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Protein Page:
XBP1 iso2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
XBP1 iso2 a transcription factor essential for hepatocyte growth, the differentiation of plasma cells, immunoglobulin secretion, and the unfolded protein response (UPR). XBP1 mRNA is spliced by IRE1 during the UPR to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. Only the spliced form of XBP1 can activate the UPR efficiently. Activates UPR target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I. Up-regulated by ATF6 via direct binding to the ERSE in response to endoplasmic reticulum stress. Genetic variations in XBP1 could be associated with susceptibility to major affective disorder type 7 (MAFD7). Major affective disorders represent a class of mental disorders characterized by a disturbance in mood as their predominant feature. Two human isoforms are produced by alternative splicing. Isoform 1 is also known as XBP-1U. Isoform 2, also known as XBP-1S, is produced by IRE1 in response to endoplasmic reticulum stress. IRE1 cleaves a 26-bp fragment causing a frameshift of the mRNA transcript. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Chromosomal Location of Human Ortholog: 22q12.1|22q12
Cellular Component: nucleoplasm; endoplasmic reticulum membrane; endoplasmic reticulum; cytoplasm; integral to membrane; integral to endoplasmic reticulum membrane; nucleus; cytosol
Molecular Function: protein binding; protein homodimerization activity; protease binding; DNA binding; protein heterodimerization activity; chromatin DNA binding; ubiquitin protein ligase binding; estrogen receptor binding; protein kinase binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; ubiquitin-dependent protein catabolic process; phosphoinositide 3-kinase cascade; muscle development; apoptosis; exocrine pancreas development; positive regulation of transcription of target genes involved in unfolded protein response; regulation of protein stability; negative regulation of transcription from RNA polymerase II promoter; cellular response to glucose starvation; protein transport; serotonin secretion, neurotransmission; positive regulation of MHC class II biosynthetic process; positive regulation of transcription factor import into nucleus; angiogenesis; cell growth; response to electrical stimulus; positive regulation of autophagy; fatty acid biosynthetic process; positive regulation of TOR signaling pathway; response to drug; positive regulation of histone methylation; protein destabilization; unfolded protein response; organelle organization and biogenesis; cellular response to nutrient; positive regulation of immunoglobulin secretion; liver development; cholesterol homeostasis; positive regulation of immunoglobulin production; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; cellular response to insulin stimulus; positive regulation of T cell differentiation; fatty acid homeostasis; endothelial cell proliferation; autophagy; positive regulation of fat cell differentiation; positive regulation of B cell differentiation; neuron development; positive regulation of transcription from RNA polymerase II promoter; immune response; positive regulation of protein amino acid phosphorylation; vascular endothelial growth factor receptor signaling pathway; sterol homeostasis; negative regulation of apoptosis
Reference #:  P17861-2 (UniProtKB)
Alt. Names/Synonyms: TREB5; X-box binding protein 1; XBP-1S; XBP1; XBP1(S); XBP2
Gene Symbols: XBP1
Molecular weight: 40,148 Da
Basal Isoelectric point: 4.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

XBP1 iso2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 S47-p VPAQRGAsPEAASGG
1 0 L55 PEAASGGLPQARKRQ
2 2 S68-p RQRLTHLsPEEKALR
0 1 S96-p DRKKARMsELEQQVV
0 1 K111-ub DLEEENQkLLLENQL
0 6 K151-ub AEEEAEAkGNEVRPV
1 0 S181-p QQVQAQLsPLQNISP
0 1 K236-ub SSQRSTQkDPVPYQP
0 1 S255-p QWGRHQPsWKPLMN_
0 1 - gap
1 0 - gap
0 1 - under review  
1 0 - gap
  XBP1 iso2  
S47 VPAQRGASPEAASGG
L55 PEAASGGLPQARKRQ
S68 RQRLTHLSPEEKALR
S96 DRKKARMSELEQQVV
K111 DLEEENQKLLLENQL
K151 AEEEAEAKGNEVRPV
- gap
- gap
- gap
K262-ub RFDHIYTkPLVLEIP
K281 SQANVVVKIEEAPLs
S288-p KIEEAPLsPSENDHP
K302 PEFIVSVKEEPVEDD
  mouse

► Hide Isoforms
 
G42 VPGPRAAGSEASGtP
T48-p AGSEASGtPQARKRQ
S61-p RQRLTHLsPEEKALR
S89 DRKKARMSELEQQVV
K104 DLEEENHKLQLENQL
K146 EVPEVEAKGSGVRLV
S176 QQVQAQLSPPQNIFP
K231 NSQRSTQKDLVPYQP
S250 QWGPHQPSWKPLMNS
- gap
- gap
- under review  
- gap
  XBP1 iso2  
G42 VPGPRAAGSEASGTP
T48 AGSEASGTPQARKRQ
S61 RQRLTHLSPEEKALR
S89 DRKKARMSELEQQVV
K104 DLEEENHKLQLENQL
K146 EVPEVEAKGSGVRLV
- gap
- gap
- gap
K257 RFDHVYTKPLVLEIP
K276-sm SQTNVVVkIEEAPLS
S283 kIEEAPLSSSEEDHP
K297-sm PEFIVSVkKEPLEDD
  rat

 
G42 VPGPRAAGSEASGTP
T48 AGSEASGTPQARKRQ
S61 RQRLTHLSPEEKALR
S89 DRKKARMSELEQQVV
K104 DLEEENQKLQLENQL
K146 EVSEAESKGNGVRLV
S176 QQVQAQLSPPQNIFP
K231 NSQRSTQKDLVPYQP
S250 QWGPHQPSWKPLMNS
- gap
- gap
- under review  
- gap
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