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Protein Page:
OCRL (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
OCRL Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5- tetrakisphosphate to inositol 1,3,4-trisphosphate. May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Belongs to the inositol-1,4,5-trisphosphate 5- phosphatase type II family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.36; Carbohydrate Metabolism - inositol phosphate; Phosphatase (non-protein)
Cellular Component: phagocytic vesicle membrane; Golgi stack; photoreceptor outer segment; clathrin-coated vesicle; early endosome membrane; cytoplasm; early endosome; plasma membrane; Golgi-associated vesicle; coated pit; trans-Golgi network; nucleus; cytosol
Molecular Function: protein binding; Rac GTPase activator activity; phosphoinositide 5-phosphatase activity; Rac GTPase binding
Biological Process: regulation of small GTPase mediated signal transduction; inositol phosphate metabolic process; in utero embryonic development; small GTPase mediated signal transduction; phospholipid metabolic process; phosphatidylinositol biosynthetic process; cilium biogenesis; phosphoinositide dephosphorylation; positive regulation of Rac GTPase activity; lipid metabolic process; regulation of Rac GTPase activity
Reference #:  Q01968 (UniProtKB)
Alt. Names/Synonyms: Inositol polyphosphate 5-phosphatase OCRL-1; INPP5F; LOCR; Lowe oculocerebrorenal syndrome protein; NPHL2; OCRL; OCRL1; oculocerebrorenal syndrome of Lowe; phosphatidylinositol polyphosphate 5-phosphatase
Gene Symbols: OCRL
Molecular weight: 104,205 Da
Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

OCRL

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K127-ub QLLVPEQkDSSSWyQ
0 27 Y133-p QkDSSSWyQKLDtKD
0 1 T138-p SWyQKLDtKDKPSVF
0 1 Y234-p LAKREKEyVNIQTFR
0 2 T346-p IATETVGtGIMGKMG
0 2 Y390-p FERRNQDyKDICARM
0 1 T405 SFVVPNQTLPQLNIM
0 2 K449-ub KDLQRLLkFDQLNIQ
0 1 K461-ub NIQRTQKkAFVDFNE
0 1 Y479 KFIPTYKYDSKTDRW
0 1 S528-p TSDHKPVsALFHIGV
0 1 K578-ub EFVFENVkFRQLQKE
0 1 K701 IREVPVTKLIDLEED
0 1 S709-p LIDLEEDsFLEKEKS
0 11 T880-p PNLMARQtPsDRQRA
0 11 S882-p LMARQtPsDRQRAIQ
  OCRL iso2  
K127 QLLVPEQKDSSSWYQ
Y133 QKDSSSWYQKLDTKD
T138 SWYQKLDTKDKPSVF
Y234 LAKREKEYVNIQTFR
T346 IATETVGTGIMGKMG
Y390 FERRNQDYKDICARM
T405 SFVVPNQTLPQLNIM
K449 KDLQRLLKFDQLNIQ
K461 NIQRTQKKAFVDFNE
Y479 KFIPTYKYDSKTDRW
S528 TSDHKPVSALFHIGV
K578 EFVFENVKFRQLQKE
K701-ub IREVPVTkLIDLEKS
- gap
T872 PNLMARQTPSDRQRA
S874 LMARQTPSDRQRAIQ
  mouse

 
K127 QLLVPEQKDSSSWyQ
Y133-p QKDSSSWyQKLDTMD
T138 SWyQKLDTMDKPAYS
Y233 LTKREKEYVNIQSFR
T345 VATETTGTGIMGKMG
Y389 FERRNQDYKDICARM
T404-p TFSVPNQtVPQVNIM
K448-ub NELHKLLkFDQLNIQ
K460 NIQRTQKKAFADFNE
Y478-p NFVPTYKyDSKTDRW
S527 TSDHKPVSALFHIGV
K577 EFFFENVKFRQLQKE
K700 IREVPVTKLIDLEED
S708 LIDLEEDSYLEKEKS
T879 PNLMTRQTPNDRQHA
N881 LMTRQTPNDRQHAIQ
  rat

 
K127 QLLVPEQKDSSNWYQ
Y133 QKDSSNWYQKLDTKD
T138 NWYQKLDTKDKPAYS
Y232 LAKREKEYVNIQSFR
T344 IATETVGTGIMGKMG
Y388 FERRNQDYKDICARM
T403 SFSVPNQTLPQVNIM
K447 NELQKLLKFDQLNIQ
K459 NIQRTQKKAFVDFNE
Y477 KFIPTYKYDSKTDRW
S526 TSDHKPVSALFHIGV
K576 EFMFENVKFRQLQKE
K699 IREVPVTKLIDLEED
S707 LIDLEEDSFLEKEKS
T878 PNLMARQTPSDRQRA
S880 LMARQTPSDRQRAIQ
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