Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
CCND1 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CCND1 a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Note: This description may include information from UniProtKB.
Protein type: Activator protein; Nuclear receptor co-regulator
Cellular Component: tight junction; transcriptional repressor complex; membrane; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; intracellular; nucleus
Molecular Function: protein binding; enzyme binding; histone deacetylase binding; protein complex binding; kinase activity; cyclin-dependent protein kinase regulator activity; transcription corepressor activity; protein kinase binding; transcription factor binding; protein kinase activity
Biological Process: fat cell differentiation; lactation; G1 DNA damage checkpoint; re-entry into mitotic cell cycle; negative regulation of Wnt receptor signaling pathway; positive regulation of cyclin-dependent protein kinase activity; regulation of cell cycle; positive regulation of mammary gland epithelial cell proliferation; negative regulation of epithelial cell differentiation; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; Leydig cell differentiation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; Wnt receptor signaling pathway; transcription, DNA-dependent; unfolded protein response; mammary gland epithelial cell proliferation; response to organic nitrogen; cell cycle; cell division; regulation of cyclin-dependent protein kinase activity; positive regulation of protein amino acid phosphorylation; regulation of protein kinase activity; response to DNA damage stimulus; G1/S transition of mitotic cell cycle
Reference #:  P25322 (UniProtKB)
Alt. Names/Synonyms: AI327039; bcl-1; Ccnd1; cD1; CycD1; cyclin D1; Cyl-1; G1/S-specific cyclin-D1; OTTMUSP00000031858; PRAD1
Gene Symbols: Ccnd1
Molecular weight: 33,429 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CCND1

Protein Structure Not Found.


STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA


Sites Implicated In
cell cycle regulation: T286‑p, T288‑p
activity, induced: T286‑p
intracellular localization: T286‑p
molecular association, regulation: T286‑p
protein degradation: T286‑p, T288‑p
protein stabilization: T286‑p
ubiquitination: T286‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 4 K33 RVLRAMLKTEETCAP
0 12 K46-ub APSVSYFkCVQKEIV
0 2 K50 SYFkCVQKEIVPSMR
1 0 S90 NYLDRFLSLEPLKKS
0 4 K95 FLSLEPLKKSRLQLL
0 1 K96 LSLEPLKKSRLQLLG
0 1 S111 ATCMFVASKMKETIP
0 1 K114 MFVASKMKETIPLTA
0 1 S131 LCIYTDNSIRPEELL
0 1 K167 FIEHFLSKMPEADEN
0 5 K175 MPEADENKQTIRKHA
1 0 S197 ATDVKFISNPPSMVA
0 1 C226 SPNNFLSCYRTTHFL
1 0 S234 YRTTHFLSRVIkCDP
0 8 K238-ub HFLSRVIkCDPDCLR
1 0 K269 AQQNVDPKATEEEGE
26 4 T286-p EEAGLACtPtDVRDV
5 0 T288-p AGLACtPtDVRDVDI
  human

 
K33-ub RVLRAMLkAEETCAP
K46-ub APSVSYFkCVQkEVL
K50-ub SYFkCVQkEVLPSMR
S90-p NYLDRFLsLEPVkkS
K95-ub FLsLEPVkkSRLQLL
K96-ub LsLEPVkkSRLQLLG
S111-p ATCMFVAsKMkETIP
K114-ub MFVAsKMkETIPLTA
S131-p LCIYTDNsIRPEELL
K167-ub FIEHFLSkMPEAEEN
K175-ub MPEAEENkQIIRKHA
S197-p ATDVKFIsNPPSMVA
Y226-p SPNNFLSyYRLTRFL
S234-p YRLTRFLsRVIkCDP
K238-ub RFLsRVIkCDPDCLR
K269-ub AQQNMDPkAAEEEEE
T286-p EEVDLACtPtDVRDV
T288-p VDLACtPtDVRDVDI
3300 : Phospho-Cyclin D1 (Thr286) (D29B3) XP(R) Rabbit mAb
8497 : Phospho-Cyclin D1 (Thr286) (D29B3) XP(R) Rabbit mAb (PE Conjugate)
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.