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Protein Page:
Dok2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Dok2 a member of the p62dok family of proteins that interact with receptor tyrosine kinases and mediate particular biological responses. Constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/Abl), a chimeric protein whose presence is associated with CML. Contains a pleckstrin homology domain at the amino terminus, 13 potential tyrosine phosphorylation sites, and six PXXP SH3 recognition motifs. Binds p120 (RasGAP) from CML cells. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: cytosol
Molecular Function: receptor signaling protein activity; transmembrane receptor protein tyrosine kinase adaptor protein activity; insulin receptor binding
Biological Process: cell surface receptor linked signal transduction; Ras protein signal transduction; blood coagulation; signal transduction; leukocyte migration
Reference #:  O60496 (UniProtKB)
Alt. Names/Synonyms: Docking protein 2; docking protein 2, 56kDa; DOK2; Downstream of tyrosine kinase 2; p56(dok-2); p56DOK; p56dok-2
Gene Symbols: DOK2
Molecular weight: 45,379 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Dok2

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y139‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K7-u _MGDGAVkQGFLYLQ
0 3 S34 GASLYGGSDCALARL
0 3 L121 FPGQRKELSGPEGKQ
1 108 Y139-p CMEENELyssAVTVG
0 2 S140-p MEENELyssAVTVGP
0 3 S141-p EENELyssAVTVGPH
0 31 Y192-p PEPGTQLyDWPYRFL
3 1 Y271-p LPRPDSPySRPHDSL
0 1 S282-p HDSLPPPsPTTPVPA
3 784 Y299-p PRGQEGEyAVPFDAV
0 2 S309-p PFDAVARsLGKNFRG
0 15 Y330-p QLLADPLyDsIEEtL
0 5 S332-p LADPLyDsIEEtLPP
0 6 T336-p LyDsIEEtLPPRPDH
6 25 Y345-p PPRPDHIyDEPEGVA
0 123 Y357-p GVAALSLyDSPQEPR
1 41 Y402-p GWQPGTEyDNVVLKK
3911 : Phospho-p56Dok-2(Tyr351) Antibody
  mouse

 
K10 RMEEPAVKQGFLHLQ
S37-p AAVLYGEsGCALARL
S124-p FPGQRKGsPGLEEKS
Y142-p CMEENELysSSTTGL
S143-p MEENELysSSTTGLC
S144 EENELysSSTTGLCK
Y194 PEPGTQLYDWPYRFL
Y276-p LPRPESPySRPHDSL
S287 HDSLPSPSPGTLVPG
Y304-p PGAPEGEyAVPFDTV
S314 PFDTVAHSLRKSFRG
Y335 PHLPDPLYDSIQEDP
S337 LPDPLYDSIQEDPGA
D341 LYDSIQEDPGAPLPD
Y351-p APLPDHIyDEPEGVA
Y363 GVAALSLYDRTQRPS
Y402-p DWPQATEyDNVILKK
3911 : Phospho-p56Dok-2(Tyr351) Antibody
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