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Protein Page:
PREX1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PREX1 Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. Interacts preferentially with RAC2. Interacts with RAC1. Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GEFs; GEFs, Rac/Rho
Cellular Component: growth cone; perinuclear region of cytoplasm; plasma membrane; dendritic shaft; cytosol
Molecular Function: protein binding; Rho guanyl-nucleotide exchange factor activity; enzyme binding; Rho GTPase activator activity; phospholipid binding
Biological Process: regulation of actin filament polymerization; regulation of Rho GTPase activity; neutrophil activation; actin filament polymerization; superoxide metabolic process; regulation of dendrite development; positive regulation of Rho GTPase activity
Reference #:  Q8TCU6 (UniProtKB)
Alt. Names/Synonyms: KIAA1415; P-Rex1; Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1; PREX1; PtdIns(3,4,5)-dependent Rac exchanger 1
Gene Symbols: PREX1
Molecular weight: 186,203 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PREX1

Protein Structure Not Found.


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Sites Implicated In
cell growth, induced: S1169‑p
activity, induced: S605‑p, S1169‑p
activity, inhibited: S313‑p, S319‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S313-p RVTGSKKsTKRTKsI
1 3 S319-p KsTKRTKsINGSLYI
1 3 S436-p KDRRRKLsTVPKCFL
0 1 S512 SELEDIMSKGVRLYC
1 0 S605-p DEEMEGTsSKNKQLR
0 1 K624-u LVENILAkRLLILPQ
0 5 K642-a YGFDIEEkNKAVVVK
0 3 T704-p PLRLLVAtKAKEIIK
1 0 S805-p ARASQEAsTEDPSGE
1 0 S834-p LSLGPRLsLCEDSPM
1 15 S1001-p IRFGRKPsLIGLDPE
1 0 S1049-p GQGLHDGsFGPASGT
0 1 Y1096 ALKEMKQYVTQINRL
1 0 S1125-p ASLAEEAsSLPLVSE
0 1 L1127 LAEEAsSLPLVSEES
1 0 S1165-p DSGHDTMsYRDsYSE
2 0 S1169-p DTMsYRDsYSECNSN
1 1 S1182-p SNRDSVLsYTSVRSN
0 1 S1185 DSVLsYTSVRSNSsY
1 0 S1191-p TSVRSNSsYLGsDEM
0 1 S1195-p SNSsYLGsDEMGsGD
1 2 S1200-p LGsDEMGsGDELPCD
  mouse

 
S308 RVTGSKKSTKRTKsI
S314-p KSTKRTKsINGSLYI
S431-p KDRRRKLsTVPKCFL
S507-p SELEDIMsKGVRLYC
S600 DEEMEGTSSKNKQLR
K619 LVENILAKRLLIPPQ
K637 YGFDLEEKNKAVVVK
T699 PLRLLVATKAKETIK
P800 ARASQGAPDEDPQED
S824 LSLGPQLSLHEDSAV
S991-p IRFGRKPsLIGLDPE
S1038 GQGLNDSSYGSASGA
Y1085-p ALKEMKQyVTQINRL
S1116 PSLVEETSSsPPVSE
S1118-p LVEETSSsPPVSEES
S1156 DSGHDTMSYRDSYSE
S1160 DTMSYRDSYSECNSN
S1173-p SNRDSVLsYTsVRSN
S1176-p DSVLsYTsVRSNSSY
S1182 TsVRSNSSYLGsDEM
S1186-p SNSSYLGsDEMGsGD
S1191-p LGsDEMGsGDELPCD
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