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NANOG
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. When overexpressed, promotes cells to enter into S phase and proliferation. Interacts with SMAD1 and SALL4. Expressed in testicular carcinoma and derived germ cell tumors. Expressed in fetal gonads, ovary and testis. Also expressed in ovary teratocarcinoma cell line and testicular embryonic carcinoma. Not expressed in many somatic organs and oocytes. Belongs to the Nanog homeobox family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor; DNA binding protein; Cell development/differentiation |
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Cellular Component: nucleoplasm; nucleolus; nucleus
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Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; chromatin binding; transcription factor activity
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Biological Process: response to retinoic acid; transcription, DNA-dependent; somatic stem cell maintenance; multicellular organismal development; stem cell division; positive regulation of transcription, DNA-dependent; endodermal cell fate specification; stem cell maintenance; negative regulation of transcription from RNA polymerase II promoter; stem cell differentiation; positive regulation of mitotic cell cycle; mesodermal cell fate commitment; response to chemical stimulus; negative regulation of cell fate commitment; negative regulation of BMP signaling pathway; cell proliferation; negative regulation of cell differentiation; embryonic development; regulation of transcription, DNA-dependent; regulation of gene expression; regulation of cell differentiation; positive regulation of cell proliferation; negative regulation of endodermal cell fate specification; positive regulation of transcription from RNA polymerase II promoter
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Reference #:
Q5TM83 (UniProtKB)
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| Alt. Names/Synonyms: 2410002E02Rik; early embryo specific expression NK family; ecat4; ENK; homeobox protein NANOG; homeobox transcription factor Nanog; Nanog; Nanog homeobox; Q5TM83; Q80Z64; Q80Z64-2 |
| Gene Symbols: Nanog |
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Molecular weight: 34,194 Da
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Basal Isoelectric point: 6.32
Predict pI for various phosphorylation states
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CST Pathways:
ESC Pluripotency and Differentiation
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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