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Protein Page:
ZP3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

ZP3 The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. Belongs to the ZP domain family. ZPC subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Extracellular matrix
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum; acrosome; extracellular region; integral to membrane; secretory granule; extracellular matrix; multivesicular body; proteinaceous extracellular matrix; perinuclear region of cytoplasm; cytoplasm; plasma membrane
Molecular Function: acrosin binding; signal transducer activity; store-operated calcium channel activity; protein binding; manganese ion transmembrane transporter activity; carbohydrate binding
Biological Process: positive regulation of type IV hypersensitivity; phosphoinositide-mediated signaling; binding of sperm to zona pellucida; positive regulation of leukocyte migration; positive regulation of transcription, DNA-dependent; manganese ion transport; blastocyst formation; positive regulation of phosphatidylinositol biosynthetic process; multicellular organism reproduction; positive regulation of interleukin-4 production; positive regulation of protein kinase B signaling cascade; intracellular protein transport; humoral immune response mediated by circulating immunoglobulin; positive regulation of interferon-gamma production; positive regulation of humoral immune response; single fertilization; positive regulation of protein kinase activity; positive regulation of T cell proliferation; negative regulation of transcription, DNA-dependent; oocyte development; positive regulation of inflammatory response
Reference #:  P21754 (UniProtKB)
Alt. Names/Synonyms: P21754; P21754-2; P21754-3; zona pellucida glycoprotein 3; zona pellucida glycoprotein 3 (sperm receptor); zona pellucida glycoprotein 3A (sperm receptor); zona pellucida glycoprotein 3B; zona pellucida protein C; zona pellucida sperm-binding protein 3; zona pellucida sperm-binding protein 3 isoform 1; zona pellucida sperm-binding protein 3 isoform 2; ZP3; ZP3A; ZP3B; ZPC
Gene Symbols: ZP3
Molecular weight: 47,018 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.



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