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Protein Page:
FosB (human)

Overview
FosB FosB interacts with Jun proteins enhancing their DNA binding activity. Heterodimer. Belongs to the bZIP family. Fos subfamily. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: nucleus
Molecular Function: DNA binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; response to drug; response to cAMP; response to mechanical stimulus; response to morphine; negative regulation of transcription from RNA polymerase II promoter; female pregnancy; response to progesterone stimulus; cellular response to hormone stimulus; response to corticosterone stimulus
Reference #:  P53539 (UniProtKB)
Alt. Names/Synonyms: activator protein 1; AP-1; DKFZp686C0818; FBJ murine osteosarcoma viral oncogene homolog B; FOSB; G0/G1 switch regulatory protein 3; G0S3; GOS3; GOSB; MGC42291; oncogene FOS-B; Protein fosB
Gene Symbols: FOSB
Molecular weight: 35,928 Da
Basal Isoelectric point: 4.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FosB

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: S27‑p
activity, induced: S27‑p
protein stabilization: S27‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y9-p FQAFPGDyDsGsRCS
0 1 S11-p AFPGDyDsGsRCSSS
0 1 S13-p PGDyDsGsRCSSSPS
4 0 S27-p SAESQYLsSVDSFGS
0 3 S321 FAGAQRTSGSDQPSD
0 3 G322 AGAQRTSGSDQPSDP
0 4 S332 QPSDPLNSPSLLAL_
0 2 S334 SDPLNSPSLLAL___
  mouse

 
Y9 FQAFPGDYDSGSRCS
S11 AFPGDYDSGSRCSSS
S13 PGDYDSGSRCSSSPS
S27-p SAESQYLsSVDSFGS
S321 FAGAQRTSGSEQPSD
G322 AGAQRTSGSEQPSDP
S332-p QPSDPLNsPsLLAL_
S334-p SDPLNsPsLLAL___
  rat

 
Y5 ___MYQDYPGNFDTS
T11 DYPGNFDTSSRGSSG
S13 PGNFDTSSRGSSGSP
- gap
S223-p CSKAHRRssSSGDQS
S224-p SKAHRRssSSGDQSS
S236-p QSSDSLNsPtLLAL_
T238-p SDSLNsPtLLAL___
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