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DOR-1 (human)

Overview DOR-1 delta opioid receptor, a G-protein coupled receptor. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. Receptor for enkephalins. Note: This description may include information from UniProtKB. Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR Cellular Component: postsynaptic membrane; integral to plasma membrane; cytoplasm; plasma membrane; nerve terminal; vesicle; lipid raft Molecular Function: protein binding Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; protein import into nucleus, translocation; neuropeptide signaling pathway; adult locomotory behavior; immune response; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein signaling, adenylate cyclase inhibiting pathway; regulation of sensory perception of pain Reference #:  P41143 (UniProtKB) Alt. Names/Synonyms: D-OR-1; delta opioid receptor 1; Delta-type opioid receptor; DOR-1; opioid receptor, delta 1; OPRD; OPRD1 Gene Symbols: OPRD1 Molecular weight: 40,369 Da Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states

Select Structure to View Below DOR-1 1OZC - A=1-372 (human) 2IQM - A=45-336 (human) 4EJ4 - A=251-342 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1OZC 2IQM  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
receptor desensitization, altered: S363‑p receptor internalization, altered: S363‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
3	0		T161	VKALDFRTPAKAKLI
1	0		Y318	SSLNPVLYAFLDENF
1	0		S344	CGRPDPSSFSRAREA
1	0		T352	FSRAREATARERVtA
2	0		A353	SRAREATARERVtAC
4	0		T358-p	ATARERVtACtPsDG
3	0		T361-p	RERVtACtPsDGPGG
10	0		S363-p	RVtACtPsDGPGGGA

	mouse
T161-p	VKALDFRtPAKAKLI
Y318-p	SSLNPVLyAFLDENF
S344-p	CGRQEPGsLRRPRQA
T352-p	LRRPRQAttRERVtA
T353-p	RRPRQAttRERVtAC
T358-p	AttRERVtACtPsDG
T361-p	RERVtACtPsDGPGG
S363-p	RVtACtPsDGPGGGA

	rat
T161-p	VKALDFRtPAKAKLI
Y318	SSLNPVLYAFLDENF
S344	CGGQEPGSLRRPRQA
T352	LRRPRQATARERVTA
A353	RRPRQATARERVTAC
T358	ATARERVTACTPSDG
T361	RERVTACTPSDGPGG
S363	RVTACTPSDGPGGGA

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