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ATG4C (human)

Overview ATG4C Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Highly expressed in skeletal muscle, heart, liver and testis. Inhibited by N-ethylmaleimide. Belongs to the peptidase C54 family. Note: This description may include information from UniProtKB. Protein type: Autophagy; Ubiquitin conjugating system; EC 3.4.22.-; Protease Cellular Component: cytoplasm; extracellular region; cytosol Molecular Function: peptidase activity; cysteine-type endopeptidase activity Biological Process: autophagy; proteolysis; protein targeting to membrane; autophagic vacuole formation Reference #:  Q96DT6 (UniProtKB) Alt. Names/Synonyms: APG4 autophagy 4 homolog C; APG4-C; APG4C; ATG4 autophagy related 4 homolog C (S. cerevisiae); ATG4C; AUT-like 1, cysteine endopeptidase; AUT-like 3 cysteine endopeptidase; AUTL1; AUTL3; Autophagin-3; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C; Cysteine protease ATG4C; FLJ14867 Gene Symbols: ATG4C Molecular weight: 52,497 Da Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states CST Pathways:  Autophagy Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ATG4C

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S18-p	KLKTKFIsAWNNMKy
0	1		Y25-p	sAWNNMKySWVLKTK
0	1		T173	SGEREFKTPTISLKE
0	1		S177	EFKTPTISLKEtIGK
0	2		T181-p	PTISLKEtIGKysDD
0	1		Y185-p	LKEtIGKysDDHEMR
0	1		S186-p	KEtIGKysDDHEMRN
0	1		S369-p	LETFHCPsPKKMSFR
0	1		S381-p	SFRKMDPsCtIGFyC
0	1		T383-p	RKMDPsCtIGFyCRN
0	2		Y387-p	PsCtIGFyCRNVQDF
0	4		S451-p	KKQLKRFstEEFVLL
0	6		T452-p	KQLKRFstEEFVLL_

	mouse
S18	KLKTKFISAWNNMKY
Y25	SAWNNMKYSWVLKTK
T173-p	SGDRELRtPAVsLKE
S177-p	ELRtPAVsLKEtSGK
T181-p	PAVsLKEtSGKCPDD
C185	LKEtSGKCPDDHAVR
P186	KEtSGKCPDDHAVRN
S369-p	LETFHCPsPKKMSFR
S381	SFRKMDPSCTIGFYC
T383	RKMDPSCTIGFYCRN
Y387	PSCTIGFYCRNVQDF
S451-p	RKNFKRFstEEFVLL
T452-p	KNFKRFstEEFVLL_

	rat
S18	KLKTKFISAWNNMKY
Y25	SAWNNMKYSWVLKTK
T173	SGERELRTPAVSLKE
S177	ELRTPAVSLKETSGK
T181	PAVSLKETSGKHPDD
H185	LKETSGKHPDDHAVQ
P186	KETSGKHPDDHAVQS
S369	LETFHCPSPKKMSFR
S381	SFRKMDPSCTIGFyC
T383	RKMDPSCTIGFyCRN
Y387-p	PSCTIGFyCRNVQDF
S451	KKNFKRFSTEEFVLL
T452	KNFKRFSTEEFVLL_

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