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Protein Page:
DOR-1 (human)

Overview
DOR-1 delta opioid receptor, a G-protein coupled receptor. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. Receptor for enkephalins. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1
Cellular Component: postsynaptic membrane; integral to plasma membrane; cytoplasm; plasma membrane; nerve terminal; intrinsic to plasma membrane; vesicle; lipid raft
Molecular Function: protein binding; opioid receptor activity
Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein coupled receptor protein signaling pathway; adult locomotory behavior; neuropeptide signaling pathway; protein import into nucleus, translocation; immune response; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of sensory perception of pain; G-protein signaling, adenylate cyclase inhibiting pathway; regulation of calcium ion transport
Reference #:  P41143 (UniProtKB)
Alt. Names/Synonyms: D-OR-1; delta opioid receptor 1; Delta-type opioid receptor; DOR-1; opioid receptor, delta 1; OPRD; OPRD1
Gene Symbols: OPRD1
Molecular weight: 40,369 Da
Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states
Select Structure to View Below

DOR-1

Protein Structure Not Found.


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Sites Implicated In
receptor desensitization, altered: S363‑p
receptor internalization, altered: S363‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
3 0 T161 VKALDFRTPAKAKLI
0 1 T211-p SPSWYWDtVtKICVF
0 1 T213-p SWYWDtVtKICVFLF
1 0 Y318 SSLNPVLYAFLDENF
1 0 S344 CGRPDPSSFSRAREA
1 0 T352 FSRAREATARERVtA
2 0 A353 SRAREATARERVtAC
4 0 T358-p ATARERVtACtPsDG
3 0 T361-p RERVtACtPsDGPGG
10 0 S363-p RVtACtPsDGPGGGA
  mouse

 
T161-p VKALDFRtPAKAKLI
T211 SPSWYWDTVTKICVF
T213 SWYWDTVTKICVFLF
Y318-p SSLNPVLyAFLDENF
S344-p CGRQEPGsLRRPRQA
T352-p LRRPRQAttRERVtA
T353-p RRPRQAttRERVtAC
T358-p AttRERVtACtPsDG
T361-p RERVtACtPsDGPGG
S363-p RVtACtPsDGPGGGA
  rat

 
T161-p VKALDFRtPAKAKLI
T211 SPSWYWDTVTKICVF
T213 SWYWDTVTKICVFLF
Y318 SSLNPVLYAFLDENF
S344 CGGQEPGSLRRPRQA
T352 LRRPRQATARERVTA
A353 RRPRQATARERVTAC
T358 ATARERVTACTPSDG
T361 RERVTACTPSDGPGG
S363 RVTACTPSDGPGGGA
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