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OCRL (human)

Overview OCRL Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5- tetrakisphosphate to inositol 1,3,4-trisphosphate. May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Belongs to the inositol-1,4,5-trisphosphate 5- phosphatase type II family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Carbohydrate Metabolism - inositol phosphate; Motility/polarity/chemotaxis; Phosphatase (non-protein); EC 3.1.3.36 Cellular Component: phagocytic vesicle membrane; Golgi stack; photoreceptor outer segment; clathrin-coated vesicle; early endosome membrane; early endosome; coated pit; Golgi-associated vesicle; cytosol Molecular Function: protein binding; phosphoinositide 5-phosphatase activity Biological Process: regulation of small GTPase mediated signal transduction; phosphoinositide phosphorylation; phospholipid metabolic process; small GTPase mediated signal transduction; phosphatidylinositol biosynthetic process; cilium biogenesis; phosphoinositide dephosphorylation; lipid metabolic process Reference #:  Q01968 (UniProtKB) Alt. Names/Synonyms: Inositol polyphosphate 5-phosphatase OCRL-1; INPP5F; LOCR; Lowe oculocerebrorenal syndrome protein; NPHL2; OCRL; OCRL1; oculocerebrorenal syndrome of Lowe; phosphatidylinositol polyphosphate 5-phosphatase Gene Symbols: OCRL Molecular weight: 104,205 Da Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below OCRL 2KIE - A=1-119 (human) 2QV2 - A=564-901 (human) 3QBT - H/F/D/B=540-678 (human) 3QIS - A=536-901 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2KIE 2QV2 3QBT 3QIS  |  ENZYME  |  Phospho3D  |  DISEASE 300009 300535 300555 309000  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		K127-u	QLLVPEQkDSSSWyQ
0	26		Y133-p	QkDSSSWyQKLDtKD
0	1		T138-p	SWyQKLDtKDKPSVF
0	1		Y234-p	LAKREKEyVNIQTFR
0	1		T346-p	IATETVGtGIMGKMG
0	2		Y390-p	FERRNQDyKDICARM
0	1		T405	SFVVPNQTLPQLNIM
0	2		K449-u	KDLQRLLkFDQLNIQ
0	1		K461-u	NIQRTQKkAFVDFNE
0	1		Y477-p	EIKFIPTyKYDSKTD
0	1		Y479	KFIPTyKYDSKTDRW
0	1		S528-p	TSDHKPVsALFHIGV
0	1		K578-u	EFVFENVkFRQLQKE
0	1		K701	IREVPVTKLIDLEED
0	1		Y838-p	CHRNVFRyLMAFLRE
0	14		T880-p	PNLMARQtPsDRQRA
0	14		S882-p	LMARQtPsDRQRAIQ

	OCRL iso2
K127	QLLVPEQKDSSSWYQ
Y133	QKDSSSWYQKLDTKD
T138	SWYQKLDTKDKPSVF
Y234	LAKREKEYVNIQTFR
T346	IATETVGTGIMGKMG
Y390	FERRNQDYKDICARM
T405	SFVVPNQTLPQLNIM
K449	KDLQRLLKFDQLNIQ
K461	NIQRTQKKAFVDFNE
Y477	EIKFIPTYKYDSKTD
Y479	KFIPTYKYDSKTDRW
S528	TSDHKPVSALFHIGV
K578	EFVFENVKFRQLQKE
K701-u	IREVPVTkLIDLEKS
Y830	CHRNVFRYLMAFLRE
T872	PNLMARQTPSDRQRA
S874	LMARQTPSDRQRAIQ

	mouse
K127	QLLVPEQKDSSSWyQ
Y133-p	QKDSSSWyQKLDTMD
T138	SWyQKLDTMDKPAYS
Y233	LTKREKEYVNIQSFR
T345	VATETTGTGIMGKMG
Y389	FERRNQDYKDICARM
T404-p	TFSVPNQtVPQVNIM
K448-u	NELHKLLkFDQLNIQ
K460	NIQRTQKKAFADFNE
Y476	EINFVPTYKyDSKTD
Y478-p	NFVPTYKyDSKTDRW
S527	TSDHKPVSALFHIGV
K577	EFFFENVKFRQLQKE
K700	IREVPVTKLIDLEED
Y837	CHRNVFRYLMAFLRE
T879	PNLMTRQTPNDRQHA
N881	LMTRQTPNDRQHAIQ

	rat
K127	QLLVPEQKDSSNWYQ
Y133	QKDSSNWYQKLDTKD
T138	NWYQKLDTKDKPAYS
Y232	LAKREKEYVNIQSFR
T344	IATETVGTGIMGKMG
Y388	FERRNQDYKDICARM
T403	SFSVPNQTLPQVNIM
K447	NELQKLLKFDQLNIQ
K459	NIQRTQKKAFVDFNE
Y475	EIKFIPTYKYDSKTD
Y477	KFIPTYKYDSKTDRW
S526	TSDHKPVSALFHIGV
K576	EFMFENVKFRQLQKE
K699	IREVPVTKLIDLEED
Y836	CHRNVFRYLMAFLRE
T878	PNLMARQTPSDRQRA
S880	LMARQTPSDRQRAIQ

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