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STMN1 (human)

Overview STMN1 a microtubule-associated protein involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Phosphorylation reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, nonleukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein Cellular Component: microtubule; intracellular; cytosol Molecular Function: tubulin binding; signal transducer activity Biological Process: mitotic spindle organization and biogenesis; axonogenesis; response to virus; negative regulation of microtubule polymerization; microtubule depolymerization; positive regulation of cell motility; signal transduction Reference #:  P16949 (UniProtKB) Alt. Names/Synonyms: C1orf215; FLJ32206; Lag; LAP18; Leukemia-associated phosphoprotein p18; Metablastin; MGC138869; MGC138870; Oncoprotein 18; OP18; phosphoprotein 19; Phosphoprotein p19; pp17; pp19; PR22; Prosolin; Protein Pr22; SMN; Stathmin; stathmin 1; stathmin 1/oncoprotein 18; STMN1; transmembrane protein C1orf215 Gene Symbols: STMN1 Molecular weight: 17,303 Da Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states CST Pathways:  Regulation of Microtubule Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below STMN1

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	Sites Implicated In
apoptosis, altered: S16‑p, S63‑p cell cycle regulation: S16‑p, S25‑p, S38‑p, S63‑p cytoskeletal reorganization: S16‑p, S25‑p, S38‑p, S63‑p inhibition: S16‑p, S25‑p, S38‑p, S63‑p molecular association, regulation: S16‑p, S25‑p, S38‑p, S63‑p phosphorylation: S25‑p, S38‑p protein degradation: S38‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S4	____MASSDIQVkEL
0	2		K9-a	ASSDIQVkELEKRAs
0	1		K9-u	ASSDIQVkELEKRAs
23	89		S16-p	kELEKRAsGQAFELI
33	136		S25-p	QAFELILsPRskEsV
0	3		S28-p	ELILsPRskEsVPEF
0	2		K29-a	LILsPRskEsVPEFP
0	7		K29-u	LILsPRskEsVPEFP
0	8		S31-p	LsPRskEsVPEFPLs
0	1		E34	RskEsVPEFPLsPPK
33	203		S38-p	sVPEFPLsPPKKKDL
0	24		S46-p	PPKKKDLsLEEIQkk
0	26		K52-u	LsLEEIQkkLEAAEE
0	1		K53-a	sLEEIQkkLEAAEER
0	1		K53-u	sLEEIQkkLEAAEER
13	43		S63-p	AAEERRKsHEAEVLk
0	1		K70-u	sHEAEVLkQLAEKRE
0	1		K80-a	AEKREHEkEVLQkAI
0	1		K80-u	AEKREHEkEVLQkAI
0	1		K85-u	HEkEVLQkAIEENNN
0	1		K95-a	EENNNFSkMAEEkLt
0	13		K95-u	EENNNFSkMAEEkLt
0	1		K100-a	FSkMAEEkLtHkMEA
0	1		T102-p	kMAEEkLtHkMEANk
0	1		K104-a	AEEkLtHkMEANkEN
0	5		K104-u	AEEkLtHkMEANkEN
0	1		K109-a	tHkMEANkENREAQM
0	17		K119-a	REAQMAAkLERLREk
0	13		K119-u	REAQMAAkLERLREk
0	2		K126-u	kLERLREkDkHIEEV
0	1		K128-a	ERLREkDkHIEEVRK
0	3		K128-u	ERLREkDkHIEEVRK
0	1		K137-a	IEEVRKNkESkDPAD
0	1		K137-u	IEEVRKNkESkDPAD
0	2		S139	EVRKNkESkDPADEt
0	4		K140-u	VRKNkESkDPADEtE
0	9		T146-p	SkDPADEtEAD____

	mouse
S4-p	____MASsDIQVKEL
K9	ASsDIQVKELEKRAs
K9	ASsDIQVKELEKRAs
S16-p	KELEKRAsGQAFELI
S25-p	QAFELILsPRskEsV
S28-p	ELILsPRskEsVPdF
K29	LILsPRsKEsVPdFP
K29-u	LILsPRskEsVPdFP
S31-p	LsPRskEsVPdFPLs
D34-ca	RskEsVPdFPLsPPK
S38-p	sVPdFPLsPPKKKDL
S46-p	PPKKKDLsLEEIQkK
K52-u	LsLEEIQkKLEAAEE
K53	sLEEIQkKLEAAEER
K53	sLEEIQkKLEAAEER
S63-p	AAEERRKsHEAEVLK
K70	sHEAEVLKQLAEKRE
K80	AEKREHEKEVLQKAI
K80	AEKREHEKEVLQKAI
K85	HEKEVLQKAIEENNN
K95	EENNNFSKMAEEKLT
K95-u	EENNNFSkMAEEKLT
K100	FSkMAEEKLTHkMEA
T102	kMAEEKLTHkMEANK
K104	AEEKLTHKMEANKEN
K104-u	AEEKLTHkMEANKEN
K109	THkMEANKENREAQM
K119	REAQMAAKLERLREk
K119-u	REAQMAAkLERLREk
K126-u	kLERLREkDKHVEEV
K128	ERLREkDKHVEEVRK
K128	ERLREkDKHVEEVRK
K137	VEEVRKNKEskDPAD
K137	VEEVRKNKEskDPAD
S139-p	EVRKNKEskDPADET
K140-u	VRKNKEskDPADETE
T146	skDPADETEAD____

	rat
S4	____MASSDIQVKEL
K9	ASSDIQVKELEKRAs
K9	ASSDIQVKELEKRAs
S16-p	KELEKRAsGQAFELI
S25-p	QAFELILsPRSKESV
S28	ELILsPRSKESVPEF
K29	LILsPRSKESVPEFP
K29	LILsPRSKESVPEFP
S31	LsPRSKESVPEFPLs
E34	RSKESVPEFPLsPPK
S38-p	SVPEFPLsPPKKKDL
S46	PPKKKDLSLEEIQKK
K52	LSLEEIQKKLEAAEE
K53	SLEEIQKKLEAAEER
K53	SLEEIQKKLEAAEER
S63	AAEERRKSHEAEVLK
K70	SHEAEVLKQLAEKRE
K80	AEKREHEKEVLQKAI
K80	AEKREHEKEVLQKAI
K85	HEKEVLQKAIEENNN
K95	EENNNFSKMAEEKLT
K95	EENNNFSKMAEEKLT
K100	FSKMAEEKLTHkMEA
T102	KMAEEKLTHkMEANK
K104	AEEKLTHKMEANKEN
K104-u	AEEKLTHkMEANKEN
K109	THkMEANKENREAQM
K119	REAQMAAKLERLREk
K119	REAQMAAKLERLREk
K126-u	KLERLREkDKHVEEV
K128	ERLREkDKHVEEVRK
K128	ERLREkDKHVEEVRK
K137	VEEVRKNKESKDPAD
K137	VEEVRKNKESKDPAD
S139	EVRKNKESKDPADET
K140	VRKNKESKDPADETE
T146	SKDPADETEAD____

	chicken
S4	____MATSDIQVKEL
K9	ATSDIQVKELEKRAS
K9	ATSDIQVKELEKRAS
S16	KELEKRASGQAFELI
G25	QAFELILGPRSKEAA
S28	ELILGPRSKEAAPEF
K29	LILGPRSKEAAPEFP
K29	LILGPRSKEAAPEFP
A31	LGPRSKEAAPEFPLs
E34	RSKEAAPEFPLsPPK
S38-p	AAPEFPLsPPKKKDL
S46	PPKKKDLSLEEIQKK
K52	LSLEEIQKKLEAAEE
K53	SLEEIQKKLEAAEER
K53	SLEEIQKKLEAAEER
S63	AAEERRKSHEAEVLK
K70	SHEAEVLKQLAEKRE
K80	AEKREHEKEVLQKAI
K80	AEKREHEKEVLQKAI
K85	HEKEVLQKAIEENNN
K95	EENNNFSKMAEEKLT
K95	EENNNFSKMAEEKLT
K100	FSKMAEEKLTHKMEA
T102	KMAEEKLTHKMEANK
K104	AEEKLTHKMEANKEN
K104	AEEKLTHKMEANKEN
K109	THKMEANKENREAQM
K119	REAQMAAKLERLREK
K119	REAQMAAKLERLREK
K126	KLERLREKDKHIEEV
K128	ERLREKDKHIEEVRK
K128	ERLREKDKHIEEVRK
K137	IEEVRKNKEGKDPGE
K137	IEEVRKNKEGKDPGE
G139	EVRKNKEGKDPGEAE
K140	VRKNKEGKDPGEAET
T147	KDPGEAETN______

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