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CCND1 (mouse)

Overview CCND1 a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Note: This description may include information from UniProtKB. Protein type: Activator protein; Nuclear receptor co-regulator Cellular Component: tight junction; membrane; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; intracellular; nucleus Molecular Function: protein binding; enzyme binding; protein complex binding; kinase activity; cyclin-dependent protein kinase regulator activity; protein kinase binding; protein kinase activity Biological Process: G1 DNA damage checkpoint; fat cell differentiation; lactation; negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway; re-entry into mitotic cell cycle; positive regulation of cyclin-dependent protein kinase activity; regulation of cell cycle; unfolded protein response; positive regulation of mammary gland epithelial cell proliferation; negative regulation of epithelial cell differentiation; mammary gland epithelial cell proliferation; Wnt receptor signaling pathway through beta-catenin; cell cycle; response to organic nitrogen; protein amino acid phosphorylation; Leydig cell differentiation; cell division; positive regulation of cell proliferation; regulation of cyclin-dependent protein kinase activity; positive regulation of protein amino acid phosphorylation; response to DNA damage stimulus; G1/S transition of mitotic cell cycle Reference #:  P25322 (UniProtKB) Alt. Names/Synonyms: AI327039; bcl-1; Ccnd1; cD1; CycD1; cyclin D1; Cyl-1; G1/S-specific cyclin-D1; OTTMUSP00000031858; PRAD1 Gene Symbols: Ccnd1 Molecular weight: 33,429 Da Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G1/S Checkpoint  |  PI3K/Akt Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CCND1 2W96 - A=1-271 (human) 2W99 - A=1-271 (human) 2W9F - A=1-271 (human) 2W9Z - A=16-271 (human)

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	Sites Implicated In
cell cycle regulation: T286‑p, T288‑p activation: T286‑p intracellular localization: T286‑p molecular association, regulation: T286‑p protein degradation: T286‑p, T288‑p protein stabilization: T286‑p ubiquitination: T286‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	4		K33	RVLRAMLKTEETCAP
0	12		K46-u	APSVSYFkCVQKEIV
0	2		K50	SYFkCVQKEIVPSMR
1	0		S90	NYLDRFLSLEPLKKS
0	4		K95	FLSLEPLKKSRLQLL
0	1		K96	LSLEPLKKSRLQLLG
0	1		K114	MFVASKMKETIPLTA
0	1		S131	LCIYTDNSIRPEELL
0	1		K167	FIEHFLSKMPEADEN
0	5		K175	MPEADENKQTIRKHA
1	0		S197	ATDVKFISNPPSMVA
0	1		C226	SPNNFLSCYRTTHFL
1	0		S234	YRTTHFLSRVIkCDP
0	8		K238-u	HFLSRVIkCDPDCLR
1	0		K269	AQQNVDPKATEEEGE
24	3		T286-p	EEAGLACtPtDVRDV
5	0		T288-p	AGLACtPtDVRDVDI

	human
K33-u	RVLRAMLkAEETCAP
K46-u	APSVSYFkCVQkEVL
K50-u	SYFkCVQkEVLPSMR
S90-p	NYLDRFLsLEPVkkS
K95-u	FLsLEPVkkSRLQLL
K96-u	LsLEPVkkSRLQLLG
K114-u	MFVASKMkETIPLTA
S131-p	LCIYTDNsIRPEELL
K167-u	FIEHFLSkMPEAEEN
K175-u	MPEAEENkQIIRKHA
S197-p	ATDVKFIsNPPSMVA
Y226-p	SPNNFLSyYRLTRFL
S234-p	YRLTRFLsRVIkCDP
K238-u	RFLsRVIkCDPDCLR
K269-u	AQQNMDPkAAEEEEE
T286-p	EEVDLACtPtDVRDV
T288-p	VDLACtPtDVRDVDI

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