVtKGQSVQQ
K414 VGNEyVtKGQSVQQV
Y422 GQSVQQVYYSIGALA
Y423 QSVQQVYYSIGALAK
T447 MVTRINATLETkQPR
K451-ub INATLETkQPRQYFI
K503 VLEQEEYKKEGIEWE
K550 KASDMTFKAKLYDNH
K550-m1 KASDMTFkAKLYDNH
Y554 MTFkAKLYDNHLGkS
K560-m1 LYDNHLGkSNNFQkP
K566-ac GkSNNFQkPRNVKGK
K599-ub MGWLEKNkDPLNETV
S623 KLMATLFSTYASADT
S627 TLFSTYASADTGDSG
K635-ub ADTGDSGkGKGGKKk
K642-m1 kGKGGKKkGssFQTV
S644-p KGGKKkGssFQTVSA
S644 KGGKKkGSsFQTVSA
S645-p GGKKkGssFQTVSAL
S645 GGKKkGsSFQTVSAL
S650 GssFQTVSALHRENL
T662 ENLNKLMTNLkTTHP
K665-ub NKLMTNLkTTHPHFV
T666 KLMTNLkTTHPHFVR
T667 LMTNLkTTHPHFVRC
K681-ub CIIPNERkAPGVMDN
Y717 GFPNRILYGDFRQRY
S750 GAEKLLGSLDIDHNQ
Y758 LDIDHNQYkFGHTkV
K759-ac DIDHNQYkFGHTkVF
K764-ub QYkFGHTkVFFKAGL
K849-ub LKSAETEkEMANMkE
K855-ub EkEMANMkEEFGRVK
K867-ub RVKDALEkSEARRKE
S881-p ELEEKMVsLLQEKND
S881 ELEEKMVSLLQEKND
K914-ub CDQLIKNkIQLEAKV
K941 MNAELTAKKRKLEDE
S950-p RKLEDECsELkkDID
K953-ac EDECsELkkDIDDLE
K953-ub EDECsELkkDIDDLE
K954 DECsELkKDIDDLEL
K954-ub DECsELkkDIDDLEL
T962 DIDDLELTLAKVEKE
K978-ub HATENKVkNLtEEMA
T981-p ENKVkNLtEEMAGLD
K1024-ub DKVNTLTkSkVkLEQ
K1026-ub VNTLTkSkVkLEQQV
K1028-ub TLTkSkVkLEQQVDD
S1039-p QVDDLEGsLEQEKKV
S1039 QVDDLEGSLEQEKKV
K1044 EGsLEQEKKVRMDLE
K1045 GsLEQEKKVRMDLER
K1054 RMDLERAKRkLEGDL
K1056-ub DLERAKRkLEGDLkL
K1062-ub RkLEGDLkLTQESIM
K1075-ub IMDLENDkLQLEEkL
K1081-ub DkLQLEEkLKKKEFD
S1090-p KKKEFDIsQQNskIE
S1094-p FDIsQQNskIEDEQA
K1095-ub DIsQQNskIEDEQAL
K1108-ub ALALQLQkkLKENQA
K1109-ub LALQLQkkLKENQAR
T1129-p EELEAERtARAKVEK
S1139 AKVEKLRSDLsRELE
S1142-p EKLRSDLsRELEEIS
S1149 sRELEEISERLEEAG
S1160-p EEAGGATsVQIEMNK
S1160 EEAGGATSVQIEMNK
K1167 sVQIEMNKKREAEFQ
T1184 RRDLEEATLQHEAtA
T1190-p ATLQHEAtAAALRKk
T1190 ATLQHEATAAALRKk
K1197-ub tAAALRKkHADsVAE
S1201-p LRKkHADsVAELGEQ
S1201 LRKkHADSVAELGEQ
K1221-ub RVKQKLEkEKsEFkL
S1224-p QKLEkEKsEFkLELD
K1227-ub EkEKsEFkLELDDVT
S1235-p LELDDVTsNMEQIIk
K1242-ub sNMEQIIkAKANLEk
K1249-ub kAKANLEkVSRTLED
Y1261-p LEDQANEyRVkLEEA
K1264-ub QANEyRVkLEEAQRs
S1271-p kLEEAQRsLNDFTtQ
T1277-p RsLNDFTtQRAkLQt
K1281-ub DFTtQRAkLQtENGE
T1284-p tQRAkLQtENGELAR
K1296-ub LARQLEEkEALIsQL
S1301-p EEkEALIsQLTRGkL
K1307-ub IsQLTRGkLsytQQM
S1309-p QLTRGkLsytQQMED
S1309 QLTRGkLSytQQMED
Y1310-p LTRGkLsytQQMEDL
T1311-p TRGkLsytQQMEDLk
K1318-ac tQQMEDLkRQLEEEG
K1318-ub tQQMEDLkRQLEEEG
S1337-p ALAHALQsSRHDCDL
S1337 ALAHALQSSRHDCDL
Y1349-p CDLLREQyEEEMEAk
K1356-ub yEEEMEAkAELQRVL
S1364-p AELQRVLskANsEVA
K1365-ub ELQRVLskANsEVAQ
S1368-p RVLskANsEVAQWRt
T1375-p sEVAQWRtkyEtDAI
K1376-ac EVAQWRtkyEtDAIQ
K1376-ub EVAQWRtkyEtDAIQ
Y1377-p VAQWRtkyEtDAIQR
T1379-p QWRtkyEtDAIQRTE
T1385 EtDAIQRTEELEEAk
K1392-ac TEELEEAkkKLAQRL
K1392-ub TEELEEAkkKLAQRL
K1393 EELEEAkKKLAQRLQ
K1393-ub EELEEAkkKLAQRLQ
K1394 ELEEAkkKLAQRLQD
K1412-ub AVEAVNAkCSSLEKT
K1446 AAAAALDKKQRNFDK
K1446-ub AAAAALDkKQRNFDK
K1447 AAAALDkKQRNFDKI
K1459-ub DKILAEWkQkyEESQ
K1461-ub ILAEWkQkyEESQsE
Y1462-p LAEWkQkyEESQsEL
S1467-p QkyEESQsELESSQk
S1471 ESQsELESSQkEARs
S1472 SQsELESSQkEARsL
S1472 SQsELESSQkEARsL
K1474-ub sELESSQkEARsLsT
S1478-p SSQkEARsLsTELFK
S1480-p QkEARsLsTELFKLk
T1481 kEARsLsTELFKLkN
K1487-ub sTELFKLkNAyEEsL
Y1490-p LFKLkNAyEEsLEHL
S1493-p LkNAyEEsLEHLETF
K1501-ac LEHLETFkRENkNLQ
K1501-ub LEHLETFkRENkNLQ
K1505-ub ETFkRENkNLQEEIs
S1512-p kNLQEEIsDLTEQLG
K1523-ub EQLGEGGkNVHELEk
K1530-ub kNVHELEkIRkQLEV
K1533-ub HELEkIRkQLEVEkL
K1539-ub RkQLEVEkLELQsAL
S1544-p VEkLELQsALEEAEA
K1559-ub SLEHEEGkILRAQLE
K1571-ub QLEFNQIkAEIERKL
K1589-ac DEEMEQAkRNHLRMV
K1589-ub DEEMEQAkRNHLRMV
S1598-p NHLRMVDsLQTsLDA
S1598 NHLRMVDSLQTsLDA
T1601 RMVDsLQTsLDAETR
S1602-p MVDsLQTsLDAETRS
T1607 QTsLDAETRSRNEAL
K1618-ub NEALRVKkkMEGDLN
K1619-ub EALRVKkkMEGDLNE
S1632-p NEMEIQLsQANRIAs
S1639-p sQANRIAsEAQkHLk
K1643-ub RIAsEAQkHLkNSQA
K1646-ub sEAQkHLkNSQAHLk
K1653-ub kNSQAHLkDTQLQLD
K1670-ub VHANDDLkENIAIVE
K1702-ub EQTERSRkLAEQELI
S1712-p EQELIETsERVQLLH
S1712 EQELIETSERVQLLH
S1720-p ERVQLLHsQNTsLIN
S1724-p LLHsQNTsLINQkKK
K1729 NTsLINQKKKMEsDL
K1729-ub NTsLINQkKKMEsDL
S1734-p NQkKKMEsDLTQLQT
K1772 AMMAEELKKEQDTSA
S1778 LKKEQDTSAHLERMK
K1786 AHLERMKKNMEQTIk
K1793-ub KNMEQTIkDLQHRLD
K1808 EAEQIALKGGkKQLQ
K1808-ub EAEQIALkGGkKQLQ
K1811 QIALkGGKKQLQkLE
K1811-ub QIALkGGkKQLQkLE
K1812 IALkGGkKQLQkLEA
K1816-ub GGkKQLQkLEARVRE
K1833 NELEAEQKRNAESVk
K1833-ub NELEAEQkRNAESVk
K1840-ub kRNAESVkGMrKSER
R1843-m1 AESVkGMrKSERRIk
K1850-ub rKSERRIkELtyQtE
T1853-p ERRIkELtyQtEEDk
Y1854-p RRIkELtyQtEEDkk
T1856-p IkELtyQtEEDkkNL
K1860 tyQtEEDKkNLMRLQ
K1860-ub tyQtEEDkkNLMRLQ
K1861-ub yQtEEDkkNLMRLQD
K1872-ub RLQDLVDkLQLkVKA
K1876-ub LVDkLQLkVKAYKRQ
T1893-p EAEEQANtNLSkFRk
S1896 EQANtNLSkFRkVQH
K1897-ub QANtNLSkFRkVQHE
K1900-ub tNLSkFRkVQHELDE
S1917-p ERADIAEsQVNkLRA
S1917 ERADIAESQVNkLRA
K1921-ub IAEsQVNkLRAKSRD
K1932-ub KSRDIGAkkMHDEE_
K1933-ub SRDIGAkkMHDEE__
  rat

 
T2 ______MTDAQMADF
K20 RYLRKSEKERLEAQT
T27 KERLEAQTRPFDIRT
K42 ECFVPDDKEEYVKAK
K47 DDKEEYVKAKIVSRE
K57 IVSREGGKVTAETEN
K66 TAETENGKTVTVKED
K71 NGKTVTVKEDQVMQQ
S172-gl LTDRENQsILITGEs
S179-gl sILITGEsGAGKTVN
S196 RVIQYFASIAAIGDR
S196-gl RVIQYFAsIAAIGDR
K205 AAIGDRSKKDNPNAN
K206 AIGDRSKKDNPNANK
K213 KDNPNANKGTLEDQI
T215 NPNANKGTLEDQIIQ
K246-ac DNSSRFGkFIRIHFG
T255-p IRIHFGAtGKLASAD
K257 IHFGAtGKLASADIE
Y266 ASADIETYLLEKSRV
K270 IETYLLEKSRVIFQL
K278 SRVIFQLKAERNYHI
Y350 AEEKAGVYKLTGAIM
K351 EEKAGVYKLTGAIMH
K351 EEKAGVYKLTGAIMH
T353 KAGVYKLTGAIMHYG
Y359 LTGAIMHYGNMKFKQ
K363 IMHYGNMKFKQKQRE
K367 GNMKFKQKQREEQAE
K383 DGTEDADKSAyLMGL
Y386-p EDADKSAyLMGLNsA
S392-gl AyLMGLNsADLLKGL
K397 LNsADLLKGLCHPRV
K405 GLCHPRVKVGNEyVt
Y410-p RVKVGNEyVtKGQSV
T412-p KVGNEyVtKGQSVQQ
K413 VGNEyVtKGQSVQQV
Y421-p GQSVQQVyySIGALA
Y422-p QSVQQVyySIGALAK
T446-p MVTRINAtLETKQPR
K450 INAtLETKQPRQYFI
K502-ac VLEQEEYkKEGIEWE
K549-ac KATDMTFkAKLyDNH
K549 KATDMTFKAKLyDNH
Y553-p MTFkAKLyDNHLGKS
K559 LyDNHLGKSNNFQkP
K565-ac GKSNNFQkPRNVKGK
K598 LGWLEKNKDPLNETV
S622-gl KLMATLFsTYAsADT
S626-gl TLFsTYAsADTGDSG
K634 ADTGDSGKGKGGKKK
K641 KGKGGKKKGssFQTV
S643 KGGKKKGSsFQTVSA
S643-gl KGGKKKGssFQTVSA
S644 GGKKKGsSFQTVSAL
S644-gl GGKKKGssFQTVSAL
S649 GssFQTVSALHRENL
T661-p ENLNKLMtNLRTTHP
R664 NKLMtNLRTTHPHFV
T665 KLMtNLRTTHPHFVR
T666 LMtNLRTTHPHFVRC
K680 CIIPNERKAPGVMDN
Y716-p GFPNRILyGDFRQRY
S749-gl GAEKLLGsLDIDHNQ
Y757-p LDIDHNQykFGHTKV
K758-ac DIDHNQykFGHTKVF
K763 QykFGHTKVFFKAGL
K848 LKSAETEKEMANMKE
K854 EKEMANMKEEFGRVK
K866 RVKDALEKSEARRKE
S880-p ELEEKMVsLLQEKND
S880-gl ELEEKMVsLLQEKND
K913 CDQLIKNKIQLEAKV
K940 MNAELTAKKRKLEDE
S949-p RKLEDECsELkkDID
K952-ac EDECsELkkDIDDLE
K952 EDECsELKkDIDDLE
K953-ac DECsELkkDIDDLEL
K953 DECsELkKDIDDLEL
T961-p DIDDLELtLAKVEKE
K977 HATENKVKNLTEEMA
T980 ENKVKNLTEEMAGLD
K1023 DKVNTLTKSKVKLEQ
K1025 VNTLTKSKVKLEQQV
K1027 TLTKSKVKLEQQVDD
S1038-p QVDDLEGsLEQEkKV
S1038-gl QVDDLEGsLEQEkKV
K1043-ac EGsLEQEkKVRMDLE
K1044 GsLEQEkKVRMDLER
K1053 RMDLERAKRKLEGDL
K1055 DLERAKRKLEGDLKL
K1061 RKLEGDLKLTQESIM
K1074 IMDLENDKLQLEEKL
K1080 DKLQLEEKLKKKEFD
S1089-p KKKEFDIsQQNSKIE
S1093 FDIsQQNSKIEDEQA
K1094 DIsQQNSKIEDEQAL
K1107 ALALQLQKKLKENQA
K1108 LALQLQKKLKENQAR
T1128 EELEAERTARAKVEK
S1138-p AKVEKLRsDLTRELE
T1141 EKLRsDLTRELEEIs
S1148-gl TRELEEIsERLEEAG
S1159 EEAGGATSVQIEMNK
S1159-gl EEAGGATsVQIEMNK
K1166 sVQIEMNKKREAEFQ
T1183-p RRDLEEAtLQHEAtA
T1189-p AtLQHEAtAAALRKK
T1189-gl AtLQHEAtAAALRKK
K1196 tAAALRKKHADsVAE
S1200-p LRKKHADsVAELGEQ
S1200-gl LRKKHADsVAELGEQ
K1220 RVKQKLEKEKSEFKL
S1223 QKLEKEKSEFKLELD
K1226 EKEKSEFKLELDDVT
S1234 LELDDVTSHMEQIIK
K1241 SHMEQIIKAKANLEK
K1248 KAKANLEKVSRTLED
Y1260-p LEDQANEyRVKLEEA
K1263 QANEyRVKLEEAQRs
S1270-p KLEEAQRsLNDFTtQ
T1276-p RsLNDFTtQRAKLQt
K1280 DFTtQRAKLQtENGE
T1283-p tQRAKLQtENGELAR
K1295 LARQLEEKEALIWQL
W1300 EEKEALIWQLTRGKL
K1306 IWQLTRGKLsytQQM
S1308-p QLTRGKLsytQQMED
S1308-gl QLTRGKLsytQQMED
Y1309-p LTRGKLsytQQMEDL
T1310-p TRGKLsytQQMEDLk
K1317-ac tQQMEDLkRQLEEEG
K1317 tQQMEDLKRQLEEEG
S1336-p ALAHALQsARHDCDL
S1336-gl ALAHALQsARHDCDL
Y1348-p CDLLREQyEEEMEAK
K1355 yEEEMEAKAELQRVL
S1363 AELQRVLSKANsEVA
K1364 ELQRVLSKANsEVAQ
S1367-p RVLSKANsEVAQWRt
T1374-p sEVAQWRtkyEtDAI
K1375-ac EVAQWRtkyEtDAIQ
K1375 EVAQWRtKyEtDAIQ
Y1376-p VAQWRtkyEtDAIQR
T1378-p QWRtkyEtDAIQRtE
T1384-p EtDAIQRtEELEEAk
K1391-ac tEELEEAkKKLAQRL
K1391 tEELEEAKKKLAQRL
K1392 EELEEAkKKLAQRLQ
K1392 EELEEAkKKLAQRLQ
K1393 ELEEAkKKLAQRLQD
K1411 AVEAVNAKCSSLEKT
K1445-ac AAAAALDkKQRNFDK
K1445 AAAAALDKKQRNFDK
K1446 AAAALDkKQRNFDKI
K1458 DKILAEWKQKyEESQ
K1460 ILAEWKQKyEESQsE
Y1461-p LAEWKQKyEESQsEL
S1466-p QKyEESQsELEssQK
S1470-gl ESQsELEssQKEARs
S1471-p SQsELEssQKEARsL
S1471-gl SQsELEssQKEARsL
K1473 sELEssQKEARsLst
S1477-p ssQKEARsLstELFK
S1479-p QKEARsLstELFKLK
T1480-p KEARsLstELFKLKN
K1486 stELFKLKNAyEEsL
Y1489-p LFKLKNAyEEsLEHL
S1492-p LKNAyEEsLEHLETF
K1500-ac LEHLETFkRENKNLQ
K1500 LEHLETFKRENKNLQ
K1504 ETFkRENKNLQEEIs
S1511-p KNLQEEIsDLTEQLG
K1522 EQLGEGGKNVHELEK
K1529 KNVHELEKIRKQLEV
K1532 HELEKIRKQLEVEKL
K1538 RKQLEVEKLELQsAL
S1543-p VEKLELQsALEEAEA
K1558 SLEHEEGKILRAQLE
K1570 QLEFNQIKAEIERKL
K1588-ac DEEMEQAkRNHLRVV
K1588 DEEMEQAKRNHLRVV
S1597-p NHLRVVDsLQtsLDA
S1597-gl NHLRVVDsLQtsLDA
T1600-gl RVVDsLQtsLDAEtR
S1601-p VVDsLQtsLDAEtRS
T1606-gl QtsLDAEtRSRNEAL
K1617 NEALRVKKKMEGDLN
K1618 EALRVKKKMEGDLNE
S1631 NEMEIQLSQANRIAS
S1638 SQANRIASEAQKHLK
K1642 RIASEAQKHLKNAQA
K1645 SEAQKHLKNAQAHLK
K1652 KNAQAHLKDTQLQLD
K1669 VRANDDLKENIAIVE
K1701 EQTERSRKLAEQELI
S1711 EQELIETSERVQLLH
S1711-gl EQELIETsERVQLLH
S1719-p ERVQLLHsQNTsLIN
S1723-p LLHsQNTsLINQkKK
K1728-ac NTsLINQkKKMDADL
K1728 NTsLINQKKKMDADL
A1733 NQkKKMDADLSQLQT
K1771-ac AMMAEELkKEQDTsA
S1777-gl LkKEQDTsAHLERMK
K1785 AHLERMKKNMEQTIk
K1792-ub KNMEQTIkDLQHRLD
K1807 EAEQIALKGGKKQLQ
K1807 EAEQIALKGGKKQLQ
K1810 QIALKGGKKQLQKLE
K1810 QIALKGGKKQLQKLE
K1811 IALKGGKKQLQKLEA
K1815 GGKKQLQKLEARVRE
K1832-ac NELEAEQkRNAESVK
K1832 NELEAEQKRNAESVK
K1839 kRNAESVKGMRKSER
R1842 AESVKGMRKSERRIK
K1849 RKSERRIKELTyQTE
T1852 ERRIKELTyQTEEDK
Y1853-p RRIKELTyQTEEDKK
T1855 IKELTyQTEEDKKNL
K1859 TyQTEEDKKNLVRLQ
K1859 TyQTEEDKKNLVRLQ
K1860 yQTEEDKKNLVRLQD
K1871 RLQDLVDKLQLKVKA
K1875 LVDKLQLKVKAYKRQ
T1892 EAEEQANTNLsKFRK
S1895-p EQANTNLsKFRKVQH
K1896 QANTNLsKFRKVQHE
K1899 TNLsKFRKVQHELDE
S1916-p ERADIAEsQVNKLRA
S1916-gl ERADIAEsQVNKLRA
K1920 IAEsQVNKLRAKSRD
K1931 KSRDIGAKQKMHDEE
K1933 RDIGAKQKMHDEE__
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