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syndecan-2 (human)

Overview syndecan-2 a heparan sulfate proteoglycan type I membrane protein that belongs to the syndecan proteoglycan family. Preferentially expressed in cells of mesenchymal origin. Is tyrosine phosphorylated and forms a complex with EphB2 in mouse brain. Plays a role in mediating adhesion and proliferation of colon carcinoma cells. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Cell adhesion; Cell surface; Motility/polarity/chemotaxis Cellular Component: lysosomal lumen; cell soma; Golgi lumen; integral to plasma membrane; plasma membrane; synapse Molecular Function: protein binding; cytoskeletal protein binding; PDZ domain binding Biological Process: chondroitin sulfate metabolic process; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; wound healing; dendrite morphogenesis; carbohydrate metabolic process; response to hypoxia; response to caffeine Reference #:  P34741 (UniProtKB) Alt. Names/Synonyms: cell surface-associated heparan sulfate proteoglycan 1; Fibroglycan; heparan sulfate proteoglycan 1, cell surface-associated; Heparan sulfate proteoglycan core protein; HSPG; HSPG1; SDC2; SYND2; syndecan 2; syndecan proteoglycan 2; Syndecan-2 Gene Symbols: SDC2 Molecular weight: 22,160 Da Basal Isoelectric point: 4.75  Predict pI for various phosphorylation states

Select Structure to View Below syndecan-2

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	Sites Implicated In
molecular association, regulation: Y179‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	8		K174-u	LVYRMRKkDEGSyDL
0	1		S41-p	NSSIEEAsGVYPIDD
2	7		Y179-p	RKkDEGSyDLGErkP
0	1		R184-m1	GSyDLGErkPssAAy
0	10		K185-u	SyDLGErkPssAAyQ
1	14		S187-p	DLGErkPssAAyQkA
1	2		S188-p	LGErkPssAAyQkAP
1	9		Y191-p	rkPssAAyQkAPtkE
0	8		K193-u	PssAAyQkAPtkEFy
0	1		T196-p	AAyQkAPtkEFyA__
0	8		K197-u	AyQkAPtkEFyA___
0	26		Y200-p	kAPtkEFyA______

	mouse
K175-u	LVYRMRKkDEGSYDL
S41	NSSIEEASGVYPIDD
Y180	RKkDEGSYDLGERKP
R185	GSYDLGERKPsSAAy
K186	SYDLGERKPsSAAyQ
S188-p	DLGERKPsSAAyQkA
S189	LGERKPsSAAyQkAP
Y192-p	RKPsSAAyQkAPTKE
K194-u	PsSAAyQkAPTKEFy
T197	AAyQkAPTKEFyA__
K198	AyQkAPTKEFyA___
Y201-p	kAPTKEFyA______

	rat
K174	LVYRMRKKDEGSyDL
S41	SSSIEEASGLYPIDD
Y179-p	RKKDEGSyDLGERKP
R184	GSyDLGERKPssAAy
K185	SyDLGERKPssAAyQ
S187-p	DLGERKPssAAyQKA
S188-p	LGERKPssAAyQKAP
Y191-p	RKPssAAyQKAPTKE
K193	PssAAyQKAPTKEFY
T196	AAyQKAPTKEFYA__
K197	AyQKAPTKEFYA___
Y200	KAPTKEFYA______

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