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LIG1 (mouse)

Overview LIG1 is an enzyme that functions in DNA replication and the base excision repair process. Mutations leading to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Note: This description may include information from UniProtKB. Protein type: DNA repair; Ligase; EC 6.5.1.1 Cellular Component: mitochondrion; chromosome; nucleus Molecular Function: DNA binding; DNA ligase activity; DNA ligase (ATP) activity; metal ion binding; nucleotide binding; ATP binding; ligase activity Biological Process: response to hydrogen peroxide; cell division; DNA ligation during DNA repair; DNA replication; DNA repair; cell cycle; response to DNA damage stimulus; lagging strand elongation; double-strand break repair via nonhomologous end joining; DNA ligation; DNA recombination Reference #:  NP_001076657 (RefSeq) Alt. Names/Synonyms: AL033288; DNA ligase 1; DNA ligase I; DNLI1; Lig-1; Lig1; ligase I, DNA, ATP-dependent; LigI; Polydeoxyribonucleotide synthase [ATP] 1 Gene Symbols: Lig1 Molecular weight: 104,093 Da Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states

Select Structure to View Below LIG1 1X9N - A=233-919 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	1		K9-a	RKKEQERkGETSAAN
0	1		K32-a	FQPTKEGkAKKPEKE
0	6		P63	KERNQVVPEsDsPVK
0	12		S65-p	RNQVVPEsDsPVKRT
3	33		S67-p	QVVPEsDsPVKRTGR
0	5		K75-u	PVKRTGRkVAQVLsC
0	4		S81-p	RkVAQVLsCEGEDED
4	26		C82	kVAQVLsCEGEDEDE
5	28		G92	EDEDEAPGtPKVQKP
0	12		T93-p	DEDEAPGtPKVQKPV
0	2		S101-p	PKVQKPVsDSEQSsP
3	6		S107-p	VsDSEQSsPPsPDtC
0	1		S110-p	SEQSsPPsPDtCPEN
0	2		T113-p	SsPPsPDtCPENsPV
0	1		C114	sPPsPDtCPENsPVF
0	1		S118-p	PDtCPENsPVFNCSS
0	1		S130-p	CSSPMDIsPSGFPKR
0	16		N157	QDTLEEQNEDKTKTA
0	6		A179	ETPKESLAEAEDVKQ
0	3		I196	EKEGDQLIVPSEPtK
0	15		V197	KEGDQLIVPSEPtKs
0	1		T202-p	LIVPSEPtKsPESVt
0	8		S204-p	VPSEPtKsPESVtLT
1	23		T209-p	tKsPESVtLTKTENI
1	5		T211	sPESVtLTKTENIPV
0	17		N215	VtLTKTENIPVCKAG
0	1		K234	PQEEEQSKPPARGAK
0	1		K241	KPPARGAKTLsSFFt
0	6		S244-p	ARGAKTLsSFFtPRK
0	1		S245	RGAKTLsSFFtPRKP
1	80		T248-p	KTLsSFFtPRKPAVK
0	1		T325	ARLKMVETLSNLLRS
0	1		S327	LKMVETLSNLLRSVV
0	3		K370-u	VGDGVLLkAVAQATG
0	1		K390	IRAEVAEKGDVGLVA
0	1		K421	TISGVFTKFCDIARL
0	1		K436	TGSASMAKKMDIIKG
0	2		S549	LPEHCKLSPGVPLKP
0	1		T562	KPMLAHPTRGVSEVL
0	1		T609-p	SRNQEDNtGKYPDII
0	1		S617-p	GKYPDIIsRIPKIKH
0	7		T653	IQPFQVLTTRKRKEV
0	1		S728	IAEFLEQSVKDSCEG
0	1		S815	CKLGTGFSDEELEEH
0	1		T833	LQALVLPTPRPYVRI
0	1		Y911	SNQVASLYRKQSQIQ
0	1		S915	ASLYRKQSQIQNQQs
0	3		S922-p	SQIQNQQssDLDsDV
0	7		S923-p	QIQNQQssDLDsDVE
0	20		L925	QNQQssDLDsDVEDy
0	28		S927-p	QQssDLDsDVEDy__
0	1		-	gap
0	2		Y932-p	LDsDVEDy_______

	human
-	gap
K16	FHPKKEGKAKKPEKE
S47-p	KEWNGVVsEsDsPVK
S49-p	WNGVVsEsDsPVKRP
S51-p	GVVsEsDsPVKRPGR
K59	PVKRPGRKAARVLGs
G65	RKAARVLGsEGEEED
S66-p	KAARVLGsEGEEEDE
S76-p	EEEDEALsPAKGQKP
P77	EEDEALsPAKGQKPA
L85	AKGQKPALDCSQVsP
S91-p	ALDCSQVsPPRPAts
R94	CSQVsPPRPAtsPEN
T97-p	VsPPRPAtsPENNAS
S98-p	sPPRPAtsPENNASL
N102	PAtsPENNASLSDTS
S114	DTSPMDSSPSGIPKR
S141-p	QEVLEEQsEDEDREA
T165-p	ETPKESLtEAEVATE
T182-p	GEDGDQPttPPKPLK
T183-p	EDGDQPttPPKPLKT
L188	PttPPKPLKTSKAEt
T190	tPPKPLKTSKAEtPt
T195-p	LKTSKAEtPtESVsE
T197-p	TSKAEtPtESVsEPE
S201-p	EtPtESVsEPEVATK
K219-a	QEEEEQTkPPRRAPk
K226-u	kPPRRAPkTLssFFt
S229-p	RRAPkTLssFFtPRK
S230-p	RAPkTLssFFtPRKP
T233-p	kTLssFFtPRKPAVK
T311-p	ARLRMVEtLsNLLRS
S313-p	LRMVEtLsNLLRSVV
K356	VGDGVLLKAVAQATG
K376-u	VRAEAAEkGDVGLVA
K407-u	TASGVFSkFRDIARL
K422-u	TGSASTAkKIDIIKG
S535-p	LPEHCKLsPGIPLKP
T548-p	KPMLAHPtRGISEVL
T595	SRNQEDNTGKYPDII
S603	GKYPDIISRIPKIKL
T639-p	IQPFQVLtTRKRKEV
S714-p	IAEFLEQsVKDSCEG
S801-p	CKLGTGFsDEELEEH
S819-p	LKALVLPsPRPYVRI
Y897-p	SAQVACLyRKQsQIQ
S901-p	ACLyRKQsQIQNQQG
G908	sQIQNQQGEDsGsDP
E909	QIQNQQGEDsGsDPE
S911-p	QNQQGEDsGsDPEDt
S913-p	QQGEDsGsDPEDty_
T918-p	sGsDPEDty______
Y919-p	GsDPEDty_______

	rat
-	gap
K17	QPTTTEGKAKKPEKE
P48	KERNRAVPESDSPVK
S50	RNRAVPESDSPVKRP
S52	RAVPESDSPVKRPGR
K60	PVKRPGRKVAQVLSS
S66	RKVAQVLSSEGEDED
S67	KVAQVLSSEGEDEDE
G77	EDEDEAPGTPQVQKP
T78	DEDEAPGTPQVQKPV
S86	PQVQKPVSDSKQSSP
S92	VSDSKQSSPPSPDSC
S95	SKQSSPPSPDSCPEN
S98	SSPPSPDSCPENSPV
C99	SPPSPDSCPENSPVF
S103	PDSCPENSPVFNCSP
S115	CSPSMDISPSGFPKR
N142	QDTLEEPNEDKAKAV
T165	QTPPESLTEAEEVNQ
T182	EQVEDQPTVPPEPTE
V183	QVEDQPTVPPEPTES
T188	PTVPPEPTESPESVT
S190	VPPEPTESPESVTLT
T195	TESPESVTLTKTENI
T197	SPESVTLTKTENIPM
N201	VTLTKTENIPMCKAG
K220	PQEEEQSKPPARGAK
K227	KPPARGAKPLSSFFT
S230	ARGAKPLSSFFTPRK
S231	RGAKPLSSFFTPRKP
T234	KPLSSFFTPRKPAVK
T311	ARLKMVETLSNLLRS
S313	LKMVETLSNLLRSVV
K356	VGDGVLLKAVAQATG
K376	IRAEVAEKGDVGLVA
K407	TVSGVFTKFCDIARL
K422	TGSASMAKKMDIIKG
S535	LPEHCKLSPGVPLKP
T548	KPMLAHPTRGVREVL
S595	SRNQEDNSGKYPDII
S603	GKYPDIISRIPKIKH
T639	IQPFQVLTTRKRKEV
S714	IAEFLEQSVKDSCEG
S801	CKLGTGFSDEELEEH
T819	MQALLLPTPRPYVRI
Y897	SDQVASLYRKQSQIQ
S901	ASLYRKQSQIQNQQS
S908	SQIQNQQSSDLDSDV
S909	QIQNQQSSDLDSDVE
L911	QNQQSSDLDSDVEDY
S913	QQSSDLDSDVEDY__
-	gap
Y918	LDSDVEDY_______

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