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Protein Page:
STMN1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STMN1 a microtubule-associated protein involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Phosphorylation reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, nonleukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Cellular Component: microtubule; membrane; intracellular; cytosol
Molecular Function: tubulin binding; signal transducer activity
Biological Process: mitotic spindle organization and biogenesis; axonogenesis; response to virus; negative regulation of microtubule polymerization; microtubule depolymerization; positive regulation of cell motility; signal transduction
Reference #:  P16949 (UniProtKB)
Alt. Names/Synonyms: C1orf215; FLJ32206; Lag; LAP18; Leukemia-associated phosphoprotein p18; Metablastin; MGC138869; MGC138870; Oncoprotein 18; OP18; phosphoprotein 19; Phosphoprotein p19; pp17; pp19; PR22; Prosolin; Protein Pr22; SMN; Stathmin; stathmin 1; stathmin 1/oncoprotein 18; STMN1; transmembrane protein C1orf215
Gene Symbols: STMN1
Molecular weight: 17,303 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STMN1

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: S16‑p, S63‑p
cell cycle regulation: S16‑p, S25‑p, S38‑p, S63‑p
cytoskeletal reorganization: S16‑p, S25‑p, S38‑p, S63‑p
activity, inhibited: S16‑p, S25‑p, S38‑p, S63‑p
molecular association, regulation: S16‑p, S25‑p, S38‑p, S63‑p
phosphorylation: S25‑p, S38‑p
protein degradation: S38‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S4-p ____MASsDIQVkEL
0 2 K9-ac ASsDIQVkELEKRAs
0 1 K9-ub ASsDIQVkELEKRAs
0 1 K9-sc ASsDIQVkELEKRAs
25 100 S16-p kELEKRAsGQAFELI
34 147 S25-p QAFELILsPRskEsV
0 4 S28-p ELILsPRskEsVPEF
0 2 K29-ac LILsPRskEsVPEFP
0 1 K29-m1 LILsPRskEsVPEFP
0 7 K29-ub LILsPRskEsVPEFP
0 11 S31-p LsPRskEsVPEFPLs
0 1 E34 RskEsVPEFPLsPPK
34 207 S38-p sVPEFPLsPPKKKDL
0 29 S46-p PPKKKDLsLEEIQkk
0 26 K52-ub LsLEEIQkkLEAAEE
0 1 K53-ac sLEEIQkkLEAAEER
0 1 K53-ub sLEEIQkkLEAAEER
14 50 S63-p AAEERRKsHEAEVLk
0 1 K70-ub sHEAEVLkQLAEKRE
0 1 K80-ac AEKREHEkEVLQkAI
0 1 K80-ub AEKREHEkEVLQkAI
0 1 K85-ub HEkEVLQkAIEENNN
0 1 S94-p IEENNNFskMAEEkL
0 1 K95-ac EENNNFskMAEEkLt
0 13 K95-ub EENNNFskMAEEkLt
0 1 K100-ac FskMAEEkLtHkMEA
0 1 T102-p kMAEEkLtHkMEANk
0 1 K104-ac AEEkLtHkMEANkEN
0 5 K104-ub AEEkLtHkMEANkEN
0 1 K109-ac tHkMEANkENREAQM
0 18 K119-ac REAQMAAkLERLREK
0 13 K119-ub REAQMAAkLERLREK
0 2 K126 kLERLREKDkHIEEV
0 1 K128-ac ERLREKDkHIEEVRK
0 3 K128-ub ERLREKDkHIEEVRK
0 1 K137-ac IEEVRKNkESkDPAD
0 1 K137-ub IEEVRKNkESkDPAD
0 2 S139 EVRKNkESkDPADEt
0 4 K140-ub VRKNkESkDPADEtE
0 9 T146-p SkDPADEtEAD____
3353 : Phospho-Stathmin (Ser16) Antibody
3426 : Phospho-Stathmin (Ser38) Antibody
4191 : Phospho-Stathmin (Ser38) (D19H10) Rabbit mAb
  mouse

 
S4-p ____MASsDIQVKEL
K9 ASsDIQVKELEKRAs
K9 ASsDIQVKELEKRAs
K9 ASsDIQVKELEKRAs
S16-p KELEKRAsGQAFELI
S25-p QAFELILsPRskEsV
S28-p ELILsPRskEsVPdF
K29 LILsPRsKEsVPdFP
K29 LILsPRsKEsVPdFP
K29-ub LILsPRskEsVPdFP
S31-p LsPRskEsVPdFPLs
D34-ca RskEsVPdFPLsPPK
S38-p sVPdFPLsPPKKKDL
S46-p PPKKKDLsLEEIQkK
K52-ub LsLEEIQkKLEAAEE
K53 sLEEIQkKLEAAEER
K53 sLEEIQkKLEAAEER
S63-p AAEERRKsHEAEVLK
K70 sHEAEVLKQLAEKRE
K80 AEKREHEKEVLQKAI
K80 AEKREHEKEVLQKAI
K85 HEKEVLQKAIEENNN
S94 IEENNNFSkMAEEKL
K95 EENNNFSKMAEEKLT
K95-ub EENNNFSkMAEEKLT
K100 FSkMAEEKLTHkMEA
T102 kMAEEKLTHkMEANK
K104 AEEKLTHKMEANKEN
K104-ub AEEKLTHkMEANKEN
K109 THkMEANKENREAQM
K119 REAQMAAKLERLREk
K119-ub REAQMAAkLERLREk
K126-ub kLERLREkDKHVEEV
K128 ERLREkDKHVEEVRK
K128 ERLREkDKHVEEVRK
K137 VEEVRKNKEskDPAD
K137 VEEVRKNKEskDPAD
S139-p EVRKNKEskDPADET
K140-ub VRKNKEskDPADETE
T146 skDPADETEAD____
3353 : Phospho-Stathmin (Ser16) Antibody
3426 : Phospho-Stathmin (Ser38) Antibody
4191 : Phospho-Stathmin (Ser38) (D19H10) Rabbit mAb
  rat

 
S4 ____MASSDIQVKEL
K9 ASSDIQVKELEKRAs
K9 ASSDIQVKELEKRAs
K9 ASSDIQVKELEKRAs
S16-p KELEKRAsGQAFELI
S25-p QAFELILsPRSKESV
S28 ELILsPRSKESVPEF
K29 LILsPRSKESVPEFP
K29 LILsPRSKESVPEFP
K29 LILsPRSKESVPEFP
S31 LsPRSKESVPEFPLs
E34 RSKESVPEFPLsPPK
S38-p SVPEFPLsPPKKKDL
S46 PPKKKDLSLEEIQKK
K52 LSLEEIQKKLEAAEE
K53 SLEEIQKKLEAAEER
K53 SLEEIQKKLEAAEER
S63-p AAEERRKsHEAEVLK
K70 sHEAEVLKQLAEKRE
K80 AEKREHEKEVLQKAI
K80 AEKREHEKEVLQKAI
K85 HEKEVLQKAIEENNN
S94 IEENNNFSKMAEEKL
K95 EENNNFSKMAEEKLT
K95 EENNNFSKMAEEKLT
K100 FSKMAEEKLTHkMEA
T102 KMAEEKLTHkMEANK
K104 AEEKLTHKMEANKEN
K104-ub AEEKLTHkMEANKEN
K109 THkMEANKENREAQM
K119 REAQMAAKLERLREk
K119 REAQMAAKLERLREk
K126-ub KLERLREkDKHVEEV
K128 ERLREkDKHVEEVRK
K128 ERLREkDKHVEEVRK
K137 VEEVRKNKESKDPAD
K137 VEEVRKNKESKDPAD
S139 EVRKNKESKDPADET
K140 VRKNKESKDPADETE
T146 SKDPADETEAD____
3353 : Phospho-Stathmin (Ser16) Antibody
3426 : Phospho-Stathmin (Ser38) Antibody
4191 : Phospho-Stathmin (Ser38) (D19H10) Rabbit mAb
  chicken

 
S4 ____MATSDIQVKEL
K9 ATSDIQVKELEKRAS
K9 ATSDIQVKELEKRAS
K9 ATSDIQVKELEKRAS
S16 KELEKRASGQAFELI
G25 QAFELILGPRSKEAA
S28 ELILGPRSKEAAPEF
K29 LILGPRSKEAAPEFP
K29 LILGPRSKEAAPEFP
K29 LILGPRSKEAAPEFP
A31 LGPRSKEAAPEFPLs
E34 RSKEAAPEFPLsPPK
S38-p AAPEFPLsPPKKKDL
S46 PPKKKDLSLEEIQKK
K52 LSLEEIQKKLEAAEE
K53 SLEEIQKKLEAAEER
K53 SLEEIQKKLEAAEER
S63 AAEERRKSHEAEVLK
K70 SHEAEVLKQLAEKRE
K80 AEKREHEKEVLQKAI
K80 AEKREHEKEVLQKAI
K85 HEKEVLQKAIEENNN
S94 IEENNNFSKMAEEKL
K95 EENNNFSKMAEEKLT
K95 EENNNFSKMAEEKLT
K100 FSKMAEEKLTHKMEA
T102 KMAEEKLTHKMEANK
K104 AEEKLTHKMEANKEN
K104 AEEKLTHKMEANKEN
K109 THKMEANKENREAQM
K119 REAQMAAKLERLREK
K119 REAQMAAKLERLREK
K126 KLERLREKDKHIEEV
K128 ERLREKDKHIEEVRK
K128 ERLREKDKHIEEVRK
K137 IEEVRKNKEGKDPGE
K137 IEEVRKNKEGKDPGE
G139 EVRKNKEGKDPGEAE
K140 VRKNKEGKDPGEAET
T147 KDPGEAETN______
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