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ZP3 (human)

Overview ZP3 The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. Belongs to the ZP domain family. ZPC subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Extracellular matrix; Membrane protein, integral; Transporter Cellular Component: extracellular matrix; Golgi apparatus; multivesicular body; extracellular space; proteinaceous extracellular matrix; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; plasma membrane; integral to membrane; acrosome; secretory granule Molecular Function: acrosin binding; store-operated calcium channel activity; signal transducer activity; protein binding; carbohydrate binding; manganese ion transmembrane transporter activity Biological Process: positive regulation of type IV hypersensitivity; phosphoinositide-mediated signaling; binding of sperm to zona pellucida; positive regulation of leukocyte migration; positive regulation of transcription, DNA-dependent; manganese ion transport; blastocyst formation; positive regulation of phosphatidylinositol biosynthetic process; positive regulation of interleukin-4 production; humoral immune response mediated by circulating immunoglobulin; intracellular protein transport; positive regulation of protein kinase B signaling cascade; positive regulation of interferon-gamma production; positive regulation of humoral immune response; positive regulation of protein kinase activity; positive regulation of T cell proliferation; negative regulation of transcription, DNA-dependent; oocyte development; positive regulation of inflammatory response Reference #:  P21754 (UniProtKB) Alt. Names/Synonyms: P21754; P21754-2; P21754-3; zona pellucida glycoprotein 3; zona pellucida glycoprotein 3 (sperm receptor); zona pellucida glycoprotein 3A (sperm receptor); zona pellucida glycoprotein 3B; zona pellucida protein C; zona pellucida sperm-binding protein 3; zona pellucida sperm-binding protein 3 isoform 1; zona pellucida sperm-binding protein 3 isoform 2; ZP3; ZP3A; ZP3B; ZPC Gene Symbols: ZP3 Molecular weight: 47,018 Da Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states

Select Structure to View Below ZP3 3D4C - A=42-143 (mouse) 3D4G - F/A/E/B/H/C/D/G=42-143 (mouse) 3EF7 - A/B=42-143 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S149-p	YPRQGNVssQAILPT
0	1		S150-p	PRQGNVssQAILPTW
0	1		K185-u	EENWNAEkRSPTFHL

	mouse
S148	YPRQGNVSSHPIQPT
S149	PRQGNVSSHPIQPTW
K184	EENWNTEKSAPTFHL

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