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Protein Page:
TRAF3IP2 (human)

Overview
TRAF3IP2 Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK. Defects in TRAF3IP2 are the cause of susceptibility to psoriasis type 13 (PSORS13). PSORS13 is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Molecular Function: protein binding
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; immunoglobulin secretion; B cell apoptosis; humoral immune response
Reference #:  O43734 (UniProtKB)
Alt. Names/Synonyms: ACT1; adapter protein CIKS isoform 2; C6orf2; C6orf4; C6orf5; C6orf6; CIKS; connection to IKK and SAPK/JNK; DKFZp586G0522; MGC3581; NFkB-activating protein ACT1; O43734; O43734-2; OTTHUMP00000017022; OTTHUMP00000017024; OTTHUMP00000040422; TRAF3 interacting protein 2; TRAF3IP2
Gene Symbols: TRAF3IP2
Molecular weight: 64,666 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
Select Structure to View Below

TRAF3IP2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S171 DSDKSDQSLPNASAD
0 2 S210-p TIDTGYDsQPQDVLG
1 0 S229 ERPLPLTSVCYPQDL
1 0 S242 DLPRPLRSREFPQFE
1 0 S328 KVILNYPSPWDHEER
0 1 Y558-p RLLREEEyVAPPRGP
  mouse

 
S147-p ESDKSDPsLPNALAD
S190 TIDTGYDSQPQDVLG
S209-p ERPLPLTsSCYLQDL
S222-p DLPGPLRsRELPPQF
S311-p KVILNDSsPQDQEER
Y539 RLLREEEYVAPPRGP
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