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NKX2-5 (human)

Overview NKX2-5 Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4. Interacts with HIPK1 and HIPK2, but not HIPK3. Interacts with the C-terminal zinc finger of GATA4 through its homeobox domain. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with FBLIM1. Expressed only in the heart. Belongs to the NK-2 homeobox family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: DNA binding protein Cellular Component: transcription factor complex; cytoplasm; nucleus Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; identical protein binding; protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; chromatin binding; transcription factor binding; transcription factor activity Biological Process: heart morphogenesis; ventricular cardiac myofibril development; positive regulation of transcription, DNA-dependent; ventricular cardiac muscle cell development; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; cardiac muscle cell differentiation; response to estradiol stimulus; BMP signaling pathway; atrial cardiac muscle cell development; cardiac muscle morphogensis; positive regulation of cell proliferation; thyroid gland development; regulation of cardiac muscle cell proliferation; hemopoiesis; heart looping; vasculogenesis; cell differentiation; cardiac muscle contraction; spleen development; adult heart development; pharyngeal system development; sarcomere organization; positive regulation of cardioblast differentiation; embryonic heart tube development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation; negative regulation of transcription, DNA-dependent; positive regulation of heart contraction; negative regulation of apoptosis Reference #:  P52952 (UniProtKB) Alt. Names/Synonyms: Cardiac-specific homeobox; cardiac-specific homeobox 1; CHNG5; CSX; CSX1; FLJ52202; FLJ97166; FLJ97195; FLJ97197; FLJ99536; Homeobox protein CSX; Homeobox protein NK-2 homolog E; Homeobox protein Nkx-2.5; NK2 transcription factor related, locus 5 (Drosophila); NKX2-5; NKX2.5; NKX25; NKX2E; NKX4-1; tinman paralog Gene Symbols: NKX2-5 Molecular weight: 34,918 Da Basal Isoelectric point: 9.46  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NKX2-5 3RKQ - A/B=138-194 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  DISEASE 108900 187500 225250 600584  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
1	0		K52	SCMLAAFKPEAYAGP
0	1		-	gap
0	1		-	gap
1	1		S164-p	FKQQRYLsAPERDQL
0	1		T180-p	SVLKLTStQVKIWFQ
0	1		R225-m2	IAVPVLVrDGKPCLG

	NKX2-5 iso4
K52	SCMLAAFKPEAYAGP
S139-p	PDFLQMLsEtCRWLP
T141-p	FLQMLsEtCRWLPVH
-	gap
-	gap
-	gap

	mouse
K51-s	SCMLAAFkPEAYSGP
-	gap
-	gap
S163-p	FKQQRYLsAPERDQL
T179	SVLKLTSTQVKIWFQ
R221	IAVPVLVRDGKPCLG

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