is an enzyme that functions in DNA replication and the base excision repair process. Mutations leading to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Note: This description may include information from UniProtKB.
Protein type: EC 220.127.116.11; DNA repair, damage; Ligase
Molecular Function: DNA binding; DNA ligase activity; DNA ligase (ATP) activity; metal ion binding; nucleotide binding; ATP binding; ligase activity
Biological Process: response to hydrogen peroxide; cell division; DNA ligation during DNA repair; DNA repair; DNA replication; cell cycle; response to DNA damage stimulus; lagging strand elongation; double-strand break repair via nonhomologous end joining; DNA ligation; DNA recombination
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.