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Protein Page:
ATG4C (human)

Overview
ATG4C Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Highly expressed in skeletal muscle, heart, liver and testis. Inhibited by N-ethylmaleimide. Belongs to the peptidase C54 family. Note: This description may include information from UniProtKB.
Protein type: Protease; EC 3.4.22.-; Ubiquitin conjugating system; Autophagy
Cellular Component: cytoplasm; extracellular region; cytosol
Molecular Function: peptidase activity; cysteine-type endopeptidase activity
Biological Process: autophagy; protein targeting to membrane; proteolysis; autophagic vacuole formation
Reference #:  Q96DT6 (UniProtKB)
Alt. Names/Synonyms: APG4 autophagy 4 homolog C; APG4-C; APG4C; ATG4 autophagy related 4 homolog C (S. cerevisiae); ATG4C; AUT-like 1, cysteine endopeptidase; AUT-like 3 cysteine endopeptidase; AUTL1; AUTL3; Autophagin-3; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C; Cysteine protease ATG4C; FLJ14867
Gene Symbols: ATG4C
Molecular weight: 52,497 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ATG4C

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T173 SGEREFKTPTISLKE
0 1 S177 EFKTPTISLKEtIGK
0 2 T181-p PTISLKEtIGKYSDD
0 2 S369-p LETFHCPsPKKMSFR
0 2 Y387-p PSCTIGFyCRNVQDF
0 5 S451-p KKQLKRFstEEFVLL
0 7 T452-p KQLKRFstEEFVLL_
  mouse

 
T173-p SGDRELRtPAVsLKE
S177-p ELRtPAVsLKEtSGK
T181-p PAVsLKEtSGKCPDD
S369-p LETFHCPsPKKMSFR
Y387 PSCTIGFYCRNVQDF
S451-p RKNFKRFstEEFVLL
T452-p KNFKRFstEEFVLL_
  rat

 
T173 SGERELRTPAVSLKE
S177 ELRTPAVSLKETSGK
T181 PAVSLKETSGKHPDD
S369 LETFHCPSPKKMSFR
Y387-p PSCTIGFyCRNVQDF
S451 KKNFKRFSTEEFVLL
T452 KNFKRFSTEEFVLL_
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