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Protein Page:
CHD-2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CHD-2 Sequence-selective DNA-binding protein. Belongs to the SNF2/RAD54 helicase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Helicase; EC 3.6.4.12; DNA binding protein; EC 3.6.1.-
Cellular Component: nucleus
Molecular Function: ATP-dependent DNA helicase activity; DNA binding; histone binding; ATP binding
Biological Process: regulation of transcription from RNA polymerase II promoter; muscle development; transcription, DNA-dependent; chromatin modification; response to DNA damage stimulus; DNA duplex unwinding
Reference #:  O14647 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase CHD2; CHD-2; CHD2; chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2; DKFZp547I1315; DKFZp686E01200; DKFZp781D1727; FLJ38614
Gene Symbols: CHD2
Molecular weight: 211,344 Da
Basal Isoelectric point: 8.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CHD-2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S20 SSLHSNASSHSASEE
0 1 S21 SLHSNASSHSASEEA
0 6 K85-a VLPEAKEkPASKkER
0 6 K90-a KEkPASKkERIADVK
0 5 S156-p EKWKQEPsEDEQEQG
0 4 T164-p EDEQEQGtsAEsEPE
0 4 S165-p DEQEQGtsAEsEPEQ
0 5 S168-p EQGtsAEsEPEQKKV
0 6 S207-p GKRKKQDssDEDDDD
0 6 S208-p KRKKQDssDEDDDDD
0 13 T240-p KEDDDFEtDsDDLIE
0 13 S242-p DDDFEtDsDDLIEMT
0 1 Y737-p KWILTRNyKALAKGT
0 1 S747-p LAKGTRGsTSGFLNI
0 1 S1012-p RENEVSTsATDELLS
0 119 Y1068-p QKELEEIyMLPRIRS
0 1 S1085-p KKAQTNDsDSDTESK
0 12 S1365-p EHGIELSsPRHsDNP
0 2 S1369-p ELSsPRHsDNPsEEG
0 4 S1373-p PRHsDNPsEEGEVKD
0 2 S1386-p KDDGLEKsPMKKKQK
0 1 S1406 ENKEKQMSSRKDKEG
0 2 S1429-p DKKEKPKsGDAKSSS
0 1 S1728-p HDSKRRRsDEFRPQN
0 1 S1792-p SDPRSPPsQKsPHDS
0 6 S1795-p RSPPsQKsPHDSKsP
0 1 S1799 sQKsPHDSKsPLDHR
0 8 S1801-p KsPHDSKsPLDHRsP
0 8 S1807-p KsPLDHRsPLERSLE
  mouse

 
S20-p SSLHSNAssRSASEE
S21-p SLHSNAssRSASEEV
K85 VLPEAKEKPASKKER
K90 KEKPASKKERIADVK
S156 EKWKQDPSEDEQEQG
T164 EDEQEQGTSAESEAE
S165 DEQEQGTSAESEAEQ
S168 EQGTSAESEAEQKKG
S207-p GKRKKQEssDDDDDD
S208-p KRKKQEssDDDDDDD
T240-p KEDDDFEtDsDDLIE
S242-p DDDFEtDsDDLIEMT
Y737 KWILTRNYKALAKGT
S747 LAKGTRGSTSGFLNI
S1012 RENEVSTSATDELLS
Y1068-p QKELEEIyMLPRIRS
S1085 KKAQTNDSDSDTESK
S1365-p EHGLEPAsPRHsDNP
S1369-p EPAsPRHsDNPsEEG
S1373-p PRHsDNPsEEGEVKD
S1386 KDDGLEKSPTKKKQK
S1406-p ENKEKPVsSRKDREG
G1429 DKKEKVKGGDGKSSS
S1727 HDSKRRRSDDFRPQN
S1791-p SDPRSPPsQKsPHDs
S1794-p RSPPsQKsPHDsKsP
S1798-p sQKsPHDsKsPLDHR
S1800-p KsPHDsKsPLDHRsP
S1806-p KsPLDHRsPLERSLE
  rat

 
S20 SSLHSNASSHSASEE
S21 SLHSNASSHSASEEA
K85 VLPEAKEKPASKKER
K90 KEKPASKKERIADVK
S156 EKWKQDPSEDDQEQG
S164 EDDQEQGSSAESEAE
S165 DDQEQGSSAESEAEQ
S168 EQGSSAESEAEQKKV
S207 GKRKKQESSDDDDDD
S208 KRKKQESSDDDDDDD
T240-p KEDDDFEtDsDDLIE
S242-p DDDFEtDsDDLIEMT
Y744 KWILTRNYKALAKGT
S754 LAKGTRGSTSGFLNI
S1019 RENEVSTSATDELLS
Y1075 QKELEEIYMLPRIRS
S1092 KKAQTNDSDSDTESK
S1372 EHGLELSSPRHSDNP
S1376 ELSSPRHSDNPSEEG
S1380 PRHSDNPSEEGEVKD
S1393 KDDGLEKSPTKKKQK
S1413 ENKEKPVSSRKDREG
G1436 DKKEKVKGGDAKSSS
S1734 HDSKRRRSDDFRPQN
A1798 SDPRSPPAQKSPHDS
S1801 RSPPAQKSPHDSKSP
S1805 AQKSPHDSKSPLDHR
S1807 KSPHDSKSPLDHRSP
S1813 KSPLDHRSPLERSLE
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