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Protein Page:
CHD-2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CHD-2 Sequence-selective DNA-binding protein. Belongs to the SNF2/RAD54 helicase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.12; Helicase; DNA binding protein; EC 3.6.1.-
Cellular Component: nucleus
Molecular Function: ATP-dependent DNA helicase activity; DNA binding; histone binding; ATP binding
Biological Process: regulation of transcription from RNA polymerase II promoter; muscle development; transcription, DNA-dependent; chromatin modification; response to DNA damage stimulus; DNA duplex unwinding
Reference #:  O14647 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase CHD2; CHD-2; CHD2; chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2; DKFZp547I1315; DKFZp686E01200; DKFZp781D1727; FLJ38614
Gene Symbols: CHD2
Molecular weight: 211,344 Da
Basal Isoelectric point: 8.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CHD-2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S20 SSLHSNASSHSASEE
0 1 S21 SLHSNASSHSASEEA
0 1 S33 EEASGSDSGSQSESE
0 1 S68 ESQSESESESAGSKS
0 1 S70 QSESESESAGSKSQP
0 1 K83-ac QPVLPEAkEkPASKk
0 6 K85-ac VLPEAkEkPASKkER
0 1 S88 EAkEkPASKkERIAD
0 6 K90-ac kEkPASKkERIADVK
0 1 S136-p SSGSESGsPKRRGQR
0 5 S156-p EKWKQEPsEDEQEQG
0 4 T164-p EDEQEQGtsAEsEPE
0 4 S165-p DEQEQGtsAEsEPEQ
0 5 S168-p EQGtsAEsEPEQKKV
0 7 S207-p GKRKKQDssDEDDDD
0 7 S208-p KRKKQDssDEDDDDD
0 14 T240-p KEDDDFEtDsDDLIE
0 14 S242-p DDDFEtDsDDLIEMT
0 1 T262-p EQQDNSEtIEKVLDs
0 1 S269-p tIEKVLDsRLGKKGA
0 1 T282-p GATGASTtVYAIEAN
0 1 Y596-p FNALITTyEILLKDK
0 1 Y728-p MSALQKQyyKWILTR
0 1 Y729-p SALQKQyyKWILTRN
0 1 Y737-p KWILTRNyKALAKGT
0 1 S747-p LAKGTRGsTSGFLNI
0 1 Y766-p KKCCNHCyLIKPPEE
0 1 T828-p DILAEYLtIKHYPFQ
0 1 S840-p PFQRLDGsIKGEIRK
0 1 S1012-p RENEVSTsATDELLs
0 1 S1019-p sATDELLsQFKVANF
0 115 Y1068-p QKELEEIyMLPRIRS
0 1 T1082-p SSTKKAQtNDsDsDt
0 2 S1085-p KKAQtNDsDsDtEsK
0 1 S1087-p AQtNDsDsDtEsKRQ
0 2 T1089-p tNDsDsDtEsKRQAQ
0 2 S1091-p DsDsDtEsKRQAQRS
0 1 T1105-p SSASESEtEDsDDDK
0 1 S1108-p SESEtEDsDDDKKPK
0 1 K1141-ub AEIRRFIkAYKKFGL
0 1 T1209-p PGKRRGPtIKISGVQ
0 1 Y1316 QLQTRADYLLKLLRK
0 1 K1338-ac VTGGEEAkLKKRKPR
0 13 S1365-p EHGIELSsPRHsDNP
0 3 S1369-p ELSsPRHsDNPsEEG
0 5 S1373-p PRHsDNPsEEGEVKD
0 2 S1386-p KDDGLEKsPMKKKQK
0 1 S1406 ENKEKQMSSRKDKEG
0 2 S1429-p DKKEKPKsGDAKsSS
0 1 S1434-p PKsGDAKsSSKSKRs
0 1 S1441-p sSSKSKRsQGPVHIt
0 1 T1448-p sQGPVHItAGSEPVP
0 1 R1546-m1 KFTEFDArKLHKLYK
0 1 S1695-p SYRPNNMsRKRPYDQ
0 1 Y1700 NMsRKRPYDQYSSDR
0 1 Y1703 RKRPYDQYSSDRDHR
0 1 Y1715-p DHRGHRDyYDRHHHD
0 1 S1728-p HDSKRRRsDEFRPQN
0 2 S1745-p QQDFRRMsDHRPAMG
0 1 Y1762-p GQGPSDHyRSFHTDK
0 2 S1792-p SDPRSPPsQKsPHDs
0 7 S1795-p RSPPsQKsPHDsKsP
0 2 S1799-p sQKsPHDsKsPLDHR
0 10 S1801-p KsPHDsKsPLDHRsP
0 10 S1807-p KsPLDHRsPLERSLE
0 1 Y1821-p EQKNNPDyNWNVRKt
0 1 T1828-p yNWNVRKt_______
  mouse

 
S20-p SSLHSNAssRSASEE
S21-p SLHSNAssRSASEEV
S33-p EEVSGSDsGSQSESE
S68-p ESQSESEsEsAGSKS
S70-p QSESEsEsAGSKSQP
K83 QPVLPEAKEKPAsKK
K85 VLPEAKEKPAsKKER
S88-p EAKEKPAsKKERIAD
K90 KEKPAsKKERIADVK
S136 SSGSESGSPKRRGQR
S156 EKWKQDPSEDEQEQG
T164 EDEQEQGTSAESEAE
S165 DEQEQGTSAESEAEQ
S168 EQGTSAESEAEQKKG
S207-p GKRKKQEssDDDDDD
S208-p KRKKQEssDDDDDDD
T240-p KEDDDFEtDsDDLIE
S242-p DDDFEtDsDDLIEMT
T262 EQQDNSETIEKVLDS
S269 TIEKVLDSRLGKKGA
T282 GATGASTTVYAVEAN
Y596 FNALITTYEILLKDK
Y728 MSALQKQYYKWILTR
Y729 SALQKQYYKWILTRN
Y737 KWILTRNYKALAKGT
S747 LAKGTRGSTSGFLNI
Y766 KKCCNHCYLIKAPED
T828 DILAEYLTIKHYPFQ
S840 PFQRLDGSIKGEIRK
S1012 RENEVSTSATDELLS
S1019 SATDELLSQFKVANF
Y1068-p QKELEEIyMLPRIRS
T1082 SSTKKAQTNDSDSDT
S1085 KKAQTNDSDSDTESK
S1087 AQTNDSDSDTESKRQ
T1089 TNDSDSDTESKRQAQ
S1091 DSDSDTESKRQAQRS
T1105 SSASESETDDSDDDK
S1108 SESETDDSDDDKKPK
K1141 AEIRRFIKAYKKFGL
T1209 PGKRRGPTIKISGVQ
Y1316-p QLQTRVDyLLKLLRK
K1338 VASGEEAKLKKRKPR
S1365-p EHGLEPAsPRHsDNP
S1369-p EPAsPRHsDNPsEEG
S1373-p PRHsDNPsEEGEVKD
S1386 KDDGLEKSPTKKKQK
S1406-p ENKEKPVsSRKDREG
G1429 DKKEKVKGGDGKSSS
S1434 VKGGDGKSSSKSKRS
S1441 SSSKSKRSQGPVHIT
T1448 SQGPVHITAGSEPVP
R1546 KFTEFDARKLHKLYK
S1694 SYRPNNMSRKRPYEQ
Y1699 NMSRKRPYEQYNSDR
Y1702 RKRPYEQYNSDRDHR
Y1714 DHRGHRDYYDRHHHD
S1727 HDSKRRRSDDFRPQN
S1744 QQDFRRMSDHRPTMG
Y1761 GQGPSDHYRSFHTDK
S1791-p SDPRSPPsQKsPHDs
S1794-p RSPPsQKsPHDsKsP
S1798-p sQKsPHDsKsPLDHR
S1800-p KsPHDsKsPLDHRsP
S1806-p KsPLDHRsPLERSLE
Y1820 EQKNNPDYNWNVRKT
T1827 YNWNVRKT_______
  rat

 
S20 SSLHSNASSHSASEE
S21 SLHSNASSHSASEEA
S33 EEASASDSGSQSESE
S68 ESQSESESESAGSKS
S70 QSESESESAGSKSQP
K83 QPVLPEAKEKPASKK
K85 VLPEAKEKPASKKER
S88 EAKEKPASKKERIAD
K90 KEKPASKKERIADVK
S136 SSGSESGSPKRRGQR
S156 EKWKQDPSEDDQEQG
S164 EDDQEQGSSAESEAE
S165 DDQEQGSSAESEAEQ
S168 EQGSSAESEAEQKKV
S207 GKRKKQESSDDDDDD
S208 KRKKQESSDDDDDDD
T240-p KEDDDFEtDsDDLIE
S242-p DDDFEtDsDDLIEMT
T262 EQQDNSETIEKVLDS
S269 TIEKVLDSRLGKKGV
T289 AATGASTTVYAVEAN
Y603 FNALITTYEILLKDK
Y735 MSALQKQYYKWILTR
Y736 SALQKQYYKWILTRN
Y744 KWILTRNYKALAKGT
S754 LAKGTRGSTSGFLNI
Y773 KKCCNHCYLIRAPED
T835 DILAEYLTIKHYPFQ
S847 PFQRLDGSIKGEIRK
S1019 RENEVSTSATDELLS
S1026 SATDELLSQFKVANF
Y1075 QKELEEIYMLPRIRS
T1089 SSTKKAQTNDSDSDT
S1092 KKAQTNDSDSDTESK
S1094 AQTNDSDSDTESKRQ
T1096 TNDSDSDTESKRQAQ
S1098 DSDSDTESKRQAQRS
T1112 SSASESETDDSDDDK
S1115 SESETDDSDDDKKPK
K1148 AEIRRFIKAYKKFGL
T1216 PGKRRGPTIKISGVQ
Y1323 QLQTRVDYLLKLLRK
K1345 VTSGEEAKLKKRKPR
S1372 EHGLELSSPRHSDNP
S1376 ELSSPRHSDNPSEEG
S1380 PRHSDNPSEEGEVKD
S1393 KDDGLEKSPTKKKQK
S1413 ENKEKPVSSRKDREG
G1436 DKKEKVKGGDAKSSS
S1441 VKGGDAKSSSKSKRS
S1448 SSSKSKRSQGPVHIT
T1455 SQGPVHITAGSEPVP
R1553 KFTEFDARKLHKLYK
S1701 SYRPNNMSRKRPyEQ
Y1706-p NMSRKRPyEQyNSDR
Y1709-p RKRPyEQyNSDRDHR
Y1721 DHRGHRDYYDRHHHD
S1734 HDSKRRRSDDFRPQN
S1751 QQDFRRMSDHRPTMG
Y1768 GQGPSDHYRSFHTDK
A1798 SDPRSPPAQKSPHDS
S1801 RSPPAQKSPHDSKSP
S1805 AQKSPHDSKSPLDHR
S1807 KSPHDSKSPLDHRSP
S1813 KSPLDHRSPLERSLE
Y1827 EQKNNPDYNWNVRKT
T1834 YNWNVRKT_______
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