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FosB (human)

Overview FosB FosB interacts with Jun proteins enhancing their DNA binding activity. Heterodimer. Belongs to the bZIP family. Fos subfamily. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein Cellular Component: nucleus Molecular Function: DNA binding; sequence-specific DNA binding; transcription factor binding; transcription factor activity Biological Process: behavior; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter Reference #:  P53539 (UniProtKB) Alt. Names/Synonyms: activator protein 1; AP-1; DKFZp686C0818; FBJ murine osteosarcoma viral oncogene homolog B; FOSB; G0/G1 switch regulatory protein 3; G0S3; GOS3; GOSB; MGC42291; oncogene FOS-B; Protein fosB Gene Symbols: FOSB Molecular weight: 35,928 Da Basal Isoelectric point: 4.78  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FosB

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	Sites Implicated In
transcription, altered: S27‑p activation: S27‑p protein stabilization: S27‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
4	0		S27-p	SAESQYLsSVDSFGS
0	2		S321	FAGAQRTSGSDQPSD
0	3		G322	AGAQRTSGSDQPSDP
0	3		S332	QPSDPLNSPSLLAL_

	mouse
S27-p	SAESQYLsSVDSFGS
S321	FAGAQRTSGSEQPSD
G322	AGAQRTSGSEQPSDP
S332-p	QPSDPLNsPSLLAL_

	rat
-	gap
S223-p	CSKAHRRssSSGDQS
S224-p	SKAHRRssSSGDQSS
S236-p	QSSDSLNsPTLLAL_

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