The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. Belongs to the ZP domain family. ZPC subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Extracellular matrix
Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum; integral to membrane; extracellular region; acrosome; secretory granule; multivesicular body; extracellular matrix; proteinaceous extracellular matrix; perinuclear region of cytoplasm; cytoplasm; plasma membrane
Molecular Function: acrosin binding; protein binding; signal transducer activity; store-operated calcium channel activity; carbohydrate binding; manganese ion transmembrane transporter activity
Biological Process: positive regulation of type IV hypersensitivity; phosphoinositide-mediated signaling; binding of sperm to zona pellucida; positive regulation of transcription, DNA-dependent; positive regulation of leukocyte migration; manganese ion transport; blastocyst formation; positive regulation of phosphatidylinositol biosynthetic process; multicellular organism reproduction; positive regulation of interleukin-4 production; intracellular protein transport; positive regulation of protein kinase B signaling cascade; humoral immune response mediated by circulating immunoglobulin; positive regulation of interferon-gamma production; positive regulation of humoral immune response; positive regulation of protein kinase activity; single fertilization; positive regulation of T cell proliferation; negative regulation of transcription, DNA-dependent; oocyte development; positive regulation of inflammatory response
Alt. Names/Synonyms: P21754; P21754-2; P21754-3; zona pellucida glycoprotein 3; zona pellucida glycoprotein 3 (sperm receptor); zona pellucida glycoprotein 3A (sperm receptor); zona pellucida glycoprotein 3B; zona pellucida protein C; zona pellucida sperm-binding protein 3; zona pellucida sperm-binding protein 3 isoform 1; zona pellucida sperm-binding protein 3 isoform 2; ZP3; ZP3A; ZP3B; ZPC
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.