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BORIS (human)

Overview BORIS Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. Interacts with histones, PRMT7 and SETD1A. Interacts (via N-terminus) with BAG6/BAT3. Testis specific. Specifically expressed in primary spermatocytes. Belongs to the CTCF zinc-finger protein family. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; C2H2-type zinc finger protein; Cancer Testis Antigen (CTA) Cellular Component: cytoplasm; nucleus Molecular Function: protein binding; DNA binding; histone binding; zinc ion binding; sequence-specific DNA binding Biological Process: histone methylation; genetic imprinting; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; DNA methylation during gametogenesis; regulation of histone H3-K4 methylation; cell cycle Reference #:  Q8NI51 (UniProtKB) Alt. Names/Synonyms: BORIS-like protein; Brother of the regulator of imprinted sites; Cancer/testis antigen 27; CCCTC-binding factor; CCCTC-binding factor (zinc finger protein)-like; CT27; CTCF paralog; CTCF-like protein; CTCF-T; CTCFL; dJ579F20.2; HMG-1L1; HMGB1L1; MGC163358; MGC169105; MGC169106; putative high mobility group protein 1-like 1; putative high mobility group protein B1-like 1; Transcriptional repressor CTCFL; Zinc finger protein CTCF-T Gene Symbols: CTCFL Molecular weight: 75,747 Da Basal Isoelectric point: 8.58  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below BORIS

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		S43-p	CREKDHRsPSELEAE
0	3		T52-p	SELEAERtsGAFQDS
0	3		S53-p	ELEAERtsGAFQDSV
0	1		T256-p	KTKGAKGtFHCDVCM
0	1		S270-p	MFTSSRMssFNRHMK
0	1		S271-p	FTSSRMssFNRHMKT
0	1		S393-p	KRHMRTHsGEKPYEC
0	1		S575-p	CGSGEAKsAAsGKGR
0	1		S578-p	GEAKsAAsGKGRRTR
0	1		T590	RTRKRKQTILKEATK
0	1		T640-p	FPVACREtTARVKEE

	mouse
-	gap
-	gap
-	gap
-	gap
S270	PFTSSKLSTFNRHIK
T271	FTSSKLSTFNRHIKI
S393-p	KRHMRTHsGEKPYEC
T574	KCDPEHETLAPNKDR
P577	PEHETLAPNKDRRPV
T587-p	DRRPVTRtQASEGEA
-	gap

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