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Protein Page:
BORIS (human)

Overview
BORIS Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. Interacts with histones, PRMT7 and SETD1A. Interacts (via N-terminus) with BAG6/BAT3. Testis specific. Specifically expressed in primary spermatocytes. Belongs to the CTCF zinc-finger protein family. Note: This description may include information from UniProtKB.
Protein type: Cancer Testis Antigen (CTA); DNA binding protein; C2H2-type zinc finger protein
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; DNA binding; histone binding; sequence-specific DNA binding; metal ion binding
Biological Process: histone methylation; genetic imprinting; transcription, DNA-dependent; DNA methylation during gametogenesis; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; regulation of histone H3-K4 methylation; cell cycle
Reference #:  Q8NI51 (UniProtKB)
Alt. Names/Synonyms: BORIS-like protein; Brother of the regulator of imprinted sites; Cancer/testis antigen 27; CCCTC-binding factor; CCCTC-binding factor (zinc finger protein)-like; CT27; CTCF paralog; CTCF-like protein; CTCF-T; CTCFL; dJ579F20.2; HMG-1L1; HMGB1L1; MGC163358; MGC169105; MGC169106; putative high mobility group protein 1-like 1; putative high mobility group protein B1-like 1; Transcriptional repressor CTCFL; Zinc finger protein CTCF-T
Gene Symbols: CTCFL
Molecular weight: 75,747 Da
Basal Isoelectric point: 8.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BORIS

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S43-p CREKDHRsPSELEAE
0 3 T52-p SELEAERtsGAFQDS
0 3 S53-p ELEAERtsGAFQDSV
0 1 T256-p KTKGAKGtFHCDVCM
0 1 S270-p MFTSSRMssFNRHMK
0 1 S271-p FTSSRMssFNRHMKT
0 1 S393-p KRHMRTHsGEKPYEC
0 1 S575-p CGSGEAKsAAsGKGR
0 1 S578-p GEAKsAAsGKGRRTR
0 1 T590 RTRKRKQTILKEATK
0 1 T640-p FPVACREtTARVKEE
  mouse

 
- gap
- gap
- gap
- gap
S270 PFTSSKLSTFNRHIK
T271 FTSSKLSTFNRHIKI
S393-p KRHMRTHsGEKPYEC
T574 KCDPEHETLAPNKDR
P577 PEHETLAPNKDRRPV
T587-p DRRPVTRtQASEGEA
- gap
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