Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
LIG1 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LIG1 is an enzyme that functions in DNA replication and the base excision repair process. Mutations leading to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Note: This description may include information from UniProtKB.
Protein type: EC 6.5.1.1; DNA repair, damage; Ligase
Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; mitochondrion; chromosome; nucleus
Molecular Function: DNA binding; DNA ligase activity; metal ion binding; DNA ligase (ATP) activity; nucleotide binding; ATP binding; ligase activity
Biological Process: response to hydrogen peroxide; cell division; DNA ligation during DNA repair; DNA repair; cell cycle; DNA replication; lagging strand elongation; response to DNA damage stimulus; double-strand break repair via nonhomologous end joining; DNA recombination; DNA ligation
Reference #:  P37913 (UniProtKB)
Alt. Names/Synonyms: AL033288; DNA ligase 1; DNA ligase I; DNLI1; Lig-1; Lig1; ligase I, DNA, ATP-dependent; LigI; Polydeoxyribonucleotide synthase [ATP] 1
Gene Symbols: Lig1
Molecular weight: 102,290 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
Select Structure to View Below

LIG1

Protein Structure Not Found.


STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  Source  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

► Hide Isoforms
 
0 1 - gap
0 1 S4 ____MQRSIMSFFQP
0 1 K16-ac FQPTKEGkAKKPEKE
0 9 P47 KERNQVVPEsDsPVK
0 13 S49-p RNQVVPEsDsPVKRT
3 38 S51-p QVVPEsDsPVKRTGR
0 5 K59-ub PVKRTGRkVAQVLsC
0 7 S65-p RkVAQVLsCEGEDED
4 32 C66 kVAQVLsCEGEDEDE
6 34 G76 EDEDEAPGtPKVQKP
0 14 T77-p DEDEAPGtPKVQKPV
0 2 S85-p PKVQKPVsDSEQssP
0 1 S90-p PVsDSEQssPPsPDt
3 7 S91-p VsDSEQssPPsPDtC
0 1 S94-p SEQssPPsPDtCPEN
0 2 T97-p ssPPsPDtCPENsPV
0 1 C98 sPPsPDtCPENsPVF
0 2 S102-p PDtCPENsPVFNCSS
0 1 S114-p CSSPMDIsPSGFPKR
0 22 - gap
0 6 - gap
0 4 - gap
0 17 - gap
0 2 T186-p LIVPSEPtKsPEsVt
0 9 S188-p VPSEPtKsPEsVtLt
0 1 S191-p EPtKsPEsVtLtKTE
1 26 T193-p tKsPEsVtLtKTENI
1 7 T195-p sPEsVtLtKTENIPV
0 1 T197 EsVtLtKTENIPVCK
0 20 - gap
0 1 - gap
0 2 K218 PQEEEQSKPPARGAK
0 1 K225 KPPARGAKTLsSFFt
0 7 S228-p ARGAKTLsSFFtPRK
0 2 S229 RGAKTLsSFFtPRKP
1 82 T232-p KTLsSFFtPRKPAVK
0 1 T309 ARLKMVETLSNLLRS
0 1 S311 LKMVETLSNLLRSVV
0 3 K354-ub VGDGVLLkAVAQATG
0 1 K374 IRAEVAEKGDVGLVA
0 1 K405 TISGVFTKFCDIARL
0 1 K420 TGSASMAKKMDIIKG
0 1 S435 LFVACRHSEARYIAR
0 1 S443 EARYIARSLSGRLRL
0 1 S445 RYIARSLSGRLRLGL
0 2 S533 LPEHCKLSPGVPLKP
0 1 T546 KPMLAHPTRGVSEVL
0 1 T593-p SRNQEDNtGKYPDII
0 1 S601-p GKYPDIIsRIPKIKH
0 7 T637 IQPFQVLTTRKRKEV
0 1 S712 IAEFLEQSVKDSCEG
0 1 T796 QAICKLGTGFSDEEL
0 2 S799 CKLGTGFSDEELEEH
0 2 T817 LQALVLPTPRPYVRI
0 1 Y821 VLPTPRPYVRIDGAV
0 1 Y895 SNQVASLYRKQSQIQ
0 1 S899 ASLYRKQSQIQNQQs
0 4 S906-p SQIQNQQssDLDsDV
0 7 S907-p QIQNQQssDLDsDVE
0 24 - gap
0 34 S911-p QQssDLDsDVEDy__
0 1 - gap
0 3 Y916-p LDsDVEDy_______
  LIG1 iso3  
K9-ac RKKEQERkGETSAAN
S20 SAANMQRSIMSFFQP
K32 FQPTKEGKAKKPEKE
P63 KERNQVVPESDSPVK
S65 RNQVVPESDSPVKRT
S67 QVVPESDSPVKRTGR
K75 PVKRTGRKVAQVLSC
S81 RKVAQVLSCEGEDED
C82 KVAQVLSCEGEDEDE
G92 EDEDEAPGTPKVQKP
T93 DEDEAPGTPKVQKPV
S101 PKVQKPVSDSEQSSP
S106 PVSDSEQSSPPSPDT
S107 VSDSEQSSPPSPDTC
S110 SEQSSPPSPDTCPEN
T113 SSPPSPDTCPENSPV
C114 SPPSPDTCPENSPVF
S118 PDTCPENSPVFNCSS
S130 CSSPMDISPSGFPKR
- gap
- gap
- gap
- gap
T202 LIVPSEPTKSPESVT
S204 VPSEPTKSPESVTLT
S207 EPTKSPESVTLTKTE
T209 TKSPESVTLTKTENI
T211 SPESVTLTKTENIPV
T213 ESVTLTKTENIPVCK
- gap
- gap
K234 PQEEEQSKPPARGAK
K241 KPPARGAKTLSSFFT
S244 ARGAKTLSSFFTPRK
S245 RGAKTLSSFFTPRKP
T248 KTLSSFFTPRKPAVK
T325 ARLKMVETLSNLLRS
S327 LKMVETLSNLLRSVV
K370 VGDGVLLKAVAQATG
K390 IRAEVAEKGDVGLVA
K421 TISGVFTKFCDIARL
K436 TGSASMAKKMDIIKG
S451 LFVACRHSEARYIAR
S459 EARYIARSLSGRLRL
S461 RYIARSLSGRLRLGL
S549 LPEHCKLSPGVPLKP
T562 KPMLAHPTRGVSEVL
T609 SRNQEDNTGKYPDII
S617 GKYPDIISRIPKIKH
T653 IQPFQVLTTRKRKEV
S728 IAEFLEQSVKDSCEG
T812 QAICKLGTGFSDEEL
S815 CKLGTGFSDEELEEH
T833 LQALVLPTPRPYVRI
Y837 VLPTPRPYVRIDGAV
Y911 SNQVASLYRKQSQIQ
S915 ASLYRKQSQIQNQQS
S922 SQIQNQQSSDLDSDV
S923 QIQNQQSSDLDSDVE
- gap
S927 QQSSDLDSDVEDY__
- gap
Y932 LDSDVEDY_______
  human

 
- gap
S4-p ____MQRsIMSFFHP
K16 FHPKKEGKAKKPEKE
S47-p KEWNGVVsEsDsPVK
S49-p WNGVVsEsDsPVKRP
S51-p GVVsEsDsPVKRPGR
K59 PVKRPGRKAARVLGs
G65 RKAARVLGsEGEEED
S66-p KAARVLGsEGEEEDE
S76-p EEEDEALsPAKGQKP
P77 EEDEALsPAKGQKPA
L85 AKGQKPALDCSQVsP
V90 PALDCSQVsPPRPAt
S91-p ALDCSQVsPPRPAts
R94 CSQVsPPRPAtsPEN
T97-p VsPPRPAtsPENNAS
S98-p sPPRPAtsPENNASL
N102 PAtsPENNASLSDTS
S114 DTSPMDSSPSGIPKR
S141-p QEVLEEQsEDEDREA
T165-p ETPKESLtEAEVATE
T182-p GEDGDQPttPPKPLK
T183-p EDGDQPttPPKPLKT
L188 PttPPKPLKTSKAEt
T190 tPPKPLKTSKAEtPt
- gap
T195-p LKTSKAEtPtEsVsE
T197-p TSKAEtPtEsVsEPE
S199-p KAEtPtEsVsEPEVA
S201-p EtPtEsVsEPEVAtK
T207-p VsEPEVAtKQELQEE
K219-ac QEEEEQTkPPRRAPk
K226-ub kPPRRAPkTLssFFt
S229-p RRAPkTLssFFtPRK
S230-p RAPkTLssFFtPRKP
T233-p kTLssFFtPRKPAVK
T311-p ARLRMVEtLsNLLRS
S313-p LRMVEtLsNLLRSVV
K356 VGDGVLLKAVAQATG
K376-ub VRAEAAEkGDVGLVA
K407-ub TASGVFSkFRDIARL
K422-ub TGSASTAkKIDIIKG
S437-p LFVACRHsEARFIAR
S445-p EARFIARsLsGRLRL
S447-p RFIARsLsGRLRLGL
S535-p LPEHCKLsPGIPLKP
T548-p KPMLAHPtRGISEVL
T595 SRNQEDNTGKYPDII
S603 GKYPDIISRIPKIKL
T639-p IQPFQVLtTRKRKEV
S714-p IAEFLEQsVKDSCEG
T798-p QAICKLGtGFsDEEL
S801-p CKLGtGFsDEELEEH
S819-p LKALVLPsPRPyVRI
Y823-p VLPsPRPyVRIDGAV
Y897-p SAQVACLyRKQsQIQ
S901-p ACLyRKQsQIQNQQG
- gap
- gap
S911-p QNQQGEDsGsDPEDt
S913-p QQGEDsGsDPEDty_
T918-p sGsDPEDty______
Y919-p GsDPEDty_______
  rat

 
- gap
S4 ____MQRSIMSFFQP
K17 QPTTTEGKAKKPEKE
P48 KERNRAVPESDSPVK
S50 RNRAVPESDSPVKRP
S52 RAVPESDSPVKRPGR
K60 PVKRPGRKVAQVLss
S66-p RKVAQVLssEGEDED
S67-p KVAQVLssEGEDEDE
G77 EDEDEAPGTPQVQKP
T78 DEDEAPGTPQVQKPV
S86 PQVQKPVSDSKQSSP
S91 PVSDSKQSSPPSPDS
S92 VSDSKQSSPPSPDSC
S95 SKQSSPPSPDSCPEN
S98 SSPPSPDSCPENSPV
C99 SPPSPDSCPENSPVF
S103 PDSCPENSPVFNCSP
S115 CSPSMDISPSGFPKR
- gap
T165 QTPPESLTEAEEVNQ
T182 EQVEDQPTVPPEPTE
- gap
T188 PTVPPEPTESPESVT
S190 VPPEPTESPESVTLT
S193 EPTESPESVTLTKTE
T195 TESPESVTLTKTENI
T197 SPESVTLTKTENIPM
T199 ESVTLTKTENIPMCK
- gap
- gap
K220 PQEEEQSKPPARGAK
K227 KPPARGAKPLSSFFT
S230 ARGAKPLSSFFTPRK
S231 RGAKPLSSFFTPRKP
T234 KPLSSFFTPRKPAVK
T311 ARLKMVETLSNLLRS
S313 LKMVETLSNLLRSVV
K356 VGDGVLLKAVAQATG
K376 IRAEVAEKGDVGLVA
K407 TVSGVFTKFCDIARL
K422 TGSASMAKKMDIIKG
S437 LFVACRYSEARFIAR
S445 EARFIARSLSGRLRL
S447 RFIARSLSGRLRLGL
S535 LPEHCKLSPGVPLKP
T548 KPMLAHPTRGVREVL
S595 SRNQEDNSGKYPDII
S603 GKYPDIISRIPKIKH
T639 IQPFQVLTTRKRKEV
S714 IAEFLEQSVKDSCEG
T798 AAICKLGTGFSDEEL
S801 CKLGTGFSDEELEEH
T819 MQALLLPTPRPYVRI
Y823 LLPTPRPYVRIDGAV
Y897 SDQVASLYRKQSQIQ
S901 ASLYRKQSQIQNQQS
S908 SQIQNQQSSDLDSDV
S909 QIQNQQSSDLDSDVE
- gap
S913 QQSSDLDSDVEDY__
- gap
Y918 LDSDVEDY_______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.